Oxidative/nitrative stress and inflammation drive progression of doxorubicin-induced renal fibrosis in rats as revealed by comparing a normal and a fibrosis-resistant rat strain

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Szalay, Csaba Imre ^a   Erdélyi, Katalin ^b   Kökény, Gábor ^a   Lajtár, Eniko ^a   Godó, Mária ^a   Révész, Csaba ^a   Kaucsár, Tamás ^a   Kiss, Norbert ^a   Sárközy, Márta ^c   Csont, Tamás ^c   Krenács, Tibor ^a   Szénási, Gábor ^a   Pacher, Pál ^b   Hamar, Péter ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; CONNECTIVE TISSUE GROWTH FACTOR; CONNEXIN 43; DOXORUBICIN; FIBRONECTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHRIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; P47 PHOX PROTEIN; P91 PHOX PROTEIN; PROTEIN; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SLIT DIAPHRAGM PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 3-NITROTYROSINE; 4-HYDROXY-2-NONENAL; ALDEHYDE; CCL2 PROTEIN, RAT; CTGF PROTEIN, RAT; MEMBRANE PROTEIN; REACTIVE NITROGEN SPECIES; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL DAMAGE; CHARLES DAWLEY RAT; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE DURATION; DOSE RESPONSE; ENZYMURIA; GLOMERULOSCLEROSIS; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY FIBROSIS; KIDNEY TUBULE DAMAGE; LIPID PEROXIDATION; MALE; NITRATIVE STRESS; NITROSYLATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PERIODIC ACID SCHIFF STAIN; PICRO SIRIUS RED STAINING; PODOCYTE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEINURIA; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; ROWETT BLACK HOODED RAT; STAINING; STRAIN DIFFERENCE; SURVIVAL RATE; TUBULOINTERSTITIAL FIBROSIS; WEIGHT GAIN; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BODY WEIGHT; COMPLICATION; DISEASE COURSE; DISEASE RESISTANCE; DRUG EFFECTS; FIBROSIS; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; SPECIES DIFFERENCE;

RATTUS;

ALDEHYDES; ANIMALS; BODY WEIGHT; CHEMOKINE CCL2; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE PROGRESSION; DISEASE RESISTANCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FIBROSIS; KIDNEY; MALE; MEMBRANE PROTEINS; OXIDATIVE STRESS; PROTEINURIA; RATS; REACTIVE NITROGEN SPECIES; SPECIES SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE;

EID: 84939204891     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127090     Document Type: Article

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