Lactoperoxidase and human airway host defense

American Journal of Respiratory Cell and Molecular Biology

Volumn 29, Issue 2, 2003, Pages 206-212

  Wijkstrom Frei, Corinne ^a   El Chemaly, Souheil ^a   Ali Rachedi, Radia ^a   Gerson, Cynthia ^a   Cobas, Miguel A ^a   Forteza, Rosanna ^a   Salathe, Matthias ^a   Conner, Gregory E ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTOPEROXIDASE; THIOCYANATE;

AIRWAY; ANTIBACTERIAL ACTIVITY; ARTICLE; BRONCHUS; BRONCHUS SECRETION; BURKHOLDERIA CEPACIA; CATALYSIS; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE AMPLIFICATION; HAEMOPHILUS INFLUENZAE; HOST RESISTANCE; HUMAN; IMMUNOHISTOCHEMISTRY; INFECTION RESISTANCE; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PSEUDOMONAS AERUGINOSA; SUBMUCOSA;

ANIMALS; BLOTTING, WESTERN; BURKHOLDERIA CEPACIA; CATALYSIS; CATTLE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HAEMOPHILUS INFLUENZAE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; LACTOPEROXIDASE; MODELS, CHEMICAL; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; RNA, MESSENGER; THIOCYANATES; TIME FACTORS; TRACHEA;

BRONCHUS; BURKHOLDERIA; BURKHOLDERIA CEPACIA; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; OVIS; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0042703130     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0152OC     Document Type: Article

References (55)

