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Volumn 15, Issue 7, 2015, Pages 856-868

Current molecularly targeting therapies in NSCLC and melanoma

Author keywords

Melanoma; Monoclonal antibodies; NSCLC; Tyrosine kinase inhibitor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AFATINIB; ALECTINIB; ANAPLASTIC LYMPHOMA KINASE; AXITINIB; B RAF KINASE; BEVACIZUMAB; CETUXIMAB; CRIZOTINIB; DABRAFENIB; DACOMITINIB; DASATINIB; ENCORAFENIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; IMATINIB; LAPATINIB; MATUZUMAB; NILOTINIB; PANITUMUMAB; SORAFENIB; SUNITINIB; TRAMETINIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN RECEPTOR; VEMURAFENIB; ZALUTUMUMAB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; TUMOR MARKER;

EID: 84938685242     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150202100130     Document Type: Article
Times cited : (12)

References (128)
  • 3
    • 58749084711 scopus 로고    scopus 로고
    • The molecular basis of cancer and the development of targeted therapy
    • Riley, L.B.; Desai, D.C. The molecular basis of cancer and the development of targeted therapy. Surg. Clin. North. Am., 2009, 89 (1), 1-15, vii.
    • (2009) Surg. Clin. North. Am , vol.89 , Issue.1
    • Riley, L.B.1    Desai, D.C.2
  • 4
    • 84892607231 scopus 로고    scopus 로고
    • Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer
    • Fong, J.T.; Jacobs, R.J.; Moravec, D.N.; Uppada, S B.; Botting, G.M.; Nlend, M.; Puri, N. Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer. PloS one, 2013, 8 (11), e78398
    • (2013) PloS one , vol.8 , Issue.11
    • Fong, J.T.1    Jacobs, R.J.2    Moravec, D.N.3    Uppada, S.B.4    Botting, G.M.5    Nlend, M.6    Puri, N.7
  • 6
    • 44249086425 scopus 로고    scopus 로고
    • Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship
    • Molina, J.R.; Yang, P.; Cassivi, S.D.; Schild, S.E.; Adjei, A.A. Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clinic. Proceed., 2008, 83(5), 584-594.
    • (2008) Mayo Clinic. Proceed , vol.83 , Issue.5 , pp. 584-594
    • Molina, J.R.1    Yang, P.2    Cassivi, S.D.3    Schild, S.E.4    Adjei, A.A.5
  • 10
    • 33644870156 scopus 로고    scopus 로고
    • First-line treatment for advanced nonsmall- cell lung cancer
    • Laskin, J. J.; Sandler, A.B. First-line treatment for advanced nonsmall- cell lung cancer. Oncology (Williston Park), 2005, 19(13), 1671-1676 discussion 1678-1680.
    • (2005) Oncology (Williston Park) , vol.19 , Issue.13 , pp. 1671-1676
    • Laskin, J.J.1    Sandler, A.B.2
  • 11
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • (a) Cohen, M.H.; Gootenberg, J.; Keegan, P.; Pazdur, R. FDA drug approval summary: Bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist, 2007, 12 (6), 713-718
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 12
    • 84901290217 scopus 로고    scopus 로고
    • FDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2
    • Ryan, Q.; Ibrahim, A.; Cohen, M.H.; Johnson, J.; Ko, C.W.; Sridhara, R.; Justice, R.; Pazdur, R. FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. Oncologist, 2008, 13(10), 1114-1119
    • (2008) Oncologist , vol.13 , Issue.10 , pp. 1114-1119
    • Ryan, Q.1    Ibrahim, A.2    Cohen, M.H.3    Johnson, J.4    Ko, C.W.5    Sridhara, R.6    Justice, R.7    Pazdur, R.8
  • 13
    • 84928893512 scopus 로고    scopus 로고
    • FDA approval summary: Crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements
    • Kazandjian, D.; Blumenthal, G.M.; Chen, H.Y.; He, K.; Patel, M.; Justice, R.; Keegan, P.; Pazdur, R. FDA approval summary: Crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements. Oncologist, 2014, 19(10), e5-11
    • (2014) Oncologist , vol.19 , Issue.10 , pp. 5-11
    • Kazandjian, D.1    Blumenthal, G.M.2    Chen, H.Y.3    He, K.4    Patel, M.5    Justice, R.6    Keegan, P.7    Pazdur, R.8
  • 14
    • 84863410315 scopus 로고    scopus 로고
    • EGFR-TKI resistant non-small cell lung cancer (NSCLC): New developments and implications for future treatment
    • Brugger, W.; Thomas, M. EGFR-TKI resistant non-small cell lung cancer (NSCLC): New developments and implications for future treatment. Lung cancer, 2012, 77(1), 2-8.
