Both perform and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease

Blood

Volumn 105, Issue 5, 2005, Pages 2023-2027

  Maeda, Yoshinobu ^b   Levy, Robert B ^b   Reddy, Pavan ^b   Liu, Chen ^b   Clouthier, Shawn G ^b   Teshima, Takanori ^b   Ferrara, James L M ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; FAS LIGAND; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; FASL PROTEIN, MOUSE; HLA ANTIGEN CLASS 1; MEMBRANE PROTEIN; PORE FORMING CYTOTOXIC PROTEIN;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ANIMAL CELL; APOPTOSIS; ARTICLE; FEMALE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; T LYMPHOCYTE; WILD TYPE; ACUTE DISEASE; ALLOTRANSPLANTATION; ANIMAL; ANIMAL MODEL; BONE MARROW TRANSPLANTATION; CD8+ T LYMPHOCYTE; CULTURE TECHNIQUE; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY; IMMUNOLOGY; LYMPHOCYTE TRANSFUSION; MOUSE STRAIN; PHYSIOLOGY; TRANSPLANTATION;

ACUTE DISEASE; ANIMALS; BONE MARROW TRANSPLANTATION; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; FAS LIGAND PROTEIN; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY ANTIGENS CLASS I; LYMPHOCYTE TRANSFUSION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; PORE FORMING CYTOTOXIC PROTEINS; TRANSPLANTATION, HOMOLOGOUS;

EID: 14944372970     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-08-3036     Document Type: Article

References (35)

1. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
2. + T cell-mediated acute graft-versus-host disease. J Clin Invest. 2002;109:1335-1344.
3. Duffner UA, Maeda Y, Cooke KR, et al. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004;172:7393-7398.
4. Teshima T, Ordemann R, Reddy P, et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575-581.
5. Graubert TA. DiPersio JF, Russell JH, Ley TJ. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest. 1997;100:904-911.
6. Jiang Z, Podack E, Levy RB. Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. Blood. 2001;98:390-397.
7. Marks L, Altman NH, Podack ER, Levy RB. Donor T cells lacking Fas ligand and pertorin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients. Transplantation. 2004;77:804-812.
8. Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative path way for granule-mediated apoptosis. Immunity. 1999;10:595-605.
9. Blazar BR, Taylor PA, Vallera DA. CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients. Transplantation. 1997;64:571-576.
10. Takahashi T, Tanaka M, Brannan CI, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969-976.
11. Adachi M, Watanabe-Fukunaga R, Nagata S. Aberrant transcription caused by the ínsertíon of an early transposable element in an intron of the Fas antigen gene of Ipr mice. Proc Nail Acad Sci U S A. 1993;90:1756-1760.
12. Spaner D, Raju K, Rabinovich B, Miller RG. A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J Immunol. 1999;162:1192-1199.
13. Binder D, van den Broek MF, Kagi D, et al. Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med. 1998;187:1903-1920.
14. Kagi D, Odermatt B, Mak TW. Homeostatic regulation of CD8+ T cells by perforin. Eur J Immunol. 1999;29:3262-3272.
15. Matloubian M, Suresh M, Glass A, et al. A role for perforin in downregulating T cell responses during chronic viral infection. J Virol. 1999;73:2527-2536.
16. Ludewig B, Bonilla WV, Dumrese T, Odermatt B, Zinkernagel RM, Hengartner H. Perforin-independent regulation of dendritic cell homeostasis by CD8(+)T cells in vivo: implications for adaptive immunotherapy. Eur J Immunol. 2001;31:1772-1779.
17. Harty JT, Badovinac VP. Influence of effector molecules on the CD8(+) T cell response to infection. Curr Opin Immunol. 2002;14:360-365.
18. Trapani JA, Smyth MJ. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol. 2002;2:735-747.
19. Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol. 2002;20:323-370.
20. Kagi D, Vignaux F. Ledermann B, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528-530.
21. Jones M, Komatsu M, Levy RB. Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex-matched bone marrow allografts. Biol Blood Marrow Transplant. 2000;6:456-464.
22. Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I, the roles of minor H antigens and endotoxin. Blood. 1996;88:3230-3239.
23. Cooke KR, Hill GR, Crawford JM, et al. Tumor necrosis factor-alpha production to lipopolysac-chande stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. J Clin Invest. 1998;102:1882-1891.
24. Hill GR, Cooke KR, Teshima T, et al. Interteukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J Clin Invest. 1998;102:115-123.
25. Teshima T, Mach N, Hill GR, et al. Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation. Cancer Res. 2001;61:162-171.
26. Braun MY, Lowin B, French L, Acha-Orbea H, Tschopp J. Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease. J Exp Med. 1996;183:657-661.
27. Korngold R, Wettstein PJ. Immunodominance in the graft-vs-host disease T cell response to minor histocompatibility antigens. J Immunol. 1990;145:4079-4088.
28. Shustov A, Luzina I, Nguyen P, et al. Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. J Clin Invest. 2000;106:R39-R47.
29. Ehl S, Hoffmann-Rohrer U, Nagata S, Hengartner H, Zinkernagel R. Different susceptibility of cyto toxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo. J Immunol. 1996;156:2357-2360.
30. Reich A, Korner H, Sedgwick JD, Pircher H. Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1). Eur J Immunol. 2000;30:678-682.
31. Nguyen LT, McKall-Faienza K, Zakarian A, Speiser DE, Mak TW, Ohashi PS. TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions. Eur J Immunol. 2000;30:683-688.
32. Badovinac VP, Tvinnereim AR, Harty JT. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science. 2000;290:1354-1358.
33. Sad S, Kagi D, Mosmann TR. Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation. J Exp Med. 1996;184:1543-1547.
34. Klenerman P, Zinkernagel RM. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature. 1998;394:482-485.
35. Merad M, Hoffmann P, Ranheim E, et al. Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med. 2004;10:510-517.