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Volumn 2015, Issue , 2015, Pages

Withaferin A Inhibits Nuclear Factor- B-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; WITHAFERIN A; ANTINEOPLASTIC AGENT; LIPOPOLYSACCHARIDE; NFKB1 PROTEIN, HUMAN; NOS2 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR; WITHANOLIDE;

EID: 84938635604     PISSN: 20905904     EISSN: 16875443     Source Type: Journal    
DOI: 10.1155/2015/381964     Document Type: Article
Times cited : (29)

References (46)
  • 1
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innate immunity
    • C. Farina, F. Aloisi, and E. Meinl, "Astrocytes are active players in cerebral innate immunity" Trends in Immunology, vol. 28, no. 3, pp. 138-145, 2007.
    • (2007) Trends in Immunology , vol.28 , Issue.3 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 2
    • 84859717206 scopus 로고    scopus 로고
    • Innate immunity in the central nervous system
    • R. M. Ransohoff and M. A. Brown, "Innate immunity in the central nervous system" The Journal of Clinical Investigation, vol. 122, no. 4, pp. 1164-1171, 2012.
    • (2012) The Journal of Clinical Investigation , vol.122 , Issue.4 , pp. 1164-1171
    • Ransohoff, R.M.1    Brown, M.A.2
  • 3
    • 84931564272 scopus 로고    scopus 로고
    • Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
    • D. Rossi, "Astrocyte physiopathology: at the crossroads of intercellular networking, inflammation and cell death" Progress in Neurobiology, vol. 130, pp. 86-120, 2015.
    • (2015) Progress in Neurobiology , vol.130 , pp. 86-120
    • Rossi, D.1
  • 4
    • 84874606434 scopus 로고    scopus 로고
    • Astrocyte signaling and neurodegeneration: New insights into CNS disorders
    • L. Brambilla, F. Martorana, and D. Rossi, "Astrocyte signaling and neurodegeneration: new insights into CNS disorders" Prion, vol. 7, no. 1, pp. 28-36, 2013.
    • (2013) Prion , vol.7 , Issue.1 , pp. 28-36
    • Brambilla, L.1    Martorana, F.2    Rossi, D.3
  • 5
    • 84877328234 scopus 로고    scopus 로고
    • DAMPs and autophagy: Cellular adaptation to injury and unscheduled cell death
    • Q. Zhang, R. Kang, H. J. Zeh III, M. T. Lotze, and D. Tang, "DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death" Autophagy, vol. 9, no. 4, pp. 451-458, 2013.
    • (2013) Autophagy , vol.9 , Issue.4 , pp. 451-458
    • Zhang, Q.1    Kang, R.2    Zeh, H.J.3    Lotze, M.T.4    Tang, D.5
  • 6
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • C. K. Glass, K. Saijo, B. Winner, M. C. Marchetto, andF. H. Gage, "Mechanisms underlying inflammation in neurodegeneration" Cell, vol. 140, no. 6, pp. 918-934, 2010.
    • (2010) Cell , vol.140 , Issue.6 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 8
    • 0042377367 scopus 로고    scopus 로고
    • Cultured astrocytes express toll-like receptors for bacterial products
    • C. C. Bowman, A. Rasley, S. L. Tranguch, and I. Marriott, "Cultured astrocytes express toll-like receptors for bacterial products" Glia, vol. 43, no. 3, pp. 281-291, 2003.
    • (2003) Glia , vol.43 , Issue.3 , pp. 281-291
    • Bowman, C.C.1    Rasley, A.2    Tranguch, S.L.3    Marriott, I.4
  • 9
    • 13544272944 scopus 로고    scopus 로고
    • Differential activation of astrocytes by innate and adaptive immune stimuli
    • P. A. Carpentier, W. S. Begolka, J. K. Olson, A. Elhofy, W. J. Karpus, and S. D. Miller, "Differential activation of astrocytes by innate and adaptive immune stimuli" Glia, vol. 49, no. 3, pp. 360-374, 2005.