    • (2012) Lung cancer , vol.77 , Issue.1 , pp. 2-8
    • Brugger, W.1    Thomas, M.2
  • 15
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • Mendelsohn, J.; Baselga, J. Epidermal growth factor receptor targeting in cancer. Seminars in oncology, 2006, 33(4), 369-385.
    • (2006) Seminars in oncology , vol.33 , Issue.4 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 16
    • 84884640384 scopus 로고    scopus 로고
    • Afatinib: First global approval
    • Dungo, R.T.; Keating, G.M. Afatinib: First global approval. Drugs, 2013, 73(13), 1503-1515.
    • (2013) Drugs , vol.73 , Issue.13 , pp. 1503-1515
    • Dungo, R.T.1    Keating, G.M.2
  • 19
    • 79958020132 scopus 로고    scopus 로고
    • EGFR-mutated lung cancer: A paradigm of molecular oncology
    • Zhang, Z.; Stiegler, A.L.; Boggon, T.J.; Kobayashi, S.; Halmos, B. EGFR-mutated lung cancer: a paradigm of molecular oncology. Oncotarget, 2010, 1(7), 497-514.
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 497-514
    • Zhang, Z.1    Stiegler, A.L.2    Boggon, T.J.3    Kobayashi, S.4    Halmos, B.5
  • 20
    • 84920555646 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in non-small cell lung cancer: Revisiting different strategies against the same target
    • Castanon, E.; Martin, P.; Rolfo, C.; Fusco, J.P.; Ceniceros, L.; Legaspi, J.; Santisteban, M.; Gil-Bazo, I. Epidermal growth factor receptor targeting in non-small cell lung cancer: Revisiting different strategies against the same target. Curr. Drug Targ., 2014, 15(14), 1273-1283.
    • (2014) Curr. Drug Targ , vol.15 , Issue.14 , pp. 1273-1283
    • Castanon, E.1    Martin, P.2    Rolfo, C.3    Fusco, J.P.4    Ceniceros, L.5    Legaspi, J.6    Santisteban, M.7    Gil-Bazo, I.8
  • 22
    • 0043210670 scopus 로고    scopus 로고
    • FDA drug approval summary: Gefitinib (ZD1839) (Iressa) tablets
    • Cohen, M.H.; Williams, G.A.; Sridhara, R.; Chen, G.; Pazdur, R. FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist, 2003, 8(4), 303-306.
    • (2003) Oncologist , vol.8 , Issue.4 , pp. 303-306
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3    Chen, G.4    Pazdur, R.5
  • 23
    • 24644458654 scopus 로고    scopus 로고
    • FDA drug approval summary: Erlotinib (Tarceva) tablets
    • Cohen, M.H.; Johnson, J.R.; Chen, Y.F.; Sridhara, R.; Pazdur, R. FDA drug approval summary: Erlotinib (Tarceva) tablets. Oncologist, 2005, 10(7), 461-466.
    • (2005) Oncologist , vol.10 , Issue.7 , pp. 461-466
    • Cohen, M.H.1    Johnson, J.R.2    Chen, Y.F.3    Sridhara, R.4    Pazdur, R.5
  • 24
    • 84911367943 scopus 로고    scopus 로고
    • Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer
    • Engle, J.A.; Kolesar, J.M. Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer. Am. J. Health Syst. Pharm., 2014, 71(22), 1933-1938.
    • (2014) Am. J. Health Syst. Pharm , vol.71 , Issue.22 , pp. 1933-1938
    • Engle, J.A.1    Kolesar, J.M.2
  • 26
    • 84904810695 scopus 로고    scopus 로고
    • Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: Comparative pharmacokinetics and drug-drug interactions
    • Peters, S.; Zimmermann, S.; Adjei, A. A. Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: Comparative pharmacokinetics and drug-drug interactions. Cancer Treat. Rev., 2014, 40(8), 917-26.
    • (2014) Cancer Treat. Rev , vol.40 , Issue.8 , pp. 917-926
    • Peters, S.1    Zimmermann, S.2    Adjei, A.A.3
  • 29
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden, Y. Biology of HER2 and its importance in breast cancer. Oncology, 2001, 61 Suppl 2, 1-13
    • (2001) Oncology , vol.61 , pp. 1-13
    • Yarden, Y.1
  • 30
    • 0037434791 scopus 로고    scopus 로고
    • Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
    • Cho, H.S.; Mason, K.; Ramyar, K.X.; Stanley, A.M.; Gabelli, S.B.; Denney, D.W.Jr.; Leahy, D.J. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature, 2003, 421(6924), 756- 60.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 756-760
    • Cho, H.S.1    Mason, K.2    Ramyar, K.X.3    Stanley, A.M.4    Gabelli, S.B.5    Denney, D.W.6    Leahy, D.J.7
  • 31
    • 77249098434 scopus 로고    scopus 로고
    • A review of epidermal growth factor receptor/HER2 inhibitors in the treatment of patients with non-small-cell lung cancer
    • Govindan, R. A review of epidermal growth factor receptor/HER2 inhibitors in the treatment of patients with non-small-cell lung cancer. Clin. Lung Cancer, 2010, 11(1), 8-12.
