Protective effect of neutralizing anti-IL-18α monoclonal antibody on a mouse model of acute graft-versus-host disease

Oncology Reports

Volumn 34, Issue 4, 2015, Pages 2031-2039

  Li, Xiaocui ^a   Zhang, Cuiping ^a,b   Chen, Wei ^a   Pan, Bin ^a   Kong, Fanyun ^a   Zheng, Kuiyang ^a   Tang, Renxian ^a   Zeng, Lingyu ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Clinical Laboratory of the TCM Hospital of Huaian   (China)

Author keywords

Acute graft versus host disease; Apoptosis; Fas; IL 18R ; P38MAPK

Indexed keywords

INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 18 RECEPTOR ALPHA MONOCLONAL ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; INTERLEUKIN 18;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE CONTROL; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; GRAFT SURVIVAL; IMMUNE RESPONSE; IMMUNOPROPHYLAXIS; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; GRAFT VS HOST DISEASE; HELPER CELL; HUMAN; IMMUNOLOGY; LIVER; MALE; METABOLISM; SMALL INTESTINE; SURVIVAL ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; HUMANS; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; INTESTINE, SMALL; LIVER; MALE; MICE; SURVIVAL ANALYSIS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84939179053     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4176     Document Type: Article

References (33)

1. Storb R: Allogeneic hematopoietic stem cell transplantation-yesterday, today, and tomorrow. Exp Hematol 31: 1-10, 2003.
2. Ferrara JL, Levine JE, Reddy P and Holler E: Graft-versus-host disease. Lancet 373: 1550-1561, 2009.
3. Tobin LM, Healy ME, English K and Mahon BP: Human mesenchymal stem cells suppress donor CD4(+) T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease. Clin Exp Immunol 172: 333-348, 2013.
4. Reddy P: Pathophysiology of acute graft-versus-host disease. Hematol Oncol 21: 149-161, 2003.
5. Antin JH and Ferrara JL: Cytokine dysregulation and acute graft-versus-host disease. Blood 80: 2964-2968, 1992.
6. Levine JE, Paczesny S and Sarantopoulos S: Clinical applications for biomarkers of acute and chronic graft-versus-host disease. Biol Blood Marrow Transplant 18 (Suppl 1): S116-S124, 2012.
7. Pan B, Zhang Y, Sun Y, Cheng H, Wu Y, Song G, Chen W, Zeng L and Xu K: Deviated balance between Th1 and Th17 cells exacerbates acute graft-versus-host disease in mice. Cytokine 68: 69-75, 2014.
8. Tawara I, Maeda Y, Sun Y, Lowler KP, Liu C, Toubai T, McKenzie AN and Reddy P: Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Exp Hematol 36: 988-996, 2008.
9. Reddy P, Arora M, Guimond M and Mackall CL: GVHD: A continuing barrier to the safety of allogeneic transplantation. Biol Blood Marrow Transplant 15 (Suppl 1): 162-168, 2009.
10. Schmaltz C, Alpdogan O, Horndasch KJ, Muriglan SJ, Kappel BJ, Teshima T, Ferrara JL, Burakoff SJ and van den Brink MR: Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood 97: 2886-2895, 2001.
11. Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T and Ferrara JL: Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood 105: 2023-2027, 2005.
12. Fremond CM, Togbe D, Doz E, Rose S, Vasseur V, Maillet I, Jacobs M, Ryffel B and Quesniaux VF: IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 179: 1178-1189, 2007.
13. Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE and Mummidi S: Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem 279: 20221-20233, 2004.
14. Lu Y, Sakamaki S, Kuroda H, Kusakabe T, Konuma Y, Akiyama T, Fujimi A, Takemoto N, Nishiie K, Matsunaga T, et al: Prevention of lethal acute graft-versus-host disease in mice by oral administration of T helper 1 inhibitor, TAK-603. Blood 97: 1123-1130, 2001.
15. Cooke KR, Kobzik L, Martin TR, Brewer J, Delmonte J Jr, Crawford JM and Ferrara JL: An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88: 3230-3239, 1996.
16. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ and Littman DR: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133, 2006.
17. Sun Y, Tawara I, Toubai T and Reddy P: Pathophysiology of acute graft-versus-host disease: Recent advances. Transl Res 150: 197-214, 2007.
18. Wilson SP and Cassel SL: Inflammasome-mediated autoinflammatory disorders. Postgrad Med 122: 125-133, 2010.
19. Miossec P: IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect 11: 625-630, 2009.
20. Nishimoto N and Kishimoto T: Interleukin 6: From bench to bedside. Nat Clin Pract Rheumatol 2: 619-626, 2006.
21. Vogelsang GB, Lee L and Bensen-Kennedy DM: Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant. Annu Rev Med 54: 29-52, 2003.
22. Reddy P, Teshima T, Kukuruga M, Ordemann R, Liu C, Lowler K and Ferrara JL: Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med 194: 1433-1440, 2001.
23. Wasem C, Frutschi C, Arnold D, Vallan C, Lin T, Green DR, Mueller C and Brunner T: Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J Immunol 167: 2936-2941, 2001.
24. Yi T, Zhao D, Lin CL, Zhang C, Chen Y, Todorov I, LeBon T, Kandeel F, Forman S and Zeng D: Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood 112: 2101-2110, 2008.
25. Kalina U, Kauschat D, Koyama N, Nuernberger H, Ballas K, Koschmieder S, Bug G, Hofmann WK, Hoelzer D and Ottmann OG: IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J Immunol 165: 1307-1313, 2000.
26. Calvani N, Tucci M, Richards HB, Tartaglia P and Silvestris F: Th1 cytokines in the pathogenesis of lupus nephritis: The role of IL-18. Autoimmun Rev 4: 542-548, 2005.
27. Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, Kennedy K, Carter R, Wei XQ, Xu D, et al: A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 104: 1393-1401, 1999.
28. Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, et al: GVHD after haploidentical transplantation: A novel, MHC-defined rhesus macaque model identifies CD28-CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood 116: 5403-5418, 2010.
29. Arnold D, Wasem C, Juillard P, Graber P, Cima I, Frutschi C, Herren S, Jakob S, Alouani S, Mueller C, et al: IL-18-independent cytotoxic T lymphocyte activation and IFN-gamma production during experimental acute graft-versus-host disease. Int Immunol 14: 503-511, 2002.
30. Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, et al: IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol 178: 1948-1959, 2007.
31. Halpern MD, Khailova L, Molla-Hosseini D, Arganbright K, Reynolds C, Yajima M, Hoshiba J and Dvorak B: Decreased development of necrotizing enterocolitis in IL-18-deficient mice. Am J Physiol Gastrointest Liver Physiol 294: G20-G26, 2008.
32. Schroder K, Hertzog PJ, Ravasi T and Hume DA: Interferon-gamma: An overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189, 2004.
33. Olee T, Hashimoto S, Quach J and Lotz M: IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol 162: 1096-1100, 1999.