메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

EID: 84939172436     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12931     Document Type: Article
Times cited : (136)

References (52)
  • 1
    • 77649337140 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathology and pathogenesis
    • Tiniakos, D. G., Vos, M. B. & Brunt, E. M. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 5, 145-171 (2010).
    • (2010) Annu Rev Pathol , vol.5 , pp. 145-171
    • Tiniakos, D.G.1    Vos, M.B.2    Brunt, E.M.3
  • 2
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini, G. et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50, 1844-1850 (2001).
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1
  • 3
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal, A. J. et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120, 1183-1192 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1
  • 4
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal, A. J. et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 43, 682-689 (2006).
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1
  • 5
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two 'hits'?
    • Day, C. P. & James, O. F. Steatohepatitis: a tale of two 'hits'?. Gastroenterology 114, 842-845 (1998).
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 6
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg, H. & Moschen, A. R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52, 1836-1846 (2010).
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 7
    • 33747626511 scopus 로고    scopus 로고
    • Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
    • Marí, M. et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab. 4, 185-198 (2006).
    • (2006) Cell Metab. , vol.4 , pp. 185-198
    • Marí, M.1
  • 8
    • 36348935003 scopus 로고    scopus 로고
    • Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    • Matsuzawa, N. et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 46, 1392-1403 (2007).
    • (2007) Hepatology , vol.46 , pp. 1392-1403
    • Matsuzawa, N.1
  • 9
    • 38549148724 scopus 로고    scopus 로고
    • NASH may be trash
    • Cassiman, D. & Jaeken, J. NASH may be trash. Gut 57, 141-144 (2008).
    • (2008) Gut , vol.57 , pp. 141-144
    • Cassiman, D.1    Jaeken, J.2
  • 10
    • 84884735611 scopus 로고    scopus 로고
    • Experimental liver fibrosis research: Update on animal models, legal issues and translational aspects
    • Liedtke, C. et al. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Fibrogenesis & Tissue Repair 6, 19 (2013).
    • (2013) Fibrogenesis & Tissue Repair , vol.6 , pp. 19
    • Liedtke, C.1
  • 11
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi, Y., Soejima, Y. & Fukusato, T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J. Gastroenterol. 18, 2300-2308 (2012).
    • (2012) World J. Gastroenterol. , vol.18 , pp. 2300-2308
    • Takahashi, Y.1    Soejima, Y.2    Fukusato, T.3
  • 12
    • 0027976942 scopus 로고
    • Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
    • Reddick, R. L., Zhang, S. H. & Maeda, N. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler. Thromb. 14, 141-147 (1994).
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 141-147
    • Reddick, R.L.1    Zhang, S.H.2    Maeda, N.3
  • 13
    • 78651431722 scopus 로고    scopus 로고
    • Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet
    • Song, G. et al. Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet. Lipids Health Dis 10, 8 (2011).
    • (2011) Lipids Health Dis , vol.10 , pp. 8
    • Song, G.1
  • 14
    • 65349093477 scopus 로고    scopus 로고
    • Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: Potential involvement of oxysterols
    • Ferré, N. et al. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G553-562 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296 , pp. G553-562
    • Ferré, N.1
  • 15
    • 73949088905 scopus 로고    scopus 로고
    • A murine model of obesity with accelerated atherosclerosis
    • King, V. L. et al. A Murine Model of Obesity With Accelerated Atherosclerosis. Obesity 18, 35-41 (2010).
    • (2010) Obesity , vol.18 , pp. 35-41
    • King, V.L.1
  • 16
    • 78649573682 scopus 로고    scopus 로고
    • Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
    • Martínez-Clemente, M. et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 52, 1980-1991 (2010).
    • (2010) Hepatology , vol.52 , pp. 1980-1991
    • Martínez-Clemente, M.1
  • 17
    • 77950619121 scopus 로고    scopus 로고
    • 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice
    • Martínez-Clemente, M. et al. 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Hepatology 51, 817-827 (2010).
    • (2010) Hepatology , vol.51 , pp. 817-827
    • Martínez-Clemente, M.1
  • 18
    • 84908481540 scopus 로고    scopus 로고
    • Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis
    • Kampschulte, M. et al. Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis. Lab. Invest. 94, 1273-1282 (2014).
