On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model

Journal of Neurosurgery

Volumn 122, Issue 6, 2015, Pages 1283-1292

  Mangubat, Erwin Z ^a   Kellogg, Robert G ^a   Harris, Timothy J ^a   Rossi, Marvin A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Convection enhanced drug delivery; Deep brain stimulation; Epilepsy; Microfluidic electrode; Neuromodulation; NeuroPace; Responsive neurostimulation; White matter

Indexed keywords

CARBON 14; CARISBAMATE; SODIUM CHLORIDE; ANTICONVULSIVE AGENT; CARBAMIC ACID DERIVATIVE; S-2-O-CARBAMOYL-1-O-CHLOROPHENYL-ETHANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN DEPTH STIMULATION; BRAIN TISSUE; CLOSED LOOP DIRECT NEUROSTIMULATION THERAPY; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DENTATE GYRUS; DEPTH ELECTRODE; DRUG DELIVERY DEVICE; ELECTROCORTICOGRAPHY; ELECTRODE IMPLANTATION; EPILEPTIC STATE; FOCAL EPILEPSY; HIPPOCAMPUS; MALE; MICROCATHETER; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT MODEL; SPONTANEOUS SELF SUSTAINED LIMBIC STATUS EPILEPTICUS; THERMODYNAMICS; WHITE MATTER; ANIMAL; DISEASE MODEL; ELECTROSTIMULATION THERAPY; EPILEPSIES, PARTIAL; FISCHER 344 RAT; MULTIMODALITY CANCER THERAPY; TREATMENT OUTCOME;

ANIMALS; ANTICONVULSANTS; CARBAMATES; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION THERAPY; EPILEPSIES, PARTIAL; MALE; RATS; RATS, INBRED F344; TREATMENT OUTCOME;

EID: 84938528181     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2015.1.JNS14946     Document Type: Article

References (42)

