메뉴 건너뛰기




Volumn 16, Issue 8, 2015, Pages 18865-18877

Major alterations of phosphatidylcholine and lysophosphotidylcholine lipids in the substantia nigra using an early stage model of parkinson’s disease

Author keywords

6 hydroxydopamine; Early stage model; HPLC ESI MS MS; Lipidomic profile; Parkinson s disease

Indexed keywords

LYSOPHOSPHATIDYLCHOLINE; OXIDOPAMINE; PHOSPHATIDYLCHOLINE;

EID: 84939214960     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160818865     Document Type: Article
Times cited : (57)

References (57)
  • 1
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K., Seiteiberger, F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 1973, 20, 415-455.
    • (1973) J. Neurol. Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seiteiberger, F.5
  • 2
    • 5444269702 scopus 로고    scopus 로고
    • Parkinson’s disease: Clinical aspects
    • Klockgether, T. Parkinson’s disease: Clinical aspects. Cell Tissue Res. 2004, 318, 115-120.
    • (2004) Cell Tissue Res , vol.318 , pp. 115-120
    • Klockgether, T.1
  • 3
    • 33745232788 scopus 로고    scopus 로고
    • Treatment of depression in Parkinson’s disease
    • Menza, M., Donkin, R., Marin, H. Treatment of depression in Parkinson’s disease. Curr. Psychiatry Rep. 2006, 8, 234-240.
    • (2006) Curr. Psychiatry Rep , vol.8 , pp. 234-240
    • Menza, M.1    Donkin, R.2    Marin, H.3
  • 4
    • 0033613715 scopus 로고    scopus 로고
    • Relationships between striatal dopamine denervation and frontal executive tests in Parkinson’s disease
    • Marié, R., Barré, L., Dupuy, B., Viader, F., Defer, G., Baron, J. Relationships between striatal dopamine denervation and frontal executive tests in Parkinson’s disease. Neurosci. Lett. 1999, 260, 77-80.
    • (1999) Neurosci. Lett , vol.260 , pp. 77-80
    • Marié, R.1    Barré, L.2    Dupuy, B.3    Viader, F.4    Defer, G.5    Baron, J.6
  • 5
    • 84938563871 scopus 로고    scopus 로고
    • Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease. Front
    • Farmer, K., Rudyk, C., Prowse, N.A., Hayley, S. Hematopoietic cytokines as therapeutic players in early stages Parkinson’s disease. Front. Aging Neurosci. 2015, 7, 126.
    • (2015) Aging Neurosci , vol.7 , pp. 126
    • Farmer, K.1    Rudyk, C.2    Prowse, N.A.3    Hayley, S.4
  • 8
    • 71849084134 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson’s disease
    • Winklhofer, K.F., Haass, C. Mitochondrial dysfunction in Parkinson’s disease. Biochim. Biophys. Acta 2010, 1802, 29-44.
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 29-44
    • Winklhofer, K.F.1    Haass, C.2
  • 12
    • 17144369859 scopus 로고    scopus 로고
    • Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer
    • Goonesinghe, A., Mundy, E.S., Smith, M., Khosravi-Far, R., Martinou, J.-C; Esposti, M.D. Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer. Biochem. J. 2005, 357, 109-118.
    • (2005) Biochem. J , vol.357 , pp. 109-118
    • Goonesinghe, A.1    Mundy, E.S.2    Smith, M.3    Khosravi-Far, R.4    Martinou, J.-C.5    Esposti, M.D.6
  • 13
    • 65249100646 scopus 로고    scopus 로고
    • Effects of lysophosphatidylcholine on ß-amyloid-induced neuronal apoptosis. Acta Pharmacol
    • Qin, Z., Zhu, H., Hu, Y. Effects of lysophosphatidylcholine on ß-amyloid-induced neuronal apoptosis. Acta Pharmacol. Sin. 2009, 30, 388-395.
    • (2009) Sin , vol.30 , pp. 388-395
    • Qin, Z.1    Zhu, H.2    Hu, Y.3
  • 14
    • 84896453676 scopus 로고    scopus 로고
    • Sphingolipids: Key regulators of apoptosis and pivotal players in cancer drug resistance
