-
1
-
-
28044468016
-
Ews-ets oncoproteins: The linchpins of ewing tumors
-
Janknecht R. EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene 2005; 363:1-14.
-
(2005)
Gene
, vol.363
, pp. 1-14
-
-
Janknecht, R.1
-
2
-
-
42049089299
-
Ews-fli-1 expression triggers a ewing's sarcoma initiation program in primary human mesenchymal stem cells
-
Riggi N, Suva ML, Suva D, Cironi L, Provero P, Tercier S, et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 2008; 68:2176-2185.
-
(2008)
Cancer Res
, vol.68
, pp. 2176-2185
-
-
Riggi, N.1
Suva, M.L.2
Suva, D.3
Cironi, L.4
Provero, P.5
Tercier, S.6
-
3
-
-
0029829794
-
Ews/fli-1 antagonists induce growth inhibition of ewing tumor cells in vitro
-
Kovar H, Aryee DN, Jug G, Henöckl C, Schemper M, Delattre O, et al. EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro. Cell Growth Differ 1996; 7:429-437.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 429-437
-
-
Kovar, H.1
Aryee, D.N.2
Jug, G.3
Henöckl, C.4
Schemper, M.5
Delattre, O.6
-
4
-
-
0028821578
-
Multiple domains mediate transformation by the ewing's sarcoma ews/fli-1 fusion gene
-
Lessnick SL, Braun BS, Denny CT, May WA. Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene 1995; 10:423-431.
-
(1995)
Oncogene
, vol.10
, pp. 423-431
-
-
Lessnick, S.L.1
Braun, B.S.2
Denny, C.T.3
May, W.A.4
-
5
-
-
0028114385
-
Diagnostic value of the molecular genetic detection of the t(11;22) translocation in ewing's tumours
-
Dockhorn-Dworniczak B, Schafer KL, Dantcheva R, Blasius S, Winkelmann W, Strehl S, et al. Diagnostic value of the molecular genetic detection of the t(11;22) translocation in Ewing's tumours. Virchows Arch 1994; 425:107-112.
-
(1994)
Virchows Arch
, vol.425
, pp. 107-112
-
-
Dockhorn-Dworniczak, B.1
Schafer, K.L.2
Dantcheva, R.3
Blasius, S.4
Winkelmann, W.5
Strehl, S.6
-
6
-
-
84937425893
-
Reversible lsd1 inhibition interferes with global ews/ets transcriptional activity and impedes ewing sarcoma tumor growth
-
Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, et al. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res 2014; 20:4584-4597.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4584-4597
-
-
Sankar, S.1
Theisen, E.R.2
Bearss, J.3
Mulvihill, T.4
Hoffman, L.M.5
Sorna, V.6
-
7
-
-
84862785899
-
Impairment of p53 acetylation by ews-fli1 chimeric protein in ewing family tumors
-
Li Y, Li X, Fan G, Fukushi J, Matsumoto Y, Iwamoto Y, Zhu Y. Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. Cancer Lett 2012; 320:14-22.
-
(2012)
Cancer Lett
, vol.320
, pp. 14-22
-
-
Li, Y.1
Li, X.2
Fan, G.3
Fukushi, J.4
Matsumoto, Y.5
Iwamoto, Y.6
Zhu, Y.7
-
8
-
-
73749088654
-
Epigenetic opportunities and challenges in cancer
-
Best JD, Carey N. Epigenetic opportunities and challenges in cancer. Drug Discov Today 2010; 15 (1-2):65-70.
-
(2010)
Drug Discov Today
, vol.15
, Issue.1-2
, pp. 65-70
-
-
Best, J.D.1
Carey, N.2
-
9
-
-
67650511419
-
Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by ezh2
-
Burdach S, Plehm S, Unland R, Dirksen U, Borkhardt A, Staege MS, et al. Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2. Cell Cycle 2009; 8:1991-1996.
-
(2009)
Cell Cycle
, vol.8
, pp. 1991-1996
-
-
Burdach, S.1
Plehm, S.2
Unland, R.3
Dirksen, U.4
Borkhardt, A.5
Staege, M.S.6
-
10
-
-
33847070442
-
The role of chromatin during transcription
-
Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell 2007; 128:707-719.
