Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Clinica Chimica Acta

Volumn 450, Issue , 2015, Pages 83-89

  Yang, Yan Kun ^a   Wang, Lin Ping ^a   Chen, Lei ^b   Yao, Xiu Ping ^c   Yang, Kun Qi ^a   Gao, Ling Gen ^b   Zhou, Xian Liang ^a  

^a FUWAI HOSPITAL   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c GENERAL HOSPITAL OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Coenzyme Q10; Endothelial dysfunction; Heart failure; Hypertension

Indexed keywords

NITRIC OXIDE; PLACEBO; PROSTACYCLIN; REACTIVE OXYGEN METABOLITE; UBIDECARENONE; ANTIOXIDANT; UBIQUINONE;

ADJUVANT THERAPY; AGING; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BIOENERGY; CHRONIC INFLAMMATION; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; DNA DAMAGE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ESSENTIAL HYPERTENSION; HEART FAILURE; HUMAN; HYPERTENSION; ISCHEMIC CARDIOMYOPATHY; LIPID PEROXIDATION; MULTICENTER STUDY (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; UNSPECIFIED SIDE EFFECT; VASODILATATION; ANALOGS AND DERIVATIVES; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; PATHOLOGY;

AGING; ANTIOXIDANTS; ENDOTHELIAL CELLS; HEART FAILURE; HUMANS; HYPERTENSION; UBIQUINONE;

EID: 84939131572     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2015.08.002     Document Type: Review

References (77)

