A systematic review and meta-analysis of buyang huanwu decoction in animal model of focal cerebral ischemia

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Wei, Rui Li ^a   Teng, Hai Juan ^a   Yin, Bo ^a   Xu, Yang ^a   Du, Yue ^a   He, Fang Pin ^a   Chu, Ke Tan ^a   Luo, Ben Yan ^a   Zheng, Guo Qing ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BUYANG HUANWU DECOCTION; HERBACEOUS AGENT; UNCLASSIFIED DRUG;

BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL TYPE; CHINESE MEDICINE; CLINICAL RESEARCH; DRUG EFFICACY; EMBASE; EVIDENCE BASED MEDICINE; MEDLINE; META ANALYSIS (TOPIC); MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; SUTURE; SYSTEMATIC REVIEW;

EID: 84879284806     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/138484     Document Type: Review

References (88)

1. O'Collins V. E., Macleod M. R., Donnan G. A., Horky L. L., Van Der Worp B. H., Howells D. W., 1,026 Experimental treatments in acute stroke. Annals of Neurology 2006 59 3 467 477 2-s2.0-33644818304 10.1002/ana.20741
2. Savitz S. I., Fisher M., Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Annals of Neurology 2007 61 5 396 402 2-s2.0-34249942190 10.1002/ana.21127
3. Wang Q. R., Yilin Gaicuo 2005 Beijing, China People's Medical Publishing House
4. Johnston L., Buyang Huanwu Decoction. http://www.healingtherapies.info/ Buyang.htm
5. Wang H. W., Liou K. T., Wang Y. H., Lu C. K., Lin Y. L., Lee I. J., Huang S. T., Tsai Y. H., Cheng Y. C., Lin H. J., Shen Y. C., Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu Decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. Journal of Ethnopharmacology 2011 138 1 22 33 2-s2.0-80255137424 10.1016/j.jep.2011.06.033
6. Cai G., Liu B., Liu W., Tan X., Rong J., Chen X., Tong L., Shen J., Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. Journal of Ethnopharmacology 2007 113 2 292 299 2-s2.0-34547821365 10.1016/j.jep.2007.06. 007
7. Li X. M., Bai X. C., Qin L. N., Huang H., Xiao Z. J., Gao T. M., Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats. Neuroscience Letters 2003 346 1-2 29 32 2-s2.0-0038383786 10.1016/S0304-3940(03)00522-6
8. Chu L. S., Yin Y. J., Ke Q., Chen W. Y., Chen F. M., Effect of buyanghuanwu Decoction on angiogenesis and Ang-1/Tie-2 expression after focal cerebral ischemia in mice. Chinese Journal of Behavioral Medicine and Brain Science 2011 20 3 202 204
9. Gao J., Lü F., Zhu C., Effects of Buyang Huanwu Decoction on cell proliferation and differentiation in the hippocampal dentate gyrus of aged rats following cerebral ischemia/reperfusion. Neural Regeneration Research 2009 4 5 390 395 2-s2.0-67649429589 10.3969/j.issn.1673-5374.2009.05.011
10. Cai G., Liu B., Buyang Huanwu Decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia. Neural Regeneration Research 2010 5 22 1733 1738 2-s2.0-78651420331 10.3969/j.issn.1673-5374.2010.22.009
11. Zhao L. D., Wang J. H., Jin G. R., Zhao Y., Zhang H. J., Neuroprotective effect of Buyang Huanwu Decoction against focal cerebral ischemia/reperfusion injury in rats-time window and mechanism. Journal of Ethnopharmacology 2012 140 2 339 344 2-s2.0-84858004652 10.1016/j.jep.2012.01.026
12. Hao C. Z., Wu F., Shen J. G., Lu L., Fu D. L., Liao W. J., Zheng G. Q., Clinical efficacy and safety of Buyang Huanwu Decoction for acute ischemic stroke: a systematic review and meta-analysis of 19 randomized controlled trials. Evidence-Based Complementary and Alternative Medicine 2012 2012 10 10.1155/2012/630124 630124
