메뉴 건너뛰기




Volumn 2, Issue 6, 2014, Pages 641-649

The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results from Q-SYMBIO: A randomized double-blind trial

Author keywords

Chronic heart failure; Coenzyme Q10; Metabolic therapy; Randomized controlled trial; Ubiquinone

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; PLACEBO; UBIDECARENONE; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; PEPTIDE FRAGMENT; PRO-BRAIN NATRIURETIC PEPTIDE (1-76); UBIQUINONE; VITAMIN;

EID: 84923212398     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2014.06.008     Document Type: Article
Times cited : (362)

References (38)
  • 1
    • 34547736390 scopus 로고    scopus 로고
    • The clinical application of metabolic therapy for cardiovascular disease
    • Hadj A., Pepe S., Rosenfeldt F. The clinical application of metabolic therapy for cardiovascular disease. Heart Lung Circ 2007, 16(Suppl 3):S56-S64.
    • (2007) Heart Lung Circ , vol.16 , pp. S56-S64
    • Hadj, A.1    Pepe, S.2    Rosenfeldt, F.3
  • 2
    • 77649232263 scopus 로고    scopus 로고
    • Energetic myocardial metabolism and oxidative stress: let's make them our friends in the fight against heart failure
    • Scolletta S., Biagioli B. Energetic myocardial metabolism and oxidative stress: let's make them our friends in the fight against heart failure. Biomed Pharmacother 2010, 64:203-207.
    • (2010) Biomed Pharmacother , vol.64 , pp. 203-207
    • Scolletta, S.1    Biagioli, B.2
  • 3
    • 33745739747 scopus 로고    scopus 로고
    • Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate
    • Sheeran F.L., Pepe S. Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate. Biochim Biophys Acta 2006, 1757:543-552.
    • (2006) Biochim Biophys Acta , vol.1757 , pp. 543-552
    • Sheeran, F.L.1    Pepe, S.2
  • 4
    • 0002532996 scopus 로고
    • The antioxidant role of coenzyme Q
    • Taylor and Francis, London, G. Lenaz, O. Barnabei, A.B.M. Rabbi (Eds.)
    • Beyer R., Ernster L. The antioxidant role of coenzyme Q. Highlights in Ubiquinone Research 1990, 191-213. Taylor and Francis, London. G. Lenaz, O. Barnabei, A.B.M. Rabbi (Eds.).
    • (1990) Highlights in Ubiquinone Research , pp. 191-213
    • Beyer, R.1    Ernster, L.2
  • 6
    • 0022021457 scopus 로고
    • Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10
    • Folkers K., Vadhanavikit S., Mortensen S. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A 1985, 82:901-904.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 901-904
    • Folkers, K.1    Vadhanavikit, S.2    Mortensen, S.3
  • 7
    • 53949123122 scopus 로고    scopus 로고
    • Coenzyme Q10: an independent predictor of mortality in chronic heart failure
    • Molyneux S.L., Florkowski C.M., George P.M., et al. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. JAm Coll Cardiol 2008, 52:1435-1441.
    • (2008) JAm Coll Cardiol , vol.52 , pp. 1435-1441
    • Molyneux, S.L.1    Florkowski, C.M.2    George, P.M.3
  • 8
    • 77957554800 scopus 로고    scopus 로고
    • Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heartfailure)
    • McMurray J.J.V., Dunselman P., Wedel H., et al. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heartfailure). JAm Coll Cardiol 2010, 56:1196-1204.
    • (2010) JAm Coll Cardiol , vol.56 , pp. 1196-1204
    • McMurray, J.J.V.1    Dunselman, P.2    Wedel, H.3
  • 9
    • 0030777310 scopus 로고    scopus 로고
    • Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials
    • Soja A., Mortensen S. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med 1997, 18(Suppl):s159-s168.
    • (1997) Mol Aspects Med , vol.18 , pp. s159-s168
    • Soja, A.1    Mortensen, S.2
  • 10
    • 33750134250 scopus 로고    scopus 로고
    • The impact of coenzyme Q10 on systolic function in patients with chronic heart failure
    • Sander S., Coleman C.I., Patel A.A., Kluger J., White C.M. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. JCard Fail 2006, 12:464-472.
    • (2006) JCard Fail , vol.12 , pp. 464-472
    • Sander, S.1    Coleman, C.I.2    Patel, A.A.3    Kluger, J.4    White, C.M.5
  • 11
    • 84873399755 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis
    • Fotino A., Thompson-Paul A., Bazzano L. Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. Am J Clin Nutr 2013, 97:268-275.
