Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia

Journal of Molecular Neuroscience

Volumn 56, Issue 4, 2015, Pages 898-906

  Yang, Junhong ^a   Gao, Feng ^b   Zhang, Yunke ^c   Liu, Ying ^d   Zhang, Di ^e  

^a THE FIRST AFFILIATED HOSPITAL OF HENAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^d Zhengzhou Hospital of Traditional Chinese Medicine   (China)

^e Luoyang Central Hospital   (China)

Author keywords

Buyang Huanwu decoction; Cerebral ischemia; Exosome; Mesenchymal stem cell

Indexed keywords

ANGIOGENESIS MODULATOR; BUYANG HUANWU DECOCTION; DICER; HERBACEOUS AGENT; KI 67 ANTIGEN; MICRORNA 126; MICRORNA 221; MICRORNA 222; RIBONUCLEASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; BUYANG HUANWU; MICRORNA; MIRN221 MICRORNA, RAT; MIRN222 MICRORNA, RAT; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN TISSUE; CARDIOVASCULAR PARAMETERS; CAROTID ARTERY LIGATION; CELL PROLIFERATION; CHINESE MEDICINE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXOSOME; IN VIVO STUDY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROVASCULATURE; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL CULTURE; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; VASCULAR DENSITY; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETICS; MALE; MESENCHYMAL STROMA CELL; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BRAIN ISCHEMIA; CELLS, CULTURED; DRUGS, CHINESE HERBAL; EXOSOMES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84938969225     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-015-0539-0     Document Type: Article

References (40)