    • Giussani, P., Tringali, C., Riboni, L., Viani, P., Venerando, B. Sphingolipids: Key regulators of apoptosis and pivotal players in cancer drug resistance. Int. J. Mol. Sci. 2014, 15, 4356-4392.
    • (2014) Int. J. Mol. Sci , vol.15 , pp. 4356-4392
    • Giussani, P.1    Tringali, C.2    Riboni, L.3    Viani, P.4    Venerando, B.5
  • 15
    • 2342530364 scopus 로고    scopus 로고
    • Cell membranes and apoptosis: Role of cardiolipin, phosphatidylcholine, and anticancer lipid
    • Wright, M.M., Howe, A.G., Zaremberg, V. Cell membranes and apoptosis: Role of cardiolipin, phosphatidylcholine, and anticancer lipid. Biochem. Cell Biol. 2004, 26, 18-26.
    • (2004) Biochem. Cell Biol , vol.26 , pp. 18-26
    • Wright, M.M.1    Howe, A.G.2    Zaremberg, V.3
  • 16
    • 80051667804 scopus 로고    scopus 로고
    • Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1
    • Gulshan, K., Moye-Rowley, W.S. Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1. Traffic 2011, 12, 1257-1268.
    • (2011) Traffic , vol.12 , pp. 1257-1268
    • Gulshan, K.1    Moye-Rowley, W.S.2
  • 18
    • 67650432423 scopus 로고    scopus 로고
    • Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: A time course study in a 6-hydroxydopamine model of Parkinson’s disease
    • Marinova-Mutafchieva, L., Sadeghian, M., Broom, L., Davis, J.B., Medhurst, A.D., Dexter, D.T. Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: A time course study in a 6-hydroxydopamine model of Parkinson’s disease. J. Neurochem. 2009, 110, 966-975.
    • (2009) J. Neurochem , vol.110 , pp. 966-975
    • Marinova-Mutafchieva, L.1    Sadeghian, M.2    Broom, L.3    Davis, J.B.4    Medhurst, A.D.5    Dexter, D.T.6
  • 19
    • 84896112929 scopus 로고    scopus 로고
    • Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson’s disease
    • Stott, S.R.W., Barker, R.A. Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson’s disease. Eur. J. Neurosci. 2014, 39, 1042-1056.
    • (2014) Eur. J. Neurosci , vol.39 , pp. 1042-1056
    • Stott, S.1    Barker, R.A.2
  • 20
    • 84864280408 scopus 로고    scopus 로고
    • A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats
    • Choudhury, M.E., Sugimoto, K., Kubo, M., Nagai, M., Nomoto, M., Takahashi, H., Yano, H., Tanaka, J. A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats. Brain Behav. 2011, 1, 26-43.
    • (2011) Brain Behav , vol.1 , pp. 26-43
    • Choudhury, M.E.1    Sugimoto, K.2    Kubo, M.3    Nagai, M.4    Nomoto, M.5    Takahashi, H.6    Yano, H.7    Tanaka, J.8
  • 21
    • 84884504550 scopus 로고    scopus 로고
    • Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration
    • Hernandes, M.S., Santos, G.D.R., Cafe-Mendes, C.C., Lima, L.S., Scavone, C., Munhoz, C.D., Britto, L.R.G. Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration. PLoS ONE 2013, 5, e75532.
    • (2013) Plos ONE , vol.75532 , pp. 5
    • Hernandes, M.S.1    Santos, G.2    Cafe-Mendes, C.C.3    Lima, L.S.4    Scavone, C.5    Munhoz, C.D.6    Britto, L.7
  • 22
    • 84887517269 scopus 로고    scopus 로고
    • Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine
    • Goes, A.T.R., Souza, L.C., Filho, C.B., del Fabbro, L., de Gomes, M.G., Boeira, S.P., Jesse, C.R. Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine. Neuroscience 2013, 256, 61-71.
    • (2013) Neuroscience , vol.256 , pp. 61-71
    • Goes, A.1    Souza, L.C.2    Filho, C.B.3    Del Fabbro, L.4    De Gomes, M.G.5    Boeira, S.P.6    Jesse, C.R.7
  • 23
    • 33646849308 scopus 로고    scopus 로고
