Traumatic Brain Injury and Mitochondrial Dysfunction

American Journal of the Medical Sciences

Volumn 350, Issue 2, 2015, Pages 132-138

  Hiebert, John B ^a   Shen, Qiuhua ^a   Thimmesch, Amanda R ^a   Pierce, Janet D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF NURSING   (United States)

Author keywords

Mitochondria; Reactive oxygen species; Traumatic brain injury

Indexed keywords

ANTIOXIDANT; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; BIOENERGY; BRAIN DAMAGE; BRAIN DYSFUNCTION; BRAIN FUNCTION; CELL ENERGY; DISEASE SEVERITY; ELECTRON TRANSPORT; EXERCISE; HEALTH CARE PERSONNEL; HUMAN; HYPERBARIC OXYGEN; HYPOTHERMIA; META ANALYSIS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRION; NEUROIMAGING; OXIDATIVE STRESS; REVIEW; TRAUMATIC BRAIN INJURY; BRAIN INJURY; ENERGY METABOLISM; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

APOPTOSIS; BRAIN INJURIES; ENERGY METABOLISM; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 84938682339     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0000000000000506     Document Type: Review

References (71)

1. Roozenbeek B, Maas AI, Menon DK. Changing patterns in the epidemiology of traumatic brain injury. Nature reviews. Neurology 2013;9: 231-6.
2. Scheff SW, Ansari MA, Roberts KN. Neuroprotective effect of pycnogenol(r) following traumatic brain injury. Exp Neurol 2013; 239:183-91.
3. Faul M, Xu L, Wald MM, et al. Traumatic brain injury in the United States: national estimates of prevalence and incidence, 2002-2006. Inj Prev 2010;16:A268-A68.
4. Cancelliere C, Hincapie CA, Keightley M, et al. Systematic review of prognosis and return to play after sport concussion: results of the international collaboration on mild traumatic brain injury prognosis. Arch Phys Med Rehabil 2014;95:S210-S29.
5. Menon DK, Schwab K, WrightDW, et al. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil 2010;91:1637-40.
6. Stroke NIONDA. NINDS traumatic brain injury information page, 2014. 2014. Available at: http://www.ninds.nih.gov/disorders/tbi/tbi.htm. Accessed March 14, 2014.
7. Ilvesmaki T, Luoto TM, Hakulinen U, et al. Acute mild traumatic brain injury is not associated with white matter change on diffusion tensor imaging. Brain 2014;137:1876-82.
8. Han Z, Chen F, Ge X, et al. miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury. Brain Res 2014;1582:12-20.
9. Hsieh HL, Yang CM. Role of redox signaling in neuroinflammation and neurodegenerative diseases. Biomed Res Int 2013;2013:484613.
10. Abdul-Muneer PM, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol 2015;51:966-79.
11. Salminen LE, Paul RH. Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review. Rev Neurosci 2014;25:805-16.
12. Kostyuk VA, Potapovich AI. Mechanisms of the suppression of free radical overproduction by antioxidants. Front Biosci (Elite Ed) 2009;1: 179-88.
13. Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol 2013;13: 349-61.
14. Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol 2014;24:R453-62.
15. Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 2014;94:909-50.
16. Semple BD. Early preservation of mitochondrial bioenergetics supports both structural and functional recovery after neurotrauma. Exp Neurol 2014;261:291-7.
17. Camara AKS, Aldakkak M, Stowe DF. Mitochondria as potential therapeutic targets in mitochondria-related diseases. In: Svensson OL, editor. Mitochondria: structure, functions, and dysfunctions. New York: Nova Science Publishers, Inc; 2010. p. 471-552.
18. Schenkel LC, Bakovic M. Formation and regulation of mitochondrial membranes. Int J Cell Biol 2014;2014:709828.
19. Galloway CA, Lee H, Yoon Y. Mitochondrial morphology-emerging role in bioenergetics. Free Radic Biol Med 2012;53:2218-28.
20. Whelan SP, Zuckerbraun BS. Mitochondrial signaling: forwards, backwards, and in between. Oxid Med Cell Longev 2013;2013:351613.
21. Esteves AR, Arduino DM, Silva DFF, et al. Mitochondrial metabolism in age-related neurodegenerative disorders: Alzheimer's and Parkinson's revisited. In: Svensson OL, editor. Mitochondria: structure, functions, and dysfunctions. New York: Nova Science Publishers, Inc; 2010. p. 187-244.
22. Scarpulla RC, Vega RB, Kelly DP. Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab 2012;23:459-66.
23. Wang X, Fang H, Huang Z, et al. Imaging ROS signaling in cells and animals. J Mol Med 2013;91:917-27.
24. Lee IH, Finkel T. Metabolic regulation of the cell cycle. Curr Opin Cell Biol 2013;25:724-9.
25. Glancy B, Willis WT, Chess DJ, et al. Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria. Biochemistry 2013;52:2793-809.
26. Chin RM, Fu X, Pai MY, et al. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 2014; 510:397-401.
27. Kawagishi H, Finkel T. Unraveling the truth about antioxidants: ROS and disease: finding the right balance. Nat Med 2014;20:711-3.
28. Holmstrom KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 2014;15:411-21.
29. Van Vliet AR, Verfaillie T, Agostinis P. New functions of mitochondria associated membranes in cellular signaling. Biochim Biophys Acta 2014;1843:2253-62.
30. Jonckheere AI, Smeitink JA, Rodenburg RJ. Mitochondrial ATP synthase: architecture, function and pathology. J Inherit Metab Dis 2012;35:211-25.
31. Deberardinis RJ, Thompson CB. Cellular metabolism and disease: what do metabolic outliers teach us? Cell 2012;148:1132-44.