    • (2010) Clin. Lung Cancer , vol.11 , Issue.1 , pp. 8-12
    • Govindan, R.1
  • 33
    • 68949213744 scopus 로고    scopus 로고
    • Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
    • Hirsch, F.R.; Varella-Garcia, M.; Cappuzzo, F. Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer. Oncogene, 2009, 28 Suppl 1, S32-37.
    • (2009) Oncogene , vol.28 , pp. S32-S37
    • Hirsch, F.R.1    Varella-Garcia, M.2    Cappuzzo, F.3
  • 34
    • 84878222664 scopus 로고    scopus 로고
    • ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers
    • Wellstein, A. ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers. Front. Oncol., 2012, 2, 192
    • (2012) Front. Oncol , vol.2 , pp. 192
    • Wellstein, A.1
  • 35
    • 0035937724 scopus 로고    scopus 로고
    • Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway
    • Souttou, B.; Carvalho, N.B.; Raulais, D.; Vigny, M. Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway. J. Biol. Chem., 2001, 276 (12), 9526-9531.
    • (2001) J. Biol. Chem , vol.276 , Issue.12 , pp. 9526-9531
    • Souttou, B.1    Carvalho, N.B.2    Raulais, D.3    Vigny, M.4
  • 36
    • 0031035052 scopus 로고    scopus 로고
    • Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
    • Iwahara, T.; Fujimoto, J.; Wen, D.; Cupples, R.; Bucay, N.; Arakawa, T.; Mori, S.; Ratzkin, B.; Yamamoto, T. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene, 1997, 14(4), 439- 449
    • (1997) Oncogene , vol.14 , Issue.4 , pp. 439-449
    • Iwahara, T.1    Fujimoto, J.2    Wen, D.3    Cupples, R.4    Bucay, N.5    Arakawa, T.6    Mori, S.7    Ratzkin, B.8    Yamamoto, T.9
  • 37
    • 0031008896 scopus 로고    scopus 로고
    • ALK, the chromosome 2 gene locus altered by the t(2; 5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
    • Morris, S.W.; Naeve, C.; Mathew, P.; James, P.L.; Kirstein, M. N.; Cui, X.; Witte, D.P. ALK, the chromosome 2 gene locus altered by the t(2; 5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene, 1997, 14(18), 2175- 2188.
    • (1997) Oncogene , vol.14 , Issue.18 , pp. 2175-2188
    • Morris, S.W.1    Naeve, C.2    Mathew, P.3    James, P.L.4    Kirstein, M.N.5    Cui, X.6    Witte, D.P.7
  • 38
    • 84872277710 scopus 로고    scopus 로고
    • Targeting ALK: A promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma
    • Morales La Madrid, A.; Campbell, N.; Smith, S.; Cohn, S.L.; Salgia, R. Targeting ALK: A promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma. Target. Oncol., 2012, 7 (3), 199-210
    • (2012) Target. Oncol , vol.7 , Issue.3 , pp. 199-210
    • Morales La Madrid, A.1    Campbell, N.2    Smith, S.3    Cohn, S.L.4    Salgia, R.5
  • 39
    • 79954606778 scopus 로고    scopus 로고
    • Targeting anaplastic lymphoma kinase in lung cancer
    • Shaw, A. T.; Solomon, B. Targeting anaplastic lymphoma kinase in lung cancer. Clin. Cancer Res., 2011, 17(8), 2081-2086.
    • (2011) Clin. Cancer Res , vol.17 , Issue.8 , pp. 2081-2086
    • Shaw, A.T.1    Solomon, B.2
  • 41
    • 79952422786 scopus 로고    scopus 로고
    • Hunting ALK to feed targeted cancer therapy
    • Wellstein, A.; Toretsky, J.A. Hunting ALK to feed targeted cancer therapy. Nat. Med., 2011, 17(3), 290-291
    • (2011) Nat. Med , vol.17 , Issue.3 , pp. 290-291
    • Wellstein, A.1    Toretsky, J.A.2
  • 43
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-small-cell lung cancer
    • Horn, L.; Pao, W. EML4-ALK: Honing in on a new target in non-small-cell lung cancer. J. Clin. oncolo., 2009, 27 (26), 4232-5
    • (2009) J. Clin. oncolo , vol.27 , Issue.26 , pp. 4232-4235
    • Horn, L.1    Pao, W.2
  • 44
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki, T.; Rodig, S.J.; Chirieac, L.R.; Janne, P.A. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur. J. Cancer, 2010, 46(10), 1773-1780.
