Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice

Thrombosis Research

Volumn 136, Issue 2, 2015, Pages 456-464

  Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

AMPK; Cilostazol; HMGB1; HO 1; Sepsis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENYLATE KINASE; CILOSTAZOL; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTOPORPHYRIN ZINC; RNA; ANTICOAGULANT AGENT; HEME OXYGENASE 1; HMGB1 PROTEIN, MOUSE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEASE NEXIN I; SERPINE2 PROTEIN, MOUSE; TETRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEPSIS; SURVIVAL; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; IMMUNOLOGY; RAW 264.7 CELL LINE; SURVIVAL RATE; TREATMENT OUTCOME;

ANIMALS; ANTICOAGULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE-1; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; RAW 264.7 CELLS; SEPSIS; SERPIN E2; SURVIVAL RATE; TETRAZOLES; TREATMENT OUTCOME;

EID: 84938550395     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2015.06.017     Document Type: Article

References (39)

1. A. Oberholzer, C. Oberholzer, and L.L. Moldawer Sepsis syndromes: understanding the role of innate and acquired immunity Shock 16 2001 83 96
2. L.J. Moore, B.A. McKinley, K.L. Turner, S.R. Todd, J.F. Sucher, A. Valdivia, R.M. Sailors, L.S. Kao, and F.A. Moore The epidemiology of sepsis in general surgery patients J. Trauma 70 2011 672 680
3. C.A. Dinarello, and R.C. Thompson Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro Immunol. Today 12 1991 404 410
4. F.P. Heinzel The role of IFN-gamma in the pathology of experimental endotoxemia J. Immunol. 145 1990 2920 2924
5. M.R. Dinapoli, C.L. Calderon, and D.M. Lopez The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene J. Exp. Med. 183 1996 1323 1329
6. A. Tyagi, A.K. Sethi, G. Girotra, and M. Mohta The microcirculation in sepsis Indian J. Anaesth. 53 2009 281 293
7. H. Wang, O. Bloom, M. Zhang, J.M. Vishnubhakat, M. Ombrellino, J. Che, A. Frazier, H. Yang, S. Ivanova, L. Borovikova, K.R. Manogue, E. Faist, E. Abraham, J. Andersson, U. Andersson, P.E. Molina, N.N. Abumrad, A. Sama, and K.J. Tracey HMG-1 as a late mediator of endotoxin lethality in mice Science 285 1999 248 251
8. R.K. Wolfson, E.T. Chiang, and J.G. Garcia HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption Microvasc. Res. 81 2011 189 197
9. T. Iba, S. Gando, and J. Thachil Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan J. Thromb. Haemost. 12 2014 1010 1019
10. T. Hatada, H. Wada, T. Nobori, K. Okabayashi, K. Maruyama, Y. Abe, S. Uemoto, S. Yamada, and I. Maruyama Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation Thromb. Haemost. 94 2005 975 979
11. K. Tsoyi, T.Y. Lee, Y.S. Lee, H.J. Kim, H.G. Seo, J.H. Lee, and K.C. Chang Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo Mol. Pharmacol. 76 2009 173 182
12. R. Takamiya, C.C. Hung, S.R. Hall, K. Fukunaga, T. Nagaishi, T. Maeno, C. Owen, A.A. Macias, L.E. Fredenburgh, A. Ishizaka, R.S. Blumberg, R.M. Baron, and M.A. Perrella High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice Am. J. Respir. Cell Mol. Biol. 41 2009 129 135
13. H. Wang, H. Yang, C.J. Czura, A.E. Sama, and K.J. Tracey HMGB1 as a late mediator of lethal systemic inflammation Am. J. Respir. Crit. Care Med. 164 2001 1768 1773
14. J. Alam, D. Stewart, C. Touchard, S. Boinapally, A.M. Choi, and J.L. Cook Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene J. Biol. Chem. 274 1999 26071 26078
15. H.J. Jang, K. Tsoyi, Y.M. Kim, E.J. Park, S.W. Park, H.J. Kim, J.H. Lee, and K.C. Chang (S)-1-alpha-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin Br. J. Pharmacol. 168 2013 1485 1496
16. H.J. Jang, Y.M. Kim, K. Tsoyi, E.J. Park, Y.S. Lee, H.J. Kim, J.H. Lee, Y. Joe, H.T. Chung, and K.C. Chang Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals Antioxid. Redox Signal. 17 2012 878 889
17. K. Tsoyi, H.J. Jang, I.T. Nizamutdinova, Y.M. Kim, Y.S. Lee, H.J. Kim, H.G. Seo, J.H. Lee, and K.C. Chang Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice Br. J. Pharmacol. 162 2011 1498 1508