1. Singh, P. K., B. F. Tack, P. B. McCray, Jr., and M. J. Welsh. 2000. Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am. J. Physiol. Lung Cell. Mol. Physiol. 279:L799-L805.
2. Akinbi, H. T., R. Epaud, H. Bhatt, and T. E. Weaver. 2000. Bacterial killing is enhanced by expression of lysozyme in the lungs of transgenic mice. J. Immunol. 165:5760-5766.
3. McClelland, D. B., and R. van Furth. 1975. In vitro synthesis of lysozyme by human and mouse tissues and leucocytes. Immunology 28:1099-1114.
4. Tournier, J. M., M. Merten, Y. Meckler, J. Hinnrasky, C. Fuchey, and E. Puchelle. 1990. Culture and characterization of human tracheal gland cells. Am. Rev. Respir. Dis. 141:1280-1288.
5. Soong, L. B., T. Ganz, A. Ellison, and G. H. Caughey. 1997. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm. Res. 46:98-102.
6. McCray, P. B., Jr., and L. Bentley. 1997. Human airway epithelia express a β-defensin. Am. J. Respir. Cell Mol. Biol. 16:343-349.
7. Goldman, M. J., G. M. Anderson, E. D. Stolzenberg, U. P. Kari, M. Zasloff, and J. M. Wilson. 1997. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560.
8. Zhao, C., I. Wang, and R. I. Lehrer. 1996. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:319-322.
9. Bals, R., X. Wang, M. Zasloff, and J. M. Wilson. 1998. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc. Natl. Acad. Sci. USA 95:9541-9546.
10. Gawel, J., J. Rudnik, J. Pryjma, J. Zebrak, J. Haluszka, I. Rudnik, and H. Majewska-Zalewska. 1979. Proteins in bronchial secretion of children with chronic pulmonary diseases: I. Relation to clinical diagnosis. Scand. J. Respir. Dis. 60:63-68.
11. Inoue, M., J. Yamada, N. Kitamura, K. Shimazaki, A. Andren, and T. Yamashita. 1993. Immunohistochemical localization of lactoferrin in bovine exocrine glands. Tissue Cell 25:791-797.
12. Hiemstra, P. S., R. J. Maassen, J. Stolk, R. Heinzel-Wieland, G. J. Steffens, and J. H. Dijkman. 1996. Antibacterial activity of antileukoprotease. Infect. Immun. 64:4520-4524.
13. Merten, M. D., J. M. Tournier, Y. Meckler, and C. Figarella. 1992. Secretory proteins and glycoconjugates synthesized by human tracheal gland cells in culture. Am. J. Respir. Cell Mol. Biol. 7:598-605.
14. Gerson, C., J. Sabater, M. Scuri, A. Torbati, R. Coffey, J. W. Abraham, I. Lauredo, R. Forteza, A. Wanner, M. Salathe, W. M. Abraham, and G. E. Conner. 2000. The lactoperoxidase system functions in bacterial clearance of airways. Am. J. Respir. Cell Mol. Biol. 22:665-671.
15. Christensen, T. G., G. C. Blanchard, G. Nolley, and J. A. Hayes. 1981. Ultrastructural localization of endogenous peroxidase in the lower respiratory tract of the guinea pig. Cell Tissue Res. 214:407-415.
16. Christensen, T. G., and J. A. Hayes. 1982. Endogenous peroxidase in the conducting airways of hamsters: morphologic evidence of synthesis and secretion. Am. Rev. Respir. Dis. 125:341-346.
17. Reiter, N., and J. P. Perraudin. 1991. Lactoperoxidase: biological function. In Peroxidases in Chemistry and Biology. Vol. I. J. Everse, K. E. Everse, and M. B. Grisham, editors. CRC Press, Boca Raton FL. 143-180.
18. Pruitt, K. M. 1987. The salivary peroxidase system: thermodynamic, kinetic and antibacterial properties. J. Oral Pathol. 16:417-420.
19. Thomas, E. L., P. M. Bozeman, and D. B. Learn. 1991. Lactoperoxidase: structure and catalytic properties. In Peroxidases in Chemistry and Biology. J. Everse, K. E. Everse, and M. B. Grisham, editors. CRC Press, Boca Raton, FL. 123-142.
20. Johansen, C., P. Falholt, and L. Gram. 1997. Enzymatic removal and disinfection of bacterial biofilms. Appl. Environ. Microbiol. 63:3724-3728.
21. Bjorck, L., C. Rosen, V. Marshall, and B. Reiter. 1975. Antibacterial activity of the lactoperoxidase system in milk against pseudomonads and other gram-negative bacteria. Appl. Microbiol. 30:199-204.
22. Reiter, B., V. M. Marshall, L. Bjorck, and C. G. Rosen. 1976. Nonspecific bactericidal activity of the lactoperoxidases-thiocyanate-hydrogen peroxide system of milk against Escherichia coli and some gram-negative pathogens. Infect. Immunol. 13:800-807.
23. Conner, G. E., and J. A. Udey. 1990. Expression and refolding of recombinant human fibroblast procathepsin D. DNA Cell Biol 9:1-9.
24. Densen, P. M., B. Davidow, H. E. Bass, and E. W. Jones. 1967. A chemical test for smoking exposure. Arch. Environ. Health 14:865-874.
25. Thomas, E. L., M. M. Jefferson, R. E. Joyner, G. S. Cook, and C. C. King. 1994. Leukocyte myeloperoxidase and salivary lactoperoxidase: identification and quantitation in human mixed saliva. J. Dent. Res. 73:544-555.
26. Salathe, M., M. Holderby, R. Forteza, W. M. Abraham, A. Wanner, and G. E. Conner. 1997. Isolation and characterization of a peroxidase from the airway. Am. J. Respir. Cell Mol. Biol. 17:97-105.
27. Purdy, M. A., J. Tenovuo, K. M. Pruitt, and W. E. White, Jr. 1983. Effect of growth phase and cell envelope structure on susceptibility of Salmonella typhimurium to the lactoperoxidase-thiocyanate-hydrogen peroxide system. Infect. Immun. 39:1187-1195.
28. Pick, E., and Y. Keisari. 1980. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J. Immunol. Methods 38:161-170.
29. Nowak, D., S. Kalucka, P. Bialasiewicz, and M. Krol. 2001. Exhalation of H202 and thiobarbituric acid reactive substances (TBARs) by healthy subjects. Free Radic. Biol. Med. 30:178-186.
