Effect of temperature, calcium and protein concentration on aggregation of whey protein isolate: Formation of gel-like micro-particles

International Dairy Journal

Volumn 51, Issue , 2015, Pages 8-15

  Ni, Yingzhou ^a   Wen, Lijie ^a   Wang, Lei ^a   Dang, Yali ^b   Zhou, Peng ^a   Liang, Li ^a,c  

^a JIANGNAN UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; GELATION; PARTICLE SIZE; PROTEINS;

CALCIUM CONCENTRATION; EFFECT OF TEMPERATURE; FUNCTIONAL PROPERTIES; HYDROPHILIC ENVIRONMENTS; INDUSTRIAL PROCESSS; PROTEIN AGGREGATION; PROTEIN CONCENTRATIONS; WHEY PROTEIN ISOLATE;

AGGLOMERATION;

BOVINAE;

EID: 84938601646     PISSN: 09586946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.idairyj.2015.07.003     Document Type: Article

References (43)

1. Ako K., Nicolai T., Durand D. Salt-induced gelation of globular protein aggregates: structure and kinetics. Biomacromolecules 2010, 11:864-871.
2. Almecija M.C., Ibanez R., Guadix A., Guadix E.M. Effect of pH on the fractionation of whey proteins with a ceramic ultrafiltration membrane. Journal of Membrane Science 2007, 288:28-35.
3. Alting A.C., Hamer R.J., De Kruif C.G., Visschers R.W. Cold-set globular protein gel: interactions, structure and rheology as a function of protein concentration. Journal of Agricultural and Food Chemistry 2003, 51:3150-3156.
4. Barbut S., Foegeding E.A. Ca2+-induced gelation of pre-heated whey protein isolate. Journal of Food Science 1993, 58:867-871.
5. Bhattacharjee C., Das K.P. Thermal unfolding and refolding of β-lactoglobulin. An intrinsic and extrinsic fluorescence study. European Journal of Biochemistry 2000, 267:3957-3964.
6. Bondos S.E., Bichnell A. Detection and prevention of protein aggregation before, during, and after purification. Analytical Biochemistry 2003, 316:223-231.
7. Chen L.Y., Remondetto G.E., Subirade M. Food protein-based materials as nutraceutical delivery systems. Trends in Food Science and Technology 2006, 17:272-283.
8. Croguennec T., Molle D., Mehra R., Bouhallab S. Spectroscopic characterization of heat-induced non-native β-lactoglobulin monomers. Protein Science 2004, 13:1340-1346.
9. De Jongh H.H.J., Broersen K. Application potential of food protein modification. Advances in chemical engineering 2012, 135-182. InTech, Rijeka, Croatia. Z. Nawaz, S. Naveed (Eds.).
10. De Wolf F.A., Brett G.M. Ligand-binding proteins: their potential for application in systems for controlled delivery and uptake of ligands. Pharmacological Reviews 2000, 52:207-236.
11. Egan T., Jacquier J.-C., Rosenberg Y., Rosenberg M. Cold-set whey protein microgels for the stable immobilization of lipids. Food Hydrocolloids 2013, 31:317-324.
12. Engstrom J.D. Stable submicron protein particles: Formation, properties, and pulmonary application 2007, (Ph.D thesis), University of Texas at Austin, Austin, TX, USA.
13. Giroux H.J., Houde J., Britten M. Preparation of nanoparticles from denatured whey protein by pH-cycling treatment. Food Hydrocolloids 2010, 24:341-346.
14. Giroux H.J., Lanouette G., Britten M. Effect of whey protein aggregates of various sizes on the formation and properties of rennet-induced milk gels. Food Hydrocolloids 2015, 45:272-278.
15. Guyomarc'h F., Law A.J.R., Dalgleish D.G. Formation of soluble and micelle-bound protein aggregates in heated milk. Journal of Agricultural Food and Chemistry 2003, 51:4652-4660.
16. Halder U.C., Chakraborty J., Das N., Bose S. Tryptophan dynamics in the exploration of micro-conformational changes of refolded β-lactoglobulin after thermal expose: a steady state and time-resolved fluorescence approach. Journal of Photochemistry and Photobiology B: Biology 2012, 109:50-57.
17. Honary S., Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems - a review (part2). Tropical Journal of Pharmaceutical Research 2013, 12:265-273.
18. Hong Y.H., Creamer L.K. Changed protein structures of bovine β-lactoglobulin B and α-lactalbumin as a consequence of heat treatment. International Dairy Journal 2002, 12:345-359.
19. Hongsprabhas P., Barbut S. Ca2+-induced cold gelation of whey protein isolate: effect of two-stage gelation. Food Research International 1998, 30:523-527.
20. Jeffrey G.C., Ottewill R.H. Reversible aggregation part 1. Reversible flocculation monitored by turbidity measurements. Colloid and Polymer Science 1988, 266:173-179.
