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Volumn 12, Issue 7, 2014, Pages 429-439

ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond

Author keywords

Alectinib; Anaplastic Lymphoma Kinase (ALK); Ceritinib; Crizotinib; Non Small Cell Lung Cancer (NSCLC)

Indexed keywords

ALECTINIB; ANAPLASTIC LYMPHOMA KINASE INHIBITOR; AP 26113; ASP 3026; AT 13387; CEP 28122; CEP 37440; CERITINIB; CRIZOTINIB; DACOMITINIB; DOCETAXEL; ENZYME INHIBITOR; ERLOTINIB; GANETESPIB; HEAT SHOCK PROTEIN 90 INHIBITOR; IPILIMUMAB; LUMINESPIB; PEMETREXED; PF 06463922; PLATINUM; RETASPIMYCIN; RO 5424802; RXDX 101; TSR 011; TSR 0117; UNCLASSIFIED DRUG; X 376; X 396; ZYKADIA;

EID: 84905190188     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (235)

References (99)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-2139
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 2
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497-1500
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 3
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101(36):13306-13311
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 4
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4- ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4- ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 5
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247-4253
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 6
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693-1703
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 7
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385-2394
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 8
    • 78049426513 scopus 로고    scopus 로고
    • EML4- ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • Choi YL, Soda M, Yamashita Y, et al; ALK Lung Cancer Study Group. EML4- ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363(18):1734-1739
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 9
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
    • Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13(10):1011-1019
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 10
    • 84866655837 scopus 로고    scopus 로고
    • Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): Potential implications for management
    • ASCO abstract 7600
    • Otterson GA, Riely GJ, Shaw AT, et al. Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): potential implications for management [ASCO abstract 7600]. J Clin Oncol. 2012;30(15)(suppl).
    • (2012) J Clin Oncol , vol.30 , Issue.15 SUPPL.
    • Otterson, G.A.1    Riely, G.J.2    Shaw, A.T.3
  • 11
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
    • Shaw AT, Yeap BY, Solomon BJ, et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol. 2011;12(11):1004-1012
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1004-1012
    • Shaw, A.T.1    Yeap, B.Y.2    Solomon, B.J.3
  • 12
    • 84865431278 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC
    • ASCO abstract 7533
    • Kim D-W, Ahn M-J, Shi Y, et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC) [ASCO abstract 7533]. J Clin Oncol. 2012;30(15).
    • (2012) J Clin Oncol , vol.30 , Issue.15
    • Kim, D.-W.1    Ahn, M.-J.2    Shi, Y.3
  • 13
    • 0034989396 scopus 로고    scopus 로고
    • ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor
    • Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol. 2001;14(6):569-576
    • (2001) Mod Pathol , vol.14 , Issue.6 , pp. 569-576
    • Coffin, C.M.1    Patel, A.2    Perkins, S.3    Elenitoba-Johnson, K.S.4    Perlman, E.5    Griffin, C.A.6
  • 14
    • 78049428879 scopus 로고    scopus 로고
    • Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
    • Butrynski JE, D'Adamo DR, Hornick JL, et al. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med. 2010;363(18):1727-1733
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1727-1733
    • Butrynski, J.E.1    D'Adamo, D.R.2    Hornick, J.L.3
  • 15
    • 84876966952 scopus 로고    scopus 로고
    • Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: A Children's Oncology Group phase 1 consortium study
    • Mosse YP, Lim MS, Voss SD, et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol. 2013;14(6):472-480
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 472-480
    • Mosse, Y.P.1    Lim, M.S.2    Voss, S.D.3
  • 17
    • 84897109567 scopus 로고    scopus 로고
    • Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients
    • djt378
    • Gambacorti Passerini C, Farina F, Stasia A, et al. Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients. J Natl Cancer Inst. 2014;106(2):djt378
    • (2014) J Natl Cancer Inst , vol.106 , Issue.2
    • Gambacorti, P.C.1    Farina, F.2    Stasia, A.3
  • 18
    • 54049149961 scopus 로고    scopus 로고
    • Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    • Janoueix-Lerosey I, Lequin D, Brugieres L, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008;455(7215):967-970
    • (2008) Nature , vol.455 , Issue.7215 , pp. 967-970
    • Janoueix-Lerosey, I.1    Lequin, D.2    Brugieres, L.3
  • 19
    • 81055126433 scopus 로고    scopus 로고
    • Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma
    • 108ra114
    • Bresler SC, Wood AC, Haglund EA, et al. Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Sci Transl Med. 2011;3(108):108ra114
    • (2011) Sci Transl Med , vol.3 , Issue.108
    • Bresler, S.C.1    Wood, A.C.2    Haglund, E.A.3
  • 20
    • 78649475696 scopus 로고    scopus 로고
    • The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
    • Sasaki T, Okuda K, Zheng W, et al. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res. 2010;70(24):10038-10043
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10038-10043
    • Sasaki, T.1    Okuda, K.2    Zheng, W.3
  • 21
    • 84868493246 scopus 로고    scopus 로고
    • ALK alterations in adult renal cell carcinoma: Frequency, clinicopathologic features and outcome in a large series of consecutively treated patients
    • Sukov WR, Hodge JC, Lohse CM, et al. ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients. Mod Pathol. 2012;25(11):1516-1525
    • (2012) Mod Pathol , vol.25 , Issue.11 , pp. 1516-1525
    • Sukov, W.R.1    Hodge, J.C.2    Lohse, C.M.3
  • 22
    • 84855993158 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: Clinical and prognostic implications
    • van Gaal JC, Flucke UE, Roeffen MH, et al. Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications. J Clin Oncol. 2012;30(3):308-315
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 308-315
    • van Gaal, J.C.1    Flucke, U.E.2    Roeffen, M.H.3
  • 23
    • 84900341053 scopus 로고    scopus 로고
    • Identification of a recurrent STRN/ALK fusion in thyroid carcinomas
    • Perot G, Soubeyran I, Ribeiro A, et al. Identification of a recurrent STRN/ALK fusion in thyroid carcinomas. PLoS ONE. 2014;9(1):e87170
    • (2014) PLoS ONE , vol.9 , Issue.1
    • Perot, G.1    Soubeyran, I.2    Ribeiro, A.3
  • 24
    • 84893116875 scopus 로고    scopus 로고
    • ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers
    • Aisner DL, Nguyen TT, Paskulin DD, et al. ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers. Mol Cancer Res. 2014;12(1):111-118
    • (2014) Mol Cancer Res , vol.12 , Issue.1 , pp. 111-118
    • Aisner, D.L.1    Nguyen, T.T.2    Paskulin, D.D.3
  • 25
    • 84892882633 scopus 로고    scopus 로고
    • Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
    • Wiesner T, He J, Yelensky R, et al. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014;5:3116
    • (2014) Nat Commun , vol.5 , pp. 3116
    • Wiesner, T.1    He, J.2    Yelensky, R.3
  • 26
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67(9):4408-4417
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 27
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30(8):863-870
    • (2012) J Clin Oncol , vol.30 , Issue.8 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 28
    • 78650436429 scopus 로고    scopus 로고
    • Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocationpositive patient with non-small cell lung cancer
    • Ou SH, Bazhenova L, Camidge DR, et al. Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocationpositive patient with non-small cell lung cancer. J Thorac Oncol. 2010;5(12):2044-2046
    • (2010) J Thorac Oncol , vol.5 , Issue.12 , pp. 2044-2046
    • Ou, S.H.1    Bazhenova, L.2    Camidge, D.R.3
  • 29
    • 84891746435 scopus 로고    scopus 로고
    • Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement
    • Schwab R, Petak I, Kollar M, et al. Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement. Lung Cancer. 2014;83(1):109-111
    • (2014) Lung Cancer , vol.83 , Issue.1 , pp. 109-111
    • Schwab, R.1    Petak, I.2    Kollar, M.3
  • 30
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29(36):4803-4810