    • 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta
    • Hanrott, K., Gudmunsen, L., O’Neill, M.J., Wonnacott, S. 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J. Biol. Chem. 2006, 251, 5373-5382.
    • (2006) J. Biol. Chem , vol.251 , pp. 5373-5382
    • Hanrott, K.1    Gudmunsen, L.2    O’Neill, M.J.3    Wonnacott, S.4
  • 25
    • 0036400817 scopus 로고    scopus 로고
    • Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
    • Wright, M.M., McMaster, C.R. Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. Biol. Res. 2002, 35, 223-229.
    • (2002) Biol. Res , vol.35 , pp. 223-229
    • Wright, M.M.1    McMaster, C.R.2
  • 26
    • 0032487663 scopus 로고    scopus 로고
    • Fatty acid incorporation depicts brain activity in a rat model of Parkinson’s disease
    • Hayakawa, T., Chang, M.C.J., Bell, J.M., Seeman, R., Rapoport, S.I., Appel, N.M. Fatty acid incorporation depicts brain activity in a rat model of Parkinson’s disease. Brain Res. 1998, 507, 177-181.
    • (1998) Brain Res , vol.507 , pp. 177-181
    • Hayakawa, T.1    Chang, M.2    Bell, J.M.3    Seeman, R.4    Rapoport, S.I.5    Appel, N.M.6
  • 27
    • 77953534900 scopus 로고    scopus 로고
    • Brain arachidonic acid cascade enzymes are up-regulated in a rat model of unilateral parkinson disease. Neurochem
    • Lee, H.-J., Bazinet, R.P., Rapoport, S.I., Bhattacharjee, A.K. Brain arachidonic acid cascade enzymes are up-regulated in a rat model of unilateral parkinson disease. Neurochem. Res. 2010, 35, 613-619.
    • (2010) Res , vol.35 , pp. 613-619
    • Lee, H.-J.1    Bazinet, R.P.2    Rapoport, S.I.3    Bhattacharjee, A.K.4
  • 28
    • 0036719167 scopus 로고    scopus 로고
    • I-PLA2 Activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation
    • Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, K.B. I-PLA2 Activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J. Exp. Med. 2002, 196, 655-665.
    • (2002) J. Exp. Med , vol.196 , pp. 655-665
    • Kim, S.J.1    Gershov, D.2    Ma, X.3    Brot, N.4    Elkon, K.B.5
  • 29
    • 0029033619 scopus 로고
    • Bcl-x and Bcl-2 inhibit TN and Fas-induced apoptosis and activation of phospholipase A1 in breast carcinoma cells
    • Jaattela, M., Benedict, M., Tewari, M., Shayman, J.A., Dixit, V.M. Bcl-x and Bcl-2 inhibit TN and Fas-induced apoptosis and activation of phospholipase A1 in breast carcinoma cells. Oncogene 1995, 10, 2297-2305.
    • (1995) Oncogene , vol.10 , pp. 2297-2305
    • Jaattela, M.1    Benedict, M.2    Tewari, M.3    Shayman, J.A.4    Dixit, V.M.5
  • 31
    • 33846641782 scopus 로고    scopus 로고
    • Lipid-lowering drugs in the MPTP mouse model of Parkinson’s disease: Fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not
    • Kreisler, A., Gelé, P., Wiart, J.-F., Lhermitte, M., Destée, A., Bordet, R. Lipid-lowering drugs in the MPTP mouse model of Parkinson’s disease: Fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not. Brain Res. 2007, 1135, 77-84.
    • (2007) Brain Res , vol.1135 , pp. 77-84
    • Kreisler, A.1    Gelé, P.2    Wiart, J.-F.3    Lhermitte, M.4    Destée, A.5    Bordet, R.6
  • 32
    • 77952683867 scopus 로고    scopus 로고
    • Mandrup, S. PPAR-y is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction
    • Ravnsjkjaer, K., Frigerio, F., Boegesen, M., Nielsen, T., Maechler, P., Mandrup, S. PPAR-y is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction. J. Lipid Res. 2014, 51, 1370-1379.
    • (2014) J. Lipid Res , vol.51 , pp. 1370-1379
