Effects of Buyang Huanwu Tang combined with bone marrow mesenchymal stem cell transplantation on the expression of VEGF and Ki-67 in the brain tissue of the cerebral ischemia-reperfusion model rat

Journal of Traditional Chinese Medicine

Volumn 30, Issue 4, 2010, Pages 278-282

  Zhang, Yun Ke ^a   Han, Xue Yong ^a   Che, Zhi Ying ^a  

^a HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Buyang Huanwu Tang; Cerebral ischemia reperfusion; Immunohistochemical method; Marrow mesenchymal stem cell; Vascular endothelial growth factor (VEGF) and Ki 67

Indexed keywords

BUYANG HUANWU TANG; CHINESE DRUG; KI 67 ANTIGEN; NEUROPROTECTIVE AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN; HERBACEOUS AGENT; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; MEDICINAL PLANT; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION; ANIMAL; BONE MARROW TRANSPLANTATION; BRAIN; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MULTIMODALITY CANCER THERAPY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN ISCHEMIA; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; HUMANS; KI-67 ANTIGEN; MESENCHYMAL STEM CELL TRANSPLANTATION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79952255697     PISSN: 02552922     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0254-6272(10)60056-8     Document Type: Article

References (17)

1. Wang YY, Sun SL, Deng ZM, et al. Clinical study on treatment of acute stroke by syndrome differentiation plus Fufang Huoxue Injector. J Beijing College of TCM (Chin) 1988; 11: 22-24.
2. Zhang YK, Che ZY. Yiqi Huoxue Recipe induces differentiation of rat bone marrow mesenchymal stem cells towards neurons in vitro. J Clinical Rehabilitative Tissue Engineering Research 2009; 13: 1171-1175.
3. Zhang YK, Che ZY, Mei XL. Effect of Buyang Huanwu Tang combined with bone marrow mesenchymal stem cells transplantation on apoptosis of nervous cells in the cerebral ischemia-reperfusion model rat. Chin J. Traditional Chinese Medicine and Pharmacy (Chin) 2009; 27: 1660-1663.
4. Zhang YK, Yiqi Huoxue Recipe induces differentiation of rat bone marrow mesenchymal stem cells towards nervous cells in vitro. J Traditional Chinese Medicine and Pharmacy (Chin) 2008; 36: 22-25.
5. Cao YJ, Cheng YB. Improvement and approach of thread-occlusion method for establishment of local cerebral ischemia-reperfusion rat model. Chinese J Applied Physiology (Chin) 2001; 17: 198-200.
6. Xu YM, Qin J, Xing Y, et al. Induction of differentiation of rat bone marrow mesenchymal stem cells towards nervous cells in vitro. J Zhengzhou University (Chin) 2004; 39: 269-271.
7. Maruotti N, Cantatore FP, Crivellato E, et al. Angiogenesis in rheumatoid arthritis. Histol Histopathol 2006; 21: 557-566.
8. Belizon A, Balik E, Feingold DL, EETAL. Major abdominal surgery increases plasma levels of vascular endothelial growth factor open more so than minimally invasive method. Ann Surg 2006; 244: 791-798.
9. Wang YQ, Guo X, Qiu MH, et al. VEGF over-expression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusion. J Neurosci Res 2007; 85: 73-82. (Pubitemid 46079798)
10. Zeng XW, Shen JK, Sun QF, et al. Treatment of experimental cerebral ischemia in rabbits with human vascular endothelial growth factor gene mediated by inverse transcriptive viral vector. China J Clin Rehab (Chin) 2006; 10: 59-62.
11. Mandyam CD, Harburg GC, Eisch AJ. Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone. Neuroscience 2007; 146: 108-122. (Pubitemid 46654600)
12. Zhong W, Peng J, He H, et al. Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med 2008; 31: E8-E15. (Pubitemid 351272175)
13. Cai XB, Pan LQ. Application of astragalus root to promoting regeneration of blood vessels. Xinglin Traditional Chinese Medicine and Pharmacy (Chin) 2009; 29: 807-808.
14. Meng H, Zhu MZ, Guo J, et al. Experimental study on extract of Chinese angelica root, chuanxiong rhizome, red sage root for promoting angiogenesis. Medicinal Substances of China (Chin) 2006; 29: 574-576.
15. Chopp M, Zhang XH, Li Y, et al. Spinal cord injury of rat treated with bone marrow stromal cell transplantation. Neuroreport 2000; 11: 3001.
16. Chen J, Zhang ZG Li Y, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 2003; 92: 692-699. (Pubitemid 36417705)
17. Jiang Q, Zhang ZG Ding GL, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat by using MRI. Neuroimage 2005; 28: 698-707. (Pubitemid 41540378)