    • (2011) J Clin Oncol , vol.29 , Issue.36 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 31
    • 84862908734 scopus 로고    scopus 로고
    • Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal- epithelial transition inhibitor
    • Chi AS, Batchelor TT, Kwak EL, et al. Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal- epithelial transition inhibitor. J Clin Oncol. 2012;30(3):e30-e33
    • (2012) J Clin Oncol , vol.30 , Issue.3
    • Chi, A.S.1    Batchelor, T.T.2    Kwak, E.L.3
  • 32
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316(5827):1039-1043
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 33
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3(75):75ra26
    • (2011) Sci Transl Med , vol.3 , Issue.75
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 34
    • 84891333707 scopus 로고    scopus 로고
    • Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors
    • Nanjo S, Yamada T, Nishihara H, et al. Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors. PLoS ONE. 2013;8(12):e84700
    • (2013) PLoS ONE , vol.8 , Issue.12
    • Nanjo, S.1    Yamada, T.2    Nishihara, H.3
  • 35
    • 84883451574 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC)
    • ASCO abstract 8032
    • Ou S-HI, Bang Y-J, Camidge DR, et al. Efficacy and safety of crizotinib in patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC) [ASCO abstract 8032]. J Clin Oncol. 2013;31(15)(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Ou, S.-H.I.1    Bang, Y.-J.2    Camidge, D.R.3
  • 36
    • 84879088863 scopus 로고    scopus 로고
    • Acquired resistance to crizotinib from a mutation in CD74-ROS1
    • Awad MM, Katayama R, McTigue M, et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. N Engl J Med. 2013;368(25):2395-2401
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2395-2401
    • Awad, M.M.1    Katayama, R.2    McTigue, M.3
  • 37
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
    • 120ra17
    • Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012;4(120):120ra17
    • (2012) Sci Transl Med , vol.4 , Issue.120
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 38
    • 84892655145 scopus 로고    scopus 로고
    • Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer
    • Davies KD, Mahale S, Astling DP, et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE. 2013;8(12):e82236
    • (2013) PLoS ONE , vol.8 , Issue.12
    • Davies, K.D.1    Mahale, S.2    Astling, D.P.3
  • 39
    • 84886695846 scopus 로고    scopus 로고
    • Long-lasting response to crizotinib in brain metastases due to EML4-ALK-rearranged non-small-cell lung cancer
    • Kinoshita Y, Koga Y, Sakamoto A, Hidaka K. Long-lasting response to crizotinib in brain metastases due to EML4-ALK-rearranged non-small-cell lung cancer. BMJ Case Rep. 2013;2013
    • (2013) BMJ Case Rep , pp. 2013
    • Kinoshita, Y.1    Koga, Y.2    Sakamoto, A.3    Hidaka, K.4
  • 40
    • 84875393191 scopus 로고    scopus 로고
    • Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement
    • Maillet D, Martel-Lafay I, Arpin D, Perol M. Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement. J Thorac Oncol. 2013;8(4):e30-e31
    • (2013) J Thorac Oncol , vol.8 , Issue.4
    • Maillet, D.1    Martel-Lafay, I.2    Arpin, D.3    Perol, M.4
  • 41
    • 84892187259 scopus 로고    scopus 로고
    • The central nervous system as a sanctuary site in ALK-positive non-small-cell lung cancer
    • Gainor JF, Ou SH, Logan J, Borges LF, Shaw AT. The central nervous system as a sanctuary site in ALK-positive non-small-cell lung cancer. J Thorac Oncol. 2013;8(12):1570-1573
    • (2013) J Thorac Oncol , vol.8 , Issue.12 , pp. 1570-1573
    • Gainor, J.F.1    Ou, S.H.2    Logan, J.3    Borges, L.F.4    Shaw, A.T.5
  • 42
    • 84905166331 scopus 로고    scopus 로고
    • Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small cell lung cancer and brain metastases in PROFILE 1005 and PROFILE 1007
    • Costa DB, Shaw AT, Ou SH, et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small cell lung cancer and brain metastases in PROFILE 1005 and PROFILE 1007. J Thorac Oncol. 2013;8(suppl 2):S294-S295
    • (2013) J Thorac Oncol , vol.8 , Issue.SUPPL. 2
    • Costa, D.B.1    Shaw, A.T.2    Ou, S.H.3
  • 43
    • 79957487193 scopus 로고    scopus 로고
    • CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
    • Costa DB, Kobayashi S, Pandya SS, et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol. 2011;29(15):e443-e445
