Memantine reduces alcohol drinking but not relapse in alcohol-dependent rats

Addiction Biology

Volumn 20, Issue 5, 2015, Pages 890-901

  Alaux Cantin, Stéphanie ^a   Buttolo, Romain ^a   Houchi, Hakim ^a   Jeanblanc, Jérôme ^a   Naassila, Mickaël ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

Acute withdrawal; AUDs; memantine; operant self administration; protracted abstinence; relapse

Indexed keywords

MEMANTINE; AMINO ACID RECEPTOR BLOCKING AGENT;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG EFFICACY; DRUG HALF LIFE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RELAPSE; SELF ADMINISTRATION TEST; ANIMAL; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; INSTRUMENTAL CONDITIONING; LONG EVANS RAT; MOTIVATION; MOTOR ACTIVITY; RECURRENT DISEASE;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MEMANTINE; MOTIVATION; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; RECURRENCE;

EID: 84939161337     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12177     Document Type: Article

References (54)

1. Alaux-Cantin S, Warnault V, Legastelois R, Botia B, Pierrefiche O, Vilpoux C, Naassila M, (2013) Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens. Neuropharmacology 67: 521-531.
2. American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th edn. Washington, DC: American Psychiatric Association.
3. Bienkowski P, Krzascik P, Koros E, Kostowski W, Scinska A, Danysz W, (2001) Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat. Eur J Pharmacol 413: 81-89.
4. Bisaga A, Evans SM, (2004) Acute effects of memantine in combination with alcohol in moderate drinkers. Psychopharmacology (Berl) 172: 16-24.
5. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW, (2013) Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res 37: 8-15.
6. Dodd PR, Beckmann AM, Davidson MS, Wilce PA, (2000) Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem Int 37: 509-533.
7. Evans SM, Levin FR, Brooks DJ, Garawi F, (2007) A pilot double-blind treatment trial of memantine for alcohol dependence. Alcohol Clin Exp Res 31: 775-782.
8. Gass JT, Olive MF, (2008) Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75: 218-265.
9. Gilpin NW, Richardson HN, Cole M, Koob GF, (2008) Vapor inhalation of alcohol in rats. Curr Protoc Neurosci. Chapter 9: Unit 9.29.
10. Heilig M, Koob GF, (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406.
11. Heilig M, Goldman D, Berrettini W, O'Brien CP, (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12: 670-684.
12. Henniger MS, Wotjak CT, Holter SM, (2003) Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex. Eur J Pharmacol 470: 33-36.
13. Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH, (2012) Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biol Psychiatry 71: 1015-1021.
14. Hoffman PL, Rabe CS, Grant KA, Valverius P, Hudspith M, Tabakoff B, (1990) Ethanol and the NMDA receptor. Alcohol 7: 229-231.
15. Holmes A, Spanagel R, Krystal JH, (2013) Glutamatergic targets for new alcohol medications. Psychopharmacology (Berl) 229: 539-554.
16. Houchi H, Persyn W, Legastelois R, Naassila M, (2013) The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals. Addict Biol 18: 812-825.
17. Hölter SM, Danysz W, Spanagel R, (1996) Evidence for alcohol anti-craving properties of memantine. Eur J Pharmacol 314: R1-R2.
18. Hölter SM, Danysz W, Spanagel R, (2000) Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 292: 545-552.
19. Hu XJ, Follesa P, Ticku MK, (1996) Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Brain Res Mol Brain Res 36: 211-218.
20. Hundt W, Danysz W, Holter SM, Spanagel R, (1998) Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology (Berl) 135: 44-51.
21. Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D, (2009) Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci 29: 13494-13502.
22. Jeanblanc J, Coune F, Botia B, Naassila M, (2013) Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. Addict Biol. doi: 10.1111/adb.12039.
23. Johnson BA, (2008) Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Biochem Pharmacol 75: 34-56.
24. Kalluri HS, Mehta AK, Ticku MK, (1998) Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Brain Res Mol Brain Res 58: 221-224.
25. Koob GF, Zorrilla EP, (2010) Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Curr Opin Investig Drugs 11: 63-71.
