메뉴 건너뛰기




Volumn 54, Issue 9, 2015, Pages 810-820

Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function

Author keywords

Breast carcinogenesis; Cancer metabolism; Diet; Fatty acids; Prevention

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; DOCOSAHEXAENOIC ACID; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; THREONINE; ANTINEOPLASTIC ANTIMETABOLITE; GLUCOSE;

EID: 84938965067     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22151     Document Type: Article
Times cited : (43)

References (53)
  • 1
    • 84938975103 scopus 로고    scopus 로고
    • Cancer Facts & Figures 2013
    • American Cancer Society. Cancer Facts & Figures 2013. Atlanta Am Cancer Soc 2013; 1-60.
    • (2013) Atlanta Am Cancer Soc , pp. 1-60
  • 2
    • 79955023800 scopus 로고    scopus 로고
    • Emerging metabolic targets in cancer therapy
    • Zhao Y, Liu H, Riker AI, et al. Emerging metabolic targets in cancer therapy. Front Biosci J Virt Libr 2011; 16:1844-1860.
    • (2011) Front Biosci J Virt Libr , vol.16 , pp. 1844-1860
    • Zhao, Y.1    Liu, H.2    Riker, A.I.3
  • 3
    • 84869504278 scopus 로고    scopus 로고
    • New strategies for targeting the hypoxic tumour microenvironment in breast cancer
    • Ward C, Langdon SP, Mullen P, et al. New strategies for targeting the hypoxic tumour microenvironment in breast cancer. Cancer Treat Rev 2013; 39:171-179.
    • (2013) Cancer Treat Rev , vol.39 , pp. 171-179
    • Ward, C.1    Langdon, S.P.2    Mullen, P.3
  • 4
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Am Assoc Adv Sci 1956; 123:309-314.
    • (1956) Am Assoc Adv Sci , vol.123 , pp. 309-314
    • Warburg, O.1
  • 5
    • 84874886049 scopus 로고    scopus 로고
    • Acidity generated by the tumor microenvironment drives local invasion
    • Estrella V, Chen T, Lloyd M, et al. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 2013; 73:1524-1535.
    • (2013) Cancer Res , vol.73 , pp. 1524-1535
    • Estrella, V.1    Chen, T.2    Lloyd, M.3
  • 6
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, Marzo A, De Laughner E, Lim M. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59:5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    Marzo, A.2    De Laughner, E.3    Lim, M.4
  • 7
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012; 148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 8
    • 84865575592 scopus 로고    scopus 로고
    • Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    • Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol Med 2012; 18:534-543.
    • (2012) Trends Mol Med , vol.18 , pp. 534-543
    • Semenza, G.L.1
  • 9
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • Semenza GL. HIF-1: Upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010; 20:51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 10
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    • Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003; 97:1573-1581.
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1    van der Groep, P.2    Greijer, A.E.3
  • 11
    • 9744250235 scopus 로고    scopus 로고
    • c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    • Giatromanolaki A, Koukourakis MI, Simopoulos C, et al. c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. Cancer Res 2004; 10:7972-7977.
    • (2004) Cancer Res , vol.10 , pp. 7972-7977
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Simopoulos, C.3
  • 12
    • 23244463512 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
    • Dales J-P, Garcia S, Meunier-Carpentier S, et al. Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: Retrospective study in a series of 745 patients. Int J Cancer 2005; 116:734-739.
    • (2005) Int J Cancer , vol.116 , pp. 734-739
    • Dales, J.-P.1    Garcia, S.2    Meunier-Carpentier, S.3
  • 13
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano H, Martin DS, Xu R-H, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25:4633-4646.
    • (2006) Oncogene , vol.25 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.-H.3    Huang, P.4
  • 14
    • 84858243360 scopus 로고    scopus 로고
    • Mechanisms of action of (n-3) fatty acids
    • Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr 2012; 142:592S-599S.
    • (2012) J Nutr , vol.142 , pp. 592S-599S
    • Calder, P.C.1
  • 15
    • 63149185866 scopus 로고    scopus 로고
    • PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells
    • Tuller ER, Brock AL, Yu H, Lou JR, Benbrook DM, Ding W-Q. PPARalpha signaling mediates the synergistic cytotoxicity of clioquinol and docosahexaenoic acid in human cancer cells. Biochem Pharmacol 2009; 77:1480-1486.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1480-1486
    • Tuller, E.R.1    Brock, A.L.2    Yu, H.3    Lou, J.R.4    Benbrook, D.M.5    Ding, W.-Q.6
  • 16
    • 53149131328 scopus 로고    scopus 로고
    • Omega-3 fatty acids and PPARgamma in cancer
    • Edwards IJ, O'Flaherty JT. Omega-3 fatty acids and PPARgamma in cancer. PPAR Res 2008; 2008:1-14.
    • (2008) PPAR Res , vol.2008 , pp. 1-14
    • Edwards, I.J.1    O'Flaherty, J.T.2
  • 17
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids,eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha,gamma
    • Kliewer SA, Sundseth SS, Jones SA, et al. Fatty acids, eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha, gamma. Proc Natl Acad Sci U S.A 1997; 94:4318-4323.
    • (1997) Proc Natl Acad Sci U S.A , vol.94 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3
  • 18
    • 0033105510 scopus 로고    scopus 로고
    • Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    • Xu HE, Lambert MH, Montana VG, et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 1999; 3:397-403.
    • (1999) Mol Cell , vol.3 , pp. 397-403
    • Xu, H.E.1    Lambert, M.H.2    Montana, V.G.3
  • 19
    • 0034712343 scopus 로고    scopus 로고
    • Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells
    • Thoennes SR, Tate PL, Price TM, Kilgore MW. Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. Mol Cell Endocrinol 2000; 160:67-73.
    • (2000) Mol Cell Endocrinol , vol.160 , pp. 67-73
    • Thoennes, S.R.1    Tate, P.L.2    Price, T.M.3    Kilgore, M.W.4
  • 20
    • 69549096508 scopus 로고    scopus 로고
    • Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: The involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling
    • Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: The involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol 2009; 76:588-595.
    • (2009) Mol Pharmacol , vol.76 , pp. 588-595
    • Tuller, E.R.1    Beavers, C.T.2    Lou, J.R.3    Ihnat, M.A.4    Benbrook, D.M.5
  • 21
    • 0029791412 scopus 로고    scopus 로고
    • PPARa,PPARy activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K, Peinado-onsurbe J, Lefebvre A, et al. PPARa, PPARy activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO.J 1996; 15:5336-5348.
    • (1996) EMBO.J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-onsurbe, J.2    Lefebvre, A.3
  • 22
    • 54249125052 scopus 로고    scopus 로고
    • Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: Comparison with other polyunsaturated fatty acids
    • Zapata-Gonzalez F, Rueda F, Petriz J, et al. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: Comparison with other polyunsaturated fatty acids. J Leukoc Biol 2008; 84:1172-1182.
    • (2008) J Leukoc Biol , vol.84 , pp. 1172-1182
    • Zapata-Gonzalez, F.1    Rueda, F.2    Petriz, J.3
  • 23
    • 10344263374 scopus 로고    scopus 로고
    • n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1α induction pathway
    • Calviello G, Di Nicuolo F, Gragnoli S, et al. n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1α induction pathway. Carcinogenesis 2004; 25:2303-2310.
    • (2004) Carcinogenesis , vol.25 , pp. 2303-2310
    • Calviello, G.1    Di Nicuolo, F.2    Gragnoli, S.3
  • 24
    • 84867409492 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells
    • Zhou J, Zhang S, Xue J, et al. Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells. J Biol Chem 2012; 287:35161-35169.
    • (2012) J Biol Chem , vol.287 , pp. 35161-35169
    • Zhou, J.1    Zhang, S.2    Xue, J.3
  • 25
    • 80053614458 scopus 로고    scopus 로고
    • Assessing bioenergetic function in response to oxidative stress by metabolic profiling
    • Dranka BP, Benavides Ga, Diers AR, et al. Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radic Biol Med 2011; 51:1621-1635.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1621-1635
    • Dranka, B.P.1    Benavides, G.2    Diers, A.R.3
  • 26
    • 84861158967 scopus 로고    scopus 로고
    • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death
    • Cheng G, Zielonka J, Dranka BP, et al. Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. Cancer Res 2012; 72:2634-2644.
