Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-κB inactivation: Not involved in cAMP mechanisms

International Immunopharmacology

Volumn 10, Issue 9, 2010, Pages 1077-1085

  Park, Won Sun ^a   Jung, Won Kyo ^b   Lee, Da Young ^c   Moon, Chisook ^d   Yea, Sung Su ^c   Park, Sae Gwang ^c   Seo, Su Kil ^c   Park, Cheol ^e   Choi, Yung Hyun ^e   Kim, Gi Young ^f   Choi, Jung Sik ^c   Choi, Il Whan ^c  

^a Kangwon National University   (South Korea)

^b Chosun University   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d Inje University College of Medicine   (South Korea)

^e Dong Eui University   (South Korea)

^f Jeju National University   (South Korea)

Author keywords

Cilostazol; Cyclic AMP; Cytokines; Mitogen activated protein kinases; Nuclear factor B; Septic shock

Indexed keywords

CILOSTAZOL; CYCLIC AMP; CYTOKINE; ENDOTOXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; FEMALE; INFLAMMATORY DISEASE; INTERMITTENT CLAUDICATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SHOCK; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLIC AMP; CYTOKINES; FEMALE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; SHOCK, SEPTIC; TETRAZOLES; UP-REGULATION;

EID: 77955923560     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.06.008     Document Type: Article

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