1. Singh U., Devaraj S., Jialal I. Coenzyme Q10 supplementation and heart failure. Nutr. Rev. 2007, 65:286-293.
2. Strobel N.A., Fassett R.G., Marsh S.A., Coombes J.S. Oxidative stress biomarkers as predictors of cardiovascular disease. Int. J. Cardiol. 2011, 147:191-201.
3. Ren J., Pulakat L., Whaley-Connell A., Sowers J.R. Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J. Mol. Med. 2010, 88:993-1001.
4. Desbats M.A., Lunardi G., Doimo M., Trevisson E., Salviati L. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. J. Inherit. Metab. Dis. 2015, 38:145-156.
5. Ayer A., Macdonald P., Stocker R. CoQ10 function and role in heart failure and ischemic heart disease. Annu. Rev. Nutr. 2015, 35:175-213.
6. Tsai K.L., Huang Y.H., Kao C.L., Yang D.M., Lee H.C., Chou H.Y., Chen Y.C., Chiou G.Y., Chen L.H., Yang Y.P., et al. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. J. Nutr. Biochem. 2012, 23:458-468.
7. Schmelzer C., Lindner I., Vock C., Fujii K., Doring F. Functional connections and pathways of coenzyme Q10-inducible genes: an in-silico study. IUBMB Life 2007, 59:628-633.
8. Schmelzer C., Lindner I., Rimbach G., Niklowitz P., Menke T., Doring F. Functions of coenzyme Q10 in inflammation and gene expression. Biofactors 2008, 32:179-183.
9. Ungvari Z., Gupte S.A., Recchia F.A., Batkai S., Pacher P. Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Curr. Vasc. Pharmacol. 2005, 3:221-229.
10. Rimbaud S., Garnier A., Ventura-Clapier R. Mitochondrial biogenesis in cardiac pathophysiology. Pharmacol. Rep. 2009, 61:131-138.
11. Bhagavan H.N., Chopra R.K. Potential role of ubiquinone (coenzyme Q10) in pediatric cardiomyopathy. Clin. Nutr. 2005, 24:331-338.
12. Bergamini C., Cicoira M., Rossi A., Vassanelli C. Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure. Eur. J. Heart Fail. 2009, 11:444-452.
13. Izumiya Y., Kim S., Izumi Y., Yoshida K., Yoshiyama M., Matsuzawa A., Ichijo H., Iwao H. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Circ. Res. 2003, 93:874-883.
14. Lim J.Y., Park S.J., Hwang H.Y., Park E.J., Nam J.H., Kim J., Park S.I. TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. J. Mol. Cell. Cardiol. 2005, 39:627-636.
15. Nakagami H., Takemoto M., Liao J.K. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J. Mol. Cell. Cardiol. 2003, 35:851-859.
16. Rocha R., Martin-Berger C.L., Yang P., Scherrer R., Delyani J., McMahon E. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002, 143:4828-4836.
17. Turunen M., Olsson J., Dallner G. Metabolism and function of coenzyme Q. Biochim. Biophys. Acta 2004, 1660:171-199.
18. Groneberg D.A., Kindermann B., Althammer M., Klapper M., Vormann J., Littarru G.P., Doring F. Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int. J. Biochem. Cell Biol. 2005, 37:1208-1218.
19. Kai H., Kuwahara F., Tokuda K., Imaizumi T. Diastolic dysfunction in hypertensive hearts: roles of perivascular inflammation and reactive myocardial fibrosis. Hypertens. Res. 2005, 28:483-490.
20. Swarnakar N.K., Jain A.K., Singh R.P., Godugu C., Das M., Jain S. Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials 2011, 32:6860-6874.
21. Jung H.J., Park E.H., Lim C.J. Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals. J. Pharm. Pharmacol. 2009, 61:1391-1395.
22. Yamamura Y. ITaYT: clinical use of coenzyme Q10 for the treatment of cardiovascular disease. Jpn Circ. J. 1967, 31:168-170.
23. Soja A.M., Mortensen S.A. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol. Aspects Med. 1997, 18:S159-S168. (Suppl.).
24. Sander S., Coleman C.I., Patel A.A., Kluger J., White C.M. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J. Card. Fail. 2006, 12:464-472.
25. Morisco C., Trimarco B., Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin. Investig. 1993, 71:S134-S136.
26. Lampertico M., Comis S. Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure. Clin. Investig. 1993, 71:S129-S133.
27. Baggio E., Gandini R., Plancher A.C., Passeri M., Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol. Aspects Med. 1994, 15:s287-4. (Suppl.).
28. Hosseini V.N. Comparison of coenzyme Q10 versus placebo in chronic heart failure. Res. J. Biol. Sci. 2008, 3:884-887.
29. Mortensen S.A., Rosenfeldt F., Kumar A., Dolliner P., Filipiak K.J., Pella D., Alehagen U., Steurer G., Littarru G.P., Investigators Q.S.S. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014, 2:641-649.
30. Hirooka Y., Kishi T., Sakai K., Takeshita A., Sunagawa K. Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 300:R818-R826.
31. Hirooka Y. Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension. Hypertens. Res. 2011, 34:407-412.
32. Briones A.M., Touyz R.M. Oxidative stress and hypertension: current concepts. Curr. Hypertens. Rep. 2010, 12:135-142.
33. Addabbo F., Montagnani M., Goligorsky M.S. Mitochondria and reactive oxygen species. Hypertension 2009, 53:885-892.
34. Datla S.R., Griendling K.K. Reactive oxygen species, NADPH oxidases, and hypertension. Hypertension 2010, 56:325-330.
35. Overvad K., Diamant B., Holm L., Holmer G., Mortensen S.A., Stender S. Coenzyme Q10 in health and disease. Eur. J. Clin. Nutr. 1999, 53:764-770.
36. McCarty M.F. Coenzyme Q versus hypertension: does CoQ decrease endothelial superoxide generation?. Med. Hypotheses 1999, 53:300-304.
37. Frei B., Kim M.C., Ames B.N. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:4879-4883.
38. Ernster L., Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1995, 1271:195-204.
39. Houston M.C. Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog. Cardiovasc. Dis. 2005, 47:396-449.
40. Lyamina N.P., Lyamina S.V., Senchiknin V.N., Mallet R.T., Downey H.F., Manukhina E.B. Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension. J. Hypertens. 2011, 29:2265-2272.
41. Wyman M., Leonard M., Morledge T. Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?. Cleve. Clin. J. Med. 2010, 77:435-442.