    • (2011) J Clin Oncol , vol.29 , Issue.15
    • Costa, D.B.1    Kobayashi, S.2    Pandya, S.S.3
  • 44
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18(5):1472-1482
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 45
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011;71(18):6051-6060
    • (2011) Cancer Res , vol.71 , Issue.18 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3
  • 46
    • 84881256393 scopus 로고    scopus 로고
    • ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: An analysis of 1,683 patients with non-small cell lung cancer
    • Gainor JF, Varghese AM, Ou SH, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res. 2013;19(15):4273-4281
    • (2013) Clin Cancer Res , vol.19 , Issue.15 , pp. 4273-4281
    • Gainor, J.F.1    Varghese, A.M.2    Ou, S.H.3
  • 47
    • 84890018871 scopus 로고    scopus 로고
    • Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer
    • Gainor JF, Shaw AT. Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer. J Clin Oncol. 2013;31(31):3987-3996
    • (2013) J Clin Oncol , vol.31 , Issue.31 , pp. 3987-3996
    • Gainor, J.F.1    Shaw, A.T.2
  • 48
    • 33846110366 scopus 로고    scopus 로고
    • Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
    • Galkin AV, Melnick JS, Kim S, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007;104(1):270-275
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.1 , pp. 270-275
    • Galkin, A.V.1    Melnick, J.S.2    Kim, S.3
  • 49
    • 84903466222 scopus 로고    scopus 로고
    • The ALK inhibitor LDK378 overcomes crizotinib resistance in non-small cell lung cancer
    • published online March 27, doi:10.1158/2159-8290.CD-13-0846
    • Friboulet L, Li N, Katayama R, et al. The ALK inhibitor LDK378 overcomes crizotinib resistance in non-small cell lung cancer [published online March 27, 2014]. Cancer Discov. doi:10.1158/2159-8290.CD-13-0846
    • (2014) Cancer Discov
    • Friboulet, L.1    Li, N.2    Katayama, R.3
  • 50
    • 84880877176 scopus 로고    scopus 로고
    • Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials
    • Marsilje TH, Pei W, Chen B, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013;56(14):5675-5690
    • (2013) J Med Chem , vol.56 , Issue.14 , pp. 5675-5690
    • Marsilje, T.H.1    Pei, W.2    Chen, B.3
  • 51
    • 84880889769 scopus 로고    scopus 로고
    • LDK378: A promising anaplastic lymphoma kinase (ALK) inhibitor
    • Chen J, Jiang C, Wang S. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013;56(14):5673-5674
    • (2013) J Med Chem , vol.56 , Issue.14 , pp. 5673-5674
    • Chen, J.1    Jiang, C.2    Wang, S.3
  • 52
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK rearranged non-small cell lung cancer
    • Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK rearranged non-small cell lung cancer. N Engl J Med. 2014;370(13):1189-1197
    • (2014) N Engl J Med , vol.370 , Issue.13 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 53
    • 84856233310 scopus 로고    scopus 로고
    • Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
    • Kinoshita K, Asoh K, Furuichi N, et al. Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). Bioorg Med Chem. 2012;20(3):1271-1280
    • (2012) Bioorg Med Chem , vol.20 , Issue.3 , pp. 1271-1280
    • Kinoshita, K.1    Asoh, K.2    Furuichi, N.3
  • 54
    • 79955964568 scopus 로고    scopus 로고
    • CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
    • Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011;19(5):679-690
    • (2011) Cancer Cell , vol.19 , Issue.5 , pp. 679-690
    • Sakamoto, H.1    Tsukaguchi, T.2    Hiroshima, S.3
  • 55
    • 84878347085 scopus 로고    scopus 로고
    • CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): A singlearm, open-label, phase 1-2 study
    • Seto T, Kiura K, Nishio M, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a singlearm, open-label, phase 1-2 study. Lancet Oncol. 2013;14(7):590-598
    • (2013) Lancet Oncol , vol.14 , Issue.7 , pp. 590-598
    • Seto, T.1    Kiura, K.2    Nishio, M.3
  • 56
    • 84887413723 scopus 로고    scopus 로고
    • A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: Updated safety and efficacy results from AF-001JP
    • ASCO abstract 8033
    • Nakagawa K, Kiura K, Nishio M, et al. A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: updated safety and efficacy results from AF-001JP [ASCO abstract 8033]. J Clin Oncol. 2013;31(15)(suppl).