    • (2005) Glia , vol.49 , Issue.3 , pp. 360-374
    • Carpentier, P.A.1    Begolka, W.S.2    Olson, J.K.3    Elhofy, A.4    Karpus, W.J.5    Miller, S.D.6
  • 10
    • 33646258023 scopus 로고    scopus 로고
    • Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators
    • M. Bsibsi, C. Persoon-Deen, R. W. H. Verwer, S. Meeuwsen, R. Ravid, and J. M. Van Noort, "Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators" Glia, vol. 53, no. 7, pp. 688-695, 2006.
    • (2006) Glia , vol.53 , Issue.7 , pp. 688-695
    • Bsibsi, M.1    Persoon-Deen, C.2    Verwer, R.W.H.3    Meeuwsen, S.4    Ravid, R.5    Van Noort, J.M.6
  • 11
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • K. Hoshino, O. Takeuchi, T. Kawai et al. , "Cutting edge: tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product" Journal of Immunology, vol. 162, no. 7, pp. 3749-3752, 1999.
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3
  • 12
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • A. Poltorak, X. He, I. Smirnova et al. , "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene" Science, vol. 282, no. 5396, pp. 2085-2088, 1998.
    • (1998) Science , vol.282 , Issue.5396 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3
  • 13
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)
    • S. T. Qureshi, L. Lariviére, G. Leveque et al. , "Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)" The Journal of Experimental Medicine, vol. 189, no. 4, pp. 615-625, 1999.
    • (1999) The Journal of Experimental Medicine , vol.189 , Issue.4 , pp. 615-625
    • Qureshi, S.T.1    Lariviére, L.2    Leveque, G.3
  • 14
    • 78650250592 scopus 로고    scopus 로고
    • Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1/Stat1 pathways
    • R. Gorina, M. Font-Nieves, L. Márquez-Kisinousky, T. Santalucia, and A. M. Planas, "Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1/Stat1 pathways" Glia, vol. 59, no. 2, pp. 242-255, 2011.
    • (2011) Glia , vol.59 , Issue.2 , pp. 242-255
    • Gorina, R.1    Font-Nieves, M.2    Márquez-Kisinousky, L.3    Santalucia, T.4    Planas, A.M.5
  • 15
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • H. L. Pahl, "Activators and target genes of Rel/NF-κB transcription factors" Oncogene, vol. 18, no. 49, pp. 6853-6866, 1999.
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6853-6866
    • Pahl, H.L.1
  • 16
    • 35348907831 scopus 로고    scopus 로고
    • Withania somnifera inhibitsNF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells
    • D. Singh, A. Aggarwal, R. Maurya, and S. Naik, "Withania somnifera inhibitsNF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells" Phytotherapy Research, vol. 21, no. 10, pp. 905-913, 2007.
    • (2007) Phytotherapy Research , vol.21 , Issue.10 , pp. 905-913
    • Singh, D.1    Aggarwal, A.2    Maurya, R.3    Naik, S.4
  • 17
    • 33947530134 scopus 로고    scopus 로고
    • Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity
    • M. Kaileh, W. Vanden Berghe, A. Heyerick et al. , "Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity" Journal of Biological Chemistry, vol. 282, no. 7, pp. 4253-4264, 2007.
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.7 , pp. 4253-4264
    • Kaileh, M.1    Vanden Berghe, W.2    Heyerick, A.3
  • 18
    • 78649785240 scopus 로고    scopus 로고
    • Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-kappaB activation suppression by Withania somniferas key metabolite withaferin A
    • article S25
    • A. Grover, A. Shandilya, A. Punetha, V. S. Bisaria, and D. Sundar, "Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-kappaB activation suppression by Withania somniferas key metabolite withaferin A" BMC Genomics, vol. 11, no. 4, article S25, 2010.
    • (2010) BMC Genomics , vol.11 , Issue.4
    • Grover, A.1    Shandilya, A.2    Punetha, A.3    Bisaria, V.S.4    Sundar, D.5
  • 19
    • 84882721062 scopus 로고    scopus 로고
    • Withaferin A: A proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone
    • article e778
    • V. Khedgikar, P. Kushwaha, J. Gautam et al. , "Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone" Cell Death and Disease, vol. 4, no. 8, article e778, 2013.
