HMGB1-LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Qin, Y ^a   Chen, Y ^a   Wang, W ^b   Wang, Z ^a   Tang, G ^a   Zhang, P ^a   He, Z ^a   Liu, Y ^a   Dai, S M ^a   Shen, Q ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

autophagy; HMGB1; rheumatoid arthritis synovial fibroblast

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; BACTERIUM LIPOPOLYSACCHARIDE; HIGH MOBILITY GROUP B1 PROTEIN; MATRIX METALLOPROTEINASE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME SYNTHESIS; FIBROBLAST; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM; UPREGULATION;

ANIMALS; APOPTOSIS; ARTHRITIS, RHEUMATOID; AUTOPHAGY; CARTILAGE; CELL ADHESION; CELL ADHESION MOLECULES; CELL CYCLE; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINES; CYTOKINES; FIBROBLASTS; HMGB1 PROTEIN; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; MICE, SCID; OSTEOARTHRITIS; RECEPTORS, IMMUNOLOGIC; SYNOVIAL MEMBRANE; TIME FACTORS;

EID: 84896757557     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.48     Document Type: Article

References (54)

1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet 2010; 376: 1094-1108.
2. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-2219.
3. Neumann E, Lefevre S, Zimmermann B, Gay S, Muller-Ladner U. Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends Mol Med 2010; 16: 458-468.
4. Hitchon CA, El-Gabalawy HS. Infection and rheumatoid arthritis: Still an open question. Curr Opin Rheumatol 2011; 23: 352-357.
5. Ogrendik M. Does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? Discov Med 2012; 13: 349-355.
6. Perruche S, Saas P, Chen W. Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: A potential cell-based therapy? Arthritis Res Ther 2009; 11: R104.
7. Marijnissen RJ, Roeleveld DM, Young D, Nickerson-Nutter C, Abdollahi-Roodsaz S, Garcia de Aquino S et al. IL-21R-deficiency increases the initial TLR2 response but protects against joint pathology by reducing Th1/17 cells during SCW-Arthritis. Arthritis Rheum 2013; e-pub ahead of print 10 December 2013; doi:10.1002/art.38312.
8. Qin YH, Dai SM, Tang GS, Zhang J, Ren D, Wang ZW et al. HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products. J Immunol 2009; 183: 6244-6250.
9. He Z-W, Qin Y-H, Wang Z-W, Chen Y, Shen Q, Dai S-M. HMGB1 acts in synergy with lipopolysaccharide in activating rheumatoid synovial fibroblasts via p38 MAPK and NF-kB signaling pathways. Mediators Inflamm 2013; 2013: 10.
10. Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T. Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 2006; 45: 669-675.
11. Matsumoto S, Muller-Ladner U, Gay RE, Nishioka K, Gay S. Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts. J Rheumatol 1996; 23: 1345-1352.
12. Tsou HK, Chen HT, Chang CH, Yang WY, Tang CH. Apoptosis signal-regulating kinase 1 is mediated in TNF-Alpha-induced CCL2 expression in human synovial fibroblasts. J Cell Biochem 2012; 113: 3509-3519.
13. Niederer F, Trenkmann M, Ospelt C, Karouzakis E, Neidhart M, Stanczyk J et al. Down-regulation of microRNA-34a in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum 2012; 64: 1771-1779.
14. Pundt N, Peters MA, Wunrau C, Strietholt S, Fehrmann C, Neugebauer K et al. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL-And TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res Ther 2009; 11: R16.
15. Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P et al. Endogenous HMGB1 regulates autophagy. J Cell Biol 2010; 190: 881-892.
16. Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 2010; 29: 5299-5310.
17. Shin YJ, Han SH, Kim DS, Lee GH, Yoo WH, Kang YM et al. Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress. Arthritis Res Ther 2010; 12: R19.
18. Connor AM, Mahomed N, Gandhi R, Keystone EC, Berger SA. TNFalpha modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 2012; 14: R62.
19. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007; 8: 487-496.
20. Nadatani Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H et al. High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4. Am J Pathol 2012; 181: 98-110.
21. Karouzakis E, Rengel Y, Jungel A, Kolling C, Gay RE, Michel BA et al. DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun 2011; 12: 643-652.
22. Andreas K, Lubke C, Haupl T, Dehne T, Morawietz L, Ringe J et al. Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro study. Arthritis Res Ther 2008; 10: R9.
23. Pavkova Goldbergova M, Lipkova J, Pavek N, Gatterova J, Vasku A, Soucek M et al. RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis. Mol Immunol 2012; 52: 273-278.