-
(2007)
Cell
, vol.128
, pp. 707-719
-
-
Li, B.1
Carey, M.2
Workman, J.L.3
-
11
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T. Chromatin modifications and their function. Cell 2007; 128:693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
12
-
-
84860233044
-
Histone deacetylase inhibitor-mediated sensitization to trail-induced apoptosis in childhood malignancies is not associated with upregulation of trail receptor expression, but with potentiated caspase-8 activation
-
Sonnemann J, Trommer N, Becker S,Wittig S, Grauel D, Palani CD, Beck JF. Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation. Cancer Biol Ther 2012; 13:417-424.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 417-424
-
-
Sonnemann, J.1
Trommer, N.2
Becker Swittig, S.3
Grauel, D.4
Palani, C.D.5
Beck, J.F.6
-
13
-
-
84893118647
-
Epigenetic repression of the dopamine receptor d4 in pediatric tumors of the central nervous system
-
Unland R, Kerl K, Schlosser S, Farwick N, Plagemann T, Lechtape B, et al. Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. J Neurooncol 2014; 116:237-249.
-
(2014)
J Neurooncol
, vol.116
, pp. 237-249
-
-
Unland, R.1
Kerl, K.2
Schlosser, S.3
Farwick, N.4
Plagemann, T.5
Lechtape, B.6
-
14
-
-
33847372445
-
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: Effects on gene expression and growth of glioma cells in vitro and in vivo
-
Yin D, Ong JM, Hu J, Desmond JC, Kawamata N, Konda BM, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clin Cancer Res 2007; 13:1045-1052.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1045-1052
-
-
Yin, D.1
Ong, J.M.2
Hu, J.3
Desmond, J.C.4
Kawamata, N.5
Konda, B.M.6
-
15
-
-
33947153003
-
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
-
Furchert SE, Lanvers-Kaminsky C, Junvers H, Jung M, Loidl A, Fridlrs MC. Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 2007; 120:1787-1794.
-
(2007)
Int J Cancer
, vol.120
, pp. 1787-1794
-
-
Furchert, S.E.1
Lanvers-Kaminsky, C.2
Junvers, H.3
Jung, M.4
Loidl, A.5
Fridlrs, M.C.6
-
16
-
-
84892378677
-
In vitro antitumor effect of sodium butyrate and zoledronic acid combined with traditional chemotherapeutic drugs: A paradigm of synergistic molecular targeting in the treatment of ewing sarcoma
-
Dos Santos MP, de Farias CB, Roesler R, Brunetto AL, Abujamra AL. In vitro antitumor effect of sodium butyrate and zoledronic acid combined with traditional chemotherapeutic drugs: a paradigm of synergistic molecular targeting in the treatment of Ewing sarcoma. Oncol Rep 2014; 31:955-968.
-
(2014)
Oncol Rep
, vol.31
, pp. 955-968
-
-
Dos Santos, M.P.1
De Farias, C.B.2
Roesler, R.3
Brunetto, A.L.4
Abujamra, A.L.5
-
17
-
-
67349095775
-
Development of vorinostat: Current applications and future perspectives for cancer therapy
-
Richon VM, Garcia-Vargas J, Hardwick JS. Development of vorinostat: current applications and future perspectives for cancer therapy. Cancer Lett 2009; 280:201-210.
-
(2009)
Cancer Lett
, vol.280
, pp. 201-210
-
-
Richon, V.M.1
Garcia-Vargas, J.2
Hardwick, J.S.3
-
18
-
-
67651205908
-
Initial testing (stage 1) of vorinostat (saha) by the pediatric preclinical testing program
-
Keshelava N, Houghton PJ, Morton CL, Lock RB, Carol H, Keir ST, et al. Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. Pediatr Blood Cancer 2009; 53:505-508.
-
(2009)
Pediatr Blood Cancer
, vol.53
, pp. 505-508
-
-
Keshelava, N.1
Houghton, P.J.2
Morton, C.L.3
Lock, R.B.4
Carol, H.5
Keir, S.T.6
-
19
-
-
84878519362
-
Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma
-
Richardson PG, Mitsiades CS, Laubach JP, Hajek R, Spicka I, Dimopoulos MA, et al. Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma. Leuk Res 2013; 37:829-837.