    • (2013) Cell Death and Disease , vol.4 , Issue.8
    • Khedgikar, V.1    Kushwaha, P.2    Gautam, J.3
  • 20
    • 67651171596 scopus 로고    scopus 로고
    • Inhibition of NFkappaB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
    • article 15
    • R. Maitra, M. A. Porter, S. Huang, andB. P. Gilmour, "Inhibition of NFkappaB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" Journal of Inflammation, vol. 6, article 15, 2009.
    • (2009) Journal of Inflammation , vol.6
    • Maitra, R.1    Porter, M.A.2    Huang, S.3    Gilmour, B.P.4
  • 21
    • 84892914226 scopus 로고    scopus 로고
    • NF-κBinduced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma
    • Article ID e78728
    • B. C. McFarland, S. W. Hong, R. Rajbhandari et al. , "NF-κBinduced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma" PLoS ONE, vol. 8, no. 11, Article ID e78728, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.11
    • McFarland, B.C.1    Hong, S.W.2    Rajbhandari, R.3
  • 22
    • 78149239365 scopus 로고    scopus 로고
    • Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
    • J. Lee, E.-R. Hahm, and S. V. Singh, "Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells" Carcinogenesis, vol. 31, no. 11, pp. 1991-1998, 2010.
    • (2010) Carcinogenesis , vol.31 , Issue.11 , pp. 1991-1998
    • Lee, J.1    Hahm, E.-R.2    Singh, S.V.3
  • 23
    • 84860389531 scopus 로고    scopus 로고
    • Withaferin A downregulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells
    • K.-J. Min, K. Choi, and T. K. Kwon, "Withaferin A downregulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells" International Immunopharmacology, vol. 11, no. 8, pp. 1137-1142, 2011.
    • (2011) International Immunopharmacology , vol.11 , Issue.8 , pp. 1137-1142
    • Min, K.-J.1    Choi, K.2    Kwon, T.K.3
  • 24
    • 84867631835 scopus 로고    scopus 로고
    • Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
    • H. J. Um, K.-J. Min, D. E. Kim, and T. K. Kwon, "Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells" Biochemical and Biophysical Research Communications, vol. 427, no. 1, pp. 24-29, 2012.
    • (2012) Biochemical and Biophysical Research Communications , vol.427 , Issue.1 , pp. 24-29
    • Um, H.J.1    Min, K.-J.2    Kim, D.E.3    Kwon, T.K.4
  • 26
    • 84856331327 scopus 로고    scopus 로고
    • The BH4 domain of Bcl-X L rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals
    • F. Martorana, L. Brambilla, C. F. Valori et al. , "The BH4 domain of Bcl-X L rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals" Human Molecular Genetics, vol. 21, no. 4, pp. 826-840, 2012.
    • (2012) Human Molecular Genetics , vol.21 , Issue.4 , pp. 826-840
    • Martorana, F.1    Brambilla, L.2    Valori, C.F.3
  • 27
    • 54049106867 scopus 로고    scopus 로고
    • Focal degeneration of astrocytes in amyotrophic lateral sclerosis
    • D. Rossi, L. Brambilla, C. F. Valori et al. , "Focal degeneration of astrocytes in amyotrophic lateral sclerosis" Cell Death and Differentiation, vol. 15, no. 11, pp. 1691-1700, 2008.
    • (2008) Cell Death and Differentiation , vol.15 , Issue.11 , pp. 1691-1700
    • Rossi, D.1    Brambilla, L.2    Valori, C.F.3
  • 28
    • 0037025051 scopus 로고    scopus 로고
    • Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge
    • L. Gautron, P. Lafon, M. Chaigniau, G. Tramu, and S. Layé, "Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge" Neuroscience, vol. 112, no. 3, pp. 717-729, 2002.
