-
1
-
-
37649012447
-
Development trends for new cancer therapeutics and vaccines
-
Rekhert JM, Wenger JB. Development trends for new cancer therapeutics and vaccines. Drug Discov Today 13:30-37, 2008.
-
(2008)
Drug Discov Today
, vol.13
, pp. 30-37
-
-
Rekhert, J.M.1
Wenger, J.B.2
-
3
-
-
78951480503
-
Pharmaceutical innovation in the 21st century: New drug approvals in the first decade 2000-2009
-
Kaitin KI, DiMasi JA. Pharmaceutical innovation in the 21st century: New drug approvals in the first decade 2000-2009. Clinical Pharmacology & Therapeutics 89(2): 183-188. 2011.
-
(2011)
Clinical Pharmacology & Therapeutics
, vol.89
, Issue.2
, pp. 183-188
-
-
Kaitin, K.I.1
Dimasi, J.A.2
-
4
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: New estimates of drug development costs. J. Health Econ 22:151-185, 2003.
-
(2003)
J. Health Econ
, vol.22
, pp. 151-185
-
-
Dimasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
5
-
-
33746678421
-
New drug development: Estimating entry from human clinical trials
-
Adams CP, Brantner W: New drug development: Estimating entry from human clinical trials. FTC Working Paper No. 262 262, 2003.
-
(2003)
FTC Working Paper
, vol.262
, pp. 262
-
-
Adams, C.P.1
Brantner, W.2
-
6
-
-
77149120426
-
The economics of drug development: A grim reality and role of clinical pharmacology
-
Honig P and Lalonde R. The economics of drug development: a grim reality and role of clinical pharmacology. Clinical Pharmacology and Therapeutics 87 (3): 247-251. 2010.
-
(2010)
Clinical Pharmacology and Therapeutics
, vol.87
, Issue.3
, pp. 247-251
-
-
Honig, P.1
Lalonde, R.2
-
7
-
-
33645675960
-
Market watch : Estimating the cost of new drug development: Is it really $802 million?
-
Adams CP, Van Brantner V: Market watch : Estimating the cost of new drug development: Is it really $802 million? Health Aff 25:420-428, 2006.
-
(2006)
Health Aff
, vol.25
, pp. 420-428
-
-
Adams, C.P.1
van Brantner, V.2
-
8
-
-
4344623391
-
R&D costs and returns by therapeutic category
-
DiMasi JA, Grabowski HG, Vernon J: R&D costs and returns by therapeutic category. Drug Inf J 38:211-223, 2004.
-
(2004)
Drug Inf J
, vol.38
, pp. 211-223
-
-
Dimasi, J.A.1
Grabowski, H.G.2
Vernon, J.3
-
9
-
-
73449101512
-
Lessons from 60 years of pharmaceutical innovation
-
Munos B. Lessons from 60 years of pharmaceutical innovation. Nature Reviews Drug Discovery 8: 959-968. 2009.
-
(2009)
Nature Reviews Drug Discovery
, vol.8
, pp. 959-968
-
-
Munos, B.1
-
11
-
-
78650407137
-
The success rate of new drug development in clinical trials: Crohn's disease
-
Parker JL and J. Clare Kohler. The success rate of new drug development in clinical trials: Crohn's disease. J Pharm Pharm Sci, 13(2): 191-197, 2010.
-
(2010)
J Pharm Pharm Sci
, vol.13
, Issue.2
, pp. 191-197
-
-
Parker, J.L.1
Clare Kohler, J.2
-
12
-
-
33747813779
-
-
U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER)
-
US Food and Drug Administration. Guidance for industry: clinical trial endpoints for the approval of cancer drugs and biologics. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), 2007.
-
(2007)
Guidance for Industry: Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics
-
-
Food, U.S.1
Administration, D.2
-
13
-
-
0042449063
-
Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas
-
Cheson BD, Horning SJ, Coiffier B, et al: Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. J Clin Oncol 17:1244-1253, 1999.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1244-1253
-
-
Cheson, B.D.1
Horning, S.J.2
Coiffier, B.3
-
14
-
-
33947496614
-
Revised Response Criteria for Malignant Lymphoma
-
Cheson BD, Pfistner B, Juweid ME, et al: Revised Response Criteria for Malignant Lymphoma. J Clin Oncol 25:579-586, 2007.
