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Volumn 37, Issue 4, 2015, Pages

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study

Author keywords

Aging; DNA methylation; Epigenetics; Gene expression; IL 6; Inflammaging

Indexed keywords

INTERLEUKIN 6; PHOSPHOTRANSFERASE; TEC KINASE; TRANSCRIPTOME; UNCLASSIFIED DRUG; IL6 PROTEIN, HUMAN;

EID: 84938901562     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-015-9814-9     Document Type: Article
Times cited : (37)

References (46)
  • 1
    • 0031943254 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist: role in biology
    • COI: 1:CAS:528:DyaK1cXislyitr4%3D
    • Arend WP, Malyak M, Guthridge CJ, Gabay C (1998) Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 16:27–55
    • (1998) Annu Rev Immunol , vol.16 , pp. 27-55
    • Arend, W.P.1    Malyak, M.2    Guthridge, C.J.3    Gabay, C.4
  • 3
    • 78650976421 scopus 로고    scopus 로고
    • Epigenetic mechanisms in inflammation
    • COI: 1:CAS:528:DC%2BC3MXovFWnsA%3D%3D
    • Bayarsaihan D (2011) Epigenetic mechanisms in inflammation. J Dent Res 90:9–17
    • (2011) J Dent Res , vol.90 , pp. 9-17
    • Bayarsaihan, D.1
  • 5
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    • COI: 1:CAS:528:DC%2BC3sXkvVGgtrs%3D
    • Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW et al (2013) Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 8:203–209
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.A.1    Lemire, M.2    Choufani, S.3    Butcher, D.T.4    Grafodatskaya, D.5    Zanke, B.W.6
  • 6
    • 84880508065 scopus 로고    scopus 로고
    • Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-kappaB-dependent pathway
    • COI: 1:CAS:528:DC%2BC3sXhtVyisLzF
    • Cheng CC, Hsueh CM, Chen CY, Chen TH, Hsu SL (2013) Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-kappaB-dependent pathway. Biochem Biophys Res Commun 437:55–61
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 55-61
    • Cheng, C.C.1    Hsueh, C.M.2    Chen, C.Y.3    Chen, T.H.4    Hsu, S.L.5
  • 7
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • De Martinis M, Franceschi C, Monti D, Ginaldi L (2005) Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 579:2035–2039
    • (2005) FEBS Lett , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 8
    • 46249088370 scopus 로고    scopus 로고
    • lumi: a pipeline for processing Illumina microarray
    • COI: 1:CAS:528:DC%2BD1cXnvV2rtLg%3D
    • Du P, Kibbe WA, Lin SM (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24:1547–1548
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 11
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • COI: 1:CAS:528:DC%2BD3cXisVelsbY%3D
    • Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51:245–270
    • (2000) Annu Rev Med , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 12
    • 4444357184 scopus 로고    scopus 로고
    • Beta regression for modelling rates and proportions
    • Ferrari C (2004) Beta regression for modelling rates and proportions. J Appl Stat 31:799–815
    • (2004) J Appl Stat , vol.31 , pp. 799-815
    • Ferrari, C.1
  • 13
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    • Franceschi C, Campisi J (2014) Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S4–S9
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 4-9
    • Franceschi, C.1    Campisi, J.2
  • 15
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • COI: 1:CAS:528:DC%2BD2sXmtVWqug%3D%3D
    • Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F et al (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128:92–105
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 16