18. M. Colucci, J.A. Paramo, and D. Collen Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation J. Clin. Investig. 75 1985 818 824
19. W.S. Park, W.K. Jung, D.Y. Lee, C. Moon, S.S. Yea, S.G. Park, S.K. Seo, C. Park, Y.H. Choi, G.Y. Kim, J.S. Choi, and I.W. Choi Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-kappaB inactivation: not involved in cAMP mechanisms Int. Immunopharmacol. 10 2010 1077 1085
20. P. Pullikotil, H. Chen, R. Muniyappa, C.C. Greenberg, S. Yang, C.E. Reiter, J.W. Lee, J.H. Chung, and M.J. Quon Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-alpha J. Nutr. Biochem. 23 2012 1134 1145
21. X.M. Liu, K.J. Peyton, A.R. Shebib, H. Wang, R.J. Korthuis, and W. Durante Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival Am. J. Physiol. Heart Circ. Physiol. 300 2011 H84 H93
22. S.J. Byun, Y. Son, B. Hwan Cho, H.T. Chung, and H.O. Pae beta-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages J. Clin. Biochem. Nutr. 52 2013 106 111
23. C. Mo, L. Wang, J. Zhang, S. Numazawa, H. Tang, X. Tang, X. Han, J. Li, M. Yang, Z. Wang, D. Wei, and H. Xiao The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice Antioxid. Redox Signal. 20 2014 574 588
24. Y.M. Ha, M.Y. Kim, M.K. Park, Y.S. Lee, Y.M. Kim, H.J. Kim, J.H. Lee, and K.C. Chang Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways Apoptosis 17 2012 463 474
25. R.R. Kew, M. Penzo, D.M. Habiel, and K.B. Marcu The IKKalpha-dependent NF-kappaB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1 J. Immunol. 188 2012 2380 2386
26. L.F. Gentile, and L.L. Moldawer HMGB1 as a therapeutic target for sepsis: it's all in the timing! Expert Opin. Ther. Targets 18 2014 243 245
27. G. Gong, L. Xiang, L. Yuan, L. Hu, W. Wu, L. Cai, L. Yin, and H. Dong Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats PLoS One 9 2014 e89450
28. L. Jia, A. Clear, F.T. Liu, J. Matthews, N. Uddin, A. McCarthy, E. Hoxha, C. Durance, S. Iqbal, and J.G. Gribben Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia Blood 123 2014 1709 1719
29. Y. Qin, Y. Chen, W. Wang, Z. Wang, G. Tang, P. Zhang, Z. He, Y. Liu, S.M. Dai, and Q. Shen HMGB1-LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype Cell Death Dis. 5 2014 e1077
30. U. Andersson, and K.J. Tracey HMGB1 is a therapeutic target for sterile inflammation and infection Annu. Rev. Immunol. 29 2011 139 162
31. A. Rouhiainen, S. Imai, H. Rauvala, and J. Parkkinen Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation Thromb. Haemost. 84 2000 1087 1094
32. L.M. Al-Huseini, H.X. Aw Yeang, J.M. Hamdam, S. Sethu, N. Alhumeed, W. Wong, and J.G. Sathish Heme Oxygenase-1 Regulates Dendritic Cell Function through Modulation of p38 MAPK-CREB/ATF1 Signaling J. Biol. Chem. 289 2014 16442 16451
33. S.Y. Park, J.H. Kim, S.J. Lee, and Y. Kim Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells Toxicol. Appl. Pharmacol. 268 2013 68 78
34. H.J. Kim, I. Tsoy, M.K. Park, Y.S. Lee, J.H. Lee, H.G. Seo, and K.C. Chang Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells Mol. Pharmacol. 69 2006 1633 1640
35. M.K. Park, Y.J. Kang, Y.M. Ha, J.J. Jeong, H.J. Kim, H.G. Seo, J.H. Lee, and K.C. Chang EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells Biochem. Biophys. Res. Commun. 379 2009 1043 1047
36. W. Durante, N. Christodoulides, K. Cheng, K.J. Peyton, R.K. Sunahara, and A.I. Schafer cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle Am. J. Physiol. 273 1997 H317 H323
37. J.A. Paramo, F.J. Fernandez Diaz, and E. Rocha Plasminogen activator inhibitor activity in bacterial infection Thromb. Haemost. 59 1988 451 454
38. L. Lorente, M.M. Martin, J.M. Borreguero-Leon, J. Sole-Violan, J. Ferreres, L. Labarta, C. Diaz, A. Jimenez, and J.A. Paramo Sustained high plasma plasminogen activator inhibitor-1 levels are associated with severity and mortality in septic patients Thromb. Res. 134 2014 182 186
39. H. Matsumoto, K. Ishikawa, H. Itabe, and Y. Maruyama Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction Mol. Cell. Biochem. 291 2006 21 28