13. Li X., Cai G. X., Study on the mechanism of synapse-1 remodeling in the cerebral ischemia rats with Buyang Huanwu Decoction [M.S. thesis] 2007 Hunan University of Chinese Medicine
14. Jiang H. Y., Shan L. L., Cao P., Guo S. J., Neuroprotection of Qileng Decoction on focal cerebral ischemia-reperfusion injury in rats. Journal of Emergency in Traditional Chinese Medicine 2005 14 5 458 459
15. Liao C. L., Tong L., Mechanism studies of protective effect of BuyangHuanwu Decoction on experimental cerebral ischemic injury [M.S. thesis] 2004 Southern Medical University
16. Yin T. L., Cai G. X., Protective effects and mechanisms of Caowei-Buyang Huanwu Decoction against neuronal Injury in MCAO rat [Ph.D. thesis] 2007 Hunan University of Chinese Medicine
17. Macleod M. R., O'Collins T., Horky L. L., Howells D. W., Donnan G. A., Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. Journal of Cerebral Blood Flow and Metabolism 2005 25 6 713 721 2-s2.0-18944375237 10.1038/sj.jcbfm.9600064
18. Macleod M. R., O'Collins T., Howells D. W., Donnan G. A., Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 2004 35 5 1203 1208 2-s2.0-2142768247 10.1161/01.STR.0000125719.25853.20
19. Horn J., De Haan R. J., Vermeulen M., Luiten P. G. M., Limburg M., Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke 2001 32 10 2433 2438 2-s2.0-0034792905
20. Bai X. S., Cai G. X., Effect of micropowder Buyang Huanwu Decoction on neurologic deficits and Nogo-a of MCAO model rat [Ph.D. thesis] 2007 Hunan University of Chinese Medicine
21. Bai X. S., Cai G. X., Yin T. L., A pharmacology method to estimate effect of Buyang Huanwu Decoction on neurologic deficits of MCAo Model Rats. World Chinese Medicine 2011 3 260 262
22. Cao P., Jiang H. Y., Effect of daqinjiao Decoction, zhenganxifeng Decoction and Buyang Huanwu Decoction on cerebral ischemia and reperfusion injuries in rats. Journal of Traditional Chinese Medicine University of Hunan 2004 24 5 16 17
23. Chen W., Wang H., Zhang S. W., Effect of trichosanthin on high plasma homocystein in rats with cerebral ischemia-reperfusion. Journal of Emergency in Traditional Chinese Medicine 20 2 275 277
24. Chu L. S., Yang W. M., Shao L., Meng D. Y., Effect of Buyanghuanwu Decoction on learning and memory in rats following focal cerebaral ischemia injury. Chinese Journal of Behavioral Medical Science 2005 14 12
25. Chu L. S., Shao L., Meng D. Y., Li J. H., Sun J., Long-term cerebroprotective effects of Buyang Huanwu Decoction in rats after focal cerebral ischemia injury. Chinese Journal of Clinical Rehabilitation 2006 10 11 56 58 2-s2.0-33646044090
26. Chu L. S., Li J. H., Sun J., Yang W. M., Ke Q., Effects of Buyanghuanwu Decoction on infiltration of neutrophils and expression of ICAM-1 after middle cerebral artery occlusion in rats. Journal of Zhejiang University of Traditional Chinese Medicine 2006 30 5 465 466
27. Chu L. S., Jiang Y. Y., Ke Q., Yin Y. J., Chen W. Y., Buyanghuanwu Decoction enhances angiogenesis and improves functional recovery after focal cerebral ischemia in rats. Chines Archives of Traditional Chinese Medicine 2011 29 2 335 338
28. Du Z. G., Wang Y. L., Effects of Buyanghuanwu tang formula on AQP-4 of rats with experimental ischemic brain. World Science and Technology 2008 10 1 72 75