    • (2002) Neuroscience , vol.112 , Issue.3 , pp. 717-729
    • Gautron, L.1    Lafon, P.2    Chaigniau, M.3    Tramu, G.4    Layé, S.5
  • 29
    • 84920886169 scopus 로고    scopus 로고
    • Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain
    • Y. Nakano, E. Furube, S. Morita, A. Wanaka, T. Nakashima, and S. Miyata, "Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain" Journal of Neuroimmunology, vol. 278, pp. 144-158, 2015.
    • (2015) Journal of Neuroimmunology , vol.278 , pp. 144-158
    • Nakano, Y.1    Furube, E.2    Morita, S.3    Wanaka, A.4    Nakashima, T.5    Miyata, S.6
  • 30
    • 63549151154 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin-3 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain
    • article 9
    • E. Beurel and R. S. Jope, "Lipopolysaccharide-induced interleukin-3 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain" Journal of Neuroinflammation, vol. 6, article 9, 2009.
    • (2009) Journal of Neuroinflammation , vol.6
    • Beurel, E.1    Jope, R.S.2
  • 31
    • 80053602196 scopus 로고    scopus 로고
    • Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2, 4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells
    • article 132
    • Y.-J. Lee, D.-Y. Choi, I. S. Choi et al. , "Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2, 4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells" Journal of Neuroinflammation, vol. 8, article 132, 2011.
    • (2011) Journal of Neuroinflammation , vol.8
    • Lee, Y.-J.1    Choi, D.-Y.2    Choi, I.S.3
  • 32
    • 84884891268 scopus 로고    scopus 로고
    • Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes
    • Article ID e75804
    • X. Liu, Y. Tian, N. Lu, T. Gin, C. H. K. Cheng, and M. T. V. Chan, "Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes" PLoS ONE, vol. 8, no. 10, Article ID e75804, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.10
    • Liu, X.1    Tian, Y.2    Lu, N.3    Gin, T.4    Cheng, C.H.K.5    Chan, M.T.V.6
  • 33
    • 0033120071 scopus 로고    scopus 로고
    • Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide
    • D. V. Kuprash, I. A. Udalova, R. L. Turetskaya, D. Kwiatkowski, N. R. Rice, and S. A. Nedospasov, "Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide" Journal of Immunology, vol. 162, no. 7, pp. 4045-4052, 1999.
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 4045-4052
    • Kuprash, D.V.1    Udalova, I.A.2    Turetskaya, R.L.3    Kwiatkowski, D.4    Rice, N.R.5    Nedospasov, S.A.6
  • 34
    • 0032538428 scopus 로고    scopus 로고
    • Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues
    • Y. Kim and S. M. Fischer, "Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues" Journal of Biological Chemistry, vol. 273, no. 42, pp. 27686-27694, 1998.
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.42 , pp. 27686-27694
    • Kim, Y.1    Fischer, S.M.2
  • 35
    • 0034603122 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclooxygenase-2 gene in activatedmast cells
    • S. T. Reddy, D. J. Wadleigh, and H. R. Herschman, "Transcriptional regulation of the cyclooxygenase-2 gene in activatedmast cells" The Journal of Biological Chemistry, vol. 275, no. 5, pp. 3107-3113, 2000.
    • (2000) The Journal of Biological Chemistry , vol.275 , Issue.5 , pp. 3107-3113
    • Reddy, S.T.1    Wadleigh, D.J.2    Herschman, H.R.3
  • 36
    • 0027255749 scopus 로고
    • Promoter of themouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide
    • Q.-W. Xie, R. Whisnant, andC. Nathan, "Promoter of themouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide" The Journal of Experimental Medicine, vol. 177, no. 6, pp. 1779-1784, 1993.
    • (1993) The Journal of Experimental Medicine , vol.177 , Issue.6 , pp. 1779-1784
    • Xie, Q.-W.1    Whisnant, R.2    Nathan, C.3
  • 37
    • 84923444904 scopus 로고    scopus 로고
    • Innate immunity in Alzheimers disease
    • M. T. Heneka, D. T. Golenbock, and E. Latz, "Innate immunity in Alzheimers disease" Nature Immunology, vol. 16, no. 3, pp. 229-236, 2015.
