메뉴 건너뛰기




Volumn 71, Issue 22, 2014, Pages 1933-1938

Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; CISPLATIN; ERLOTINIB; GEFITINIB; GEMCITABINE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

EID: 84911367943     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp130654     Document Type: Review
Times cited : (17)

References (22)
  • 3
    • 80053639884 scopus 로고    scopus 로고
    • 2011 Focused update of 2009 American Society of Clinical Oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer
    • Azzoli CG, Temin S, Aliff T et al. 2011 focused update of 2009 American Society of Clinical Oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol. 2011; 29:3825-31.
    • (2011) J Clin Oncol , vol.29 , pp. 3825-3831
    • Azzoli, C.G.1    Temin, S.2    Aliff, T.3
  • 5
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase II trial
    • Chih-Hsin Yang J, Shih JY, Su WC et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase II trial. Lancet Oncol. 2012; 13:539-48.
    • (2012) Lancet Oncol , vol.13 , pp. 539-548
    • Chih-Hsin Yang, J.1    Shih, J.Y.2    Su, W.C.3
  • 6
    • 84908134619 scopus 로고    scopus 로고
    • Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.
    • Gilotrif (afatinib) prescribing information. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2013.
    • (2013) Gilotrif (Afatinib) Prescribing Information
  • 7
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer. 2005; 5:341-54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 8
    • 77349125581 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in lung cancer: The evolving role of individualized therapy
    • Gazdar AD. Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev. 2010; 29:37-48.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 37-48
    • Gazdar, A.D.1
  • 9
    • 84861203302 scopus 로고    scopus 로고
    • EGFR-mutated oncogene-addicted nonsmall cell lung cancer: Current trends and future prospects
    • Soria JC, Mok TS, Cappuzzo F, Janne PA. EGFR-mutated oncogene-addicted nonsmall cell lung cancer: current trends and future prospects. Cancer Treat Rev. 2012; 38:416-30.
    • (2012) Cancer Treat Rev , vol.38 , pp. 416-430
    • Soria, J.C.1    Mok, T.S.2    Cappuzzo, F.3    Janne, P.A.4
  • 10
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • Solca F, Dahl G, Zoephel A et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012; 343:342-50.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 11
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008; 27:4702-11.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 12
    • 79952704441 scopus 로고    scopus 로고
    • EGFR inhibitors in non-small cell lung cancer (NSCLC): The emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992
    • Spicer JF, Rudman SM. EGFR inhibitors in non-small cell lung cancer (NSCLC): the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992. Target Oncol. 2010; 5:245-55.
    • (2010) Target Oncol , vol.5 , pp. 245-255
    • Spicer, J.F.1    Rudman, S.M.2
  • 13
    • 84859793822 scopus 로고    scopus 로고
    • Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
    • Stopfer P, Marzin K, Narjes H et al. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012; 69:1051-61.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 1051-1061
    • Stopfer, P.1    Marzin, K.2    Narjes, H.3
  • 14
    • 77957585027 scopus 로고    scopus 로고
    • Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • Yap TA, Vidal L, Adam J et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol. 2010; 28:3965-72.
    • (2010) J Clin Oncol , vol.28 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3
  • 15
    • 84859795661 scopus 로고    scopus 로고
    • Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4)
    • Murakami H, Tamura T, Takahashi T et al. Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4). Cancer Chemother Pharmacol. 2012; 69:891-9.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 891-899
    • Murakami, H.1    Tamura, T.2    Takahashi, T.3
  • 16
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J et al. Afatinib versus placebo for patients with advanced, metastatic non-small cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012; 13:528-38.
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 17
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • Yang JC, Shih JY, Su WC et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012; 13:539-48.
    • (2012) Lancet Oncol , vol.13 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 18
    • 84884618137 scopus 로고    scopus 로고
    • LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both
    • Katakami N, Atagi S, Goto K et al. LUX-Lung 4: a phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both. J Clin Oncol. 2013; 31:3335-41.
    • (2013) J Clin Oncol , vol.31 , pp. 3335-3341
    • Katakami, N.1    Atagi, S.2    Goto, K.3
  • 19
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013; 31:3327-34.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 20
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in luxlung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
    • Yang JC, Hirsh V, Schuler M et al. Symptom control and quality of life in LUXLung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013; 31:3342-50.
    • (2013) J Clin Oncol , vol.31 , pp. 3342-3350
    • Yang, J.C.1    Hirsh, V.2    Schuler, M.3
  • 21
    • 84969932603 scopus 로고    scopus 로고
    • LUX-Lung 6: A randomized, open-label, phase III study of afatinib versus gemcitabine/cisplatin as first-line treatment for Asian patients with EGFR mutation-positive advanced adenocarcinoma of the lung
    • Chicago, IL; Jun
    • Wu YL, Zhou C, Hu CP et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib versus gemcitabine/cisplatin as first-line treatment for Asian patients with EGFR mutation-positive advanced adenocarcinoma of the lung. Abstract presented at ASCO Annual Meeting. Chicago, IL; 2013 Jun.
    • (2013) Abstract Presented at ASCO Annual Meeting
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 22
    • 84879551355 scopus 로고    scopus 로고
    • A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors
    • Gordon MS, Mendelson DS, Gross M et al. A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors. Invest New Drugs. 2013; 31:409-16.
    • (2013) Invest New Drugs , vol.31 , pp. 409-416
    • Gordon, M.S.1    Mendelson, D.S.2    Gross, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.