29. Du K., Liu B. Y., Zeng R., Yi J., Cai G. X., Effect of ultramicro-Naodejian on GAP-43 and cerebral nerve regeneration after focal cerebral ischemia in rats. Hunan Journal of Traditional Chinese Medicine 2011 27 6 102 104
30. Gao Y., Cai D. f., Effect of BuYangHuanWu recipe on the cerebral microcirculation in MCAO rat after reperfusion [Ph.D. thesis] 2004 Fudan University
31. Gao J. f., Wang X. H., Liu K., Lu M., Influence of Buyanghuanwu Decoction on expression changes of cerebral TNF-a, ICAM-1 and VCAM-1 in aged rats with cerebral ischemia-reperfusion lesion. Journal of Beijing University of Traditional Chinese Medicine 2008 15 4 1 4
32. Gao J. F., Lu F. H., Wang X. H., Influence of Buyang Huanwu Decoction on dentate gyrus cell proliferation and differentiation in senile rats with cerebral ischemia-reperfusion lesion. Chinese Journal of Gerontology 2009 29 18 2348 2350
33. Guo N. Y., Wei W., HU L. J., The effects of Injection of Buyanghuanwutang on volume of infarction and changes of electroencephalography. Journal of Clinical Internal Medicine 2004 21 10 702 703
34. Han D., Liao F. L., Li W., Liang R. X., Ying X. J., Effect of BuYanHanWu (BYHW) Tang upon infarction, vessel damage penumbra (VDP) fibrinolytic system activity and endothelin. China Journal of Experimental Traditional Medical Formulae 2001 7 2 21 24
35. Jiang H. Y., Zhang S. W., Pathomorphology study of qileng Decoction on focal cerebral ischemia and reperfusion in rats. China Journal of Traditional Chinese Medicine and Pharmacy 2004 19 3 145 147
36. Jiang H. Y., Yu Q. H., Cao P., Deng S. F., Effects of Qileng Decoction on glial fibrillary acidic protein expression in the ischemic penumbra of rats following cerebral ischemia/reperfusion. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2005 12 5 267 270
37. Li J., Wang C. Y., Experimental study of Buyang Huanwu Decoction on angiogenesis after cerebaral ischemia reperfusion injury in rats. Journal of Emergency in Traditional Chinese Medicine 2011 2 273 274
38. Liang Y. K., Zhang J. R., Study on the method of Nourishing yin, filling Pith and benifiting brain towards the Protective mechanism of rat focal cerebral ischemia-reperfusion chronic injury [M.S. thesis] 2010 Hubei University of Chinese Medicine
39. Liu C., Wu J. L., Protection of Buyang Huanwu Decoction on the change of behavior and pathology of focal cerebral ischemia re-perfusion injury in rats. Hubei Journal of Traditional Chinese Medicine 2004 26 4 10 12
40. Liu C., Wu J. L., Chang E. Z., Cai F., Effect of Buyang Huanwu Decoction on apoptosis after focal cerebral ischemia-reperfusion in rats. Chinese Journal of Gerontology 2005 25 7 818 819
41. Liu N. P., Peng K., Effect of Buyang Huanwu Decoction on the change of motor function and structure of neurons synapse in brain tissue of the stroke sequela models of rats which are lack of Qi and with blood silted [M.S. thesis] 2005 First Military Medical University
42. Liu B. Y., Cai G. X., Liu W., Chen X. M., Effect of Buyang Huanwu Decoction on vascular endothelial growth factor and its receptor Flk1 in rats after focal cerebral ischemia. Chinese Traditional and Herbal Drugs 2007 38 3 394 397 2-s2.0-34248342707
43. Liu F., Bai X. S., Liu B. Y., Cai G. X., Effect of Bu Yang Huan wu Decoction on basic fibroblast growth factor in rats with cerebral ischemia. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2008 15 1 9 12