    • (2012) Cancer Res , vol.72 , pp. 2634-2644
    • Cheng, G.1    Zielonka, J.2    Dranka, B.P.3
  • 27
    • 77956295532 scopus 로고    scopus 로고
    • Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association
    • Rogers KR, Kikawa KD, Mouradian M, et al. Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association. Carcinogenesis 2010; 31:1523-1530.
    • (2010) Carcinogenesis , vol.31 , pp. 1523-1530
    • Rogers, K.R.1    Kikawa, K.D.2    Mouradian, M.3
  • 28
    • 77951233410 scopus 로고    scopus 로고
    • Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition
    • Fan Y, Dickman KG, Zong W-X. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem 2010; 285:7324-7333.
    • (2010) J Biol Chem , vol.285 , pp. 7324-7333
    • Fan, Y.1    Dickman, K.G.2    Zong, W.-X.3
  • 29
    • 0030823179 scopus 로고    scopus 로고
    • Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9)
    • Liang Y, Buettger C, Berner DK, Matschinsky FM. Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9). Diabetologia 1997; 40:1018-1027.
    • (1997) Diabetologia , vol.40 , pp. 1018-1027
    • Liang, Y.1    Buettger, C.2    Berner, D.K.3    Matschinsky, F.M.4
  • 30
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • Vander Heiden M, Plas D, Rathmell J, Fox C, Harris M, Thompson C. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 2001; 21:5899-5912.
    • (2001) Mol Cell Biol , vol.21 , pp. 5899-5912
    • Vander Heiden, M.1    Plas, D.2    Rathmell, J.3    Fox, C.4    Harris, M.5    Thompson, C.6
  • 31
    • 0015297746 scopus 로고
    • The pentose cycle and insulin release in mouse pancreatic islets
    • Ashcroft S, Weerasinghe L, Bassett J, Randle P. The pentose cycle and insulin release in mouse pancreatic islets. Biochem J 1972; 126:525-532.
    • (1972) Biochem J , vol.126 , pp. 525-532
    • Ashcroft, S.1    Weerasinghe, L.2    Bassett, J.3    Randle, P.4
  • 32
    • 2342530363 scopus 로고    scopus 로고
    • Baldwin R 4th, Bequette B. Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels
    • Oba M. Baldwin R 4th, Bequette B. Oxidation of glucose, glutamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels. J Anim Sci 2004; 82:479-486.
    • (2004) J Anim Sci , vol.82 , pp. 479-486
    • Oba, M.1
  • 33
    • 80051495155 scopus 로고    scopus 로고
    • Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice
    • Fan Y-Y, Ran Q, Toyokuni S, et al. Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice. Cancer Prev Res 2011; 4:1267-1274.
    • (2011) Cancer Prev Res , vol.4 , pp. 1267-1274
    • Fan, Y.-Y.1    Ran, Q.2    Toyokuni, S.3
  • 34
    • 77249126523 scopus 로고    scopus 로고
    • Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    • Dranka BP, Hill BG, Darley-Usmar VM. Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radic Biol Med 2010; 48:905-914.
    • (2010) Free Radic Biol Med , vol.48 , pp. 905-914
    • Dranka, B.P.1    Hill, B.G.2    Darley-Usmar, V.M.3
  • 35
    • 0026583808 scopus 로고
    • Relationship between dietary fat and experimental mammary tumorigenesis: A review and critique
    • Welsch C. Relationship between dietary fat and experimental mammary tumorigenesis: A review and critique. Cancer Res 1992; 52:2040-2048.
    • (1992) Cancer Res , vol.52 , pp. 2040-2048
    • Welsch, C.1
  • 36
    • 84896399543 scopus 로고    scopus 로고
    • Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth
    • Mouradian M, Kikawa KD, Johnson ED, Beck KL, Pardini RS. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. Prostaglandins Leukot Essent Fatty Acids 2014; 90:105-115.
    • (2014) Prostaglandins Leukot Essent Fatty Acids , vol.90 , pp. 105-115
    • Mouradian, M.1    Kikawa, K.D.2    Johnson, E.D.3    Beck, K.L.4    Pardini, R.S.5
  • 37
    • 0002528128 scopus 로고    scopus 로고
    • Dietary fat, fatty acids and breast cancer
    • Rose D. Dietary fat, fatty acids and breast cancer. Breast Cancer 1997; 4:7-16.
    • (1997) Breast Cancer , vol.4 , pp. 7-16
    • Rose, D.1
  • 38
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003; 23:9361-9374.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.1    Wang, L.2    Chodosh, L.3    Keith, B.4    Simon, M.5
  • 40
  • 41
    • 0036569941 scopus 로고    scopus 로고
    • Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients
