Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: A double-blind randomized controlled study

Journal of Medicinal Food

Volumn 14, Issue 4, 2011, Pages 386-390

  Lee, Yong Jae ^a   Cho, Wan Je ^a   Kim, Jong Koo ^b   Lee, Duk Chul ^a,c  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

coenzyme Q10; fatigue; obesity; randomized clinical trial

Indexed keywords

GLUCOSE; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; UBIDECARENONE; C REACTIVE PROTEIN; DRUG DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UBIQUINONE;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTERIAL STIFFNESS; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENZYME BLOOD LEVEL; FATIGUE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN SENSITIVITY; LABORATORY TEST; MALE; METABOLIC PARAMETERS; OBESITY; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; ANKLE BRACHIAL INDEX; ARTERY; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; QUESTIONNAIRE; VASCULAR RESISTANCE;

ADMINISTRATION, ORAL; ADULT; ANKLE BRACHIAL INDEX; ARTERIES; BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; FATIGUE; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; QUESTIONNAIRES; UBIQUINONE; VASCULAR RESISTANCE;

EID: 79953211125     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.1202     Document Type: Article

References (27)

1. Højlund K, Mogensen M, Sahlin K, Beck-Nielsen H: Mitochondrial dysfunction in type 2 diabetes and obesity. Endocrinol Metab Clin North Am 2008;37:713-731.
2. Nisoli E, Clementi E, Carruba MO, Moncada S: Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 2007;100:795-806. (Pubitemid 46555684)
3. Kelley DE, He J, Menshikova EV, Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002;51:2944-2950.
4. Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE: Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005;54:8-14. (Pubitemid 40105089)
5. Qatanani M, Lazar MA: Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev 2007;21: 1443-1455. (Pubitemid 46955717)
6. Puddu P, Puddu GM, Galletti L, Cravero E, Muscari A: Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesis. Cardiology 2005;103:137-141. (Pubitemid 41094860)
7. Rogge MM: The role of impaired mitochondrial lipid oxidation in obesity. Biol Res Nurs 2009;10:356-373.
8. Lenaz G, Fato R, Formiggini G, Genova ML: The role of Coenzyme Q in mitochondrial electron transport. Mitochondrion 2007; 7(Suppl):S8-S33. (Pubitemid 46712238)
9. Thomas SR, Neuzil J, Stocker R: Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis? Mol Aspects Med 1997;18(Suppl):S85-S103.
10. Navas P, Villalba JM, de Cabo R: The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 2007;7(Suppl):S34-S40. (Pubitemid 46722290)
11. Crane FL: Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20:591-598.
12. Hodgson JM, Watts GF: Can coenzyme Q10 improve vascular function and blood pressure? Potential for effective therapeutic reduction in vascular oxidative stress. Biofactors 2003;18:129-136. (Pubitemid 38030707)
13. Estornell E, Fato R, Castelluccio C, Cavazzoni M, Parenti Castelli G, Lenaz G: Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria. FEBS Lett 1992; 311:107-109.
14. Lenaz G, Parenti Castelli G, Fato, D'Aurelio M, Bovina C, Formiggini G, Marchetti M, Estornell E, Rauchova H: Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation. Mol Aspects Med 1997;18(Suppl):S25-S31.
15. Rosenfeldt F, Hilton D, Pepe S, Krum H: Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 2003;18:91-100. (Pubitemid 38030703)
16. Shults CW: Coenzyme Q10 in neurodegenerative diseases. Curr Med Chem 2003;10:1917-1921.
17. Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR Jr: Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA 2008;299:2287-2293. (Pubitemid 351724395)
18. Krupp I, LaRocca NG, Muir-Nash J, Steinberg AD: The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erytheromatosus. Arch Neurol 1989;46:1121-1123. (Pubitemid 19246303)
19. Lean ME: Pathophysiology of obesity. Proc Nutr Soc 2000;59: 331-336.
20. Hulens M, Vansant G, Lysens R, Claessens AL, Muls E: Exercise capacity in lean versus obese women. Scand J Med Sci Sports 2001;11:305-309. (Pubitemid 33645157)
21. Hopps E, Noto D, Caimi G, Averna MR: A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis 2009;20:72-77.
22. Chew GT, Watts GF: Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis.' QJ Med 2004;97:537-548. (Pubitemid 39144601)
23. Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V: Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 2002;45: 420-426. (Pubitemid 34267365)
24. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF: Coenzyme Q10 in the treatment of hypertension: a metaanalysis of the clinical trials. J Hum Hypertens 2007;21:297-306. (Pubitemid 46453530)
25. Werbach MR: Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 2000;5:93-108. (Pubitemid 30226467)
26. Dhanasekaran M, Ren J: The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res 2005;2:447-459. (Pubitemid 41789609)
27. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y: Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 2008;24:293-299.