Insight into the binding properties of MEKK3 PB1 to MEK5 PB1 from its solution structure

Biochemistry

Volumn 46, Issue 47, 2007, Pages 13478-13489

  Hu, Qi ^a   Shen, Weiqun ^a   Huang, Hongda ^a   Liu, Jiangxin ^a   Zhang, Jiahai ^a   Huang, Xiaojuan ^a   Wu, Jihui ^a,b   Shi, Yunyu ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROPERTIES; MILLISECOND TIME SCALES; SOLUTION STRUCTURES; STRUCTURAL HETEROGENEITY;

BINDING ENERGY; CONFORMATIONS; MOLECULAR INTERACTIONS; MOLECULAR STRUCTURE; PHOSPHORYLATION;

ENZYME ACTIVITY;

ARGININE DERIVATIVE; GLUTAMINE DERIVATIVE; LEUCINE; LYSINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5 PB1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3 PB1; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; ISOMERIZATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; HELA CELLS; HUMANS; MAP KINASE KINASE 5; MAP KINASE KINASE KINASE 3; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROLINE; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36749044194     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701341n     Document Type: Article

References (44)

1. Ravingerova, T., Barancik, M., and Strniskova, M. (2003) Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology, Mol. Cell. Biochem. 247, 127-138.
2. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo, J. Biol. Chem. 270, 27489-27494.
3. Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Van Dyk, D. E., Pitts, W. J., Earl, R. A., Hobbs, F., Copeland, R. A., Magolda, R. L., Scherle, P. A., and Trzaskos, J. M. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase, J. Biol. Chem. 273, 18623-18632.
4. Johnson, G. L., Dohlman, H. G., and Graves, L. M. (2005) MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression, Curr. Opin. Chem. Biol. 9, 325-331.
5. Zhao, Q., and Lee, F. S. (1999) Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β, J. Biol. Chem. 274, 8355-8358.
6. Huang, Q., Yang, J., Lin, Y., Walker, C., Cheng, J., Liu, Z. G., and Su, B. (2004) Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3, Nat. Immunol. 5, 98-103.
7. Chao, T. H., Hayashi, M., Tapping, R. I., Kato, Y., and Lee, J. D. (1999) MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway, J. Biol. Chem. 274, 36035-36038.
8. Nakamura, K., and Johnson, G. L. (2003) PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway, J. Biol. Chem. 278, 36989-36992.
9. Gao, L., Joberty, G., and Macara, I. G. (2002) Assembly of epithelial tight junctions is negatively regulated by Par6, Curr. Biol. 12, 221-225.
10. Kuribayashi, F., Nunoi, H., Wakamatsu, K., Tsunawaki, S., Sato, K., Ito, T., and Sumimoto, H. (2002) The adaptor protein p40-(phox) as a positive regulator of the superoxide-producing phagocyte oxidase, EMBO J. 21, 6312-6320.
11. Betschinger, J., Mechtler, K., and Knoblich, J. A. (2003) The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl, Nature 422, 326-330.
12. Cai, Y., Yu, F., Lin, S., Chia, W., and Yang, X. (2003) Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions, Cell 112, 51-62.
13. Etienne-Manneville, S., and Hall, A. (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity, Nature 421, 753-756.
14. Hurd, T. W., Gao, L., Roh, M. H., Macara, I. G., and Margolis, B. (2003) Direct interaction of two polarity complexes implicated in epithelial tight junction assembly, Nat. Cell Biol. 5, 137-142.
15. Plant, P. J., Fawcett, J. P., Lin, D. C., Holdorf, A. D., Binns, K., Kulkarni, S., and Pawson, T. (2003) A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl, Nat. Cell Biol. 5, 301-308.
16. Hirano, Y., Yoshinaga, S., Takeya, R., Suzuki, N. N., Horiuchi, M., Kohjima, M., Sumimoto, H., and Inagaki, F. (2005) Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains, J. Biol. Chem. 280, 9653-9661.
17. Honbou, K., Minakami, R., Yuzawa, S., Takeya, R., Suzuki, N. N., Kamakura, S., Sumimoto, H., and Inagaki, F. (2007) Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding, EMBO J. 26, 1176-1186.
18. Iturrioz, X., and Parker, P. J. (2007) PKCzetaII is a target for degradation through the tumour suppressor protein pVHL, FEBS Lett. 581, 1397-1402.