26. Krupitsky EM, Neznanova O, Masalov D, Burakov AM, Didenko T, Romanova T, Tsoy M, Bespalov A, Slavina TY, Grinenko AA, Petrakis IL, Pittman B, Gueorguieva R, Zvartau EE, Krystal JH, (2007) Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients. Am J Psychiatry 164: 519-523.
27. Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC, (2003) N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther 99: 79-94.
28. Kumari M, Ticku MK, (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54: 152-189.
29. Litten RZ, Egli M, Heilig M, Cui C, Fertig JB, Ryan ML, Falk DE, Moss H, Huebner R, Noronha A, (2012) Medications development to treat alcohol dependence: a vision for the next decade. Addict Biol 17: 513-527.
30. Lovinger DM, White G, Weight FF, (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721-1724.
31. Malpass GE, Williams HL, McMillen BA, (2010) Effects of the non-competitive NMDA receptor antagonist memantine on the volitional consumption of ethanol by alcohol-preferring rats. Basic Clin Pharmacol Toxicol 106: 435-444.
32. Marvanova M, Wong G, (2004a) Adenosine A2A receptor mRNA expression is increased in rat striatum and nucleus accumbens after memantine administration. Brain Res Mol Brain Res 120: 193-196.
33. Marvanova M, Lakso M, Pirhonen J, Nawa H, Wong G, Castren E, (2001) The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci 18: 247-258.
34. Marvanova M, Lakso M, Wong G, (2004b) Identification of genes regulated by memantine and MK-801 in adult rat brain by cDNA microarray analysis. Neuropsychopharmacology 29: 1070-1079.
35. McMillen BA, Joyner PW, Parmar CA, Tyer WE, Williams HL, (2004) Effects of NMDA glutamate receptor antagonist drugs on the volitional consumption of ethanol by a genetic drinking rat. Brain Res Bull 64: 279-284.
36. Muir KW, (2006) Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol 6: 53-60.
37. Pandey SC, Carr LG, Heilig M, Ilveskoski E, Thiele TE, (2003) Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. Alcohol Clin Exp Res 27: 149-154.
38. Parsons CG, Danysz W, Quack G, (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data. Neuropharmacology 38: 735-767.
39. Peer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR, (2013) Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample. Drug Alcohol Depend 127: 215-219.
40. Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgansberger W, Schadrack J, (2001) The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40: 749-760.
41. Rassnick S, Pulvirenti L, Koob GF, (1992) Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens. Psychopharmacology (Berl) 109: 92-98.
42. Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ, (2003) Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med 348: 1333-1341.
43. Sabino V, Narayan AR, Zeric T, Steardo L, Cottone P, (2013) mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behav Brain Res 247: 9-16.
44. Samson HH, (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10: 436-442.
45. Shelton KL, Balster RL, (1997) Effects of gamma-aminobutyric acid agonists and N-methyl-D-aspartate antagonists on a multiple schedule of ethanol and saccharin self-administration in rats. J Pharmacol Exp Ther 280: 1250-1260.
46. Simon O'Brien E, Legastelois R, Houchi H, Vilpoux C, Alaux-Cantin S, Pierrefiche O, Andre E, Naassila M, (2011) Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology 36: 1518-1530.
47. Spanagel R, Zieglgansberger W, (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18: 54-59.
48. Spanagel R, Eilbacher B, Wilke R, (1994) Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat-a pharmacokinetic microdialysis study. Eur J Pharmacol 262: 21-26.
49. Spanagel R, Vengeliene V, Jandeleit B, Fischer WN, Grindstaff K, Zhang X, Gallop MA, Krstew EV, Lawrence AJ, Kiefer F, (2014) Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology 39: 783-791.
50. Tsai G, Coyle JT, (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49: 173-184.
51. Vendruscolo LF, Roberts AJ, (2013) Operant alcohol self-administration in dependent rats: focus on the vapor model. Alcohol 48: 277-286.
52. World Health Organization (2014) Global status report on alcohol and health 2014. Available at: http://www.who.int/substance-abuse/publications/global-alcohol-report/msb-gsr-2014-1.pdf?ua=1. Accessed 14 August 2014.
53. Zdanys K, Tampi RR, (2008) A systematic review of off-label uses of memantine for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 32: 1362-1374.
54. Zorrilla EP, Valdez GR, Weiss F, (2001) Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats. Psychopharmacology (Berl) 158: 374-381.