    • (2010) Eur. J. Cancer , vol.46 , Issue.10 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Janne, P.A.4
  • 46
    • 84856877692 scopus 로고    scopus 로고
    • The potential for crizotinib in nonsmall cell lung cancer: A perspective review
    • Bang, Y.J. The potential for crizotinib in nonsmall cell lung cancer: A perspective review. Therap. Adv. Med. Oncol., 2011, 3(6), 279-291.
    • (2011) Therap. Adv. Med. Oncol , vol.3 , Issue.6 , pp. 279-291
    • Bang, Y.J.1
  • 48
    • 84905190188 scopus 로고    scopus 로고
    • ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond
    • Awad, M.M.; Shaw, A.T. ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond. Clin. Adv. Hematol. Oncol., , 2014, 12(7), 429-439.
    • (2014) Clin. Adv. Hematol. Oncol. , vol.12 , Issue.7 , pp. 429-439
    • Awad, M.M.1    Shaw, A.T.2
  • 49
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • Byrne, A.M.; Bouchier-Hayes, D.J.; Harmey, J.H. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell. Mol. Med., 2005, 9(4), 777-794
    • (2005) J. Cell. Mol. Med , vol.9 , Issue.4 , pp. 777-794
    • Byrne, A.M.1    Bouchier-Hayes, D.J.2    Harmey, J.H.3
  • 50
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G.; Cohen, T.; Gengrinovitch, S.; Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB, 1999, 13(1), 9-22.
    • (1999) FASEB , vol.13 , Issue.1 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 52
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe, E.; Wakelee, H. Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr. Treat. Opt. Oncol., 2007, 8(1), 15-27.
    • (2007) Curr. Treat. Opt. Oncol , vol.8 , Issue.1 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 53
    • 0035155064 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis
    • Han, H.; Silverman, J.F.; Santucci, T.S.; Macherey, R.S.; d'Amato, T.A.; Tung, M.Y.; Weyant, R.J.; Landreneau, R.J. Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis. Ann. Surg. Oncol., 2001, 8(1), 72-79
    • (2001) Ann. Surg. Oncol , vol.8 , Issue.1 , pp. 72-79
    • Han, H.1    Silverman, J.F.2    Santucci, T.S.3    Macherey, R.S.4    d'Amato, T.A.5    Tung, M.Y.6    Weyant, R.J.7    Landreneau, R.J.8
  • 54
    • 84897109903 scopus 로고    scopus 로고
    • Targeting angiogenesis in squamous non-small cell lung cancer
    • Piperdi, B.; Merla, A.; Perez-Soler, R. Targeting angiogenesis in squamous non-small cell lung cancer. Drugs, 2014, 74(4), 403-413.
    • (2014) Drugs , vol.74 , Issue.4 , pp. 403-413
    • Piperdi, B.1    Merla, A.2    Perez-Soler, R.3
  • 55
    • 84892634758 scopus 로고    scopus 로고
    • Wnt signaling pathway in non-small cell lung cancer
    • Stewart, D.J. Wnt signaling pathway in non-small cell lung cancer. J. Natl. Cancer Inst., 2014, 106 (1), djt356.
    • (2014) J. Natl. Cancer Inst , vol.106 , Issue.1 , pp. 356
    • Stewart, D.J.1
  • 57
    • 84898460568 scopus 로고    scopus 로고
    • Inhibition of MAPKs, Myc/Max, NFkappaB, and hypoxia pathways by Phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line
    • Tang, Y.Q.; Jaganath, I.B.; Manikam, R.; Sekaran, S.D. Inhibition of MAPKs, Myc/Max, NFkappaB, and hypoxia pathways by Phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line. Int. J. Med. Sci., 2014, 11(6), 564-577.
    • (2014) Int. J. Med. Sci , vol.11 , Issue.6 , pp. 564-577
    • Tang, Y.Q.1    Jaganath, I.B.2    Manikam, R.3    Sekaran, S.D.4
  • 58
    • 0036105574 scopus 로고    scopus 로고
    • Long-term survival in 2,505 patients with melanoma with regional lymph node metastasis
    • White, R.R.; Stanley, W.E.; Johnson, J.L.; Tyler, D.S.; Seigler, H.F. Long-term survival in 2,505 patients with melanoma with regional lymph node metastasis. Ann. Surg., 2002, 235(6), 879-887.