44. Liu J. X., Li J. S., Yu W., Hei C. C., Liu H. X., Ren F. F., Effects of Xinglou Chengqi Decoction and Buyang Huanwu Decoction on the injury of hippocampal neurons in rats with cerebral ischemia. Chinese Journal of Experimental Traditional Medical Formulae 2012 18 12 233 237
45. Lu Y. K., Peng K., Study of expression of vascular endothelial growth factor and effect of BuYang HuanWu decotion on the stroke sequela models of rats with deficiencyof Qi and blood stasis [M.S. thesis] 2008 Medical University
46. Ma T. G., Fang J. K., Experimental study of different quantity ratio of Huang Qi in Buyanghuanwu Decoction on cerebral infarciton [degree paper] 2009 Liaoning University of Traditional Chinese Medicine
47. Mo S. L., Zheng Y. S., Effect of Buyang Huanwu disassembled prescriptions on brain cortical infarct size and plasma endothelin level in experimental cerebral ischemic injury rats. Pharmacology and Clinics of Chinese Materia Medica 1997 13 1 2 4
48. Su X. H., Kong X. Y., Pang Z. R., Lin N., Effect of Buyang Huanwu Decoction on migration of neural stem cells after focal cerebral ischemia in rats. Chinese Journal of Experimental Traditional Medical Formulae 2012 18 6 159 162
49. 2+ contents in the brains of rats with deficiency of qi and blood stasis after stroke. Chinese Journal of Clinical Rehabilitation 2004 8 7 1296 1298 2-s2.0-2442541078
50. Sun L. Q., Zhao Y. N., Li J. M., Cui J. Z., Zhang Y. X., Buyanghuanwu recipe inhibits neuronal apoptosis after cerebral ischemia/reperfusion injury possibly through the p38MAPK/COX2 signal pathway in rats. China Journal of Modern Medicine 2010 20 10 1450 1452
51. Tan X. H., Qu H. D., Peng K., Chen Y. Y., Tong L., Shen J. G., Zhu C. W., Effects of Buyanghuanwu Decoction on nerve proliferation in rats with sequelae of ischemic stroke. Journal of Southern Medical University 2006 26 2 189 192 2-s2.0-41949109033
52. Tian Z. H., Liu B. Y., Effect of buyangHuanwu Decoction on angiogenesis in rats after focal cerebral ischemia. Chinese Journal of Arteriosclerosis 2010 18 3 193 198
53. Wang X. G., Tong E. T., Sun S. G., Protection effects of buyang huanwu decocton on cerebral ischemia and reperfusion injures. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine 2005 15 1 6 9
54. Wang Y., Wang Y. L., Feng X., Chen C. L., A Comparative study on the treatment of experimental ischemic stroke with Buyang Huanwu Decoction or daqinjiao Decoction. Shanxi Journal of Traditional Chinese Medicine 2006 27 7 882 884
55. Wang H. T., Yang M. F., Cao X. L., Sun B. L., Effect of Buyang Huanwu Decoction combined with sports training on neurons synapse remodeling in rats with focal cerebral infarction. Chinese Journal of Experimental Traditional Medical Formulae 2010 16 13 132 135
56. Wei S. C., Li W. Q., Wang Z. W., Gao J. D., Influence of ultrafiltration to protective effect of buyang-huanwu Decoction on the cerebral ischemia-reperfusion injury. Lishizhen Medicin and Materia Medica Research 2010 3 630 631
57. Wu H. Y., Luo R., The effects of pulsed magnetic field and Buyanghuanwu Decoction on IGF-1 expression in cerebral ischemia reperIusion rats [Ph.D. thesis] 2008 Southern Medical University
58. Xu Y. L., Liao L., Effects of method of supplement qi and activating blood cirulation and channel combined with mild-hypothermia on neurlogic deficits and infarct size in cerebral infarction model rats of qi-deficiency and blood. Traditional Chinese Medicine Journal 2006 5 1 56 58