-
(2013)
Leuk Res
, vol.37
, pp. 829-837
-
-
Richardson, P.G.1
Mitsiades, C.S.2
Laubach, J.P.3
Hajek, R.4
Spicka, I.5
Dimopoulos, M.A.6
-
20
-
-
60849106339
-
Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models
-
Pitts TM, Morrow M, Kaufman SA, Tentler JJ, Eckhardt SG. Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models. Mol Cancer Ther 2009; 8:342-349.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 342-349
-
-
Pitts, T.M.1
Morrow, M.2
Kaufman, S.A.3
Tentler, J.J.4
Eckhardt, S.G.5
-
21
-
-
34250696097
-
Phase i and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
-
Ramalingam SS, Parise RA, Ramanathan RK, Lagattuta TF, Musguire LA, Stoller RG, et al. Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies. Clin Cancer Res 2007; 13:3605-3610.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3605-3610
-
-
Ramalingam, S.S.1
Parise, R.A.2
Ramanathan, R.K.3
Lagattuta, T.F.4
Musguire, L.A.5
Stoller, R.G.6
-
22
-
-
70749118328
-
Suberoylanilide hydroxamic acid (saha) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines
-
Dietrich CS 3rd, Greenberg VL, DeSimone CP, Modesitt SC, van Nagell JR, Craven R, Zimmer SG. Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines. Gynecol Oncol 2010; 116:126-130.
-
(2010)
Gynecol Oncol
, vol.116
, pp. 126-130
-
-
Dietrich, C.S.1
Greenberg, V.L.2
DeSimone, C.P.3
Modesitt, S.C.4
Van Nagell, J.R.5
Craven, R.6
Zimmer, S.G.7
-
23
-
-
79958084461
-
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
-
Munster PN, Thurn KT, Thomas S, Raha P, Lacevic M, Miller A, et al. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer 2011; 104:1828-1835.
-
(2011)
Br J Cancer
, vol.104
, pp. 1828-1835
-
-
Munster, P.N.1
Thurn, K.T.2
Thomas, S.3
Raha, P.4
Lacevic, M.5
Miller, A.6
-
24
-
-
77955900071
-
Pediatric phase i trial and pharmacokinetic study of vorinostat: A children's oncology group phase i consortium report
-
Fouladi M, Park JR, Stewart CF, Gilbertson RJ, Schaiquevich P, Sun J, et al. Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report. J Clin Oncol 2010; 28:3623-3629.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3623-3629
-
-
Fouladi, M.1
Park, J.R.2
Stewart, C.F.3
Gilbertson, R.J.4
Schaiquevich, P.5
Sun, J.6
-
25
-
-
84880349569
-
A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: A children's oncology group phase 1 consortium study
-
Hummel TR, Wagner L, Ahern C, Fouladi M, Reid JM, McGovern RM, et al. A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study. Pediatr Blood Cancer 2013; 60:1452-1457.
-
(2013)
Pediatr Blood Cancer
, vol.60
, pp. 1452-1457
-
-
Hummel, T.R.1
Wagner, L.2
Ahern, C.3
Fouladi, M.4
Reid, J.M.5
McGovern, R.M.6
-
26
-
-
84872470330
-
A phase i trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A children's oncology group phase i consortium study (advl0916
-
Muscal JA, Thompson PA, Horton TM, Ingle AM, Ahern CH, McGovern RM, et al. A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916). Pediatr Blood Cancer 2013; 60:390-395.
-
(2013)
Pediatr Blood Cancer
, vol.60
, pp. 390-395
-
-
Muscal, J.A.1
Thompson, P.A.2
Horton, T.M.3
Ingle, A.M.4
Ahern, C.H.5
McGovern, R.M.6
-
27
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22:27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
28
-
-
0030752603
-
The cd95 (apo-1/fas) system mediates drug-induced apoptosis in neuroblastoma cells
-
Fulda S, Sieverts H, Friesen C, Herr I, Debatin KM. The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res 1997; 57:3823-3829.
-
(1997)
Cancer Res
, vol.57
, pp. 3823-3829
-
-
Fulda, S.1
Sieverts, H.2
Friesen, C.3
Herr, I.4
Debatin, K.M.5
-
29
-
-
17444417521
-
Cancer epigenetics
-
Laird PW. Cancer epigenetics. Hum Mol Genet 2005; 14:R65-R76.