    • (2002) Ann. Surg , vol.235 , Issue.6 , pp. 879-887
    • White, R.R.1    Stanley, W.E.2    Johnson, J.L.3    Tyler, D.S.4    Seigler, H.F.5
  • 60
    • 0037400510 scopus 로고    scopus 로고
    • Mechanisms of regulating the Raf kinase family
    • Chong, H.; Vikis, H.G.; Guan, K.L. Mechanisms of regulating the Raf kinase family. Cell. Signalling, 2003, 15(5), 463-439
    • (2003) Cell. Signalling , vol.15 , Issue.5 , pp. 433-469
    • Chong, H.1    Vikis, H.G.2    Guan, K.L.3
  • 61
    • 77956124562 scopus 로고    scopus 로고
    • RAF protein-serine/threonine kinases: Structure and regulation
    • Roskoski, R.Jr. RAF protein-serine/threonine kinases: Structure and regulation. Biochem. Biophys. Res. Commun., 2010, 399(3), 313-317.
    • (2010) Biochem. Biophys. Res. Commun , vol.399 , Issue.3 , pp. 313-317
    • Roskoski, R.1
  • 62
    • 84899721866 scopus 로고    scopus 로고
    • Melanoma: Clinical features and genomic insights
    • Hawryluk, E.B.; Tsao, H. Melanoma: Clinical features and genomic insights. Cold Spring Harb. Perspect Med., 2014, 4(9), a015388.
    • (2014) Cold Spring Harb. Perspect Med , vol.4 , Issue.9
    • Hawryluk, E.B.1    Tsao, H.2
  • 63
    • 84903305200 scopus 로고    scopus 로고
    • New developments in the treatment of metastatic melanoma - role of dabrafenib-trametinib combination therapy
    • Luke, J.J.; Ott, P.A. New developments in the treatment of metastatic melanoma - role of dabrafenib-trametinib combination therapy. Drug, Healthc. Patient Saf., 2014, 6, 77-88.
    • (2014) Drug, Healthc. Patient Saf , vol.6 , pp. 77-88
    • Luke, J.J.1    Ott, P.A.2
  • 64
    • 84902252466 scopus 로고    scopus 로고
    • New developments in the treatment of metastatic melanoma: Immune checkpoint inhibitors and targeted therapies
    • Azijli, K.; Stelloo, E.; Peters, G.J.; Van Dan, A.J. New developments in the treatment of metastatic melanoma: Immune checkpoint inhibitors and targeted therapies. Anticancer Res., 2014, 34(4), 1493-1505.
    • (2014) Anticancer Res , vol.34 , Issue.4 , pp. 1493-1505
    • Azijli, K.1    Stelloo, E.2    Peters, G.J.3    Van Dan, A.J.4
  • 66
    • 84855460517 scopus 로고    scopus 로고
    • BRAF inhibitors for the treatment of metastatic melanoma: Clinical trials and mechanisms of resistance
    • Alcala, A.M.; Flaherty, K.T. BRAF inhibitors for the treatment of metastatic melanoma: Clinical trials and mechanisms of resistance. Clin. Cancer Res., 2012, 18(1), 33-39.
    • (2012) Clin. Cancer Res , vol.18 , Issue.1 , pp. 33-39
    • Alcala, A.M.1    Flaherty, K.T.2
  • 68
    • 17344362761 scopus 로고    scopus 로고
    • Signaling by dual specificity kinases
    • Dhanasekaran, N.; Premkumar Reddy, E. Signaling by dual specificity kinases. Oncogene, 1998, 17 (11), 1447-1455.
    • (1998) Oncogene , vol.17 , Issue.11 , pp. 1447-1455
    • Dhanasekaran, N.1    Premkumar Reddy, E.2
  • 69
    • 0025875819 scopus 로고
    • Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
    • Gomez, N.; Cohen, P. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature, 1991, 353(6340), 170-173.
    • (1991) Nature , vol.353 , Issue.6340 , pp. 170-173
    • Gomez, N.1    Cohen, P.2
  • 70
    • 84862294189 scopus 로고    scopus 로고
    • ERK1/2 MAP kinases: Structure, function, and regulation
    • Roskoski, R.Jr. ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol. Res., 2012, 66(2), 105-143.
    • (2012) Pharmacol. Res , vol.66 , Issue.2 , pp. 105-143
    • Roskoski, R.1
  • 73
    • 77954218212 scopus 로고    scopus 로고
    • BRAF as therapeutic target in melanoma
    • Wellbrock, C.; Hurlstone, A. BRAF as therapeutic target in melanoma. Biochem. Pharmacol., 2010, 80(5), 561-567.