24. Santiago B, Izquierdo E, Rueda P, Del Rey MJ, Criado G, Usategui A et al. CXCL12gamma isoform is expressed on endothelial and dendritic cells in rheumatoid arthritis synovium and regulates T cell activation. Arthritis Rheum 2012; 64: 409-417.
25. Morales-Ducret J, Wayner E, Elices MJ, Alvaro-Gracia JM, Zvaifler NJ, Firestein GS. Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J Immunol 1992; 149: 1424-1431.
26. Johnson BA, Haines GK, Harlow LA, Koch AE. Adhesion molecule expression in human synovial tissue. Arthritis Rheum 1993; 36: 137-146.
27. Luo SF, Fang RY, Hsieh HL, Chi PL, Lin CC, Hsiao LD et al. Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2010; 62: 105-116.
28. Yang CM, Luo SF, Hsieh HL, Chi PL, Lin CC, Wu CC et al. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of ERK, JNK, AP-1, and NF-kappaB. J Cell Physiol 2010; 224: 516-526.
29. Okamoto H, Cujec TP, Yamanaka H, Kamatani N. Molecular aspects of rheumatoid arthritis: Role of transcription factors. FEBS J 2008; 275: 4463-4470.
30. Bondeson J, Foxwell B, Brennan F, Feldmann M. Defining therapeutic targets by using adenovirus: Blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Proc Natl Acad Sci USA 1999; 96: 5668-5673.
31. Kew RR, Penzo M, Habiel DM, Marcu KB. The IKKalpha-dependent NF-kappaB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1. J Immunol 2012; 188: 2380-2386.
32. Seemayer CA, Kuchen S, Kuenzler P, Rihoskova V, Rethage J, Aicher WK et al. Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis. Am J Pathol 2003; 162: 1549-1557.
33. Smerdon MJ, Isenberg I. Interactions between the subfractons of calf thymus H1 and nonhistone chromosomal proteins HMG1 and HMG2. Biochemistry 1976; 15: 4242-4247.
34. Bustin M, Hopkins RB, Isenberg I. Immunological relatedness of high mobility group chromosomal proteins from calf thymus. J Biol Chem 1978; 253: 1694-1699.
35. Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011; 29: 139-162.
36. Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 2010; 28: 367-388.
37. Ding HS, Yang J, Gong FL, Ding JW, Li S, Jiang YR. High mobility box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway. Gene 2012; 509: 149-153.
38. Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J et al. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 2011; 54: 1620-1630.
39. Wang X, Sun R, Wei H, Tian Z. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced damageassociated lethal hepatitis: Interaction of gammadelta T cells with macrophages. Hepatology 2012; 57: 373-384.
40. Kokkola R, Sundberg E, Ulfgren AK, Palmblad K, Li J, Wang H et al. High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis. Arthritis Rheum 2002; 46: 2598-2603.
41. Andersson U, Harris HE. The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta 2010; 1799: 141-148.
42. Gong Q, Zhang H, Li JH, Duan LH, Zhong S, Kong XL et al. High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice. J Mol Med (Berl) 2010; 88: 1289-1298.
43. Apetoh L, Ghiringhelli F, Tesniere A, Criollo A, Ortiz C, Lidereau R et al. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev 2007; 220: 47-59.
44. Mills KH. TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 2011; 11: 807-822.
45. Ciucci A, Gabriele I, Percario ZA, Affabris E, Colizzi V, Mancino G. HMGB1 and cord blood: Its role as immuno-Adjuvant factor in innate immunity. PLoS One 2011; 6: E23766.
46. Steer SA, Scarim AL, Chambers KT, Corbett JA. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med 2006; 3: E17.
47. Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D et al. Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination. Gene Ther 2011; 18: 1070-1077.
48. Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009; 15: 1414-1420.
49. Brentano F, Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 2005; 233: 90-96.
50. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13: 1050-1059.
51. Zager RA, Johnson AC, Lund S, Randolph-Habecker J. Toll-like receptor (TLR4) shedding and depletion: Acute proximal tubular cell responses to hypoxic and toxic injury. Am J Physiol Renal Physiol 2007; 292: F304-F312.
52. Krause A, Scaletta N, Ji JD, Ivashkiv LB. Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J Immunol 2002; 169: 6610-6616.
53. Judex M, Neumann E, Fleck M, Pap T, Mountz JD, Gay RE et al. "Inverse wrap": An improved implantation technique for virus-Transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis. Mod Rheumatol 2001; 11: 145-150.
54. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-324.