    • (2013) Am J Clin Nutr , vol.97 , pp. 268-275
    • Fotino, A.1    Thompson-Paul, A.2    Bazzano, L.3
  • 12
    • 0348049914 scopus 로고    scopus 로고
    • Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
    • Rosenfeldt F., Hilton D., Pepe S., Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 2003, 18:91-100.
    • (2003) Biofactors , vol.18 , pp. 91-100
    • Rosenfeldt, F.1    Hilton, D.2    Pepe, S.3    Krum, H.4
  • 14
    • 0346158465 scopus 로고    scopus 로고
    • Overview on coenzyme Q10 asadjunctive therapy in chronic heart failure: rationale, design and end-points of "Q-symbio"-a multinational trial
    • Mortensen S. Overview on coenzyme Q10 asadjunctive therapy in chronic heart failure: rationale, design and end-points of "Q-symbio"-a multinational trial. Biofactors 2003, 18:79-89.
    • (2003) Biofactors , vol.18 , pp. 79-89
    • Mortensen, S.1
  • 15
    • 80055011831 scopus 로고    scopus 로고
    • Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction
    • Januzzi J.L., Rehman S.U., Mohammed A.A., et al. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. JAm Coll Cardiol 2011, 58:1881-1889.
    • (2011) JAm Coll Cardiol , vol.58 , pp. 1881-1889
    • Januzzi, J.L.1    Rehman, S.U.2    Mohammed, A.A.3
  • 16
    • 16844364826 scopus 로고    scopus 로고
    • The effect of cardiac resynchronization on morbidity and mortality in heart failure
    • Cleland J.G.F., Daubert J.-C., Erdmann E., et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. NEngl J Med 2005, 352:1539-1549.
    • (2005) NEngl J Med , vol.352 , pp. 1539-1549
    • Cleland, J.G.F.1    Daubert, J.-C.2    Erdmann, E.3
  • 17
    • 19944380418 scopus 로고    scopus 로고
    • Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and invitro contractility of myocardial tissue
    • Rosenfeldt F., Marasco S., Lyon W., et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and invitro contractility of myocardial tissue. JThorac Cardiovasc Surg 2005, 129:25-32.
    • (2005) JThorac Cardiovasc Surg , vol.129 , pp. 25-32
    • Rosenfeldt, F.1    Marasco, S.2    Lyon, W.3
  • 19
    • 0032601546 scopus 로고    scopus 로고
    • Development of a novel, N-terminal-proBNP (NT-proBNP) assay with a low detection limit
    • Karl J., Borgya A., Gallusser A., et al. Development of a novel, N-terminal-proBNP (NT-proBNP) assay with a low detection limit. Scand J Clin Lab Invest Suppl 1999, 230:177-181.
    • (1999) Scand J Clin Lab Invest Suppl , vol.230 , pp. 177-181
    • Karl, J.1    Borgya, A.2    Gallusser, A.3
  • 20
    • 0028609515 scopus 로고
    • Aone year bioavailability study of coenzyme Q10 with 3 months withdrawal period
    • Folkers K., Moesgaard S., Morita M. Aone year bioavailability study of coenzyme Q10 with 3 months withdrawal period. Mol Aspects Med 1994, 15(Suppl):s281-s285.
    • (1994) Mol Aspects Med , vol.15 , pp. s281-s285
    • Folkers, K.1    Moesgaard, S.2    Morita, M.3
  • 22
    • 0020606114 scopus 로고
    • Aplacebo-controlled trial of captopril in refractory chronic congestive heart failure: Captopril Multicenter Research Group
    • No authors listed
    • No authors listed Aplacebo-controlled trial of captopril in refractory chronic congestive heart failure: Captopril Multicenter Research Group. JAm Coll Cardiol 1983, 2:755-763.
    • (1983) JAm Coll Cardiol , vol.2 , pp. 755-763
  • 23
    • 10544251442 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure: the PRECISE trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise
    • Packer M., Colucci W.S., Sackner-Bernstein J.D., et al. Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure: the PRECISE trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise. Circulation 1996, 94:2793-2799.
    • (1996) Circulation , vol.94 , pp. 2793-2799
    • Packer, M.1    Colucci, W.S.2    Sackner-Bernstein, J.D.3
  • 24
    • 84892992720 scopus 로고    scopus 로고
    • Prognostic value of the physical examination in patients with heart failure and atrial fibrillation: insights from the AF-CHF trial (Atrial Fibrillation and Chronic Heart Failure)
    • Caldentey G., Khairy P., Roy D., et al. Prognostic value of the physical examination in patients with heart failure and atrial fibrillation: insights from the AF-CHF trial (Atrial Fibrillation and Chronic Heart Failure). JAm Coll Cardiol HF 2014, 2:15-23.
