Medullary Colorectal Carcinoma Revisited: A Clinical and Pathological Study of 102 Cases

Annals of Surgical Oncology

Volumn 22, Issue 9, 2015, Pages 2988-2996

  Knox, Robert D ^a,b   Luey, Nathan ^a   Sioson, Loretta ^b,c   Kedziora, Andrew ^c   Clarkson, Adele ^b,c   Watson, Nicole ^c   Toon, Christopher W ^a,b,c,d   Cussigh, Carmen ^c   Pincott, Stuart ^a,b   Pillinger, Stephen ^a,b   Salama, Yasser ^a,b   Evans, Justin ^a,b   Percy, John ^a,b   Schnitzler, Margaret ^a,b   Engel, Alexander ^a,b   Gill, Anthony J ^a,b,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Histopath Pathology   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

AGED; ARTICLE; CANCER MORTALITY; CANCER SURVIVAL; CLINICAL FEATURE; COHORT ANALYSIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE MUTATION; GROUPS BY AGE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDULLARY CARCINOMA; MULTICENTER STUDY; OVERALL SURVIVAL; PHENOTYPE; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SEX DIFFERENCE; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR INVASION; ADENOCARCINOMA; CANCER STAGING; COLORECTAL TUMOR; FOLLOW UP; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; SURVIVAL RATE; VERY ELDERLY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CARCINOMA, MEDULLARY; COLORECTAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84938984820     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-014-4355-5     Document Type: Article

References (27)

1. Gibbs NM. Undifferentiated carcinoma of the large intestine. Histopathology. 1977;1:77–84.
2. Marzouk O, Schofield J. Review of histopathological and molecular prognostic features in colorectal cancer. Cancers. 2011;3:2767–810.
3. Thirunavukarasu P, Sathaiah M. Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol. 2010;37:901–7.
4. Fleming M, Ravula S, Tatishchev SF, Wang HL. Colorectal carcinoma: pathologic aspects. J Gastrointest Oncol. 2012;3:153–73.
5. Hamilton SR, Bosman FT, Boffetta P, et al. Carcinoma of the colon and rectum. In: Hamilton SR, Aaltonen LA, editors. WHO classification of tumours of the digestive system. Lyon: IARC Press, 2010:134–46.
6. Rüschoff J, Dietmaier W, Lüttges J, Seitz G. Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. Am J Pathol. 1997;150:1815–25.
7. Alexander J, Watanabe T, Wu TT, Rashid A, Li S, Hamilton SR. Histopathological identification of colon cancer with microsatellite instability. Am J Pathol. 2001;158:527–35.
8. Arai T, Kasahara I, Sawabe M. Microsatellite‐unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma. Pathology. 2007;57:205–12.
9. Arai T, Esaki Y, Sawabe M, Honma N, Nakamura K-I, Takubo K. Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly. Mod Pathol. 2004;17:172–9.
10. Lanza G, Gafà R, Matteuzzi M, Santini A. Medullary-type poorly differentiated adenocarcinoma of the large bowel: a distinct clinicopathologic entity characterized by microsatellite instability and improved survival. J Clin Oncol. 1999;17:2429–38.
11. Hinoi T, Tani M, Lucas PC, et al. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol. 2001;159:2239–48.
12. Wick MR, Vitsky JL, Ritter JH. Sporadic medullary carcinoma of the colon: a clinicopathologic comparison with nonhereditary poorly differentiated enteric-type adenocarcinoma and neuroendocrine colorectal carcinoma. Am J Clin Pathol. 2005;123:56–65.
13. Jessurun J, Romero-Guadarrama M, Manivel JC. Medullary adenocarcinoma of the colon: clinicopathologic study of 11 cases. Hum Pathol. 1999;30:843–8.
14. Winn B, Tavares R, Fanion J, Noble L, Gao J, Sabo E. Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation. Hum Pathol. 2009;40:398–404.
15. Sugao Y, Yao T, Kubo C, Tsuneyoshi M. Improved prognosis of solid-type poorly differentiated colorectal adenocarcinoma: a clinicopathological and immunohistochemical study. Histopathology. 1997;31:123–33.
16. Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging handbook. 7th ed. New York: Springer, 2010:173–206.
17. Toon CW, Walsh MD, Chou A, et al. BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome. Am J Surg Pathol. 2013;37:1592–1602.
18. Toon CW, Chou A, DeSilva K, Chan J, Patterson J. BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer. Mod Pathol. 2013;27:644–50.
19. Bullock M, O’Neill C, Chou A, Clarkson A. Utilization of a MAB for BRAFV600E detection in papillary thyroid carcinoma. Endocr Relat Cancer. 2012;19:779–84.
20. Hall G, Clarkson A, Shi A, Langford E, Leung H. Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma. Pathology. 2010;42:409–13.
21. Toon CW, Chou A, Clarkson A, et al. Immunohistochemistry for myc predicts survival in colorectal cancer. PLoS ONE. 2014;9:e87456.
22. Chou A, Toon CW, Clarkson A, et al. Loss of ARID1A expression in colorectal carcinoma is strongly associated with mismatch repair deficiency. Hum Pathol. 2014;45(8):1697–1703.
23. Houang M, Toon CW, Clarkson A, et al. ALK and ROS1 overexpression is very rare in colorectal adenocarcinoma. Appl Immunohistochem Mol Morphol. Epub 2 Jul 2014. doi: 10.1097/PAI.0000000000000025.
24. Harrell FE Jr. Regression modeling strategies package for R, version 4.2-0.http://cran.r-project.org/web/packages/rms/index.html. Accessed Jul 2014.
25. Gafà R, Maestri I, Matteuzzi M, Santini A, Ferretti S. Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability. Cancer. 2000;89:2025–37.
26. Rosty C, Williamson EJ, Clendenning M, et al. Should the grading of colorectal adenocarcinoma include microsatellite instability status? Hum Pathol. 2014;45(10):2077–84.
27. Ogino S, Shima K, Meyerhardt JA, McCleary NJ. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clinical Cancer Res. 2012;18(3):890–900.