A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8

Kidney International

Volumn 78, Issue 5, 2010, Pages 453-462

  Chua Jr , Streamson ^a   Li, Yifu ^b   Liu, Shun Mei ^a   Liu, Ruijie ^b   Chan, Ka Tak ^b   Martino, Jeremiah ^b   Zheng, Zongyu ^b   Susztak, Katalin ^a   D'Agati, Vivette D ^b   Gharavi, Ali G ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Russ Berrie Pavilion 302 ^*  (United States)

Author keywords

diabetic glomerulopathy; diabetic nephropathy; genetic renal disease

Indexed keywords

LEPTIN RECEPTOR;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 8; CHROMOSOME MAP; CONTROLLED STUDY; DBNPH1 LOCUS; DIABETIC NEPHROPATHY; DISEASE MODEL; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GLOMERULOSCLEROSIS; HYPERGLYCEMIA; KIDNEY DISEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SCLEROSIS;

EID: 77955661194     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.160     Document Type: Article

References (43)

1. Maisonneuve P, Agodoa L, Gellert R et al. Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis 2000; 35: 157-165.
2. Sheetz MJ, King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002; 288: 2579-2588.
3. Moczulski DK, Rogus JJ, Antonellis A et al. Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis. Diabetes 1998; 47: 1164-1169.
4. Vardarli I, Baier LJ, Hanson RL et al. Gene for susceptibility to diabetic nephropathy in type 2 diabetes maps to 18q22.3-23. Kidney Int 2002; 62: 2176-2183.
5. Osterholm AM, He B, Pitkaniemi J et al. Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q. Kidney Int 2007; 71: 140-145.
6. Schelling JR, Abboud HE, Nicholas SB et al. Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes 2008; 57: 235-243.
7. Freedman BI, Bowden DW, Rich SS et al. Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med 2008; 25: 268-276.
8. Iyengar SK, Abboud HE, Goddard KA et al. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes 2007; 56: 1577-1585.
9. Bowden DW, Colicigno CJ, Langefeld CD et al. A genome scan for diabetic nephropathy in African Americans. Kidney Int 2004; 66: 1517-1526.
10. Kopp JB, Smith MW, Nelson GW et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet 2008; 40: 1175-1184.
11. Kao WH, Klag MJ, Meoni LA et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 2008; 40: 1185-1192.
12. Pezzolesi MG, Poznik GD, Mychaleckyj JC et al. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes 2009; 58: 1403-1410.
13. Breyer MD, Böttinger E, Brosius III FC et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol 2005; 16: 27-45.
14. Brosius III FC, Alpers CE, Bottinger EP et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2503-2512.
15. Sharma K, McCue P, Dunn SR. Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 2003; 284: F1138-F1144.
16. Qi Z, Fujita H, Jin J et al. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 2005; 54: 2628-2637.
17. Gurley SB, Clare SE, Snow KP et al. Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol 2006; 290: F214-F222.
18. Leiter EH, Chapman HD, Coleman DL. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 1989; 124: 912-922.
19. Haluzik M, Colombo C, Gavrilova O et al. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 2004; 145: 3258-3264.
20. Qiu J, Ogus S, Mounzih K et al. Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes. Endocrinology 2001; 142: 3421-3425.
21. Chua Jr. S, Liu SM, Li Q et al. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB-Lepr (db)) and obese (DBA-Lep (ob)) mice. Diabetologia 2002; 45: 976-990.
22. Luo N, Liu SM, Liu H et al. Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice. Endocrinology 2006; 147: 2287-2295.
23. Wang Z, Jiang T, Li J et al. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes 2005; 54: 2328-2335.
24. Papeta N, Chan KT, Prakash S et al. Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression. J Clin Invest 2009; 119: 1178-1188.
25. Seghers V, Nakazaki M, DeMayo F et al. Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. J Biol Chem 2000; 275: 9270-9277.
26. Subramanian A, Tamayo P, Mootha VK et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550.
27. Park CW, Kim HW, Ko SH et al. Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. Diabetes 2006; 55: 885-893.
28. Cha DR, Zhang X, Zhang Y et al. Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice. Diabetes 2007; 56: 2036-2045.
29. Miyazaki Y, Cersosimo E, Triplitt C et al. Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int 2007; 72: 1367-1373. (Pubitemid 350126770)
30. Huang C, Kim Y, Caramori ML et al. Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways. Diabetes 2006; 55: 1826-1831.
31. Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008; 57: 1446-1454.
32. Frazer KA, Eskin E, Kang HM et al. A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 2007; 448: 1050-1053.
33. Proctor G, Jiang T, Iwahashi M et al. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 2006; 55: 2502-2509.
34. Hubner N, Wallace CA, Zimdahl H et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet 2005; 37: 243-253.
35. Pillebout E, Weitzman JB, Burtin M et al. JunD protects against chronic kidney disease by regulating paracrine mitogens. J Clin Invest 2003; 112: 843-852.
36. Behmoaras J, Bhangal G, Smith J et al. Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet 2008; 40: 553-559.
37. Zhang J, Yang J, Roy SK et al. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci USA 2003; 100: 9342-9347.
38. Lu TC, Wang ZH, Feng X et al. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int 2009; 76: 63-71.
39. Kottgen A, Glazer NL, Dehghan A et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet 2009; 41: 712-717.
40. Li C, Ioffe E, Fidahusein N et al. Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice. J Biol Chem 1998; 273: 10078-10082.
41. Broman KW, Wu H, Sen S et al. R/qtl: QTL mapping in experimental crosses. Bioinformatics 2003; 19: 889-890.
42. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
43. Ng PC, Henikoff S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 2003; 31: 3812-3814.