-
(2005)
Hum Mol Genet
, vol.14
, pp. R65-R76
-
-
Laird, P.W.1
-
30
-
-
33645226815
-
Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and trail in medulloblastoma cells
-
Sonnemann J, Kumar KS, Heesch S, Müller C, Hartwig C, Maass M, et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. Int J Oncol 2006; 28:755-766.
-
(2006)
Int J Oncol
, vol.28
, pp. 755-766
-
-
Sonnemann, J.1
Kumar, K.S.2
Heesch, S.3
Müller, C.4
Hartwig, C.5
Maass, M.6
-
31
-
-
66649094233
-
Esmo guidelines working group Ewing's sarcoma of the bone: Esmo clinical recommendations for diagnosis, treatment and follow-up
-
Paulussen M, Bielack S, Jürgens H, Casali PG. ESMO Guidelines Working Group. Ewing's sarcoma of the bone: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2009; 20 (Suppl 4):140-142.
-
(2009)
Ann Oncol
, vol.20
, pp. 140-142
-
-
Paulussen, M.1
Bielack, S.2
Jürgens, H.3
Casali, P.G.4
-
32
-
-
84869447819
-
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized ewing sarcoma: A report from the children's oncology group
-
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol 2012; 30:4148-4154.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4148-4154
-
-
Womer, R.B.1
West, D.C.2
Krailo, M.D.3
Dickman, P.S.4
Pawel, B.R.5
Grier, H.E.6
-
33
-
-
33749169684
-
Topotecan and cyclophosphamide in patients with refractory or relapsed ewing tumors
-
Hunold A, Weddeling N, Paulussen M, Ranft A, Liebscher C, Jürgens H. Topotecan and cyclophosphamide in patients with refractory or relapsed ewing tumors. Pediatr Blood Cancer 2006; 47:795-800.
-
(2006)
Pediatr Blood Cancer
, vol.47
, pp. 795-800
-
-
Hunold, A.1
Weddeling, N.2
Paulussen, M.3
Ranft, A.4
Liebscher, C.5
Jürgens, H.6
-
34
-
-
1642540093
-
Rapamycin induces the fusion-type independent downregulation of the ews/fli-1 proteins and inhibits ewing's sarcoma cell proliferation
-
Mateo-Lozano S, Tirado OM, Notario V. Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 2003; 22:9282-9287.
-
(2003)
Oncogene
, vol.22
, pp. 9282-9287
-
-
Mateo-Lozano, S.1
Tirado, O.M.2
Notario, V.3
-
35
-
-
83855162134
-
Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide
-
Zhao H, Rybak P, Dobrucki J, Traganos F, Darzynkiewicz Z. Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide. Cytometry A 2012; 81:45-51.
-
(2012)
Cytometry A
, vol.81
, pp. 45-51
-
-
Zhao, H.1
Rybak, P.2
Dobrucki, J.3
Traganos, F.4
Darzynkiewicz, Z.5
-
36
-
-
79955777649
-
Ku70 and rad51 vary in their importance for the repair of doxorubicin-versus etoposide-induced DNA damage
-
Schonn I, Hennesen J, Dartsch DC. Ku70 and Rad51 vary in their importance for the repair of doxorubicin-versus etoposide-induced DNA damage. Apoptosis 2011; 16:359-369.
-
(2011)
Apoptosis
, vol.16
, pp. 359-369
-
-
Schonn, I.1
Hennesen, J.2
Dartsch, D.C.3
-
37
-
-
77949268266
-
Cellular responses to etoposide: Cell death despite cell cycle arrest and repair of DNA damage
-
Schonn I, Hennesen J, Dartsch DC. Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage. Apoptosis 2010; 15:162-172.
-
(2010)
Apoptosis
, vol.15
, pp. 162-172
-
-
Schonn, I.1
Hennesen, J.2
Dartsch, D.C.3
-
38
-
-
79955865327
-
Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent bax activation
-
Häcker S, Karl S, Mader I, Cristofanon S, Schweitzer T, Krauss J, et al. Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. Oncogene 2011; 30:2275-2281.
-
(2011)
Oncogene
, vol.30
, pp. 2275-2281
-
-
Häcker, S.1
Karl, S.2
Mader, I.3
Cristofanon, S.4
Schweitzer, T.5
Krauss, J.6
|