1. Amaral DG, Witter MP: The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31:571-591, 1989
2. Andermann E, Andermann F, Meyvisch P, Vandendriessche A, Schiemann Delgado J: Antiepileptic drugs: all ages. Epilepsia 46 (Suppl s8):205-222, 2005
3. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH: Convection-enhanced delivery of macromole cules in the brain. Proc Natl Acad Sci U S A 91:2076-2080, 1994
4. Chen MY, Lonser RR, Morrison PF, Governale LS, Oldfield EH: Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of influsion, cannula size, infusate concentration, and tissue-cannula sealing time. J Neurosurg 90:315-320, 1999
5. Devinsky O: Patients with refractory seizures. N Engl J Med 340:1565-1570, 1999
6. Gasior M, White NA, Rogawski MA: Prolonged attenuation of amygdala-kindled seizure measures in rats by convection enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA. J Pharmacol Exp Ther 323:458-468, 2007
7. Grabenstatter HL, Ferraro DJ, Williams PA, Chapman PL, Dudek FE: Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy. Epilepsia 46:8-14, 2005
8. 14C-sucrose delivery to the brain by intravenous, intraventricular, and convection enhanced intracerebral infusion. J Neurosurg 90:321-331, 1999
9. Hasulak N, Breeden M, Nathwani N, Wang C, Saghyan A, Skarpaas T, et al: Continuous video/EEG system with closed loop stimulation for rat models of epilepsy. Presented at the 65th annual meeting American Epilepsy Society, Baltimore, MD, 2011 (Abstract) (https://www.aesnet.org/meetings-events/annual-meeting-abstracts/view/15096) [Accessed January 12, 2015]
10. Inoue T, Yamashita Y, Nishihara M, Sugiyama S, Sonoda Y, Kumabe T, et al: Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models. Neuro Oncol 11:151-157, 2009
11. Ivanchenko O, Sindhwani N, Linninger AA: Exact solution of the diffusion-convection equation in cylindrical geometry. AIChE J 58:1299-1302, 2012
12. Krauze MT, Mcknight TR, Yamashita Y, Bringas J, Noble CO, Saito R, et al: Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc 16:20-26, 2005
13. Kwan P, Brodie MJ: Early identification of refractory epilepsy. N Engl J Med 342:314-319, 2000
14. Levy RH, Mattson RH, Meldrum BS, Perucca E (eds): Antiepileptic Drugs, ed 5. Philadelphia: Lippincott Williams & Wilkins, 2002
15. Litt B, Echauz J: Prediction of epileptic seizures. Lancet Neurol 1:22-30, 2002
16. Lonser RR, Corthésy ME, Morrison PF, Gogate N, Oldfield EH: Convection-enhanced selective excitotoxic ablation of the neurons of the globus pallidus internus for treatment of parkinsonism in nonhuman primates. J Neurosurg 91:294-302, 1999
17. Lonser RR, Walbridge S, Garmestani K, Butman JA, Walters HA, Vortmeyer AO, et al: Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion. J Neurosurg 97:905-913, 2002
18. Löscher W, Schmidt D: Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 52:657-678, 2011
19. Lothman EW, Bertram EH, Bekenstein JW, Perlin JB: Self sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation: electrographic and behavioral characteristics. Epilepsy Res 3:107-119, 1989
20. Mangubat E, Rossi M: On-demand pulsatile intracerebral delivery of carisbamate concurrent with closed-loop direct neurostimulation therapy in a self-sustained limbic status epilepticus (SSLSE) rat model. Presented at the 64th annual meeting of the American Epilepsy Society, San Antonio, TX, 2010 (Abstract) (https://www.aesnet.org/meetings-events/annual-meeting-abstracts/view/13076) [Accessed January 12, 2015]
21. Mardor Y, Last D, Daniels D, Shneor R, Maier SE, Nass D, et al: Convection-enhanced drug delivery of interleukin-4 Pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring. J Pharmacol Exp Ther 330:520-525, 2009
22. Mazarati AM, Wasterlain CG, Sankar R, Shin D: Self-sustaining status epilepticus after brief electrical stimulation of the perforant path. Brain Res 801:251-253, 1998
23. Mormann F, Andrzejak RG, Elger CE, Lehnertz K: Seizure prediction: the long and winding road. Brain 130:314-333, 2007
24. Morrell M: Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures? Curr Opin Neurol 19:164-168, 2006
25. Morrell MJ: Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology 77:1295-1304, 2011
26. Morrison PF, Laske DW, Bobo H, Oldfield EH, Dedrick RL: High-flow microinfusion: tissue penetration and pharmaco dynamics. Am J Physiol 266:R292-R305, 1994
27. Nilsen KE, Cock HR: Focal treatment for refractory epilepsy: hope for the future? Brain Res Brain Res Rev 44:141-153, 2004
28. Occhiogrosso G, Edgar MA, Sandberg DI, Souweidane MM: Prolonged convection-enhanced delivery into the rat brain stem. Neurosurgery 52:388-394, 2003
29. Ono T, Moshé SL, Galanopoulou AS: Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. Epilepsia 52:1678-1684, 2011
30. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, ed 4. London: Academic Press, 1998
31. Racine RJ: Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294, 1972
32. Raghunathan S, Gupta SK, Ward M P, Worth RM, Roy K, Irazoqui PP: The design and hardware implementation of a low-power real-time seizure detection algorithm. J Neural Eng 6:056005 2009
33. Rogawski MA: Convection-enhanced delivery in the treatment of epilepsy. Neurotherapeutics 6:344-351, 2009
34. Rossi MA: Targeting anti-epileptic drug therapy without collateral damage: nanocarrier-based drug delivery. Epilepsy Curr 12:199-200, 2012
35. Rossi MA, Stebbins G, Murphy C, Greene D, Brinker S, Sarcu D, et al: Predicting white matter targets for direct neurostimulation therapy. Epilepsy Res 91:176-186, 2010
36. Saito R, Krauze MT, Noble CO, Tamas M, Drummond DC, Kirpotin DB, et al: Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery. J Neurosci Methods 154:225-232, 2006
37. Sindhwani N, Ivanchenko O, Lueshen E, Prem K, Linninger AA: Methods for determining agent concentration profiles in agarose gel during convection-enhanced delivery. IEEE Trans Biomed Eng 58:626-632, 2011
38. Srivastava AK, White HS: Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats. Epilepsy Res 104:26-34, 2013
39. Van Dycke A, Raedt R, Dauwe I, Sante T, Wyckhuys T, Meurs A, et al: Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures. Epilepsia 51:1721-1728, 2010
40. White E, Bienemann A, Malone J, Megraw L, Bunnun C, Wyatt M, et al: An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery. J Neurosci Methods 199:87-97, 2011
41. White G, Levy WB, Steward O: Evidence that associative interactions between synapses during the induction of longterm potentiation occur within local dendritic domains. Proc Natl Acad Sci U S A 85:2368-2372, 1988
42. Wyckhuys T, Boon P, Raedt R, Van Nieuwenhuyse B, Vonck K, Wadman W: Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation. Epilepsia 51:2297-2304, 2010