42. Lonnrot K., Porsti I., Alho H., Wu X., Hervonen A., Tolvanen J.P. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br. J. Pharmacol. 1998, 124:1500-1506.
43. Burke B.E., Neuenschwander R., Olson R.D. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South. Med. J. 2001, 94:1112-1117.
44. Rosenfeldt F.L., Haas S.J., Krum H., Hadj A., Ng K., Leong J.Y., Watts G.F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J. Hum. Hypertens. 2007, 21:297-306.
45. Ho M.J., Bellusci A., Wright J.M. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst. Rev. 2009, CD007435.
46. Dai Y.L., Luk T.H., Yiu K.H., Wang M., Yip P.M., Lee S.W., Li S.W., Tam S., Fong B., Lau C.P., et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis 2011, 216:395-401.
47. Lim S.C., Lekshminarayanan R., Goh S.K., Ong Y.Y., Subramaniam T., Sum C.F., Ong C.N., Lee B.L. The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus. Atherosclerosis 2008, 196:966-969.
48. Hamilton S.J., Chew G.T., Watts G.F. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 2009, 32:810-812.
49. Lee Y.J., Cho W.J., Kim J.K., Lee D.C. Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study. J. Med. Food 2011, 14:386-390.
50. Giannotti G., Landmesser U. Endothelial dysfunction as an early sign of atherosclerosis. Herz 2007, 32:568-572.
51. Seals D.R., Jablonski K.L., Donato A.J. Aging and vascular endothelial function in humans. Clin. Sci. (Lond.) 2011, 120:357-375.
52. Belardinelli R., Tiano L., Littarru G.P. Oxidative stress, endothelial function and coenzyme Q10. Biofactors 2008, 32:129-133.
53. Tiano L., Belardinelli R., Carnevali P., Principi F., Seddaiu G., Littarru G.P. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur. Heart J. 2007, 28:2249-2255.
54. Belardinelli R., Mucaj A., Lacalaprice F., Solenghi M., Seddaiu G., Principi F., Tiano L., Littarru G.P. Coenzyme Q10 and exercise training in chronic heart failure. Eur. Heart J. 2006, 27:2675-2681.
55. Madamanchi N.R., Vendrov A., Runge M.S. Oxidative stress and vascular disease. Arterioscler. Thromb. Vasc. Biol. 2005, 25:29-38.
56. Kunitomo M., Yamaguchi Y., Kagota S., Otsubo K. Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. J. Pharmacol. Sci. 2008, 107:128-137.
57. Lee B.J., Tseng Y.F., Yen C.H., Lin P.T. Effects of coenzyme Q10 supplementation (300mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr. J. 2013, 12:142.
58. Schmelzer C., Lorenz G., Rimbach G., Doring F. In vitro effects of the reduced form of coenzyme Q(10) on secretion levels of TNF-alpha and chemokines in response to LPS in the human monocytic cell line THP-1. J. Clin. Biochem. Nutr. 2009, 44:62-66.
59. Kuettner A., Pieper A., Koch J., Enzmann F., Schroeder S. Influence of coenzyme Q(10) and cerivastatin on the flow-mediated vasodilation of the brachial artery: results of the ENDOTACT study. Int. J. Cardiol. 2005, 98:413-419.
60. Watts G.F., Playford D.A., Croft K.D., Ward N.C., Mori T.A., Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 2002, 45:420-426.
61. Dai Y.L., Luk T.H., Siu C.W., Yiu K.H., Chan H.T., Lee S.W., Li S.W., Tam S., Fong B., Lau C.P., Tse H.F. Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in patients with coronary artery disease. Cardiovasc. Toxicol. 2010, 10:130-138.
62. Raitakari O.T., McCredie R.J., Witting P., Griffiths K.A., Letters J., Sullivan D., Stocker R., Celermajer D.S. Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radic. Biol. Med. 2000, 28:1100-1105.
63. Langsjoen P.H., Vadhanavikit S., Folkers K. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:4240-4244.
64. Judy W., Hall J., Toth P., Folkers K. Double blind-double crossover study of coenzyme Q10 in heart failure. Biomed. Clin. Aspects Coenzyme Q 1986, 5:315-323.
65. Poggesi L., Galanti G., Comeglio M., Toncelli L., Vinci M. Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy: a medium-term randomized double-blind study versus placebo. Curr. Ther. Res. 1991, 49:878-886.
66. Permanetter B., Rossy W., Klein G., Weingartner F., Seidl K.F., Blomer H. Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. Eur. Heart J. 1992, 13:1528-1533.
67. Rengo F., Abete P., Landino P., Leosco D., Covelluzzi F., Vitale D., Fedi V., Ferrara N. Role of metabolic therapy in cardiovascular disease. Clin. Investig. 1993, 71:S124-S128.
68. Morisco C., Nappi A., Argenziano L., Sarno D., Fonatana D., Imbriaco M., Nicolai E., Romano M., Rosiello G., Cuocolo A. Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment. Mol. Aspects Med. 1994, 15:s155-s163. (Suppl.).
69. Hofman-Bang C., Rehnqvist N., Swedberg K., Wiklund I., Astrom H. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group. J. Card. Fail. 1995, 1:101-107.
70. Watson P.S., Scalia G.M., Galbraith A., Burstow D.J., Bett N., Aroney C.N. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J. Am. Coll. Cardiol. 1999, 33:1549-1552.
71. Munkholm H., Hansen H.H., Rasmussen K. Coenzyme Q10 treatment in serious heart failure. Biofactors 1999, 9:285-289.
72. Khatta M., Alexander B.S., Krichten C.M., Fisher M.L., Freudenberger R., Robinson S.W., Gottlieb S.S. The effect of coenzyme Q10 in patients with congestive heart failure. Ann. Intern. Med. 2000, 132:636-640.
73. Keogh A., Fenton S., Leslie C., Aboyoun C., Macdonald P., Zhao Y.C., Bailey M., Rosenfeldt F. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003, 12:135-141.
74. Langsjoen P.H., Langsjoen A.M. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors 2008, 32:119-128.
75. Yamagami T., Takagi M., Akagami H., Kubo H., Toyama S., Okamoto T., Kishi T., Folkers K. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. Biomed. Clin. Aspects Coenzyme Q 1986, 5:337-343.
76. Digiesi V., Cantini F., Oradei A., Bisi G., Guarino G.C., Brocchi A., Bellandi F., Mancini M., Littarru G.P. Coenzyme Q10 in essential hypertension. Mol. Aspects Med. 1994, 15:s257-s263. (Suppl.).
77. Singh R.B., Niaz M.A., Rastogi S.S., Shukla P.K., Thakur A.S. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J. Hum. Hypertens. 1999, 13:203-208.