    • (2010) Biochem. Pharmacol , vol.80 , Issue.5 , pp. 561-567
    • Wellbrock, C.1    Hurlstone, A.2
  • 75
    • 0036837671 scopus 로고    scopus 로고
    • Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352
    • Delaney, A.M.; Printen, J.A.; Chen, H.; Fauman, E.B.; Dudley, D. T. Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352. Mol. Cell. Biol., 2002, 22(21), 7593-7602.
    • (2002) Mol. Cell. Biol , vol.22 , Issue.21 , pp. 7593-7602
    • Delaney, A.M.1    Printen, J.A.2    Chen, H.3    Fauman, E.B.4    Dudley, D.T.5
  • 76
    • 84898998810 scopus 로고    scopus 로고
    • Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma
    • Menzies, A.M.; Long, G.V. Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma. Clin. Cancer Res., 2014, 20(8), 2035-2043.
    • (2014) Clin. Cancer Res , vol.20 , Issue.8 , pp. 2035-2043
    • Menzies, A.M.1    Long, G.V.2
  • 81
    • 84911416288 scopus 로고    scopus 로고
    • Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma
    • Rebecca, V.W.; Alicea, G.M.; Paraiso, K.H.; Lawrence, H.; Gibney, G.T.; Smalley, K.S. Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma. Pig. Cell Mel. Res., 2014, 27(6), 1154-1158.
    • (2014) Pig. Cell Mel. Res , vol.27 , Issue.6 , pp. 1154-1158
    • Rebecca, V.W.1    Alicea, G.M.2    Paraiso, K.H.3    Lawrence, H.4    Gibney, G.T.5    Smalley, K.S.6
  • 83
    • 84864123612 scopus 로고    scopus 로고
    • Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A
    • Desch, A.; Strozyk, E.A.; Bauer, A.T.; Huck, V.; Niemeyer, V.; Wieland, T.; Schneider, S.W. Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A. Am. J. Pathol., 2012, 181(2), 693-705.
    • (2012) Am. J. Pathol , vol.181 , Issue.2 , pp. 693-705
    • Desch, A.1    Strozyk, E.A.2    Bauer, A.T.3    Huck, V.4    Niemeyer, V.5    Wieland, T.6    Schneider, S.W.7
  • 84
    • 54549107723 scopus 로고    scopus 로고
    • The role of platelet activation in tumor metastasis
    • Borsig, L. The role of platelet activation in tumor metastasis. Exp. Rev. Anticancer Ther., 2008, 8 (8), 1247-1255.
    • (2008) Exp. Rev. Anticancer Ther , vol.8 , Issue.8 , pp. 1247-1255
    • Borsig, L.1
  • 85
    • 0037133173 scopus 로고    scopus 로고
    • Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
    • Borsig, L.; Wong, R.; Hynes, R.O.; Varki, N.M.; Varki, A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc. Nat. Acad. Sci. USA, 2002, 99 (4), 2193-2198.
    • (2002) Proc. Nat. Acad. Sci. USA , vol.99 , Issue.4 , pp. 2193-2198
    • Borsig, L.1    Wong, R.2    Hynes, R.O.3    Varki, N.M.4    Varki, A.5
  • 87
    • 84904258598 scopus 로고    scopus 로고
    • Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis
    • Peppicelli, S.; Bianchini, F.; Calorini, L. Inflammatory cytokines induce vascular endothelial growth factor-C expression in melanoma-associated macrophages and stimulate melanoma lymph node metastasis. Oncol. Lett., 2014, 8(3), 1133-1138.
    • (2014) Oncol. Lett , vol.8 , Issue.3 , pp. 1133-1138
    • Peppicelli, S.1    Bianchini, F.2    Calorini, L.3
  • 88
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu, L.; Cao, Y.; Chen, C.; Zhang, X.; McNabola, A.; Wilkie, D.; Wilhelm, S.; Lynch, M.; Carter, C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res., 2006, 66(24), 11851-11858.
    • (2006) Cancer Res , vol.66 , Issue.24 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 91
    • 79959482485 scopus 로고    scopus 로고
    • Axitinib for the management of metastatic renal cell carcinoma
    • Escudier, B.; Gore, M. Axitinib for the management of metastatic renal cell carcinoma. Drugs in R&D, 2011, 11(2), 113-26.
    • (2011) Drugs in R&D , vol.11 , Issue.2 , pp. 113-126
    • Escudier, B.1    Gore, M.2
  • 92
    • 84891863408 scopus 로고    scopus 로고
    • Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity
    • Zhang, X.; Fang, X.; Gao, Z.; Chen, W.; Tao, F.; Cai, P.; Yuan, H.; Shu, Y.; Xu, Q.; Sun, Y.; Gu, Y. Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity. Anticancer Drugs, 2014, 25(2), 204-211.