    • (2014) JAm Coll Cardiol HF , vol.2 , pp. 15-23
    • Caldentey, G.1    Khairy, P.2    Roy, D.3
  • 25
    • 0029257854 scopus 로고
    • Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure: the Q10 Study Group
    • Hofman-Bang C., Rehnqvist N., Swedberg K., Wiklund I., Åström H. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure: the Q10 Study Group. JCard Fail 1995, 1:101-107.
    • (1995) JCard Fail , vol.1 , pp. 101-107
    • Hofman-Bang, C.1    Rehnqvist, N.2    Swedberg, K.3    Wiklund, I.4    Åström, H.5
  • 26
    • 0027281056 scopus 로고
    • Angiotensin converting enzyme inhibitors in heart failure: how good are they?
    • Townend J.N., Littler W.A. Angiotensin converting enzyme inhibitors in heart failure: how good are they?. Br Heart J 1993, 69:373-375.
    • (1993) Br Heart J , vol.69 , pp. 373-375
    • Townend, J.N.1    Littler, W.A.2
  • 27
    • 0027293550 scopus 로고
    • Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study
    • Morisco C., Trimarco B., Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig 1993, 71(Suppl):134-136.
    • (1993) Clin Investig , vol.71 , pp. 134-136
    • Morisco, C.1    Trimarco, B.2    Condorelli, M.3
  • 28
    • 34248175243 scopus 로고    scopus 로고
    • The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease
    • Haas R.H. The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. Mitochondrion 2007, 7(Suppl):S136-S145.
    • (2007) Mitochondrion , vol.7 , pp. S136-S145
    • Haas, R.H.1
  • 29
    • 0027279764 scopus 로고
    • Heart failure is a dominant deficiency of coenzyme Q10 and challenges for future clinical research on CoQ10
    • Folkers K. Heart failure is a dominant deficiency of coenzyme Q10 and challenges for future clinical research on CoQ10. Clin Investig 1993, 71(Suppl):s51-s54.
    • (1993) Clin Investig , vol.71 , pp. s51-s54
    • Folkers, K.1
  • 30
    • 8444246276 scopus 로고    scopus 로고
    • The metabolic vicious cycle in heart failure
    • Opie L.H. The metabolic vicious cycle in heart failure. Lancet 2004, 364:1733-1734.
    • (2004) Lancet , vol.364 , pp. 1733-1734
    • Opie, L.H.1
  • 31
    • 33750904106 scopus 로고    scopus 로고
    • Coenzyme Q10 and exercise training in chronic heart failure
    • Belardinelli R., Macaj A., Lacalaprice F., et al. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J 2006, 27:2675-2681.
    • (2006) Eur Heart J , vol.27 , pp. 2675-2681
    • Belardinelli, R.1    Macaj, A.2    Lacalaprice, F.3
  • 33
    • 0027158373 scopus 로고
    • Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study
    • Ghirlanda G., Oradei A., Manto A., et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. JClin Pharmacol 1993, 33:226-229.
    • (1993) JClin Pharmacol , vol.33 , pp. 226-229
    • Ghirlanda, G.1    Oradei, A.2    Manto, A.3
  • 34
    • 0030770430 scopus 로고    scopus 로고
    • Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors
    • Mortensen S., Leth A., Agner E., Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997, 18(Suppl):s137-s144.
    • (1997) Mol Aspects Med , vol.18 , pp. s137-s144
    • Mortensen, S.1    Leth, A.2    Agner, E.3    Rohde, M.4
  • 35
    • 0024401216 scopus 로고
    • Age-related changes in the lipid compositions of rat and human tissues
    • Kalén A., Appelkvist E., Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989, 24:579-584.
    • (1989) Lipids , vol.24 , pp. 579-584
    • Kalén, A.1    Appelkvist, E.2    Dallner, G.3
  • 36
    • 84883285659 scopus 로고    scopus 로고
    • Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
    • Alehagen U., Johansson P., Björnstedt M., Rosén A., Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013, 167:1860-1866.
    • (2013) Int J Cardiol , vol.167 , pp. 1860-1866
    • Alehagen, U.1    Johansson, P.2    Björnstedt, M.3    Rosén, A.4    Dahlström, U.5
  • 37
    • 70350020285 scopus 로고    scopus 로고
    • Micronutrient deficiencies an unmet need in heart failure
    • Soukoulis V., Dihu J.B., Sole M., et al. Micronutrient deficiencies an unmet need in heart failure. JAm Coll Cardiol 2009, 54:1660-1673.
    • (2009) JAm Coll Cardiol , vol.54 , pp. 1660-1673
    • Soukoulis, V.1    Dihu, J.B.2    Sole, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.