21. Ju Z.Y., Kilara A. Aggregation induced by calcium chloride and subsequent thermal gelation of whey protein isolate. Journal of Dairy Science 1998, 81:925-931.
22. Kundu B., Guptasarma P. Use of a hydrophobic dye to indirectly probe the structural organization and conformational plasticity of molecules in amorphous aggregates of carbonic anhydrase. Biochemical and Biophysical Research Communications 2002, 293:572-577.
23. Kunn K.R., Cavallieri A.L.F., da Cunha R.L. Cold-set whey protein gels induced by calcium or sodium salt addition. International Journal of Food Science and Technology 2010, 45:348-357.
24. Leung Sok Line V., Remondetto G.E., Subirade M. Cold gelation of β-lactoglobulin oil-in-water emulsion. Food Hydrocolloids 2005, 19:269-278.
25. Liang L., Pinier M., Leroux J.C., Subirade M. Interaction of α-gliadin with poly(HEMA-co-SS): structural characterization and biological implications. Biopolymers 2009, 91:169-178.
26. Liang L., Yao P., Gong J., Jiang M. Interaction of apo cytochrome c with sulfonated polystyrene nanoparticles. Langmuir 2004, 20:3333-3338.
27. Liang L., Yao P., Jiang M. Structural transformation of apocytochrome c induced by alternating copolymers of maleic acid and alkene. Biomacromolecules 2005, 6:2748-2755.
28. Liang L., Zhang J., Zhou P., Subirade M. Protective effect of ligand-binding proteins against folic acid loss due to photodecomposition. Food Chemistry 2013, 141:754-761.
29. Li M., Jiang M., Wu C. Fluorescence and light-scattering studies on the formation of stable colloidal nanoparticles made of sodium sulfonated polystyrene ionomers. Journal of Polymer Science Part B: Polymer Physics 1997, 35:1593-1599.
30. Morris A.M., Watzky M.A., Finke R.G. Protein aggregation kinetics mechanism, and curve-fitting: a review of the literature. Biochimica et Biophysica Acta: Proteins and Proteomics 2009, 1794:375-397.
31. Mudgal P., Daubert C.R., Foegeding E.A. Effect of protein concentration and CaCl2 on cold-set thickening mechanism of β-lactoglobulin at low pH. International Dairy Journal 2011, 21:319-326.
32. Nicolai T., Britten M., Schmitt C. β-lactoglobulin and WPI aggregates: formation, structure and applications. Food Hydrocolloids 2011, 25:1945-1962.
33. O'Kennedy B.T., Mounsey J.S. The dominating effect of ionic strength on the heat-induced denaturation and aggregation of β-lactoglobulin in simulated milk ultrafiltrate. International Dairy Journal 2009, 19:123-128.
34. Oldfield D.J. Heat-induced whey protein reactions in milk. Kinetics of denaturation and aggregation as related to milk powder manufacture 1996, (Ph.D thesis), Massey University, Palmerston North, New Zealand.
35. Relkin P. Thermal unfolding of β-lactoglobulin, α-lactalbumin, and bovine serum albumin. A thermodynamic approach. Critical Reviews in Food Science and Nutrition 1996, 36:565-601.
36. Remondetto G.E., Subirade M. Molecular mechanisms of Fe2+-induced β-lactoglobulin cold gelation. Biopolymers 2003, 69:461-469.
37. Renard D., Lefebvre J., Griffin M.C.A., Griffin W.G. Effect of pH and salt environment on the association of β-lactoglobulin revealed by intrinsic fluorescence studies. International Journal of Biological Macromolecules 1998, 22:41-49.
38. Schmitt C., Bovay C., Vuilliomenet A.-M., Rouvet M., Bovetto L. Influence of protein and mineral composition on the formation of whey protein heat-induced microgels. Food Hydrocolloids 2011, 25:558-567.
39. Wang W. Protein aggregation and its inhibition in biopharmaceutics. International Journal of Pharmaceutics 2005, 289:1-30.
40. Wang W., Nema S., Teagarden D. Protein aggregation - pathways and influencing factors. International Journal of Pharmaceutics 2010, 390:89-99.
41. Wei Z.P., Polozova A. Biopysical techniques for protein size distribution analysis. Biophysics for therapeutic protein development 2013, 83-97. Springer, New York, NY, USA. L.O. Narhi (Ed.).
42. Yang X.Q., Liu X.M., Zhou P. Effect of calcium-chelating salts on stability of formulated milk beverage during processing and storage. Journal of Dairy Science and Technology 2012, 35:4-8.
43. Zhang J., Liang L., Tian Z., Chen L., Subirade M. Preparation and invitro evaluation of calcium-induced soy protein isolate nanoparticles and their formation mechanism study. Food Chemistry 2012, 133:390-399.