    • (2013) Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Nakagawa, K.1    Kiura, K.2    Nishio, M.3
  • 58
    • 84894483050 scopus 로고    scopus 로고
    • AP26113 possesses pan-inhibitory activity versus crizotinib-resistant ALK mutants and oncogenic ROS1 fusions
    • AACR abstract 5655
    • Squillace RM, Anjum R, Miller D, et al. AP26113 possesses pan-inhibitory activity versus crizotinib-resistant ALK mutants and oncogenic ROS1 fusions [AACR abstract 5655]. Cancer Res. 2013;73(8)(suppl):5655
    • (2013) Cancer Res , vol.73 , Issue.8 SUPPL. , pp. 5655
    • Squillace, R.M.1    Anjum, R.2    Miller, D.3
  • 59
    • 84884268356 scopus 로고    scopus 로고
    • First-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies: Updated results
    • ASCO abstract 8031
    • Camidge DR, Bazhenova L, Salgia R, et al. First-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies: updated results [ASCO abstract 8031]. J Clin Oncol. 2013;31(15)(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Camidge, D.R.1    Bazhenova, L.2    Salgia, R.3
  • 61
    • 84894159378 scopus 로고    scopus 로고
    • The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice
    • Mori M, Ueno Y, Konagai S, et al. The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice. Mol Cancer Ther. 2014;13(2):329-340
    • (2014) Mol Cancer Ther , vol.13 , Issue.2 , pp. 329-340
    • Mori, M.1    Ueno, Y.2    Konagai, S.3
  • 62
    • 84888637339 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of an oral ALK inhibitor, ASP3026, observed in a phase I dose escalation trial
    • ASCO abstract 2602
    • Patnaik A, LoRusso P, Ball HA, et al. Pharmacokinetics and safety of an oral ALK inhibitor, ASP3026, observed in a phase I dose escalation trial [ASCO abstract 2602]. J Clin Oncol. 2013;31(15)(suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Patnaik, A.1    Lorusso, P.2    Ball, H.A.3
  • 63
    • 84867487366 scopus 로고    scopus 로고
    • Characterization of a novel series of potent, selective inhibitors of wild type and mutant/fusion anaplastic lymphoma kinase
    • AACR abstract 1795
    • Wilcoxen KM, Brake RL, Saffran D, et al. Characterization of a novel series of potent, selective inhibitors of wild type and mutant/fusion anaplastic lymphoma kinase [AACR abstract 1795]. Cancer Res. 2012;72(8)(suppl 1):1795
    • (2012) Cancer Res , vol.72 , Issue.8 SUPPL. 1 , pp. 1795
    • Wilcoxen, K.M.1    Brake, R.L.2    Saffran, D.3
  • 64
    • 84905169266 scopus 로고    scopus 로고
    • TSR-011, a potent ALK inhibitor with clinical activity in phase I/IIa development [IASLC abstract P1.11-049]
    • Weiss GJ, Sachdev JC, Infante JR, et al. TSR-011, a potent ALK inhibitor with clinical activity in phase I/IIa development [IASLC abstract P1.11-049]. J Thorac Oncol. 2013;8(suppl 2):S618
    • (2013) J Thorac Oncol , vol.8 , Issue.SUPPL. 2
    • Weiss, G.J.1    Sachdev, J.C.2    Infante, J.R.3
  • 65
    • 84887445619 scopus 로고    scopus 로고
    • Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
    • Vaishnavi A, Capelletti M, Le AT, et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med. 2013;19(11):1469-1472
    • (2013) Nat Med , vol.19 , Issue.11 , pp. 1469-1472
    • Vaishnavi, A.1    Capelletti, M.2    Le, A.T.3
  • 66
    • 0022641294 scopus 로고
    • A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
    • Martin-Zanca D, Hughes SH, Barbacid M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 1986;319(6056):743-748
    • (1986) Nature , vol.319 , Issue.6056 , pp. 743-748
    • Martin-Zanca, D.1    Hughes, S.H.2    Barbacid, M.3
  • 68
    • 84905185163 scopus 로고    scopus 로고
    • PF-06463922, a novel ROS1/ALK inhibitor, demonstrates sub-nanomolar potency against oncogenic ROS1 fusions and capable of blocking the resistant ROS1G2032R mutant in preclinical tumor models
    • EORTC-NCI-AACR abstract A277
    • Zou HY, Engstrom LR, Li Q, et al. PF-06463922, a novel ROS1/ALK inhibitor, demonstrates sub-nanomolar potency against oncogenic ROS1 fusions and capable of blocking the resistant ROS1G2032R mutant in preclinical tumor models [EORTC-NCI-AACR abstract A277]. Mol Cancer Ther. 2013;12(11)(suppl):A277
    • (2013) Mol Cancer Ther , vol.12 , Issue.11 SUPPL.
    • Zou, H.Y.1    Engstrom, L.R.2    Li, Q.3
  • 69
    • 84905192083 scopus 로고    scopus 로고
    • PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical models in vitro and in vivo
    • EORTCNCI- AACR abstract C253
    • Zou HY, Engstrom LR, Li Q, et al. PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical models in vitro and in vivo [EORTCNCI- AACR abstract C253]. Mol Cancer Ther. 2013;12(11)(suppl):C253
    • (2013) Mol Cancer Ther , vol.12 , Issue.11 SUPPL.
