Accelerated renal fibrosis in cardiorenal syndrome is associated with long-term increase in urine neutrophil gelatinase-associated lipocalin levels

American Journal of Nephrology

Volumn 36, Issue 2, 2012, Pages 190-200

  Entin Meer, Michal ^a   Ben Shoshan, Jeremy ^a   Maysel Auslender, Sofia ^a   Levy, Ran ^a   Goryainov, Pavel ^a   Schwartz, Idit ^b   Barshack, Iris ^c   Avivi, Camila ^c   Sharir, Rinat ^a   Keren, Gad ^a,b  

^a Department of Cardiology   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Cardiorenal syndrome; Chronic kidney disease; Fibrosis; Left ventricular dysfunction; Neutrophil gelatinase associated lipocalin; Subtotal nephrectomy

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITROGEN; UREA;

ACUTE HEART INFARCTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CARDIORENAL SYNDROME; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE CLEARANCE; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HISTOLOGY; KIDNEY FIBROSIS; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; SERUM; UREA NITROGEN BLOOD LEVEL; URINALYSIS;

ACUTE-PHASE PROTEINS; ANIMALS; BIOLOGICAL MARKERS; CARDIO-RENAL SYNDROME; DISEASE MODELS, ANIMAL; FIBROSIS; KIDNEY; LIPOCALINS; MALE; MYOCARDIAL INFARCTION; NEPHRECTOMY; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED LEW; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84864812370     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000341651     Document Type: Article

References (28)

1. Bagshaw SM, Cruz DN: Epidemiology of cardiorenal syndromes. Contrib Nephrol. Basel, Karger, 2010, vol 165, pp 68-82.
2. Burke SW, Solomon AJ: Cardiac complications of end-stage renal disease. Adv Ren Replace Ther 2000;7:210-219. (Pubitemid 30456912)
3. Lekston A, Kurek A, Tynior B: Impaired renal function in acute myocardial infarction. Cardiol J 2009;16:400-406.
4. Shah RV, Givertz MM: Managing acute renal failure in patients with acute decompensated heart failure: the cardiorenal syndrome. Curr Heart Fail Rep 2009;6:176-181.
5. Tsagalis G, Zerefos S, Zerefos N: Cardiorenal syndrome at different stages of chronic kidney disease. Int J Artif Organs 2007;30:564-576. (Pubitemid 47484600)
6. Ronco C, Haapio M, House AA, Anavekar N, Bellomo R: Cardiorenal syndrome. J Am Coll Cardiol 2008;52:1527-1539.
7. MacGregor M, Boag DE, Innes A: Chronic kidney disease: evolving strategies for detection and management of impaired renal function. QJM 2006;99:365-375. (Pubitemid 43985775)
8. Windt WA, Henning RH, Kluppel AC, Xu Y, de Zeeuw D, van Dokkum RP: Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats. Nephrol Dial Transplant 2008;23:3103-3110.
9. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P: Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 2003;14:2534-2543. (Pubitemid 37169339)
10. Grenier FC, Ali S, Syed H, Workman R, Martens F, Liao M, Wang Y, Wong PY: Evaluation of the Architect urine NGAL assay: assay performance, specimen handling requirements and biological variability. Clin Biochem 2010;43:615-620.
11. Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV: Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int 2008;73:863-869. (Pubitemid 351398278)
12. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993;268:10425-10432. (Pubitemid 23150227)
13. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P: Neutrophil gelatinase-associated lipocalin as a biomarker for acute renal injury after cardiac surgery. Lancet 2005;365:1231-1238. (Pubitemid 40469655)
14. Schwartz D, Ozery Y, Schwartz IF, Wollman Y, Chernichovsky T, Blum M, Iaina A: Glomerular arginine transport is attenuated in chronic renal failure in rats. J Med 2003;34:113-120. (Pubitemid 47457278)
15. Sviglerova J, Kuncova J, Nalos L, Tonar Z, Rajdl D, Stengl M: Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomy. Physiol Res 2010;59(suppl 1):S81-S88.
16. Tisher CC, Brenner BM: Benign and Malignant Nephrosclerosis and Renovascular Disease. Renal Pathology with Clinical and Functional Correlations. Philadelphia, Lippincott, 1994, vol 2, pp 1202-1203.
17. Churg J, Sobin LH: Renal Disease: Benign Nephrosclerosis. Classification and Atlas of Glomerular Diseases. Tokyo, Igaku-Shoin 1982;211-224.
18. Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Gröne HJ, Schlöndorff D, Cohen CD: Human nephrosclerosis triggers a hypoxiarelated glomerulopathy. Am J Pathol 2010:176:594-607.
19. Ding H, He Y, Li K, Yang J, Li X, Lu R, Gao W: Urinary neutrophil gelatinase-associated lipocalin is an early biomarker for renal tubulointerstitial injury in IgA nephropathy. Clin Immunol 2007;123:227-234. (Pubitemid 46613869)
20. Cruz DN, Soni S, Ronco C: NGAL and cardiac surgery-associated acute kidney injury. Am J Kidney Dis 2009;5:565-566.
21. Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P: Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 2008;3:665-673.
22. Nickolas TL, Forster CS, Sise ME, Barasch N, Solá-Del Valle V, Viltard M, Buchen C, Kupferman S, Carnevali ML, Bennett M, Mattei S, Bovino A, Argentiero L, Magnano A, Devarajan P, Mori K, Erdjument-Bromage H, Tempst P, Allegri L, Barasch J: NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int 2012 (E-pub ahead of print).
23. Zeisberg M, Neilson EG: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010;21:1819-1834.
24. Liu Y: Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 2011;7:684-696.
25. Goldfarb M, Abassi Z, Rosen S, Shina A, Brezis M, Heyman SN: Compensated heart failure predisposes to outer medullary tubular injury: studies in rats. Kidney Int 2001;60:607-613. (Pubitemid 32678904)
26. Damman K, Masson S, Hillege HL, Maggioni AP, Voors AA, Opasich C, van Veldhuisen DJ, Montagna L, Cosmi F, Tognoni G, Tavazzi L, Latini R: Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J 2011;32:2705-2712.
27. Wang AY, Li PK, Lui SF, Sanderson JE: Angiotensinconverting enzyme inhibition for cardiac hypertrophy in patients with endstage renal disease: what is the evidence? Nephrology (Carlton) 2004;9:190-197. (Pubitemid 39318641)
28. Krishnan A, Oreopoulos DG: Peritoneal dialysis in congestive heart failure. Adv Perit Dial 2007;23:82-89.