    • (2014) Lab. Invest. , vol.94 , pp. 1273-1282
    • Kampschulte, M.1
  • 19
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq, I. A., Farrell, G. C., Schriemer, R. & Robertson, G. R. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 37, 206-213 (2002).
    • (2002) J. Hepatol. , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 20
    • 33947264902 scopus 로고    scopus 로고
    • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
    • Nakayama, H. et al. Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. Metabolism 56, 470-475 (2007).
    • (2007) Metabolism , vol.56 , pp. 470-475
    • Nakayama, H.1
  • 21
    • 48449096011 scopus 로고    scopus 로고
    • MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes
    • Larter, C. Z., Yeh, M. M., Williams, J., Bell-Anderson, K. S. & Farrell, G. C. MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. Journal of Hepatology 49, 407-416 (2008).
    • (2008) Journal of Hepatology , vol.49 , pp. 407-416
    • Larter, C.Z.1    Yeh, M.M.2    Williams, J.3    Bell-Anderson, K.S.4    Farrell, G.C.5
  • 22
    • 70350317887 scopus 로고    scopus 로고
    • Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis
    • Kawasaki, T. et al. Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis. J. Nutr. 139, 2067-2071 (2009).
    • (2009) J. Nutr. , vol.139 , pp. 2067-2071
    • Kawasaki, T.1
  • 23
    • 84919764259 scopus 로고    scopus 로고
    • Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis
    • Simon, Y. et al. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol 20, 17839-17850 (2014).
    • (2014) World J Gastroenterol , vol.20 , pp. 17839-17850
    • Simon, Y.1
  • 24
    • 61849095626 scopus 로고    scopus 로고
    • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
    • Caballero, F. et al. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. Journal of Hepatology 50, 789-796 (2009).
    • (2009) Journal of Hepatology , vol.50 , pp. 789-796
    • Caballero, F.1
  • 25
    • 84883212986 scopus 로고    scopus 로고
    • Desmosterol in human nonalcoholic steatohepatitis
    • Simonen, M. et al. Desmosterol in human nonalcoholic steatohepatitis. Hepatology 58, 976-982 (2013).
    • (2013) Hepatology , vol.58 , pp. 976-982
    • Simonen, M.1
  • 26
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M. & Diehl, A. M. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc. Natl. Acad. Sci. USA 94, 2557-2562 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 27
    • 33947137852 scopus 로고    scopus 로고
    • Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet
    • Ito, M. et al. Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet. Hepatol. Res. 37, 50-57 (2007).
    • (2007) Hepatol. Res. , vol.37 , pp. 50-57
    • Ito, M.1
  • 28
    • 84879132692 scopus 로고    scopus 로고
    • Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome
    • Van Rooyen, D. M. et al. Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome. J. Hepatol. 59, 144-152 (2013).
    • (2013) J. Hepatol. , vol.59 , pp. 144-152
    • Van Rooyen, D.M.1
  • 29
    • 84856297712 scopus 로고    scopus 로고
    • LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease
    • Bieghs, V. et al. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS ONE 7, e30668 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e30668
    • Bieghs, V.1
  • 30
    • 77956634470 scopus 로고    scopus 로고
    • High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    • Kohli, R. et al. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 52, 934-944 (2010).
    • (2010) Hepatology , vol.52 , pp. 934-944
    • Kohli, R.1
  • 31
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: Novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
    • Charlton, M. et al. Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G825-834 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.301 , pp. G825-834
    • Charlton, M.1
  • 32
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters, K. et al. Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48, 474-486 (2008).
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1
  • 33
    • 78349313190 scopus 로고    scopus 로고
    • Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis
    • Francque, S. et al. Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis. Eur J Gastroenterol Hepatol 22, 1449-1457 (2010).
    • (2010) Eur J Gastroenterol Hepatol , vol.22 , pp. 1449-1457
    • Francque, S.1
  • 34
    • 80055004124 scopus 로고    scopus 로고
    • Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis
    • Itoh, M. et al. Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis. Am. J. Pathol. 179, 2454-2463 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 2454-2463
    • Itoh, M.1
  • 35
    • 84907976095 scopus 로고    scopus 로고
    • Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
    • Wolf, M. J. et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 26, 549-564 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 549-564
    • Wolf, M.J.1
  • 36
    • 77953099666 scopus 로고    scopus 로고
    • CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function
    • Tiyerili, V. et al. CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res. Cardiol. 105, 465-477 (2010).