59. Xue Y. H., Effect of buyanghuanwu liquid on the content of Insulin-like growth factor-I (IGF-I) and brain-derived neurotrophic factor (BDNF) in focal cerebral ischemia and reperfusion rats. Chinese Journal of the Practical Chinese With Modern Medicine 2006 19 7 743 744
60. Yang C. G., Protective effect of buyang-huanwu Decoction on the cerebral ischemia-reperfusion injury in rats. Research and Practice on Chinese Medicine 2010 24 1 36 39
61. Yi J., Huan X., Xie Y., Yang Y., Chen X. M., Liu B. Y., Effect of naodejian Decoction on nerve function and infarct volume in rats after focal cerebral ischemia. Journal of TCM University of Hunan 2010 30 1 9 11
62. Yin Y. H., Wu X. G., Study on effect of Buyang Huanwu Decoction on expression of VEGF and Ang-1 in gerbils with cerebral ischemia-reperfusion. Journal of Clinical and Experimental Medicine 2012 11 7 487 488
63. Zhang L., Li R., Chen J., Ma T. G., Effect of Buyang Huanwu Decoction on cerebral infarction volume, nerve function and Serum IL-10 level in focal cerebral ischemia rats. China Journal of Traditional Chinese Medicine and Pharmacy 2009 S1 142 144
64. Zhao H., Zhang Q. J., Wang T., Xu X., Liu Y., Effect of zhongfen jiedu Decoction on cerebral infarction area and nerve deficit in acute cerebral ischemia rats. Shanghai Journal of Traditional Chinese Medicine 2005 39 6 54 55
65. Zhao Y. L., Qu Y. Z., Influence of Buyang Huanwu Decoction on cerebral infarct volume and pathological changes after cerebral ischemia and reperfusion. Chinese Journal of Information on Traditional Chinese Medicine 2007 14 2 41 42
66. Zhou S. N., Cai G. X., The effects of Buyang Huanwu Decoction on proliferation of nerve cell and expressions of TLR2, TLR4, MyD88, NF-KBp65 in rats with cerebral ischemia [Ph.D. thesis] 2012 Hunan University of Chinese Medicine
67. Deng C. Q., Xiao S. H., Ge J. W., Ji A. G., Effects of Buyang Huanwu Decoction on injury of cerebral ischemic reperfusion in gerbils. Journal of Hunan College of Traditional Chinese Medicine 1992 2 48 50
68. Ginsberg M. D., Current status of neuroprotection for cerebral ischemia synoptic overview. Stroke 2009 40 3 S111 S114 2-s2.0-62949204563 10.1161/STROKEAHA.108.528877
69. Moskowitz M. A., Lo E. H., Iadecola C., The science of stroke: mechanisms in search of treatments. Neuron 2010 67 2 181 198 2-s2.0-77955487488 10.1016/j.neuron.2010.07.002
70. Barone F. C., Ischemic stroke intervention requires mixed cellular protection of the penumbra. Current Opinion in Investigational Drugs 2009 10 3 220 223 2-s2.0-62249217322
71. Faraci F. M., Reactive oxygen species: influence on cerebral vascular tone. Journal of Applied Physiology 2006 100 2 739 743 2-s2.0-33646359238 10.1152/japplphysiol.01044.2005
72. Feuerstein G. Z., Wang X., Inflammation and stroke: benefits without harm? Archives of Neurology 2001 58 4 672 674 2-s2.0-0035072458
73. Ceulemans A. G., Zgavc T., Kooijman R., Hachimi-Idrissi S., Sarre S., Michotte Y., The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. Journal of Neuroinflammation 2010 7 article 74 2-s2.0-78549247765 10.1186/1742-2094-7-74
74. Hoyte L., Barber P. A., Buchan A. M., Hill M., The rise and fall of NMDA antagonists for ischemic stroke. Current Molecular Medicine 2004 4 2 131 136 2-s2.0-1842483228 10.2174/1566524043479248