    • Zou, H.Y.1    Engstrom, L.R.2    Li, Q.3
  • 70
    • 84905173908 scopus 로고    scopus 로고
    • Is CNS availability for oncology a nobrainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations
    • EORTC-NCI-AACR abstract PR10
    • Johnson TW, Bailey S, Burke BJ, et al. Is CNS availability for oncology a nobrainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations [EORTC-NCI-AACR abstract PR10]. Mol Cancer Ther. 2013;12(11) (suppl):PR10
    • (2013) Mol Cancer Ther , vol.12 , Issue.11 SUPPL.
    • Johnson, T.W.1    Bailey, S.2    Burke, B.J.3
  • 71
    • 79955770627 scopus 로고    scopus 로고
    • Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models
    • EORTC-NCIAACR abstract A243
    • Ardini E, Menichincheri M, De Ponti C, et al. Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models [EORTC-NCIAACR abstract A243]. Mol Cancer Ther. 2009;8(12)(suppl):A244
    • (2009) Mol Cancer Ther , vol.8 , Issue.12 SUPPL.
    • Ardini, E.1    Menichincheri, M.2    de Ponti, C.3
  • 72
    • 84905173703 scopus 로고    scopus 로고
    • In vitro and in vivo activity of NMSE628 against ALK mutations resistant to Xalkori
    • EORTC-NCI-AACR abstract A232
    • Ardini E, Menichincheri M, Banfi P, et al. In vitro and in vivo activity of NMSE628 against ALK mutations resistant to Xalkori [EORTC-NCI-AACR abstract A232]. Mol Cancer Ther. 2011;10(11)(suppl):A232
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 SUPPL.
    • Ardini, E.1    Menichincheri, M.2    Banfi, P.3
  • 73
    • 84905181831 scopus 로고    scopus 로고
    • The ALK inhibitor NMS-E628 also potently inhibits ROS1 and induces tumor regression in ROS-driven models
    • AACR abstract 2092
    • Ardini E, Menichincheri M, Banfi P, et al. The ALK inhibitor NMS-E628 also potently inhibits ROS1 and induces tumor regression in ROS-driven models [AACR abstract 2092]. Cancer Res. 2013;73(8)(suppl):2092
    • (2013) Cancer Res , vol.73 , Issue.8 SUPPL. , pp. 2092
    • Ardini, E.1    Menichincheri, M.2    Banfi, P.3
  • 74
    • 84915784462 scopus 로고    scopus 로고
    • Phase 1 open label, dose escalation study of RXDX101, an oral pan-trk, ROS1, and ALK inhibitor, in patients with advanced solid tumors with relevant molecular alterations
    • ASCO abstract 2502
    • De Braud FG, Pilla L, Niger M, et al. Phase 1 open label, dose escalation study of RXDX101, an oral pan-trk, ROS1, and ALK inhibitor, in patients with advanced solid tumors with relevant molecular alterations [ASCO abstract 2502]. J Clin Oncol. 2014;32(15)(suppl).
    • (2014) J Clin Oncol , vol.32 , Issue.15 SUPPL.
    • de Braud, F.G.1    Pilla, L.2    Niger, M.3
  • 75
    • 79960250811 scopus 로고    scopus 로고
    • Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors
    • Lovly CM, Heuckmann JM, de Stanchina E, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res. 2011;71(14):4920-4931
    • (2011) Cancer Res , vol.71 , Issue.14 , pp. 4920-4931
    • Lovly, C.M.1    Heuckmann, J.M.2    de Stanchina, E.3
  • 76
    • 84905160569 scopus 로고    scopus 로고
    • A phase I trial of X-396, a novel ALK inhibitor, in patients with advanced solid tumors
    • ASCO abstract 8030
    • Horn L, Infante JR, Blumenschein GR, et al. A phase I trial of X-396, a novel ALK inhibitor, in patients with advanced solid tumors [ASCO abstract 8030]. J Clin Oncol. 2014;32(15)(suppl).
    • (2014) J Clin Oncol , vol.32 , Issue.15 SUPPL.
