Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Journal of Medicinal Chemistry

Volumn 58, Issue 15, 2015, Pages 5863-5888

  Cioffi, Christopher L ^a   Racz, Boglarka ^c   Freeman, Emily E ^a   Conlon, Michael P ^a   Chen, Ping ^a   Stafford, Douglas G ^a   Schwarz, Daniel M C ^a   Zhu, Lei ^b   Kitchen, Douglas B ^b   Barnes, Keith D ^a   Dobri, Nicoleta ^c   Michelotti, Enrique ^f   Cywin, Charles L ^g   Martin, William H ^e   Pearson, Paul G ^d   Johnson, Graham ^d   Petrukhin, Konstantin ^c  

^a East Campus ^*  (United States)

^b AMRI   (United States)

^c Department of Medicine   (United States)

^d iCuraVision LLC   (United States)

^e WHM Consulting LLC   (United States)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^g NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLIC [3.3.0] OCTAHYDROCYCLOPENTA[C]PYRROLE DERIVATIVE; PYRIMIDINE; PYRROLE DERIVATIVE; RETINOL BINDING PROTEIN 4; UNCLASSIFIED DRUG; BICYCLO COMPOUND; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG HALF LIFE; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MACACA FASCICULARIS; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; STARGARDT DISEASE; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOG; GEOGRAPHIC ATROPHY; MACULAR DEGENERATION; MDCK CELL LINE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BICYCLO COMPOUNDS; DOGS; GEOGRAPHIC ATROPHY; HUMANS; MACULAR DEGENERATION; MADIN DARBY CANINE KIDNEY CELLS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RETINOL-BINDING PROTEINS, PLASMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84939166740     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00423     Document Type: Article

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