Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth

Clinical cancer research : an official journal of the American Association for Cancer Research

Volumn 20, Issue 17, 2014, Pages 4584-4597

  Sankar, Savita ^a   Theisen, Emily R ^a   Bearss, Jared ^a   Mulvihill, Timothy ^a   Hoffman, Laura M ^a   Sorna, Venkataswamy ^a   Beckerle, Mary C ^a   Sharma, Sunil ^a   Lessnick, Stephen L ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERG PROTEIN, HUMAN; HISTONE DEMETHYLASE; KDM1A PROTEIN, HUMAN; ONCOPROTEIN; RNA BINDING PROTEIN EWS; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR FLI 1;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BONE TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION; EWING SARCOMA; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEMETHYLASES; HUMANS; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEIN C-FLI-1; RNA-BINDING PROTEIN EWS; SARCOMA, EWING; TRANS-ACTIVATORS;

EID: 84937425893     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0072     Document Type: Article

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