Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process

Cancer Letters

Volumn 185, Issue 2, 2002, Pages 145-151

  Nasu, Sachiko ^a   Milas, Luka ^a   Kawabe, Shinichiro ^a   Raju, Uma ^a   Newman, Robert A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cardiac glycosides; Caspase 3; Oleandrin; Radiotherapy

Indexed keywords

ANVIRZEL; BENZOYLCARBONYL ASPARTYL GLUTAMYL VALYL ASPARTYL FLUOROMETHYL KETONE; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; CARDENOLIDE; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CYSTEINE PROTEINASE INHIBITOR; ENZYME PRECURSOR; OLEANDRIN; OLIGOPEPTIDE; RADIOSENSITIZING AGENT; TUMOR PROTEIN; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CARDIAC GLYCOSIDE; CESIUM 137; UNCLASSIFIED DRUG;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; MALE; PATHOLOGY; PHYSIOLOGY; PHYTOTHERAPY; PROSTATE TUMOR; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CANCER RADIOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME INHIBITION; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIZATION;

ADENOCARCINOMA; APOPTOSIS; CARDENOLIDES; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PRECURSORS; HUMANS; MALE; NEOPLASM PROTEINS; OLIGOPEPTIDES; PHYTOTHERAPY; PROSTATIC NEOPLASMS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; HUMAN; SUPPORT, NON-U.S. GOV'T;

STROPHANTHUS GRATUS;

EID: 0037191504     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00263-X     Document Type: Article

References (14)

1. Cardiac glycosides and breast cancer
2. Is digitalis a therapy for breast carcinoma?
3. Digitoxin is a potential anticancer agent for several types of cancer
4. Anvirzel: An extract of Nerium oleander induces cell death in human but not murine cancer cells
5. Oleandrin suppresses activation of nuclear transcription factor-kB, activator protein-1, and c-jun N-terminal kinase
6. Cardiac glycosides stimulate calcium increases and apoptosis in androgen-dependent metastatic human prostate adenocarcinoma cells
7. Phase I study of Anvirzel in patients with advanced solid tumors
8. Ouabain sensitizes tumor cells but not normal cells to radiation
9. Influence of apoptosis on the enhancement of radiotoxicity by ouabain
10. Influence of cell inactivation by irradiation
11. Na, K-ATPase inhibitor, ouabain accentuates irradiation damage in human tumor cell lines
12. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy
13. Tamoxifen is a Na antagonist inhibitor of Na/K-transporting ATPase from tumor and normal cells
14. Enhancement of radiosensitivity by tamoxifen in C6 glioma cells