    • Ravnsjkjaer, K.1    Frigerio, F.2    Boegesen, M.3    Nielsen, T.4    Maechler, P.5
  • 34
    • 84904293075 scopus 로고    scopus 로고
    • Involvement ofactivation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by a-iso-cubebenol
    • Park, S.Y., Kim, D.Y., Kang, J.-K., Park, G., Choi, Y.-W. Involvement ofactivation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by a-iso-cubebenol. Neurotoxicology 2014, 44, 160-180.
    • (2014) Neurotoxicology , vol.44 , pp. 160-180
    • Park, S.Y.1    Kim, D.Y.2    Kang, J.-K.3    Park, G.4    Choi, Y.-W.5
  • 35
    • 77950594327 scopus 로고    scopus 로고
    • Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson’s disease
    • Khan, M.M., Ahmad, A., Ishrat, T., Khan, M.B., Hoda, M.N., Khuwaja, G., Raza, S.S., Khan, A., Javed, H., Vaibhav, K., et al. Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson’s disease. Brain Res. 2010, 1328, 139-151.
    • (2010) Brain Res , vol.1328 , pp. 139-151
    • Khan, M.M.1    Ahmad, A.2    Ishrat, T.3    Khan, M.B.4    Hoda, M.N.5    Khuwaja, G.6    Raza, S.S.7    Khan, A.8    Javed, H.9    Vaibhav, K.10
  • 36
    • 84900530067 scopus 로고    scopus 로고
    • Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress
    • Asaithambi, A., Ay, M., Jin, H., Gosh, A., Anantharam, V., Kanthasamy, A., Kanthasamy, A.G. Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PLoS ONE 2014, 9, e96947.
    • (2014) Plos ONE , vol.9
    • Asaithambi, A.1    Ay, M.2    Jin, H.3    Gosh, A.4    Anantharam, V.5    Kanthasamy, A.6    Kanthasamy, A.G.7
  • 37
    • 55649115984 scopus 로고    scopus 로고
    • Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines’ unexpected therapeutic properties
    • Cunningham, T.J., Yao, L., Lucena, A. Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines’ unexpected therapeutic properties. J. Inflamm. 2008, 5, 17.
    • (2008) J. Inflamm , vol.5 , pp. 17
    • Cunningham, T.J.1    Yao, L.2    Lucena, A.3
  • 38
    • 0032055384 scopus 로고    scopus 로고
    • Lysophosphatidylcholine induces the production of IL-1ß by human monocytes
    • Liu-Wu, Y., Hurt-Camejo, E., Wiklund, O. Lysophosphatidylcholine induces the production of IL-1ß by human monocytes. Atherosclerosis 1998, 137, 351-357.
    • (1998) Atherosclerosis , vol.137 , pp. 351-357
    • Liu-Wu, Y.1    Hurt-Camejo, E.2    Wiklund, O.3
  • 41
    • 0027306764 scopus 로고
    • Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes
    • McMurray, H.F., Parthasarathy, S., Steinberg, D. Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. J. Clin. Investig. 1993, 92, 1004-1008.
    • (1993) J. Clin. Investig , vol.92 , pp. 1004-1008
    • McMurray, H.F.1    Parthasarathy, S.2    Steinberg, D.3
  • 42
    • 0001096583 scopus 로고
    • Lysophosphatidylcholine: A chemotactic factor for human monocytes and its potential role in atherogenesis
    • Quinn, M.T., Parthasarathy, S., Steinberg, D. Lysophosphatidylcholine: A chemotactic factor for human monocytes and its potential role in atherogenesis. Proc. Natl. Acad. Sci. USA 1988, 85, 2805-2809.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2805-2809
    • Quinn, M.T.1    Parthasarathy, S.2    Steinberg, D.3
  • 43
    • 84855973361 scopus 로고    scopus 로고
    • Diaz, M. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson’s disease and incidental Parkinson’s disease. Mol
    • Fabelo, N., Martin, V., Santpere, G., Marin, R., Torrent, L., Ferrer, I., Diaz, M. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson’s disease and incidental Parkinson’s disease. Mol. Med. 2011, 17, 1107-1118.
