The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus

Atherosclerosis

Volumn 196, Issue 2, 2008, Pages 966-969

  Lim, Su Chi ^a   Lekshminarayanan, Rajmohan ^a   Goh, Siew Kheng ^a   Ong, Yuen Yeng ^a   Subramaniam, Tavintharan ^a   Sum, Chee Fang ^a   Ong, Choon Nam ^b   Lee, Bee Lan ^b  

^a ALEXANDRA HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Coenzyme Q10; Endothelial function; Type 2 diabetes

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; UBIDECARENONE; UBIQUINONE; CELL ADHESION MOLECULE; DRUG DERIVATIVE; UBIQUINOL; UNCLASSIFIED DRUG;

BLOOD SAMPLING; BLOOD VESSEL INJURY; BLOOD VESSEL REACTIVITY; CLINICAL TRIAL; DIABETIC ANGIOPATHY; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LETTER; METABOLIC REGULATION; MICROCIRCULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; ADULT; BLOOD; COENZYME; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

ADULT; CELL ADHESION MOLECULES; COENZYMES; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; UBIQUINONE;

EID: 38349110224     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.11.012     Document Type: Letter

References (18)

1. Brownlee M. Banting Lecture 2004. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 54 (2005) 1615-1625
2. Ceriello A. New insights on oxidative stress and diabetic complications may lead to a "Causal" antioxidant therapy. Diabetes Care 26 (2003) 1589-1596
3. Crane F.L. Biochemical functions of coenzyme Q10. J Am Coll Nutr 20 (2001) 591-598
4. Sohal R.S. Coenzyme Q and vitamin E interactions. Methods Enzymol 378 (2004) 146-151
5. Bhagavan H.N., and Chopra R.K. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 40 (2006) 445-453
6. Widlansky M.E., Gokce N., Keaney Jr. J.F., and Vita J.A. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42 (2003) 1149-1160
7. Alam T.A., Seifalian A.M., and Baker D. A review of methods currently used for assessment of in vivo endothelial function. Eur J Vasc Endovasc Surg 29 (2005) 269-276
8. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 338 7 (1998) 436-445
9. Caballero A.E., Saouaf R., Arora S., et al. Reactivity of the micro- and macro-circulation is impaired in those at risk for type 2 diabetes. Diabetes 48 (1999) 1856-1862
10. Goldfine A.B., Beckman J.A., Betensky R.A., et al. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol 47 (2006) 2456-2461
11. Lim S.C., Tan H.H., Goh S.K., et al. Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q (10). Diabet Med 23 (2006) 1344-1349
12. Playford D.A., Watts G.F., Croft K.D., and Burke V. Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes. Atherosclerosis 168 (2003) 169-179
13. Watts G.F., Playford D.A., Croft K.D., Ward N.C., Mori T.A., and Burke V. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 45 (2002) 420-426
14. Hughes K., Lee B.L., Feng X., Lee J., and Ong C.N. Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese. Free Radic Biol Med 32 (2002) 132-138
15. Lim S.C., Morgenthaler N.G., Subramaniam T., Wu Y.S., Goh S.K., and Sum C.F. The relationship between adrenomedullin, metabolic factors and vascular function in individuals with type 2 diabetes mellitus. Diabetes Care 30 (2007) 1513-1519
16. Sohal R.S., Kamzalov S., Sumien N., et al. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radic Biol Med 40 (2006) 480-487
17. Tiano L., Belardinelli R., Carnevali P., Principi F., Seddaiu G., and Littarru G.P. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur Heart J 28 (2007) 2249-2255
18. Williams M.E. New potential agents in treating diabetic kidney disease: the fourth act. Drugs 66 (2006) 2287-2298