1. Belizon A, Balik E, Feingold DL, Bessler M, Arnell TD, Forde KA, Horst PK, Jain S, Cekic V, Kirman I, Whelan RL (2006) Major abdominal surgery increases plasma levels of vascular endothelial growth factor: open more so than minimally invasive methods. Ann Surg 244:792–798
2. Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, Morando L, Busca A, Falda M, Bussolati B, Tetta C, Camussi G (2009) Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20:1053–1067
3. Cai GX, Liu BY (2010) Effect of ultra-micronized Buyang Huanwu decoction on neurological function, quality of life, and serum vascular endothelial growth factor in patients convalescent from cerebral infarction. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:591–594
4. Chen G, Wu L, Deng CQ (2011) The effects of BuYang HuanWu decoction and its effective components on proliferation-related factors and ERK1/2 signal transduction pathway in cultured vascular smooth muscle cells. J Ethnopharmacol 135:7–14
5. Chen YJ (2009) Effect of Buyang Huanwu decoction on serum vascular endothelial growth factor level of the patients with acute cerebral infarction. J Liaoning Univ Tradit Chin Med 11:113–115
6. Feigin VL, Lawes CM, Bennett DA, Anderson CS (2003) Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2:43–53
7. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15:272–284
8. Hao CZ, Wu F, Shen J, Lu L, Fu DL, Liao WJ, Zheng GQ (2012) Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: a systematic review and meta-analysis of 19 randomized controlled trials. Evid Based Complement Alternat Med 630124:21
9. Huang F, Fang ZF, Hu XQ, Tang L, Zhou SH, Huang JP (2013) Overexpression of miR-126 promotes the differentiation of mesenchymal stem cells toward endothelial cells via activation of PI3K/Akt and MAPK/ERK pathways and release of paracrine factors. Biol Chem 394:1223–1233
10. Jiang C, Liu P, Zhang J, Bao W, Qiu S, Liang Y, Jiang L (2014) Clinical study of effects of Jian Ji Ning, a Chinese herbal medicine compound preparation, in treating patients with myasthenia gravis via the regulation of differential microRNAs expression in serum. Evid Based Complement Alternat Med 518942:5
11. Katoh M (2013) Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (review). Int J Mol Med 32:763–767
12. Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N (2013) Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct. Neuropathology 33:140–148
13. Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK (2010) Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 4:214–222
14. Lai RC, Tan SS, Teh BJ, Sze SK, Arslan F, de Kleijn DP, Choo A, Lim SK (2012) Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome. Int J Proteomics 971907:18
15. Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, Kim YG, Jang JY, Kim CW (2013) Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One 8:e84256
16. Lin CY, Chang C, Cheung WM, Lin MH, Chen JJ, Hsu CY, Chen JH, Lin TN (2008) Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab 28:1491–1501
17. Liu X, Cheng Y, Chen X, Yang J, Xu L, Zhang C (2011) MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. J Biol Chem 286:42371–42380
18. Miyamoto M, Kuroda S, Zhao S, Magota K, Shichinohe H, Houkin K, Kuge Y, Tamaki N (2013) Bone marrow stromal cell transplantation enhances recovery of local glucose metabolism after cerebral infarction in rats: a serial 18F-FDG PET study. J Nucl Med 54:145–150
19. Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G (2006) MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108:3068–3071
20. Ragusa M, Statello L, Maugeri M, Majorana A, Barbagallo D, Salito L, Sammito M, Santonocito M, Angelica R, Cavallaro A, Scalia M, Caltabiano R, Privitera G, Biondi A, Di Vita M, Cappellani A, Vasquez E, Lanzafame S, Tendi E, Celeste S, Di Pietro C, Basile F, Purrello M (2012) Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors. J Mol Med 90:1421–1438
21. Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S (2013) 123I-iomazenil single photon emission computed tomography visualizes recovery of neuronal integrity by bone marrow stromal cell therapy in rat infarct brain. Stroke 44:2869–2874
22. Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M (2006) Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 137:393–399
23. Shen LH, Ye M, Ding XS, Han Q, Zhang C, Liu XF, Huang H, Wu EB, Huang HF, Gu XS (2012) Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model. Neuroscience 223:315–324
24. Sheng YH, Jin RM, Yao GT, Zhou L, Qiao JY (2013) Study on early change features of microRNA in the peripheral blood of Sophorae Tonkinensis Radix et Rhizoma induced liver injury rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 33:385–391
25. Song KH, Kim YH, Kim BY (2014) Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes. BMC Complement Altern Med 14:1472–6882
26. Taylor DD, Gercel-Taylor C (2011) Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol 33:441–454
27. Thery C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569–579
28. Wang HW, Liou KT, Wang YH, Lu CK, Lin YL, Lee IJ, Huang ST, Tsai YH, Cheng YC, Lin HJ, Shen YC (2011) Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol 138:22–33
29. Wang JY, Gao YB, Zhang N, Zou DW, Xu LP, Zhu ZY, Li JY, Zhou SN, Cui FQ, Zeng XJ, Geng JG, Yang JK (2014) Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy. Am J Physiol Ren Physiol 306:26
30. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15:261–271
31. Wang S, Olson EN (2009) AngiomiRs—key regulators of angiogenesis. Curr Opin Genet Dev 19:205–211
32. Wei RL, Teng HJ, Yin B, Xu Y, Du Y, He FP, Chu KT, Luo BY, Zheng GQ (2013) A systematic review and meta-analysis of Buyang Huanwu decoction in animal model of focal cerebral ischemia. Evid Based Complement Alternat Med 138484:4
33. Wei SY, Zhang PX, Yang DM, Zhang HB, Jiang BG (2008) Traditional Chinese medicine and formulas of improving peripheral nerve regeneration. Zhongguo Zhong Yao Za Zhi 33:2069–2072
34. Xin H, Li Y, Buller B, Katakowski M, Zhang Y, Wang X, Shang X, Zhang ZG, Chopp M (2012) Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 30:1556–1564
35. Xu JN, Que HF, Tang HJ (2009) Effects and action mechanisms of Buyang Huanwu decoction in wound healing of chronic skin ulcers of rats. Zhong Xi Yi Jie He Xue Bao 7:1145–1149
36. Zhang Q, Zhao YH (2014) Therapeutic angiogenesis after ischemic stroke: Chinese medicines, bone marrow stromal cells (BMSCs) and their combinational treatment. Am J Chin Med 42:61–77
37. Zhang YK, Han XY, Che ZY (2010) Effects of Buyang Huanwu tang combined with bone marrow mesenchymal stem cell transplantation on the expression of VEGF and Ki-67 in the brain tissue of the cerebral ischemia-reperfusion model rat. J Tradit Chin Med 30:278–282
38. Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK, Tsui SK, Lee HM, Wong HK, Zhu X, Siu JJ, He L, Guan J, Liu LZ, Xu HX, Tong PC, Chan JC (2012a) Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes 61:933–943
39. Zhao LD, Wang JH, Jin GR, Zhao Y, Zhang HJ (2012b) Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats—time window and mechanism. J Ethnopharmacol 140:339–344
40. Zhong W, Peng J, He H, Wu D, Han Z, Bi X, Dai Q (2008) Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med 31:E8–E15