32. Kaila VR, Wikstrom M, Hummer G. Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex i. Proc Natl Acad Sci U S A 2014;111:6988-93.
33. Rutter J,Winge DR, Schiffman JD. Succinate dehydrogenase-assembly, regulation and role in human disease. Mitochondrion 2010;10:393-401.
34. Xia D, Esser L, Tang WK, et al. Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function. Biochim Biophys Acta 2013;1827:1278-94.
35. Bleier L, Drose S. Superoxide generation by complex III: from mechanistic rationales to functional consequences. Biochim Biophys Acta 2013;1827:1320-31.
36. Kim HJ, Khalimonchuk O, Smith PM, et al. Structure, function, and assembly of heme centers in mitochondrial respiratory complexes. Biochim Biophys Acta 2012;1823:1604-16.
37. Acin-Perez R, Fernandez-Silva P, Peleato ML, et al. Respiratory active mitochondrial supercomplexes. Mol Cell 2008;32:529-39.
38. Chaban Y, Boekema EJ, Dudkina NV. Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation. Biochim Biophys Acta 2014;1837:418-26.
39. Kawane K, Motani K, Nagata S. DNA degradation and its defects. Cold Spring Harb Perspect Biol 2014;6:a016394.
40. Kasahara A, Scorrano L. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol 2014;24:761-70.
41. Ola MS, Nawaz M, Ahsan H. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 2011;351:41-58.
42. De Lores Arnaiz GR, Bersier MG. Relationship between Na+, K+-ATPase and NMDA receptor at central synapses. Curr Protein Pept Sci 2014;15:761-77.
43. Tewari A, Mahendru V, Sinha A, et al. Antioxidants: the new frontier for translational research in cerebroprotection. J Anaesthesiol Clin Pharmacol 2014;30:160-71.
44. Werner CE, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth 2007;99:5.
45. Cheng G, Kong RH, Zhang LM, et al. Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol 2012;167:699-719.
46. Sandestig A, Romner B, Grande PO. Therapeutic hypothermia in children and adults with severe traumatic brain injury. Ther Hypothermia Temp Manag 2014;4:10-20.
47. Fox JL, Vu EN, Doyle-Waters M, et al. Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review. CJEM 2010;12: 355-64.
48. Dietrich WD, Bramlett HM. The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics 2010;7:43-50.
49. Bayir H, Adelson PD, Wisniewski SR, et al. Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med 2009;37:689-95.
50. Crossley S, Reid J, Mclatchie R, et al. A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury. Crit Care 2014;18:R75.
51. Urbano LA, Oddo M. Therapeutic hypothermia for traumatic brain injury. Curr Neurol Neurosci Rep 2012;12:580-91.
52. Raj R, Bendel S, Reinikainen M, et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care 2013;17:R177.
53. Narotam PK. Eubaric hyperoxia: controversies in the management of acute traumatic brain injury. Crit Care 2013;17:197.
54. Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res 2008;1221:126-33.
55. Wei XE, Li YH, Zhao H, et al. Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study. Neurol Sci 2014;35:295-302.
56. Kraitsy K, Uecal M, Grossauer S, et al. Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function. PLoS One 2014;9:e97750.
57. Bitterman H. Optimization of intermittent oxygen/air exposure protocols prolongs the safe use of hyperoxia. J Exp Integr Med 2012;2:2.
58. Rockswold SB, Rockswold GL, Zaun DA, et al. A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury. J Neurosurg 2010;112:1080-94.
59. Sjoberg F, Singer M. The medical use of oxygen: a time for critical reappraisal. J Intern Med 2013;274:505-28.
60. Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Cochrane Database Syst Rev 2012;12:CD004609.
61. Jacqmain J, Nudi ET, Fluharty S, et al. Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats. Behav Brain Res 2014;275C:201-11.
62. Archer T. Influence of physical exercise on traumatic brain injury deficits: scaffolding effect. Neurotox Res 2012;21:418-34.
63. Itoh T, Imano M, Nishida S, et al. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury. J Neural Transm 2011;118:1263-72.
64. Hashemzadeh E, Movassaghi S, Shafaroodi H, et al. Effect of coenzyme Q10 (ubiquinone) on hippocampal CA1 pyramidal cells following transient global ischemia/reperfusion in male wistar rat. J Pharm Health Sci 2014;3:7.
65. Duberley KE, Abramov AY, Chalasani A, et al. Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. J Inherit Metab Dis 2013;36:63-73.
66. Duberley KE, Heales SJ, Abramov AY, et al. Effect of coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in coenzyme Q10 deficient human neuronal cells. Int J Biochem Cell Biol 2014;50:60-3.
67. Kalayci M, Unal MM, Gul S, et al. Effect of coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic braininjury model in rats. BMC Neurosci 2011;12:75.
68. Ishaq GM, Saidu Y, Bilbis LS, et al. Effects of alpha-tocopherol and ascorbic acid in the severity and management of traumatic brain injury in albino rats. J Neurosci Rural Pract 2013;4:292-7.
69. Marcano DC, Bitner BR, Berlin JM, et al. Design of poly(ethylene glycol)-functionalized hydrophilic carbon clusters for targeted therapy of cerebrovascular dysfunction in mild traumatic brain injury. J Neurotrauma 2013;30:789-96.
70. Ye S, Chen M, Jiang Y, et al. Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system. Int J Nanomedicine 2014;9: 2073-87.
71. Bitner BR, Marcano DC, Berlin JM, et al. Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury. ACS Nano 2012;6:8007-14.