30. van Beurden, W. J., G. A. Harff, P. N. Dekhuijzen, M. J. van den Bosch, J. P. Creemers, and F. W. Smeenk. 2002. An efficient and reproducible method for measuring hydrogen peroxide in exhaled breath condensate. Respir. Med. 96:197-203.
31. Ferreira, I. M., M. S. Hazari, C. Gutierrez, N. Zamel, and K. R. Chapman 2001. Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease: effects of inhaled beclomethasone. Am. J. Respir. Crit. Care Med. 164:1012-1015.
32. Worlitzsch, D., G. Herberth, M. Ulrich, and G. Doring. 1998. Catalase, myeloperoxidase and hydrogen peroxide in cystic fibrosis. Eur. Respir. J. 11:377-383.
33. Jobsis, R. Q., S. L. Schellekens, A. Fakkel-Kroesbergen, R. H. Raatgeep, and J. C. de Jongste. 2001. Hydrogen peroxide in breath condensate during a common cold. Mediators Inflamm. 10:351-354.
34. Baldwin, S. R., R. H. Simon, C. M. Grum, L. H. Ketai, L. A. Boxer, and L. J. Devall. 1986. Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1:11-14.
35. Shin, K., M. Tomita, and B. Lonnerdal. 2000. Identification of lactoperoxidase in mature human milk. J. Nutr. Biochem 11:94-102.
36. Mansson-Rahemtulla, B., F. Rahemtulla, D. C. Baldone, K. M. Pruitt, and A. Hjerpe. 1988. Purification and characterization of human salivary peroxidase. Biochemistry 27:233-239.
37. Christensen, T. G. 1984. The distribution and function of peroxidases in the respiratory tract. Surv. Synth. Pathol. Res. 3:201-218.
38. Dacre, J. C., and I. R. Tabershaw. 1970. Thiocyanate in saliva and sputum: relationship to smoking and industrial exposures. Arch. Environ. Health 21:47-49.
39. Pruitt, K. M., B. Mansson-Rahemtulla, and J. Tenovuo. 1983. Detection of the hypothiocyanite (OSCN-) ion in human parotid saliva and the effect of pH on OSCN- generation in the salivary peroxidase antimicrobial system. Arch. Oral Biol. 28:517-525.
40. Tenovuo, J., K. K. Makinen, and G. Sievers. 1985. Antibacterial effect of lactoperoxidase and myeloperoxidase against Bacillus cereus. Antimicrob. Agents Chemother. 27:96-101.
41. Pruitt, K. M., B. Mansson-Rahemtulla, D. C. Baldone, and F. Rahemtulla. 1988. Steady-state kinetics of thiocyanate oxidation catalyzed by human salivary peroxidase. Biochemistry 27:240-245.
42. Tenovuo, J., B. Mansson-Rahemtulla, K. M. Pruitt, and R. Arnold. 1981. Inhibition of dental plaque acid production by the salivary lactoperoxidase antimicrobial system. Infect. Immunol. 34:208-214.
43. El-Chemaly, S., M. Salathe, S. Baier, G. E. Conner, and R. Forteza. 2003. Hydrogen peroxide-scavenging properties of normal human airway secretions. Am. J. Respir. Crit. Care Med. 167:425-430.
44. Loukides, S., I. Horvath, T. Wodehouse, P. J. Cole, and P. J. Barnes. 1998. Elevated levels of expired breath hydrogen peroxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 158:991-994.
45. Jobsis, Q., H. C. Raatgeep, S. L. Schellekens, W. C. Hop, P. W. Hermans, and J. C. de Jongste. 1998. Hydrogen peroxide in exhaled air of healthy children: reference values. Eur. Respir. J. 12:483-485.
46. Jobsis, Q., H. C. Raatgeep, S. L. Schellekens, A. Kroesbergen, W. C. Hop, and J. C. de Jongste. 2000. Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur. Respir. J. 16:95-100.
47. Effros, R. M., K. W. Hoagland, M. Bosbous, D. Castillo, B. Foss, M. Dunning, M. Gare, W. Lin, and F. Sun. 2002. Dilution of respiratory solutes in exhaled condensates. Am. J. Respir. Crit. Care Med. 165:663-669.
48. Corradi, M., G. Folesani, R. Andreoli, P. Manini, A. Bodini, G. Piacentini, S. Carraro, S. Zanconato, and E. Baraldi. 2003. Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation. Am. J. Respir. Crit. Care Med. 167:395-399.
49. Hunt, J. F., K. Fang, R. Malik, A. Snyder, N. Malhotra, T. A. Platts-Mills, and B. Gaston. 2000. Endogenous airway acidification: implications for asthma pathophysiology. Am. J. Respir. Crit. Care Med. 161:694-699.
50. Hunt, J. F., E. Erwin, L. Palmer, J. Vaughan, N. Malhotra, T. A. Platts-Mills, and B. Gaston. 2002. Expression and activity of pH-regulatory glutaminase in the human airway epithelium. Am. J. Respir. Crit. Care Med. 165:101-107.
51. Kostikas, K., G. Papatheodorou, K. Ganas, K. Psathakis, P. Panagou, and S. Loukides. 2002. pH in expired breath condensate of patients with inflammatory airway diseases. Am. J. Respir. Crit. Care Med. 165:1364-1370.
52. Adler, K., O. Wooten, W. Philippoff, E. Lerner, and M. J. Dulfano. 1972. Physical properties of sputum: 3. Rheologic variability and intrinsic relationships. Am. Rev. Respir. Dis. 106:86-96.
53. El-Chemaly, S., S. Baier, M. Salathe, G. E. Conner, and R. Forteza. 2001. The relative contribution of lactoperoxidase and glutathione peroxidase to hydrogen peroxide scavenging in normal human airway secretions. Am. J. Respir. Crit. Care Med. 163:A534. (Abstr.)
54. Kobayashi, K., M. Salathe, M. M. Pratt, N. J. Cartagena, F. Soloni, and Z. V. Seybold. 1992. Mechanism of hydrogen peroxide-induced inhibition of sheep airway cilia. Am. J. Respir. Crit. Care Med. 6:667-673.
55. Fischer, H., J. H. Widdicombe, and B. Illek. 2002. Acid secretion and proton conductance in human airway epithelium. Am. J. Physiol. Cell Physiol. 282:C736-C743.