    • (2014) Anticancer Drugs , vol.25 , Issue.2 , pp. 204-211
    • Zhang, X.1    Fang, X.2    Gao, Z.3    Chen, W.4    Tao, F.5    Cai, P.6    Yuan, H.7    Shu, Y.8    Xu, Q.9    Sun, Y.10    Gu, Y.11
  • 93
    • 84865647762 scopus 로고    scopus 로고
    • The effect of bevacizumab on human malignant melanoma cells with functional VEGF/VEGFR2 autocrine and intracrine signaling loops
    • Adamcic, U.; Skowronski, K.; Peters, C.; Morrison, J.; Coomber, B. L. The effect of bevacizumab on human malignant melanoma cells with functional VEGF/VEGFR2 autocrine and intracrine signaling loops. Neoplasia, 2012, 14(7), 612-623.
    • (2012) Neoplasia , vol.14 , Issue.7 , pp. 612-623
    • Adamcic, U.1    Skowronski, K.2    Peters, C.3    Morrison, J.4    Coomber, B.L.5
  • 94
    • 77956839364 scopus 로고    scopus 로고
    • 3rd, Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: A phase 2 trial of the Sarah Cannon Oncology Research Consortium
    • Hainsworth, J.D.; Infante, J.R.; Spigel, D.R.; Peyton, J.D.; Thompson, D.S.; Lane, C.M.; Clark, B.L.; Rubin, M S.; Trent, D. F.; Burris, H.A. 3rd, Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium. Cancer, 2010, 116(17), 4122-4129.
    • (2010) Cancer , vol.116 , Issue.17 , pp. 4122-4129
    • Hainsworth, J.D.1    Infante, J.R.2    Spigel, D.R.3    Peyton, J.D.4    Thompson, D.S.5    Lane, C.M.6    Clark, B.L.7    Rubin, M.S.8    Trent, D.F.9    Burris, H.A.10
  • 95
    • 84886425815 scopus 로고    scopus 로고
    • Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma
    • Kwong, L.N.; Davies, M.A. Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma. Clin. Cancer Res., 2013, 19(19), 5310-5319.
    • (2013) Clin. Cancer Res , vol.19 , Issue.19 , pp. 5310-5319
    • Kwong, L.N.1    Davies, M.A.2
  • 96
    • 84891052481 scopus 로고    scopus 로고
    • Genomic Rearrangements of PTEN in Prostate Cancer
    • Phin, S.; Moore, M.W.; Cotter, P.D. Genomic Rearrangements of PTEN in Prostate Cancer. Front. Oncol., 2013, 3, 240.
    • (2013) Front. Oncol , vol.3 , pp. 240
    • Phin, S.1    Moore, M.W.2    Cotter, P.D.3
  • 97
    • 75749086084 scopus 로고    scopus 로고
    • The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: Interaction with B-Raf/ERK
    • Babchia, N.; Calipel, A.; Mouriaux, F.; Faussat, A. M.; Mascarelli, F. The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: Interaction with B-Raf/ERK. Invest. Ophthalmol. Visual Sci., 2010, 51(1), 421-429.
    • (2010) Invest. Ophthalmol. Visual Sci , vol.51 , Issue.1 , pp. 421-429
    • Babchia, N.1    Calipel, A.2    Mouriaux, F.3    Faussat, A.M.4    Mascarelli, F.5
  • 98
    • 80054716488 scopus 로고    scopus 로고
    • PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer
    • Zhu, C.; Qi, X.; Chen, Y.; Sun, B.; Dai, Y.; Gu, Y. PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer. J.Cancer Res., 2011, 137 (11), 1587-1594.
    • (2011) J.Cancer Res , vol.137 , Issue.11 , pp. 1587-1594
    • Zhu, C.1    Qi, X.2    Chen, Y.3    Sun, B.4    Dai, Y.5    Gu, Y.6
  • 99
    • 84874196138 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: Activation mechanisms, regulation and impact on cellular functions
    • Pauls, S.D.; Lafarge, S.T.; Landego, I.; Zhang, T.; Marshall, A.J. The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front. Immunol., 2012, 3, 224.
    • (2012) Front. Immunol , vol.3 , pp. 224
    • Pauls, S.D.1    Lafarge, S.T.2    Landego, I.3    Zhang, T.4    Marshall, A.J.5
  • 100
    • 0034100051 scopus 로고    scopus 로고
    • In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
    • Hu, L.; Zaloudek, C.; Mills, G.B.; Gray, J.; Jaffe, R.B. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin. Cancer Res., 2000, 6(3), 880- 886.