    • (2010) Basic Res. Cardiol. , vol.105 , pp. 465-477
    • Tiyerili, V.1
  • 37
    • 80055107075 scopus 로고    scopus 로고
    • Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo
    • Hoyer, F. F. et al. Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J. Mol. Cell. Cardiol. 51, 1007-1014 (2011).
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 1007-1014
    • Hoyer, F.F.1
  • 38
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Baeck, C. et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61, 416-426 (2012).
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1
  • 39
    • 84869222173 scopus 로고    scopus 로고
    • HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects
    • Klein, S. et al. HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. Journal of Hepatology 57, 1220-1227 (2012).
    • (2012) Journal of Hepatology , vol.57 , pp. 1220-1227
    • Klein, S.1
  • 40
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka, J. et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 46, 242-253 (2007).
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1
  • 41
    • 42249103587 scopus 로고    scopus 로고
    • Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats
    • Trebicka, J. et al. Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats. Hepatology 47, 1264-1276 (2008).
    • (2008) Hepatology , vol.47 , pp. 1264-1276
    • Trebicka, J.1
  • 42
    • 77956268976 scopus 로고    scopus 로고
    • Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    • Trebicka, J. et al. Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J. Hepatol. 53, 702-712 (2010).
    • (2010) J. Hepatol. , vol.53 , pp. 702-712
    • Trebicka, J.1
  • 43
    • 73149117594 scopus 로고    scopus 로고
    • Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
    • Trebicka, J. et al. Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis. Hepatology 50, 1924-1935 (2009).
    • (2009) Hepatology , vol.50 , pp. 1924-1935
    • Trebicka, J.1
  • 44
    • 79955635993 scopus 로고    scopus 로고
    • Role of cannabinoid receptors in alcoholic hepatic injury: Steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts
    • Trebicka, J. et al. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. Liver Int. 31, 860-870 (2011).
    • (2011) Liver Int. , vol.31 , pp. 860-870
    • Trebicka, J.1
  • 45
    • 84875382650 scopus 로고    scopus 로고
    • Glucagon-induced acetylation of foxa2 regulates hepatic lipid metabolism
    • Von Meyenn, F. et al. Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism. Cell Metabolism 17, 436-447 (2013).
    • (2013) Cell Metabolism , vol.17 , pp. 436-447
    • Von Meyenn, F.1
  • 46
    • 79959466350 scopus 로고    scopus 로고
    • Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice
    • Parathath, S. et al. Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice. Diabetes 60, 1759-1769 (2011).
    • (2011) Diabetes , vol.60 , pp. 1759-1769
    • Parathath, S.1
  • 47
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • Ishak, K. et al. Histological grading and staging of chronic hepatitis. J. Hepatol. 22, 696-699 (1995).
    • (1995) J. Hepatol. , vol.22 , pp. 696-699
    • Ishak, K.1
  • 48
    • 79958067943 scopus 로고    scopus 로고
    • Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis
    • Huss, S. et al. Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. Fibrogenesis Tissue Repair 3, 10 (2010).
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 10
    • Huss, S.1
  • 49
    • 81155131056 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor- α agonist, BAY PP1, attenuates renal fibrosis in rats
    • Boor, P. et al. The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats. Kidney Int. 80, 1182-1197 (2011).
    • (2011) Kidney Int. , vol.80 , pp. 1182-1197
    • Boor, P.1
  • 50
    • 0036314309 scopus 로고    scopus 로고
    • Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
    • Lütjohann, D. et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J. Lipid Res. 43, 1078-1085 (2002).
    • (2002) J. Lipid Res. , vol.43 , pp. 1078-1085
    • Lütjohann, D.1
  • 51
    • 33644781781 scopus 로고    scopus 로고
    • Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
    • Thelen, K. M. et al. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J. Pharmacol. Exp. Ther. 316, 1146-1152 (2006).
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , pp. 1146-1152
    • Thelen, K.M.1
  • 52
    • 44949087861 scopus 로고    scopus 로고
    • Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice
    • Dullens, S. P. J., Mensink, R. P., Bragt, M. C. E., Kies, A. K. & Plat, J. Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice. J. Lipid Res. 49, 790-796 (2008).
    • (2008) J. Lipid Res. , vol.49 , pp. 790-796
    • Dullens, S.P.J.1    Mensink, R.P.2    Bragt, M.C.E.3    Kies, A.K.4    Plat, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.