-
(2007)
J Clin Oncol
, vol.25
, pp. 579-586
-
-
Cheson, B.D.1
Pfistner, B.2
Juweid, M.E.3
-
16
-
-
84857119822
-
-
National Cancer Institute, Retrieved on 2009-01-25
-
National Cancer Institute. Definition of targeted therapy - NCI Dictionary of Cancer Terms. http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=270742. Retrieved on 2009-01-25, 2009.
-
(2009)
Definition of Targeted Therapy - NCI Dictionary of Cancer Terms
-
-
-
17
-
-
23044503407
-
Long-Term Results of the R-CHOP Study in the Treatment of Elderly Patients With Diffuse Large B-Cell Lymphoma: A Study by the Groupe d'Etude des Lymphomes de l'Adulte
-
Feugier P, Van Hoof A, Sebban C, et al: Long-Term Results of the R-CHOP Study in the Treatment of Elderly Patients With Diffuse Large B-Cell Lymphoma: A Study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 23:4117-4126, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4117-4126
-
-
Feugier, P.1
van Hoof, A.2
Sebban, C.3
-
18
-
-
33646004738
-
CHOPlike chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with goodprognosis diffuse large-B-cell lymphoma: A randomised controlled trial by the MabThera International Trial (MInT) Group
-
Pfreundschuh M, Truper L, Oterborg A, et al. CHOPlike chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with goodprognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 7:379-391, 2006.
-
(2006)
Lancet Oncol
, vol.7
, pp. 379-391
-
-
Pfreundschuh, M.1
Truper, L.2
Oterborg, A.3
-
19
-
-
33845996135
-
Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M, Talpur R, Ni X, et al. Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109:31-39, 2007.
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
-
20
-
-
34547683194
-
Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma
-
Olsen EA, Kim YH, Kuzel TM, et al. Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma. J Clin Oncol 25:3109-3115, 2007.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
-
21
-
-
34848870352
-
Bortezomib for the Treatment of Mantle Cell Lymphoma
-
Kane RC, Dagher R, Farrell A, et al. Bortezomib for the Treatment of Mantle Cell Lymphoma. Clin Cancer Res 13:5291-5294, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5291-5294
-
-
Kane, R.C.1
Dagher, R.2
Farrell, A.3
-
22
-
-
0345337254
-
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
-
McLaughlin P, Grillo-Lopez AJ, Link BK, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 16:2825-2833, 1998.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2825-2833
-
-
McLaughlin, P.1
Grillo-Lopez, A.J.2
Link, B.K.3
-
23
-
-
77149155968
-
Trends in risks associated with new drug development: Success rates for investigational drugs
-
J.A. DiMasi, L. Feldman and A. Wilson. Trends in risks associated with new drug development: success rates for investigational drugs. J Clin Pharm and Ther. 87(3):272-277, 2010.
-
(2010)
J Clin Pharm and Ther
, vol.87
, Issue.3
, pp. 272-277
-
-
Dimasi, J.A.1
Feldman, L.2
Wilson, A.3
-
24
-
-
77149155968
-
Trends in risks associated with new drug development: Success rates for investigational drugs
-
DiMasi, L. Feldman and A. Wilson. Trends in risks associated with new drug development: success rates for investigational drugs. Clin Pharmacol Ther. 87(3):272-277, 2010.
-
(2010)
Clin Pharmacol Ther
, vol.87
, Issue.3
, pp. 272-277
-
-
Dimasi, L.F.1
Wilson, A.2
-
25
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3:711-715, (2004)
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
27
-
-
0141973782
-
The phase III trial in the era of targeted therapy: unraveling the go or no go decision
-
Roberts TG, Jr., Lynch TJ, Jr., Chabner BA. The Phase III Trial in the Era of Targeted Therapy: Unraveling the Go or No Go Decision. J Clin Oncol 21:3683-3695, 2003.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3683-3695
-
-
Roberts Jr., T.G.1
Lynch Jr., T.J.2
Chabner, B.A.3
-
28
-
-
33947603295
-
Design of randomized controlled trials
-
Stanley, K. Design of randomized controlled trials. Circulation 115(9): 1164-1169. 2007.
-
(2007)
Circulation
, vol.115
, Issue.9
, pp. 1164-1169
-
-
Stanley, K.1
-
29
-
-
79959288115
-
Evolving options for the treatment of metastatic breast cancer: Progression-free survival as an endpoint
-
Feb 9
-
Hurvitz, S. A. Evolving options for the treatment of metastatic breast cancer: Progression-free survival as an endpoint. Cancer Treat Rev. Feb 9, 2011.
-
(2011)
Cancer Treat Rev
-
-
Hurvitz, S.A.1
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