19. Ito, T., Matsui, Y., Ago, T., Ota, K., and Sumimoto, H. (2001) Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions, EMBO J. 20, 3938-3946.
20. Moscat, J., Diaz-Meco, M. T., Albert, A., and Campuzano, S. (2006) Cell signaling and function organized by PB1 domain interactions, Mol. Cell 23, 631-640.
21. Nakamura, K., Uhlik, M. T., Johnson, N. L., Hahn, K. M., and Johnson, G. L. (2006) PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation, Mol. Cell. Biol. 26, 2065-2079.
22. Nakamura, K., and Johnson, G. L. (2007) Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling, Mol. Cell. Biol. 27, 4566-4577.
23. Cornilescu, G., Delaglio, F., and Bax, A. (1999) Protein backbone angle restraints from searching a database for chemical shift and sequence homology, J. Biomol. NMR 13, 289-302.
24. 13C chemical-shift data, J. Biomol. NMR 4, 171-180.
25. Koradi, R., Billeter, M., and Wuthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures, J. Mol. Graphics 14, 51-55.
26. Laskowski, R. A., Rullmann, J. A., MacArthur, M. W., Kaptein, R., and Thornton, J. M. (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR, J. Biomol. NMR 8, 477-486.
27. 15N NMR relaxation, Biochemistry 33, 5984-6003.
28. Cole, R., and Loria, J. P. (2003) FAST-Modelfree: a program for rapid automated analysis of solution NMR spin-relaxation data, J. Biomol. NMR 26, 203-213.
29. Zhou, H., Xu, Y., Yang, Y., Huang, A., Wu, J., and Shi, Y. (2005) Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr, J. Biol. Chem. 280, 13841-13847.
30. Leavitt, S., and Freire, E. (2001) Direct measurement of protein binding energetics by isothermal titration calorimetry, Curr. Opin. Struct. Biol. 11, 560-566.
31. Liang, Y., Du, F., Sanglier, S., Zhou, B. R., Xia, Y., Van Dorsselaer, A., Maechling, C., Kilhoffer, M. C., and Haiech, J. (2003) Unfolding of rabbit muscle creatine kinase induced by acid. A study using electrospray ionization mass spectrometry, isothermal titration calorimetry, and fluorescence spectroscopy, J. Biol. Chem. 278, 30098-30105.
32. 13C chemical shift statistics, J. Biomol. NMR 24, 149-154.
33. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res 22, 4673-4680.
34. Gouet, P., Courcelle, E., Stuart, D. I., and Metoz, F. (1999) ESPript: analysis of multiple sequence alignment in PostScript, Bioinformatics 15, 305-308.
35. Wilmot, C. M., and Thornton, J. M. (1988) Analysis and prediction of the different types of beta-turn in proteins, J. Mol. Biol. 203, 221-232.
36. Lipari, G., and Szabo, A. (1982) Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity, J. Am. Chem. Soc. 104, 4546-4559.
37. Fisher, K. E., Ruan, B., Alexander, P. A., Wang, L., and Bryan, P. N. (2007) Mechanism of the kinetically-controlled folding reaction of subtilisin, Biochemistry 46, 640-651.
38. Brandts, J. F., Halvorson, H. R., and Brennan, M. (1975) Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues, Biochemistry 14, 4953-4963.
39. Wilson, M. I., Gill, D. J., Perisic, O., Quinn, M. T., and Williams, R. L. (2003) PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62, Mol. Cell 12, 39-50.
40. Stewart, D. E., Sarkar, A., and Wampler, J. E. (1990) Occurrence and role of cis peptide bonds in protein structures, J. Mol. Biol. 214, 253-260.
41. Sumimoto, H., Kamakura, S., and Ito, T. (2007) Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants, Sci STKE 2007, re6.
42. Santiveri, C. M., Perez-Canadillas, J. M., Vadivelu, M. K., Allen, M. D., Rutherford, T. J., Watkins, N. A., and Bycroft, M. (2004) NMR structure of the alpha-hemoglobin stabilizing protein: insights into conformational heterogeneity and binding, J. Biol. Chem. 279, 34963-34970.
43. Lummis, S. C., Beene, D. L., Lee, L. W., Lester, H. A., Broadhurst, R. W., and Dougherty, D. A. (2005) Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel, Nature 438, 248-252.
44. Sarkar, P., Reichman, C., Saleh, T., Birge, R. B., and Kalodimos, C. G. (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein, Mol. Cell 25, 413-426.