Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis

Journal of Pathology

Volumn 237, Issue 1, 2015, Pages 38-49

  Zhu, Ranxu ^a,b   Mok, Myth T S ^a   Kang, Wei ^a   Lau, Suki S K ^a   Yip, Wing Kit ^a   Chen, Yangchao ^a   Lai, Paul B S ^a   Wong, Vincent W S ^a   To, Ka Fai ^a   Sung, Joseph J Y ^a   Cheng, Alfred S L ^a   Chan, Henry L Y ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE UNIVERSITY OF HONG KONG SHENZHEN HOSPITAL   (China)

Author keywords

apoptosis; cell cycle; GAS2; HBV; hepatocellular carcinoma; senescence; truncated HBx

Indexed keywords

CASPASE 3; CYCLINE; ETOPOSIDE; GROWTH ARREST SPECIFIC 2 PROTEIN; HEPATITIS B ANTIGEN; HEPATITIS B VIRUS X PROTEIN; PROTEIN; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; GAS2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOINFORMATICS; CARBOXY TERMINAL SEQUENCE; CARCINOGENICITY; CELL AGING; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION INITIATION SITE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; COMPLICATION; GENE EXPRESSION REGULATION; GENETICS; HEPATITIS B; HEPATITIS B VIRUS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NUDE MOUSE; PATHOGENICITY; PATHOLOGY; SIGNAL TRANSDUCTION; TIME; TUMOR VOLUME; VIROLOGY; VIRUS CELL TRANSFORMATION;

ANIMALS; APOPTOSIS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELL CYCLE; CELL TRANSFORMATION, VIRAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HEP G2 CELLS; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; MICROFILAMENT PROTEINS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84938975715     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4554     Document Type: Article

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