    • Horn, L.1    Infante, J.R.2    Blumenschein, G.R.3
  • 77
    • 84859400151 scopus 로고    scopus 로고
    • CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers
    • Cheng M, Quail MR, Gingrich DE, et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2012;11(3):670-679
    • (2012) Mol Cancer Ther , vol.11 , Issue.3 , pp. 670-679
    • Cheng, M.1    Quail, M.R.2    Gingrich, D.E.3
  • 78
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005;5(10):761-772
    • (2005) Nat Rev Cancer , vol.5 , Issue.10 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 79
    • 84894047818 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitors in non-small-cell lung cancer
    • Pillai RN, Ramalingam SS. Heat shock protein 90 inhibitors in non-small-cell lung cancer. Curr Opin Oncol. 2014;26(2):159-164
    • (2014) Curr Opin Oncol , vol.26 , Issue.2 , pp. 159-164
    • Pillai, R.N.1    Ramalingam, S.S.2
  • 80
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
    • Katayama R, Khan TM, Benes C, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011;108(18):7535-7540
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.18 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3
  • 81
    • 79957896979 scopus 로고    scopus 로고
    • The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models
    • Normant E, Paez G, West KA, et al. The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models. Oncogene. 2011;30(22):2581-2586
    • (2011) Oncogene , vol.30 , Issue.22 , pp. 2581-2586
    • Normant, E.1    Paez, G.2    West, K.A.3
  • 82
    • 79951885125 scopus 로고    scopus 로고
    • Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol. 2010;28(33):4953-4960
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3
  • 83
    • 84877679409 scopus 로고    scopus 로고
    • Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
    • Sang J, Acquaviva J, Friedland JC, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov. 2013;3(4):430-443
    • (2013) Cancer Discov , vol.3 , Issue.4 , pp. 430-443
    • Sang, J.1    Acquaviva, J.2    Friedland, J.C.3
  • 84
    • 84878971581 scopus 로고    scopus 로고
    • A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
    • Socinski MA, Goldman J, El-Hariry I, et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res. 2013;19(11):3068-3077
    • (2013) Clin Cancer Res , vol.19 , Issue.11 , pp. 3068-3077
    • Socinski, M.A.1    Goldman, J.2    El-Hariry, I.3
  • 85
    • 84878358097 scopus 로고    scopus 로고
    • Phase II activity of the Hsp90 inhibitor AUY922 in patients with ALK-rearranged (ALK) or EGFR-mutated advanced nonsmall cell lung cancer [JSMO abstract 4380
    • Felip E, Carcereny E, Barlesi F, et al. Phase II activity of the Hsp90 inhibitor AUY922 in patients with ALK-rearranged (ALK) or EGFR-mutated advanced nonsmall cell lung cancer [JSMO abstract 4380]. Ann Oncol. 2012;23(suppl 9).
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Felip, E.1    Carcereny, E.2    Barlesi, F.3
  • 86
    • 84890294429 scopus 로고    scopus 로고
    • The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models
    • Miyajima N, Tsutsumi S, Sourbier C, et al. The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models. Cancer Res. 2013;73(23):7022-7033
    • (2013) Cancer Res , vol.73 , Issue.23 , pp. 7022-7033
    • Miyajima, N.1    Tsutsumi, S.2    Sourbier, C.3
  • 87
    • 84865973305 scopus 로고    scopus 로고
    • Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer
    • Beckman RA, Schemmann GS, Yeang CH. Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer. Proc Natl Acad Sci U S A. 2012;109(36):14586-14591
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.36 , pp. 14586-14591
    • Beckman, R.A.1    Schemmann, G.S.2    Yeang, C.H.3
  • 88
    • 82955240672 scopus 로고    scopus 로고
    • Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer
    • Mumenthaler SM, Foo J, Leder K, et al. Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Mol Pharm. 2011;8(6):2069-2079
    • (2011) Mol Pharm , vol.8 , Issue.6 , pp. 2069-2079
    • Mumenthaler, S.M.1    Foo, J.2    Leder, K.3
  • 89
    • 79960085862 scopus 로고    scopus 로고
    • Optimization of dosing for EGFRmutant non-small cell lung cancer with evolutionary cancer modeling
    • 90ra59
