Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in patients with coronary artery disease

Cardiovascular Toxicology

Volumn 10, Issue 2, 2010, Pages 130-138

  Dai, Yuk Ling ^a   Luk, Ting Hin ^a   Siu, Chung Wah ^a,b   Yiu, Kai Hang ^a   Chan, Hiu Ting ^a   Lee, Stephen W L ^a   Li, Sheung Wai ^c   Tam, Sidney ^d   Fong, Bonnie ^d   Lau, Chu Pak ^a   Tse, Hung Fat ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c TUNG WAH HOSPITAL   (Hong Kong)

^d QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Endothelial dysfunction; Mitochondrial dysfunction; Statin

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTIC ACID; LIPID; SIMVASTATIN; BIOLOGICAL MARKER; PYRUVIC ACID;

AGED; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BRACHIAL ARTERY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG MEGADOSE; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; LACTATE BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; BLOOD; BLOOD FLOW; CHEMICALLY INDUCED; DRUG EFFECTS; HEART MITOCHONDRION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASODILATATION;

AGED; BIOLOGICAL MARKERS; BRACHIAL ARTERY; CORONARY ARTERY DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LACTIC ACID; MALE; MITOCHONDRIA, HEART; MITOCHONDRIAL DISEASES; PYRUVIC ACID; REGIONAL BLOOD FLOW; SIMVASTATIN; VASODILATION;

EID: 77956394303     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-010-9071-1     Document Type: Article

References (31)

1. LaRosa, J. C., He, J., & Vupputuri, S. (1999). Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials. JAMA, 282, 2340-2346.
2. Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., et al. (2005). Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. New England Journal of Medicine, 352, 29-38.
3. Langsjoen, P. H., & Langsjoen, A. M. (2003). The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. Biofactors, 18, 101-111.
4. Thompson, P. D., Clarkson, P., & Karas, R. H. (2003). Statinassociated myopathy. JAMA, 289, 1681-1690.
5. Phillips, P. S., Haas, R. H., Bannykh, S., Hathaway, S., Gray, N. L., Kimura, B. J., et al. (2002). Statin-associated myopathy with normal creatine kinase levels. Annals of Internal Medicine, 137, 581-585.
6. Chariot, P., Monnet, I., Mouchet, M., Rohr, M., Lefaucheur, J. P., Dubreuil-Lemaire, M. L., et al. (1994). Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy. Arthritis and Rheumatism, 37, 583-586.
7. Munnich, A., Rotig, A., Chretien, D., Saudubray, J. M., Cormier, V., & Rustin, P. (1996). Clinical presentations and laboratory investigations in respiratory chain deficiency. European Journal of Pediatrics, 155, 262-274.
8. De Pinieux, G., Chariot, P., Ammi-Said, M., Louarn, F., Lejonc, J. L., Astier, A., et al. (1996). Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. British Journal of Clinical Pharmacology, 42, 333-337.
9. Heart Protection Study Collaborative Group. (2002). MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet, 360, 7-22.
10. Madamanchi, N. R., & Runge, M. S. (2007). Mitochondrial dysfunction in atherosclerosis. Circulation Research, 100, 460-473.
11. Puddu, P., Puddu, G. M., Galletti, L., Cravero, E., & Muscari, A. (2005). Mitochondrial dysfunction as an initiating event in atherogenesis: A plausible hypothesis. Cardiology, 103, 137-141.
12. Lerman, A., & Zeiher, A. M. (2005). Endothelial function: Cardiac events. Circulation, 111, 363-368.
13. Chan, Y. H., Lau, K. K., Yiu, K. H., Li, S. W., Chan, H. T., Tam, S., et al. (2007). Isoflavone intake in persons at high risk of cardiovascular events: Implications for vascular endothelial function and the carotid atherosclerotic burden. American Journal of Clinical Nutrition, 86, 938-945.
14. Lau, K. K., Chan, Y. H., Yiu, K. H., Li, S. W., Tam, S., Lau, C. P., et al. (2007). Burden of carotid atherosclerosis in patients with stroke: Relationships with circulating endothelial progenitor cells and hypertension. Journal of Human Hypertension, 21, 445-451.
15. Scranton, R. E., Young, M., Lawler, E., Solomon, D., Gagnon, D., & Gaziano, J. M. (2005). Statin use and fracture risk: Study of a US veterans population. Archives of Internal Medicine, 165, 2007-2012.
16. Tan, K. C., Wat, N. M., Tam, S. C., Janus, E. D., Lam, T. H., & Lam, K. S. (2003). C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance. Diabetes Care, 26, 2323-2328.
17. Debray, F. G., Mitchell, G. A., Allard, P., Robinson, B. H., Hanley, J. A., & Lambert, M. (2007). Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. Clinical Chemistry, 53, 916-921.
18. Ip, M. S., Tse, H. F., Lam, B., Tsang, K. W., & Lam, W. K. (2004). Endothelial function in obstructive sleep apnea and response to treatment. American Journal of Respiratory and Critical Care Medicine, 169, 348-353.
19. Lamperti, C., Naini, A. B., Lucchini, V., Prelle, A., Bresolin, N., Moggio, M., et al. (2005). Muscle coenzyme Q10 level in statinrelated myopathy. Archives of Neurology, 62, 1709-1712.
20. Gutierrez, J., Ballinger, S. W., Darley-Usmar, V. M., & Landar, A. (2006). Free radicals, mitochondria, and oxidized lipids: The emerging role in signal transduction in vascular cells. Circulation Research, 99, 924-932.
21. Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S., Matsumura, T., Kaneda, Y., et al. (2000). Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature, 404, 787-790.
22. Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z. Y., Uyeminami, D., Pinkerton, K. E., et al. (2002). Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues. Circulation, 105, 849-854.
23. Kavanagh, T., Mertens, D. J., Hamm, L. F., Beyene, J., Kennedy, J., Corey, P., et al. (2003). Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. Journal of the American College of Cardiology, 42, 2139-2143.
24. Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002). Exercise capacity and mortality among men referred for exercise testing. New England Journal of Medicine, 346, 793-801.
25. Csiszar, A., Labinskyy, N., Orosz, Z., & Ungvari, Z. (2006). Altered mitochondrial energy metabolism may play a role in vascular aging. Medical Hypotheses, 67, 904-908.
26. Lee, J. Y., Jung, G. Y., Heo, H. J., Yun, M. R., Park, J. Y., Bae, S. S., et al. (2006). 4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen species. Toxicology Letters, 166, 212-221.
27. Kinscherf, R., Deigner, H. P., Usinger, C., Pill, J., Wagner, M., Kamencic, H., et al. (1997). Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: Its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits. FASEB J, 11, 1317-1328.
28. Van Etten, R. W., de Koning, E. J., Honing, M. L., Stroes, E. S., Gaillard, C. A., & Rabelink, T. J. (2002). Intensive lipid lowering by statin therapy does not improve vasoreactivity in patients with type 2 diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 799-804.
29. Ridker, P. M., Danielson, E., Fonseca, F. A., Genest, J., Gotto, A. M., Jr., Kastelein, J. J., et al. (2009). Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial. Lancet, 373, 1175-1182.
30. Wenzel, P., Schuhmacher, S., Kienhofer, J., Muller, J., Hortmann, M., Oelze, M., et al. (2008). Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovascular Research, 80, 280-289.
31. Yufu, K., Takahashi, N., Hara, M., Saikawa, T., & Yoshimatsu, H. (2007). Measurement of the brachial-ankle pulse wave velocity and flow-mediated dilatation in young, healthy smokers. Hypertension Research, 30, 607-612.