    • (2000) Clin. Cancer Res , vol.6 , Issue.3 , pp. 880-886
    • Hu, L.1    Zaloudek, C.2    Mills, G.B.3    Gray, J.4    Jaffe, R.B.5
  • 103
    • 25844507795 scopus 로고    scopus 로고
    • Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
    • Roskoski, R.Jr. Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. Biochem. Biophys. Res. Communi, 2005, 337 (1), 1-13.
    • (2005) Biochem. Biophys. Res. Communi , vol.337 , Issue.1 , pp. 1-13
    • Roskoski, R.1
  • 105
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • (a) Curtin, J. A.; Busam, K.; Pinkel, D.; Bastian, B. C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol., 2006, 24(26), 4340-4346
    • (2006) J. Clin. Oncol , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 108
    • 84891932035 scopus 로고    scopus 로고
    • The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma
    • Todd, J.R.; Scurr, L.L.; Becker, T.M.; Kefford, R.F.; Rizos, H. The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene, 2014, 33(2), 236-245.
    • (2014) Oncogene , vol.33 , Issue.2 , pp. 236-245
    • Todd, J.R.1    Scurr, L.L.2    Becker, T.M.3    Kefford, R.F.4    Rizos, H.5
  • 110
    • 24344482346 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of imatinib
    • Peng, B.; Lloyd, P.; Schran, H. Clinical pharmacokinetics of imatinib. Clini. Pharmacokinet., 2005, 44(9), 879-894.
    • (2005) Clini. Pharmacokinet , vol.44 , Issue.9 , pp. 879-894
    • Peng, B.1    Lloyd, P.2    Schran, H.3
  • 112
    • 84891523317 scopus 로고    scopus 로고
    • Another option in our KIT of effective therapies for advanced melanoma
    • Carvajal, R.D. Another option in our KIT of effective therapies for advanced melanoma. J. Clin. Oncol., 2013, 31 (26), 3173-3175.
    • (2013) J. Clin. Oncol , vol.31 , Issue.26 , pp. 3173-3175
    • Carvajal, R.D.1
  • 115
    • 84867867288 scopus 로고    scopus 로고
    • Nilotinib in patients with metastatic melanoma harboring KIT gene aberration
    • Cho, J.H.; Kim, K.M.; Kwon, M.; Kim, J.H.; Lee, J. Nilotinib in patients with metastatic melanoma harboring KIT gene aberration. Investig. New Drugs, 2012, 30(5), 2008-2014.
    • (2012) Investig. New Drugs , vol.30 , Issue.5 , pp. 2008-2014
    • Cho, J.H.1    Kim, K.M.2    Kwon, M.3    Kim, J.H.4    Lee, J.5
  • 119
    • 0033996413 scopus 로고    scopus 로고
    • Ras protein signalling
    • Olson, M.F.; Marais, R. Ras protein signalling. Semin. Immuno., 2000, 12(1), 63-73.
    • (2000) Semin. Immuno , vol.12 , Issue.1 , pp. 63-73
    • Olson, M.F.1    Marais, R.2
  • 120
    • 0032776822 scopus 로고    scopus 로고
    • The molecular perspective: The ras oncogene
    • Goodsell, D.S. The molecular perspective: The ras oncogene. Stem Cells, 1999, 17(4), 235-236.
    • (1999) Stem Cells , vol.17 , Issue.4 , pp. 235-236
    • Goodsell, D.S.1
  • 121
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer, 2003, 3(1), 11-22.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 124
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Kiras
    • Shirasawa, S.; Furuse, M.; Yokoyama, N.; Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Kiras. Science, 1993, 260(5104), 85-88.
    • (1993) Science , vol.260 , Issue.5104 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 126
    • 80054936061 scopus 로고    scopus 로고
    • Inhibition of Ras for cancer treatment: The search continues
    • Baines, A.T.; Xu, D.; Der, C.J. Inhibition of Ras for cancer treatment: the search continues. Future Med. Chem., 2011, 3(14), 1787-1808.
    • (2011) Future Med. Chem , vol.3 , Issue.14 , pp. 1787-1808
    • Baines, A.T.1    Xu, D.2    Der, C.J.3
  • 128
    • 3843113670 scopus 로고    scopus 로고
    • Re-evaluating the role of dacarbazine in metastatic melanoma: What have we learned in 30 years?
    • Eggermont, A.M.; Kirkwood, J.M. Re-evaluating the role of dacarbazine in metastatic melanoma: What have we learned in 30 years? Eur. J. Cancer, 2004, 40(12), 1825-1836.
    • (2004) Eur. J. Cancer , vol.40 , Issue.12 , pp. 1825-1836
    • Eggermont, A.M.1    Kirkwood, J.M.2


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