Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures

Advanced Healthcare Materials

Volumn 4, Issue 11, 2015, Pages 1664-1674

  Engel, Brian J ^a   Constantinou, Pamela E ^a   Sablatura, Lindsey K ^a   Doty, Nathaniel J ^b   Carson, Daniel D ^a   Farach Carson, Mary C ^a   Harrington, Daniel A ^a   Zarembinski, Thomas I ^b  

^a RICE UNIVERSITY   (United States)

^b BIOTIME INC   (United States)

Author keywords

3D culture; Coculture; Drug screening; High throughput; Hyaluronic acid

Indexed keywords

CELL CULTURE; CELLS; DISEASES; HYDROGELS; ORGANIC ACIDS;

3-D CULTURES; COCULTURE; DRUG SCREENING; ENDOMETRIAL CANCER CELLS; HIGH THROUGHPUT; HYALURONIC ACID HYDROGELS; MULTI-LAYERED; STROMAL CELLS;

HYALURONIC ACID;

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; BMS 536924; CELECOXIB; CHLORMETHINE; CISPLATIN; DASATINIB; ELESCLOMOL; FIBROBLAST GROWTH FACTOR 2; FLINDOKALNER; GELDENAMYCIN; HISTONE DEACETYLASE 2; HYALURONIC ACID; HYDROXYUREA; IFOSFAMIDE; LAPATINIB; MIDOSTAURIN; MITOXANTRONE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; NVPAUY 922; PICTILISIB; RAPAMYCIN; TEMSIROLIMUS; UNCLASSIFIED DRUG; VALRUBICIN; VANDETANIB; VASCULOTROPIN; HYDROGEL;

ANALYSIS OF VARIANCE; ARTICLE; AUTOMATION; BIOCOMPATIBILITY; CANCER CELL; CANCER SURVIVAL; CELL ADHESION; CELL DENSITY; CELL GROWTH; CELL SURVIVAL; CELLS BY BODY ANATOMY; COCULTURE; CONFOCAL MICROSCOPY; CROSS-SECTIONAL STUDY; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG MECHANISM; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; IC50; IMAGE ANALYSIS; MINIMUM EFFECTIVE CONCENTRATION; MONOCULTURE; PHENOTYPE; PRIORITY JOURNAL; REPRODUCIBILITY; STROMA CELL; THICKNESS; THREE DIMENSIONAL IMAGING; CELL CULTURE TECHNIQUE; CHEMISTRY; CYTOLOGY; DEVICES; DRUG EFFECTS; HYDROGEL; METABOLISM; PRECLINICAL STUDY; PROCEDURES; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; AUTOMATION; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; COCULTURE TECHNIQUES; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYALURONIC ACID; HYDROGEL; MICROSCOPY, CONFOCAL; STROMAL CELLS;

EID: 84938746247     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201500258     Document Type: Article

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