VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption

International Journal of Pharmaceutics

Volumn 493, Issue 1-2, 2015, Pages 451-459

  He, Haibing ^a   Wang, Puxiu ^a   Cai, Cuifang ^a   Yang, Rui ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Double emulsion technology; Gel Core SLN; Insulin; Oral Absorption; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; DICHLOROMETHANE; GLUCOSE; INSULIN; SOLID LIPID NANOPARTICLE; STEARIC ACID; WATER; ANTIDIABETIC AGENT; GEL; GLUCOSE BLOOD LEVEL; NANOPARTICLE; STEARIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; DRUG SYNTHESIS; EMULSION; ENDOCYTOSIS; GEL; GLUCOSE BLOOD LEVEL; HEATING; HYDROPHILICITY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INSULIN RELEASE; INTESTINE EPITHELIUM CELL; INTRAJEJUNAL DRUG ADMINISTRATION; LIPOPHILICITY; MACROMOLECULE; MALE; MASS SPECTROMETRY; NANOENCAPSULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TIGHT JUNCTION; ULTRASOUND; WATER SUPPLY; ZETA POTENTIAL; ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG RELEASE; INTESTINE ABSORPTION; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DRUG LIBERATION; GELS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; MALE; NANOPARTICLES; PARTICLE SIZE; RATS, SPRAGUE-DAWLEY; STEARIC ACIDS; VITAMIN B 12;

EID: 84939136048     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.004     Document Type: Article

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