Convection-enhanced selective excitotoxic ablation of the neurons of the globus pallidus internus for treatment of parkinsonism in nonhuman primates

Journal of Neurosurgery

Volumn 91, Issue 2, 1999, Pages 294-302

  Lonser, Russell R ^a,b   Corthésy, Marc Etienne ^a   Morrison, Paul F ^a   Gogate, Nitin ^a   Oldfield, Edward H ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Bulk flow; Convection; Drug delivery; Macaca mulatta; Parkinson's disease; Quinolinic acid

Indexed keywords

EXCITOTOXIN; QUINOLINIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SELECTIVITY; GLOBUS PALLIDUS; HISTOPATHOLOGY; INTRACEREBRAL DRUG ADMINISTRATION; MACACA; NONHUMAN; PALLIDOTOMY; PARKINSONISM; PRIORITY JOURNAL; SCORING SYSTEM; SYMPTOM; TREATMENT OUTCOME;

EID: 0344642605     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1999.91.2.0294     Document Type: Article

References (43)

1. Albin RL, Makowiec RL, Hollingsworth ZR, et al: Excitatory amino acid binding sites in the basal ganglia of the rat: a quantitative autoradiographic study. Neuroscience 46:35-48, 1991
2. Albin RL, Young AB, Penney JB: The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375, 1989
3. Alexander GE, Crutcher MD: Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13:266-271, 1990
4. Bankiewicz KS, Oldfield EH, Chiueh CC, et al: Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci 39:7-16, 1986
5. Baron MS, Vitek JL, Bakay RAE, et al: Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol 40:355-366, 1996
6. Beagles KE, Morrison PF, Heyes MP: Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis. J Neurochem 70:281-291, 1998
7. Bergman H, Wichmann T, DeLong MR: Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 249:1436-1438, 1990
8. Biousse V, Newman NJ, Carroll C, et al: Visual fields in patients with posterior GPi pallidotomy. Neurology 50:258-265, 1998
9. Blasberg RG, Patlak C, Fenstermacher JD: Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J Pharmacol Exp Ther 195:73-83, 1975
10. Bobo RH, Laske DW, Akbasak A, et al: Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91:2076-2080, 1994
11. Burns RS, Chiueh CC, Markey SP, et al: A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80:4546-4550, 1983
12. Ceballos-Baumann AO, Obeso JA, Vitek JL, et al: Restoration of thalamocortical activity after posteroventral pallidotomy in Parkinson's disease. Lancet 344:814, 1994 (Letter)
13. Colburn TR, Smith BA, Guarini JJ, et al: An ambulatory activity monitor with solid state memory. ISA Trans 15:149-154, 1976
14. Crossman AR, Peggs D, Boyce S, et al: Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey. Neuropharmacology 28:1271-1273, 1989
15. DeLong MR: Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13:281-285, 1990
16. Dykstra KH, Hsaio JK, Morrison PF, et al: Quantitative examination of tissue concentration profiles associated with microdialysis. J Neurochem 58:931-940, 1992
17. Ehringer H, Homykiewicz O: [Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system.] Klin Wochenschr 38:1236-1239, 1960 (Ger)
18. Foster AC, Zinkand WC, Schwarcz R: Quinolinic acid phosphoribosyltransferase in rat brain. J Neurochem 44:446-454, 1985
19. Fukui S, Schwarcz R, Rapoport SI, et al: Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 56:2007-2017, 1991
20. Graybiel AM: Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 13:244-254, 1990
21. Heyes MP, Markey SP: Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations. Anal Biochem 174:349-359, 1988
22. Heyes MP, Morrison PF: Quantification of local de novo synthesis versus blood contributions to quinolinic acid concentrations in brain and systemic tissues. J Neurochem 68:280-288, 1997
23. Heyes MP, Saito K, Crowley JS, et al: Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain 115:1249-1273, 1992
24. Krack P, Pollak P, Limousin P, et al: Opposite motor effects of pallidal stimulation in Parkinson's disease. Ann Neurol 43: 180-192, 1998
25. Kurlan R, Kim MH, Gash DM: Oral levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys: assessment with a new rating scale for monkey parkinsonism. Mov Disord 6:111-118, 1991
26. Laitinen LV, Bergenheim AT, Hariz MI: Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J Neurosurg 76:53-61, 1992
27. Lang AE, Lozano AM, Montgomery E, et al: Posteroventral medial pallidotomy in advanced Parkinson's disease. N Engl J Med 337:1036-1042, 1997
28. Langer R: New methods of drug delivery. Science 249: 1527-1533, 1990
29. Langer R, Folkman J: Polymers for the sustained release of proteins and other macromolecules. Nature 263:797-800, 1976
30. Laske DW, Morrison PF, Lieberman DM, et al: Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging. J Neurosurg 87:586-594, 1997
31. Lieberman DM, Corthesy ME, Cummins A, et al: Reversal of experimental parkinsonism by using selective chemical ablation of the medial globus pallidus. J Neurosurg 90:928-934, 1999
32. Lieberman DM, Laske DW, Morrison PF, et al: Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82:1021-1029, 1995
33. Lim JY, De Salles AAF, Bronstein J, et al: Delayed internal capsule infarctions following radiofrequency pallidotomy. Report of three cases. J Neurosurg 87:955-960, 1997
34. Marsden CD: Parkinson's disease. Lancet 335:948-952, 1990
35. Marsden CD, Parkes JD: "On-off ' effects in patients with Parkinson's disease on chronic levodopa therapy. Lancet 1: 292-296, 1976
36. Marsden CD, Parkes JD: Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1:345-349, 1977
37. McDowell F: Parkinson's disease and related disorders, in Hazard W, Bierman E, Blass J, et al (eds): Principles of Geriatric Medicine and Gerontology. New York: McGraw Hill, 1994, pp 1051-1061
38. Morrison PF, Laske DW, Bobo H, et al: High-flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 266:R292-R305, 1994
39. Pardridge WM: Brain drug delivery and blood-brain barrier transport. Drug Delivery 3:99-115, 1996
40. Patlak CS, Fenstermacher JD: Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion. Am J Physiol 229:877-884, 1975
41. Vezzani A, Forloni GL, Serafini R, et al: Neurogenerative effects induced by chronic infusion of quinolinic acid in rat striatum and hippocampus. Eur J Neurosci 3:40-46, 1991
42. Vitek JL: Stereotaxic surgery and deep brain stimulation for Parkinson's disease and movement disorders, in Watts RL, Koller WC (eds): Movement Disorders: Neurologic Principles and Practice. New York: McGraw-Hill, 1997, pp 237-254
43. Zirzow GC, Sanchez OA, Murray GJ, et al: Delivery, distribution, and neuronal uptake of the exogenous mannose-terminal glucocerebrosidase in the intact rat brain. Neurochem Res 24:301-305, 1999