Loss of ARID1A expression in colorectal carcinoma is strongly associated with mismatch repair deficiency

Human Pathology

Volumn 45, Issue 8, 2014, Pages 1697-1703

  Chou, Angela ^a,b   Toon, Christopher W ^a,c,d   Clarkson, Adele ^a,e   Sioson, Loretta ^a,e   Houang, Michelle ^a,d,e   Watson, Nicole ^a,e   Desilva, Keshani ^e   Gill, Anthony J ^a,d,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c Histopath Pathology   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

ARID1A; BAF250a; Colon cancer; Microsatellite instability; Mismatch repair deficiency

Indexed keywords

ARID1A PROTEIN; B RAF KINASE; MISMATCH REPAIR PROTEIN; PROTEIN MSH2; PROTEIN MSH6; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; WILD TYPE;

ARID1A; BAF250A; COLON CANCER; MICROSATELLITE INSTABILITY; MISMATCH REPAIR DEFICIENCY;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASTIC SYNDROMES, HEREDITARY; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; SEX FACTORS; TISSUE ARRAY ANALYSIS; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84904623554     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.04.009     Document Type: Article

References (21)

1. K.C. Wiegand, S.P. Shah, and O.M. Al-Agha et al. ARID1A mutations in endometriosis-associated ovarian carcinomas N Engl J Med 363 2010 1532 1543
2. S. Jones, T.L. Wang, and M. Shih Ie et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma Science 330 2010 228 231
3. B. Guan, T.L. Wang, and Ie M. Shih ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers Cancer Res 71 2011 6718 6727
4. B.G. Wilson, and C.W. Roberts SWI/SNF nucleosome remodellers and cancer Nat Rev Cancer 11 2011 481 492
5. D. Reisman, S. Glaros, and E.A. Thompson The SWI/SNF complex and cancer Oncogene 28 2009 1653 1668
6. N.G. Nagl Jr., A. Patsialou, and D.S. Haines et al. The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest Cancer Res 65 2005 9236 9244
7. X. Gao, P. Tate, and P. Hu et al. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a Proc Natl Acad Sci U S A 105 2008 6656 6661
8. B. Guan, T.L. Mao, and P.K. Panuganti et al. Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma Am J Surg Pathol 35 2011 625 632
9. K.C. Wiegand, A.F. Lee, and O.M. Al-Agha et al. Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas J Pathol 224 2011 328 333
10. T. Bosse, N.T. Ter Haar, and L.M. Seeber et al. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer Mod Pathol 26 2013 1525 1535
11. H. Abe, D. Maeda, and R. Hino et al. ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability Virchows Arch 461 2012 367 377
12. A. Katagiri, K. Nakayama, and M.T. Rahman et al. Loss of ARID1A expression is related to shorter progression-free survival and chemoresistance in ovarian clear cell carcinoma Mod Pathol 25 2012 282 288
13. D.D. Wang, Y.B. Chen, and K. Pan et al. Decreased expression of the ARID1A gene is associated with poor prognosis in primary gastric cancer PLoS One 7 2012 e40364
14. Z.M. Zhang, S. Xiao, and G.Y. Sun et al. The clinicopathologic significance of the loss of BAF250a (ARID1A) expression in endometrial carcinoma Int J Gynecol Cancer 24 2014 534 540
15. S. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, and A. Trotti AJCC cancer staging manual 7th ed. 2010 Spinger
16. C.W. Toon, A. Chou, and K. Desilva et al. BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer Available at Mod Pathol 27 2014 644 650
17. C.W. Toon, M.D. Walsh, and A. Chou et al. BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome Am J Surg Pathol 37 2013 1592 1602
18. C.W. Toon, A. Chou, and A. Clarkson et al. Immunohistochemistry for myc predicts survival in colorectal cancer PLoS One 9 2014 e87456
19. B. Guan, M. Gao, and C.H. Wu et al. Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions Neoplasia 14 2012 986 993
20. K. Wang, J. Kan, and S.T. Yuen et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer Nat Genet 43 2011 1219 1223
21. S. Jones, M. Li, and D.W. Parsons et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types Hum Mutat 33 2012 100 103