    • (2011) Med , vol.17 , pp. 1107-1118
    • Fabelo, N.1    Martin, V.2    Santpere, G.3    Marin, R.4    Torrent, L.5    Ferrer, I.6
  • 44
    • 84864046701 scopus 로고    scopus 로고
    • Moser, A.B. Functions of plasmalogen lipids in health and disease
    • Braverman, N.E., Moser, A.B. Functions of plasmalogen lipids in health and disease. Biochim. Biophys. Acta 2012, 1522, 1442-1452.
    • (2012) Biochim. Biophys. Acta , vol.1522 , pp. 1442-1452
    • Braverman, N.E.1
  • 45
    • 0028597086 scopus 로고
    • Antitumore ether lipids and alkylphosphocholines
    • Lohmeyer, M., Bittman, R. Antitumore ether lipids and alkylphosphocholines. Drugs Future 1994, 19, 1021-1037.
    • (1994) Drugs Future , vol.19 , pp. 1021-1037
    • Lohmeyer, M.1    Bittman, R.2
  • 46
    • 25844513230 scopus 로고    scopus 로고
    • Interaction of alamethicin with ether-linked phospholipid bilayers: Oriented circular dichroism, 31P solid-state NMR, and differential scanning calorimetry studies
    • Dave, P.C., Billington, E., Pan, Y.-L., Straus, S.K. Interaction of alamethicin with ether-linked phospholipid bilayers: Oriented circular dichroism, 31P solid-state NMR, and differential scanning calorimetry studies. Biophys. J. 2005, 59, 2434-2442.
    • (2005) Biophys. J , vol.59 , pp. 2434-2442
    • Dave, P.C.1    Billington, E.2    Pan, Y.-L.3    Straus, S.K.4
  • 48
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson’s disease: Dopamine, vesicles and a-synuclein
    • Lotharius, J., Brundin, P. Pathogenesis of Parkinson’s disease: Dopamine, vesicles and a-synuclein. Nat. Rev. Neurosci. 2002, 3, 932-942.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 49
    • 0033539664 scopus 로고    scopus 로고
    • Axon pathology in Parkinson ‘ s disease and Lewy body dementia hippocampus contains a-, ß- and y-synuclein
    • Galvin, J.E., Uryu, K., Lee, V.M., Trojanowski, J.Q. Axon pathology in Parkinson ‘ s disease and Lewy body dementia hippocampus contains a-, ß- and y-synuclein. PNAS 1999, 96, 13450-13455.
    • (1999) PNAS , vol.96 , pp. 13450-13455
    • Galvin, J.E.1    Uryu, K.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 50
    • 77952926102 scopus 로고    scopus 로고
    • Burke, R. Clinical progression in Parkinson’s disease and the neurobiology of axons
    • Cheng, H., Ulane, C., Burke, R. Clinical progression in Parkinson’s disease and the neurobiology of axons. Ann. Neurol. 2010, 67, 715-725.
    • (2010) Ann. Neurol , vol.67 , pp. 715-725
    • Cheng, H.1    Ulane, C.2
  • 52
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer, H., Oertel, W.H. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 1994, 59, 401-415.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 53
    • 84893865299 scopus 로고    scopus 로고
    • NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice
    • Hernandes, M.S., Cafe-Mendes, C.C., Britto, L.R.G. NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice. Oxid. Med. Cell. Longev. 2013, 2013, 157-857.
    • (2013) Oxid. Med. Cell. Longev , pp. 157-2857
    • Hernandes, M.S.1    Cafe-Mendes, C.C.2    Britto, L.3
  • 54
    • 84925482929 scopus 로고    scopus 로고
    • Neurotoxin mechanisms and processes relevant to Parkinson’s disease: An update
    • Segura-Aguilar, J., Kostrzewa, R.M. Neurotoxin mechanisms and processes relevant to Parkinson’s disease: An update. Neurotox. Res. 2015, 27, 328-354.
    • (2015) Neurotox. Res , vol.27 , pp. 328-354
    • Segura-Aguilar, J.1    Kostrzewa, R.M.2
  • 55


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.