    • (2015) Nature Immunology , vol.16 , Issue.3 , pp. 229-236
    • Heneka, M.T.1    Golenbock, D.T.2    Latz, E.3
  • 38
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation inmotor neuron disease
    • T. Philips and W. Robberecht, "Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation inmotor neuron disease" The Lancet Neurology, vol. 10, no. 3, pp. 253-263, 2011.
    • (2011) The Lancet Neurology , vol.10 , Issue.3 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 39
    • 0032518514 scopus 로고    scopus 로고
    • Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
    • P. Bezzi, G. Carmignoto, L. Pasti et al. , "Prostaglandins stimulate calcium-dependent glutamate release in astrocytes" Nature, vol. 391, no. 6664, pp. 281-285, 1998.
    • (1998) Nature , vol.391 , Issue.6664 , pp. 281-285
    • Bezzi, P.1    Carmignoto, G.2    Pasti, L.3
  • 40
    • 0034960228 scopus 로고    scopus 로고
    • CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity
    • P. Bezzi, M. Domercq, L. Brambilla et al. , "CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity" Nature Neuroscience, vol. 4, no. 7, pp. 702-710, 2001.
    • (2001) Nature Neuroscience , vol.4 , Issue.7 , pp. 702-710
    • Bezzi, P.1    Domercq, M.2    Brambilla, L.3
  • 42
    • 32244436334 scopus 로고    scopus 로고
    • Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice
    • S. R. Parathath, S. Parathath, and S. E. Tsirka, "Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice" Journal of Cell Science, vol. 119, no. 2, pp. 339-349, 2006.
    • (2006) Journal of Cell Science , vol.119 , Issue.2 , pp. 339-349
    • Parathath, S.R.1    Parathath, S.2    Tsirka, S.E.3
  • 43
    • 22344431751 scopus 로고    scopus 로고
    • Inhibition of astroglial nuclear factor κb reduces inflammation and improves functional recovery after spinal cord injury
    • R. Brambilla, V. Bracchi-Ricard, W.-H. Hu et al. , "Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury" The Journal of Experimental Medicine, vol. 202, no. 1, pp. 145-156, 2005.
    • (2005) The Journal of Experimental Medicine , vol.202 , Issue.1 , pp. 145-156
    • Brambilla, R.1    Bracchi-Ricard, V.2    Hu, W.-H.3
  • 44
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-κB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous systeminflammation
    • R. Brambilla, T. Persaud, X. Hu et al. , "Transgenic inhibition of astroglial NF-κB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous systeminflammation" Journal of Immunology, vol. 182, no. 5, pp. 2628-2640, 2009.
    • (2009) Journal of Immunology , vol.182 , Issue.5 , pp. 2628-2640
    • Brambilla, R.1    Persaud, T.2    Hu, X.3
  • 45
    • 76349109675 scopus 로고    scopus 로고
    • Transgenic inhibition of glial NF-κ B reduces pain behavior and inflammation after peripheral nerve injury
    • E. S. Fu, Y. P. Zhang, J. Sagen et al. , "Transgenic inhibition of glial NF-κ B reduces pain behavior and inflammation after peripheral nerve injury" Pain, vol. 148, no. 3, pp. 509-518, 2010.
    • (2010) Pain , vol.148 , Issue.3 , pp. 509-518
    • Fu, E.S.1    Zhang, Y.P.2    Sagen, J.3
  • 46
    • 84865852211 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
    • article 213
    • R. Brambilla, G. Dvoriantchikova, D. Barakat, D. Ivanov, J. R. Bethea, and V. I. Shestopalov, "Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis" Journal of Neuroinflammation, vol. 9, article 213, 2012.
    • (2012) Journal of Neuroinflammation , vol.9
    • Brambilla, R.1    Dvoriantchikova, G.2    Barakat, D.3    Ivanov, D.4    Bethea, J.R.5    Shestopalov, V.I.6


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