Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer

International Journal of Cancer

Volumn 131, Issue 5, 2012, Pages

  Simpson, Melanie A ^a,b   Weigel, Janet A ^c   Weigel, Paul H ^c  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

HARE; Hyaluronan; Metastasis; Mouse orthotopic model; Prostate cancer; Stab2; Stabilin 2

Indexed keywords

HYALURONAN RECEPTOR; HYALURONIC ACID; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 174; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METASTASIS; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; ENDOCYTOSIS; HUMAN; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR BLOCKING; TUMOR VOLUME;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; CELL ADHESION MOLECULES, NEURONAL; ENDOCYTOSIS; HUMANS; HYALURONIC ACID; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 84863204680     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27427     Document Type: Article

References (25)

1. Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004;4:528-39. (Pubitemid 38868622)
2. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med 1997;242:27-33. (Pubitemid 27323862)
3. Weigel JA, Raymond RC, McGary C, Singh A, Weigel PH. A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liver. J Biol Chem 2003;278:9808-12. (Pubitemid 36800482)
4. Gomez CS, Gomez P, Knapp J, Jorda M, Soloway MS, Lokeshwar VB. Hyaluronic acid and HYAL-1 in prostate biopsy specimens: predictors of biochemical recurrence. J Urol 2009;182:1350-6.
5. Bharadwaj AG, Kovar JL, Loughman E, Elowsky C, Oakley GG, Simpson MA. Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing. Am J Pathol 2009;174:1027-36.
6. Cher ML. Mechanisms governing bone metastasis in prostate cancer. Curr Opin Urol 2001;11:483-8. (Pubitemid 32783695)
7. Simpson MA, Reiland J, Burger SR, Furcht LT, Spicer AP, Oegema TR, Jr., McCarthy JB. Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. J Biol Chem 2001;276:17949-57.
8. Simpson MA, Wilson CM, Furcht LT, Spicer AP, Oegema TR, Jr., McCarthy JB. Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. J Biol Chem 2002;277:10050-7. (Pubitemid 34968115)
9. Simpson MA, Wilson CM, McCarthy JB. Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice. Am J Pathol 2002;161:849-57. (Pubitemid 34988372)
10. McCarthy JB, Turley EA, Wilson CM, Price M, Bullard KM, Beck M, Simpson MA. Hyaluronan biosynthesis in prostate carcinoma growth and metastasis. In: Balasz EA, Hascall VC, eds. Hyaluronan: structure, metabolism, biological activities, therapeutic applications, Chapter 4, Hyaluronan and tumors, Matrix Biology Institute, Edgewater, NJ, 2005.
11. Falkowski M, Schledzewski K, Hansen B, Goerdt S. Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces. Histochem Cell Biol 2003; 120:361-9. (Pubitemid 38005355)
12. Zhou B, Weigel JA, Fauss L, Weigel PH. Identification of the hyaluronan receptor for endocytosis (HARE). J Biol Chem 2000;275: 37733-41. (Pubitemid 32004888)
13. Pandey MS, Harris EN, Weigel JA, Weigel PH. The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) containsmultiple endocytic motifs targeting coated pit-mediated internalization. J BiolChem2008;283:21453-61.
14. Harris EN, Weigel PH. The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E. Glycobiology 2008;18:638-48.
15. Pettaway CA, Pathak S, Greene G, Ramirez E, Wilson MR, Killion JJ, Fidler IJ. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res 1996; 2:1627-36. (Pubitemid 126447459)
16. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990;61:1303-13.
17. Bockhorn M, Jain RK, Munn LL. Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? Lancet Oncol 2007;8:444-8. (Pubitemid 46621773)
18. Pflicke H, Sixt M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med 2009;206:2925-35.
19. Azzali G. Tumor cell transendothelial passage in the absorbing lymphatic vessel of transgenic adenocarcinoma mouse prostate. Am J Pathol 2007;170:334-46. (Pubitemid 47339211)
20. He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005;65:4739-46. (Pubitemid 40740810)
21. Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer 2007;121: 2153-61. (Pubitemid 47585593)
22. Johnson LA, Prevo R, Clasper S, Jackson DG. Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1. J Biol Chem 2007;282: 33671-80. (Pubitemid 350159526)
23. Trojan L, Michel MS, Rensch F, Jackson DG, Alken P, Grobholz R. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1). J Urol 2004;172:103-7. (Pubitemid 41615048)
24. Trojan L, Rensch F, Voss M, Grobholz R, Weiss C, Jackson DG, Alken P, Michel MS. The role of the lymphatic system and its specific growth factor, vascular endothelial growth factor C, for lymphogenic metastasis in prostate cancer. Br J Urol Int 2006;98: 903-6. (Pubitemid 44368047)
25. Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG. Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Mol Cell Biol 2007;27: 595-604. (Pubitemid 46080127)