    • 84938875016 scopus 로고    scopus 로고
    • Francisco Cribari-neto, A.Z., 2010—last update, beta regression in R. [Homepage of Journal of Statistical Software 34(2), 1-24.], [Online]
    • Francisco Cribari-neto, A.Z., 2010—last update, beta regression in R. [Homepage of Journal of Statistical Software 34(2), 1-24.], [Online]. Available: http://www.jstatsoft.org/v34/i02/
  • 17
    • 0038044873 scopus 로고    scopus 로고
    • Medical history, cognitive status and mobility at the age of 90. A population-based study in Tampere, Finland
    • Goebeler S, Jylha M, Hervonen A (2003) Medical history, cognitive status and mobility at the age of 90. A population-based study in Tampere, Finland. Aging Clin Exp Res 15:154–161
    • (2003) Aging Clin Exp Res , vol.15 , pp. 154-161
    • Goebeler, S.1    Jylha, M.2    Hervonen, A.3
  • 18
    • 0032526358 scopus 로고    scopus 로고
    • IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections
    • COI: 1:CAS:528:DyaK1cXjvVaitro%3D
    • Gregory SH, Wing EJ, Danowski KL, van Rooijen N, Dyer KF, Tweardy DJ (1998) IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol 160:6056–6061
    • (1998) J Immunol , vol.160 , pp. 6056-6061
    • Gregory, S.H.1    Wing, E.J.2    Danowski, K.L.3    van Rooijen, N.4    Dyer, K.F.5    Tweardy, D.J.6
  • 19
    • 84872806231 scopus 로고    scopus 로고
    • Genome-wide methylation profiles reveal quantitative views of human aging rates
    • COI: 1:CAS:528:DC%2BC38XhslajsrzF
    • Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S et al (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49:359–367
    • (2013) Mol Cell , vol.49 , pp. 359-367
    • Hannum, G.1    Guinney, J.2    Zhao, L.3    Zhang, L.4    Hughes, G.5    Sadda, S.6
  • 20
    • 0033134682 scopus 로고    scopus 로고
    • Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • COI: 1:STN:280:DyaK1M3ms1OmsA%3D%3D
    • Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr et al (1999) Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106:506–512
    • (1999) Am J Med , vol.106 , pp. 506-512
    • Harris, T.B.1    Ferrucci, L.2    Tracy, R.P.3    Corti, M.C.4    Wacholder, S.5    Ettinger, W.H.6
  • 21
    • 38149032931 scopus 로고    scopus 로고
    • IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase
    • COI: 1:CAS:528:DC%2BD1cXnsVyqsQ%3D%3D
    • Hodge DR, Cho E, Copeland TD, Guszczynski T, Yang E, Seth AK et al (2007) IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase. Cancer Genomics Proteomics 4:387–398
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 387-398
    • Hodge, D.R.1    Cho, E.2    Copeland, T.D.3    Guszczynski, T.4    Yang, E.5    Seth, A.K.6
  • 22
    • 79958170373 scopus 로고    scopus 로고
    • DNA methylation in neurodegenerative disorders: a missing link between genome and environment?
    • COI: 1:CAS:528:DC%2BC3MXpsVCru7o%3D
    • Iraola-Guzman S, Estivill X, Rabionet R (2011) DNA methylation in neurodegenerative disorders: a missing link between genome and environment? Clin Genet 80:1–14
    • (2011) Clin Genet , vol.80
    • Iraola-Guzman, S.1    Estivill, X.2    Rabionet, R.3
  • 24
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • COI: 1:CAS:528:DC%2BC38Xns1SqtLw%3D
    • Jones PA (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13:484–492
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 25
    • 34948813493 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study
    • Jylha M, Paavilainen P, Lehtimaki T, Goebeler S, Karhunen PJ, Hervonen A et al (2007) Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study. J Gerontol A Biol Sci Med Sci 62:1016–1021