    • Beasley N, Leek R, Alam M, Turley H. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res 2002; 62:2493-2497.
    • (2002) Cancer Res , vol.62 , pp. 2493-2497
    • Beasley, N.1    Leek, R.2    Alam, M.3    Turley, H.4
  • 42
    • 3042767902 scopus 로고    scopus 로고
    • Dietary long-chain n-3 fatty acids for the prevention of cancer: A review of potential mechanisms
    • Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Dietary long-chain n-3 fatty acids for the prevention of cancer: A review of potential mechanisms. Am J Clin Nutr 2004; 79:935-945.
    • (2004) Am J Clin Nutr , vol.79 , pp. 935-945
    • Larsson, S.C.1    Kumlin, M.2    Ingelman-Sundberg, M.3    Wolk, A.4
  • 43
    • 78249247430 scopus 로고    scopus 로고
    • Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid
    • Kikawa KD, Herrick JS, Tateo RE, Mouradian M, Tay JS, Pardini RS. Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid. Nutr Cancer 2010; 62:1017-1024.
    • (2010) Nutr Cancer , vol.62 , pp. 1017-1024
    • Kikawa, K.D.1    Herrick, J.S.2    Tateo, R.E.3    Mouradian, M.4    Tay, J.S.5    Pardini, R.S.6
  • 44
    • 84857055262 scopus 로고    scopus 로고
    • Update on lipids and mitochondrial function: Impact of dietary n-3 polyunsaturated fatty acids
    • Stanley WC, Khairallah RJ, Dabkowski ER. Update on lipids and mitochondrial function: Impact of dietary n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care 2012; 15:122-126.
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 122-126
    • Stanley, W.C.1    Khairallah, R.J.2    Dabkowski, E.R.3
  • 45
    • 0031820708 scopus 로고    scopus 로고
    • Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production
    • Watkins SM, Carter LC, German JB. Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. J Lipid Res 1998; 39:1583-1588.
    • (1998) J Lipid Res , vol.39 , pp. 1583-1588
    • Watkins, S.M.1    Carter, L.C.2    German, J.B.3
  • 46
    • 34247111763 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage
    • Lee M, Bae M-A. Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. J Nutr Biochem 2007; 18:348-354.
    • (2007) J Nutr Biochem , vol.18 , pp. 348-354
    • Lee, M.1    Bae, M.-A.2
  • 47
    • 77951127327 scopus 로고    scopus 로고
    • Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic
    • Giros A, Grzybowski M, Sohn VR, et al. Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. Cancer Prev Res 2009; 2:732-742.
    • (2009) Cancer Prev Res , vol.2 , pp. 732-742
    • Giros, A.1    Grzybowski, M.2    Sohn, V.R.3
  • 48
    • 36849056135 scopus 로고    scopus 로고
    • Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex
    • Stravopodis DJ, Margaritis LH, Voustinas GE. Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. Curr Med Chem 2007; 14:3122-3138.
    • (2007) Curr Med Chem , vol.14 , pp. 3122-3138
    • Stravopodis, D.J.1    Margaritis, L.H.2    Voustinas, G.E.3
  • 49
    • 16844371490 scopus 로고    scopus 로고
    • Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes
    • Peng X, Guo X, Borkan SC, et al. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem 2005; 280:13148-13152.
    • (2005) J Biol Chem , vol.280 , pp. 13148-13152
    • Peng, X.1    Guo, X.2    Borkan, S.C.3
  • 50
    • 57649168862 scopus 로고
    • The carbohydrate metabolism of certain pathological overgrowths
    • Crabtree H. The carbohydrate metabolism of certain pathological overgrowths. Biochem J 1928; 22:8-11.
    • (1928) Biochem J , vol.22 , pp. 8-11
    • Crabtree, H.1
  • 51
    • 33747060171 scopus 로고    scopus 로고
    • Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents
    • Pardini RS. Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents. Chem Biol Interact 2006; 162:89-105.
    • (2006) Chem Biol Interact , vol.162 , pp. 89-105
    • Pardini, R.S.1
  • 52
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway-new players upstream and downstream
    • Hardie DG. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 2004; 117:5479-5487.
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 53
    • 80655134737 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
    • Jing K, Song K-S, Shin S, et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy 2011; 7:1348-1358.
    • (2011) Autophagy , vol.7 , pp. 1348-1358
    • Jing, K.1    Song, K.-S.2    Shin, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.