75. Savitz S. I., Schäbitz W. R., A critique of SAINT II: wishful thinking, dashed hopes, and the future of neuroprotection for acute stroke. Stroke 2008 39 4 1389 1391 2-s2.0-41149114028 10.1161/STROKEAHA.107.504415
76. Lo E. H., Experimental models, neurovascular mechanisms and translational issues in stroke research. British Journal of Pharmacology 2008 153 supplement 1 S396 S405 2-s2.0-40349085617 10.1038/sj.bjp.0707626
77. Guo P., Wang J., Wang H., Study of the effects of Bu Yang Huan Wu Tang on SOD and MDA brain tissue in cerebral ischemia and reperfusion of rats. Chinese Journal of Applied Physiology 2002 18 2 108
78. Lin R., Liu Y., Shi X., Fang Z., Wang W., Lin Q., Zhang J., Zhang H., Ji Q., The roles of Buyang Huanwu Decoction in anti-inflammation, antioxidation and regulation of lipid metabolism in rats with myocardial ischemia. Evidence-Based Complementary and Alternative Medicine 2011 2011 8 2-s2.0-79955093842 10.1093/ecam/neq028 561396
79. Wang L., Jiang D. M., Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia/reperfusion injury in rats. Journal of Ethnopharmacology 2009 124 2 219 223 2-s2.0-67449132104 10.1016/j.jep.2009.04.045
80. Fan L., Wang K., Cheng B., Effects of Buyang Huanwu Decoction on apoptosis of nervous cells and expressions of Bcl-2 and Bax in the spinal cord of ischemia-reperfusion injury in rabbits. Journal of Traditional Chinese Medicine 2006 26 2 153 156 2-s2.0-33846420989
81. Yang G., Fang Z., Liu Y., Zhang H., Shi X., Ji Q., Lin Q., Lin R., Protective effects of Chinese traditional medicine Buyang Huanwu Decoction on myocardial injury. Evidence-Based Complementary and Alternative Medicine 2011 2011 7 2-s2.0-80052698839 10.1093/ecam/nep013 930324
82. Sun J., Bi Y., Guo L., Qi X., Zhang J., Li G., Tian G., Ren F., Li Z., Buyang Huanwu Decoction promotes growth and differentiation of neural progenitor cells: using a serum pharmacological method. Journal of Ethnopharmacology 2007 113 2 199 203 2-s2.0-34547766424 10.1016/j.jep.2007.05.018
83. Zhang Y. K., Han X. Y., Che Z. Y., Effects of Buyang Huanwu Tang combined with bone marrow mesenchymal stem cell transplantation on the expression of VEGF and Ki-67 in the brain tissue of the cerebral ischemia-reperfusion model rat. Journal of Traditional Chinese Medicine 2010 30 4 278 282 2-s2.0-79952255697
84. Chen S. Q., Yan F., Xu D. J., Liu X. Y., Chen S. J., Studies on pharmacodynamics and acute toxicity of buyang huanwu tang granule. West China Journal of Pharmaceutical Sciences 2000 4 259 261
85. Banwell V., Sena E. S., Macleod M. R., Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke. Journal of Stroke and Cerebrovascular Diseases 2009 18 4 269 276 2-s2.0-67649117904 10.1016/j.jstrokecerebrovasdis.2008.11.009
86. Minnerup J., Heidrich J., Rogalewski A., Schäbitz W. R., Wellmann J., The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis. Stroke 2009 40 9 3113 3120 2-s2.0-70349234479 10.1161/STROKEAHA.109.555789
87. MacLeod M. R., Van Der Worp H. B., Sena E. S., Howells D. W., Dirnagl U., Donnan G. A., Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke 2008 39 10 2824 2829 2-s2.0-54049103993 10.1161/STROKEAHA.108.515957
88. Minnerup J., Heidrich J., Wellmann J., Rogalewski A., Schneider A., Schabitz W. R., Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia. Stroke 2008 39 6 1855 1861 2-s2.0-46249090912 10.1161/STROKEAHA.107.506816