    • (2007) J Gerontol A Biol Sci Med Sci , vol.62 , pp. 1016-1021
    • Jylha, M.1    Paavilainen, P.2    Lehtimaki, T.3    Goebeler, S.4    Karhunen, P.J.5    Hervonen, A.6
  • 26
    • 84877808128 scopus 로고    scopus 로고
    • Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty
    • COI: 1:CAS:528:DC%2BC3sXovFKgu7c%3D
    • Jylhava J, Nevalainen T, Marttila S, Jylha M, Hervonen A, Hurme M (2013) Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell 12:388–397
    • (2013) Aging Cell , vol.12 , pp. 388-397
    • Jylhava, J.1    Nevalainen, T.2    Marttila, S.3    Jylha, M.4    Hervonen, A.5    Hurme, M.6
  • 27
    • 84879744665 scopus 로고    scopus 로고
    • Interleukin-6 mediates angiotensinogen gene expression during liver regeneration
    • COI: 1:CAS:528:DC%2BC3sXhtFKktrbE
    • Lai HS, Lin WH, Lai SL, Lin HY, Hsu WM, Chou CH et al (2013) Interleukin-6 mediates angiotensinogen gene expression during liver regeneration. PLoS One 8:e67868
    • (2013) PLoS One , vol.8 , pp. 67868
    • Lai, H.S.1    Lin, W.H.2    Lai, S.L.3    Lin, H.Y.4    Hsu, W.M.5    Chou, C.H.6
  • 28
    • 77955906264 scopus 로고    scopus 로고
    • The nuclear factor NF-kappaB pathway in inflammation
    • Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1:a001651
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. 1651
    • Lawrence, T.1
  • 31
    • 84878862434 scopus 로고    scopus 로고
    • Transcriptional analysis reveals gender-specific changes in the aging of the human immune system
    • COI: 1:CAS:528:DC%2BC3sXhtVantrfL
    • Marttila S, Jylhava J, Nevalainen T, Nykter M, Jylha M, Hervonen A et al (2013) Transcriptional analysis reveals gender-specific changes in the aging of the human immune system. PLoS One 8:e66229
    • (2013) PLoS One , vol.8 , pp. 66229
    • Marttila, S.1    Jylhava, J.2    Nevalainen, T.3    Nykter, M.4    Jylha, M.5    Hervonen, A.6
  • 32
    • 84928012878 scopus 로고    scopus 로고
    • Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
    • Marttila S, Kananen L, Hayrynen S, Jylhava J, Nevalainen T, Hervonen A et al (2015) Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics 16:179
    • (2015) BMC Genomics , vol.16 , pp. 179
    • Marttila, S.1    Kananen, L.2    Hayrynen, S.3    Jylhava, J.4    Nevalainen, T.5    Hervonen, A.6
  • 34
    • 0036604985 scopus 로고    scopus 로고
    • New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
    • COI: 1:CAS:528:DC%2BD38XjtVeit7Y%3D
    • Miller AT, Berg LJ (2002) New insights into the regulation and functions of Tec family tyrosine kinases in the immune system. Curr Opin Immunol 14:331–340
    • (2002) Curr Opin Immunol , vol.14 , pp. 331-340
    • Miller, A.T.1    Berg, L.J.2
  • 35
    • 84904746130 scopus 로고    scopus 로고
    • Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    • COI: 1:CAS:528:DC%2BC2cXhtlSqsLjJ
    • Morrisette-Thomas V, Cohen AA, Fulop T, Riesco E, Legault V, Li Q et al (2014) Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev 139:49–57
    • (2014) Mech Ageing Dev , vol.139 , pp. 49-57
    • Morrisette-Thomas, V.1    Cohen, A.A.2    Fulop, T.3    Riesco, E.4    Legault, V.5    Li, Q.6
  • 36
    • 84901044149 scopus 로고    scopus 로고
    • Inflammation, ageing and chronic disease
    • COI: 1:CAS:528:DC%2BC2cXht1Kht7jE
    • Pawelec G, Goldeck D, Derhovanessian E (2014) Inflammation, ageing and chronic disease. Curr Opin Immunol 29:23–28
    • (2014) Curr Opin Immunol , vol.29 , pp. 23-28
    • Pawelec, G.1    Goldeck, D.2    Derhovanessian, E.3
  • 37
    • 84876806540 scopus 로고    scopus 로고
    • A data-driven approach to preprocessing Illumina 450K methylation array data
    • Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013) A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics 14, 293. doi:10.1186/1471-2164-14-293
    • (2013) BMC Genomics , vol.14 , pp. 293
    • Pidsley, R.1    Y Wong, C.C.2    Volta, M.3    Lunnon, K.4    Mill, J.5    Schalkwyk, L.C.6
  • 38
    • 33747172229 scopus 로고    scopus 로고
    • Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
    • COI: 1:CAS:528:DC%2BD28Xotlalt7Y%3D
    • Salvioli S, Capri M, Valensin S, Tieri P, Monti D, Ottaviani E et al (2006) Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology. Curr Pharm Des 12:3161–3171
    • (2006) Curr Pharm Des , vol.12 , pp. 3161-3171
    • Salvioli, S.1    Capri, M.2    Valensin, S.3    Tieri, P.4    Monti, D.5    Ottaviani, E.6
  • 39
    • 84879079390 scopus 로고    scopus 로고
    • Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    • COI: 1:CAS:528:DC%2BC3sXptlKqsrc%3D
    • Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S et al (2013) Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arterioscler Thromb Vasc Biol 33:1728–1733
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1728-1733
    • Schnabel, R.B.1    Yin, X.2    Larson, M.G.3    Yamamoto, J.F.4    Fontes, J.D.5    Kathiresan, S.6
  • 40
    • 79955973916 scopus 로고    scopus 로고
    • Inflammatory markers in population studies of aging
    • COI: 1:CAS:528:DC%2BC3MXmtlyrsb8%3D
    • Singh T, Newman AB (2011) Inflammatory markers in population studies of aging. Ageing Res Rev 10:319–329
    • (2011) Ageing Res Rev , vol.10 , pp. 319-329
    • Singh, T.1    Newman, A.B.2
  • 42
    • 84872564830 scopus 로고    scopus 로고
    • A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
    • COI: 1:CAS:528:DC%2BC3sXhtFygsro%3D
    • Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D et al (2013) A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 29:189–196
    • (2013) Bioinformatics , vol.29 , pp. 189-196
    • Teschendorff, A.E.1    Marabita, F.2    Lechner, M.3    Bartlett, T.4    Tegner, J.5    Gomez-Cabrero, D.6
  • 43
    • 0344326341 scopus 로고    scopus 로고
    • Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain
    • COI: 1:CAS:528:DyaK1MXktVelsLg%3D
    • Vannahme C, Schubel S, Herud M, Gosling S, Hulsmann H, Paulsson M et al (1999) Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. J Neurochem 73:12–20
    • (1999) J Neurochem , vol.73 , pp. 12-20
    • Vannahme, C.1    Schubel, S.2    Herud, M.3    Gosling, S.4    Hulsmann, H.5    Paulsson, M.6
  • 44
    • 84907426794 scopus 로고    scopus 로고
    • Immunologic changes in frail older adults
    • Wang GC, Casolaro V (2014) Immunologic changes in frail older adults. Transl Med UniSa 9:1–6
    • (2014) Transl Med UniSa , vol.9
    • Wang, G.C.1    Casolaro, V.2
  • 45
    • 0026497223 scopus 로고
    • Increase of plasma IL-6 concentration with age in healthy subjects
    • COI: 1:CAS:528:DyaK3sXitVOgsA%3D%3D
    • Wei J, Xu H, Davies JL, Hemmings GP (1992) Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci 51:1953–1956
    • (1992) Life Sci , vol.51 , pp. 1953-1956
    • Wei, J.1    Xu, H.2    Davies, J.L.3    Hemmings, G.P.4
  • 46
    • 0035868761 scopus 로고    scopus 로고
    • A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
    • COI: 1:CAS:528:DC%2BD3MXisVCksLs%3D
    • Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, Shimizu Y (2001) A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor. EMBO J 20:1232–1244
    • (2001) EMBO J , vol.20 , pp. 1232-1244
    • Woods, M.L.1    Kivens, W.J.2    Adelsman, M.A.3    Qiu, Y.4    August, A.5    Shimizu, Y.6


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