    • Chmielecki J, Foo J, Oxnard GR, et al. Optimization of dosing for EGFRmutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med. 2011;3(90):90ra59
    • (2011) Sci Transl Med , vol.3 , Issue.90
    • Chmielecki, J.1    Foo, J.2    Oxnard, G.R.3
  • 90
    • 84897466891 scopus 로고    scopus 로고
    • Treatment with therapies matched to oncogenic drivers improves survival in patients with lung cancers: Results from the lung cancer mutation consortium [WCLC abstract PL03.07]
    • Kris M, Johnson BE, Berry L, et al. Treatment with therapies matched to oncogenic drivers improves survival in patients with lung cancers: results from the lung cancer mutation consortium [WCLC abstract PL03.07]. J Thorac Oncol. 2013;8(suppl 2):S3
    • (2013) J Thorac Oncol , vol.8 , Issue.SUPPL. 2
    • Kris, M.1    Johnson, B.E.2    Berry, L.3
  • 91
    • 84858297956 scopus 로고    scopus 로고
    • The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers
    • Atherly AJ, Camidge DR. The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers. Br J Cancer. 2012;106(6):1100-1106
    • (2012) Br J Cancer , vol.106 , Issue.6 , pp. 1100-1106
    • Atherly, A.J.1    Camidge, D.R.2
  • 92
    • 84901191153 scopus 로고    scopus 로고
    • Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer
    • Djalalov S, Beca J, Hoch JS, et al. Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer. J Clin Oncol. 2014;32(10):1012-1019
    • (2014) J Clin Oncol , vol.32 , Issue.10 , pp. 1012-1019
    • Djalalov, S.1    Beca, J.2    Hoch, J.S.3
  • 93
    • 84901608386 scopus 로고    scopus 로고
    • Cost-effectiveness of crizotinib for anaplastic lymphoma kinase-positive, non-small-cell lung cancer: Who is going to blink at the cost?
    • Kelly RJ, Hillner BE, Smith TJ. Cost-effectiveness of crizotinib for anaplastic lymphoma kinase-positive, non-small-cell lung cancer: who is going to blink at the cost? J Clin Oncol. 2014;32(10):983-985
    • (2014) J Clin Oncol , vol.32 , Issue.10 , pp. 983-985
    • Kelly, R.J.1    Hillner, B.E.2    Smith, T.J.3
  • 94
    • 84940177095 scopus 로고    scopus 로고
    • AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066)
    • AACR abstract LB-298
    • Zhang S, Wang F, Keats J, et al. AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066) [AACR abstract LB-298]. Cancer Res. 2011;70(8)(suppl):LB-298
    • (2011) Cancer Res , vol.70 , Issue.8 SUPPL.
    • Zhang, S.1    Wang, F.2    Keats, J.3
  • 95
    • 84945166840 scopus 로고    scopus 로고
    • Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK)
    • AACR abstract 3623
    • Rivera VM, Anjum R, Wang F, et al. Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK) [AACR abstract 3623]. Cancer Res. 2011;70(8)(suppl):3623
    • (2011) Cancer Res , vol.70 , Issue.8 SUPPL. , pp. 3623
    • Rivera, V.M.1    Anjum, R.2    Wang, F.3
  • 96
    • 84875948814 scopus 로고    scopus 로고
    • AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC
    • AACR abstract 1794
    • Rivera VM, Wang F, Anjum R, et al. AP26113 is a dual ALK/EGFR inhibitor: characterization against EGFR T790M in cell and mouse models of NSCLC [AACR abstract 1794]. Cancer Res. 2012;72(8)(suppl):1794
    • (2012) Cancer Res , vol.72 , Issue.8 SUPPL. , pp. 1794
    • Rivera, V.M.1    Wang, F.2    Anjum, R.3
  • 97
    • 84875396927 scopus 로고    scopus 로고
    • Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer
    • Kim S, Kim TM, Kim DW, et al. Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer. J Thorac Oncol. 2013;8(4):415-422
    • (2013) J Thorac Oncol , vol.8 , Issue.4 , pp. 415-422
    • Kim, S.1    Kim, T.M.2    Kim, D.W.3
  • 98
    • 84882668835 scopus 로고    scopus 로고
    • Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment
    • Huang D, Kim DW, Kotsakis A, et al. Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment. Genomics. 2013;102(3):157-162
    • (2013) Genomics , vol.102 , Issue.3 , pp. 157-162
    • Huang, D.1    Kim, D.W.2    Kotsakis, A.3
  • 99
    • 84857836570 scopus 로고    scopus 로고
    • Acquired resistance to the ALK inhibitor crizotinib in the absence of an ALK mutation
    • Costa DB, Kobayashi S. Acquired resistance to the ALK inhibitor crizotinib in the absence of an ALK mutation. J Thorac Oncol. 2012;7(3):623-625.
    • (2012) J Thorac Oncol , vol.7 , Issue.3 , pp. 623-625
    • Costa, D.B.1    Kobayashi, S.2


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