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Volumn 59, Issue 2, 2015, Pages 163-177

Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology

Author keywords

Alzheimer's disease; melatonin; neurodegeneration; neuroinflammation; neuroplasticity; OXYS rats; synapse

Indexed keywords

MELATONIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I; AMYLOID BETA PROTEIN;

EID: 84938416838     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12248     Document Type: Article
Times cited : (69)

References (77)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe DJ,. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001; 81: 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ,. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 3
    • 20844458090 scopus 로고    scopus 로고
    • Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    • Lacor PN, Buniel MC, Chang L, et al., Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 2004; 24: 10191-10200.
    • (2004) J Neurosci , vol.24 , pp. 10191-10200
    • Lacor, P.N.1    Buniel, M.C.2    Chang, L.3
  • 4
    • 77953953898 scopus 로고    scopus 로고
    • Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    • Choi SH, Bosetti F,. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging 2009; 1: 234-244.
    • (2009) Aging , vol.1 , pp. 234-244
    • Choi, S.H.1    Bosetti, F.2
  • 5
    • 77956635942 scopus 로고    scopus 로고
    • Mitochondrial superoxide: a key player in Alzheimer's disease
    • Massaad CA, Pautler RG, Klann E,. Mitochondrial superoxide: a key player in Alzheimer's disease. Aging 2009; 1: 758-761.
    • (2009) Aging , vol.1 , pp. 758-761
    • Massaad, C.A.1    Pautler, R.G.2    Klann, E.3
  • 6
    • 84055213663 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis and its role in Alzheimer's disease
    • Mu YL, Gage FH,. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 2011; 6: 85.
    • (2011) Mol Neurodegener , vol.6 , pp. 85
    • Mu, Y.L.1    Gage, F.H.2
  • 7
    • 24644443839 scopus 로고    scopus 로고
    • Oxidative stress: the old enemy in Alzheimer's disease pathophysiology
    • Moreira PI, Honda K, Liu Q, et al., Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr Alzheimer Res 2005; 2: 403-408.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 403-408
    • Moreira, P.I.1    Honda, K.2    Liu, Q.3
  • 9
    • 84871922036 scopus 로고    scopus 로고
    • Deciphering the mechanism underlying late-onset Alzheimer disease
    • Krstic D, Knuesel I,. Deciphering the mechanism underlying late-onset Alzheimer disease. Nat Rev Neurol 2013; 9: 25-34.
    • (2013) Nat Rev Neurol , vol.9 , pp. 25-34
    • Krstic, D.1    Knuesel, I.2
  • 10
    • 84899639780 scopus 로고    scopus 로고
    • The amyloid hypothesis, time to move on: amyloid is the downstream result, not cause, of Alzheimer's disease
    • Drachman DA,. The amyloid hypothesis, time to move on: amyloid is the downstream result, not cause, of Alzheimer's disease. Alzheimers Dement 2014; 3: 372-380.
    • (2014) Alzheimers Dement , vol.3 , pp. 372-380
    • Drachman, D.A.1
  • 11
    • 84899835214 scopus 로고    scopus 로고
    • Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease
    • Shinohara M, Fujioka S, Murray ME, et al., Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain 2014; 137: 1533-1549.
    • (2014) Brain , vol.137 , pp. 1533-1549
    • Shinohara, M.1    Fujioka, S.2    Murray, M.E.3
  • 12
    • 84901036009 scopus 로고    scopus 로고
    • The intersection of amyloid beta and tau at synapses in Alzheimer's disease
    • Spires-Jones TL, Hyman BT,. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron 2014; 82: 756-771.
    • (2014) Neuron , vol.82 , pp. 756-771
    • Spires-Jones, T.L.1    Hyman, B.T.2
  • 13
    • 84856454190 scopus 로고    scopus 로고
    • Trans-synaptic spread of tau pathology in vivo
    • Liu L, Drouet V, Wu JW, et al., Trans-synaptic spread of tau pathology in vivo. PLoS ONE 2012; 7: e31302.
    • (2012) PLoS ONE , vol.7 , pp. e31302
    • Liu, L.1    Drouet, V.2    Wu, J.W.3
  • 14
    • 84856718797 scopus 로고    scopus 로고
    • Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin
    • Rosales-Corral SA, Acuna-Castroviejo D, Coto-Montes A, et al., Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin. J Pineal Res 2012; 52: 167-202.
    • (2012) J Pineal Res , vol.52 , pp. 167-202
    • Rosales-Corral, S.A.1    Acuna-Castroviejo, D.2    Coto-Montes, A.3
  • 15
    • 84885640190 scopus 로고    scopus 로고
    • Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
    • Hardeland R,. Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms. J Pineal Res 2013; 55: 325-356.
    • (2013) J Pineal Res , vol.55 , pp. 325-356
    • Hardeland, R.1
  • 16
    • 84904506620 scopus 로고    scopus 로고
    • Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs
    • Herrera EA, MacChiavello R, Montt C, et al., Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs. J Pineal Res 2014; 57: 33-42.
    • (2014) J Pineal Res , vol.57 , pp. 33-42
    • Herrera, E.A.1    Macchiavello, R.2    Montt, C.3
  • 17
    • 84936077755 scopus 로고    scopus 로고
    • Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces
    • Reiter RJ, Tan DX, Kim SJ, et al., Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin perivascular spaces. Brain Struct Funct 2014; 219: 1873-1887.
    • (2014) Brain Struct Funct , vol.219 , pp. 1873-1887
    • Reiter, R.J.1    Tan, D.X.2    Kim, S.J.3
  • 18
    • 84858439689 scopus 로고    scopus 로고
    • Melatonin: both master clock output and internal time-giver in the circadian clocks network
    • Pevet P, Challet E,. Melatonin: both master clock output and internal time-giver in the circadian clocks network. J Physiol Paris 2011; 105: 170-182.
    • (2011) J Physiol Paris , vol.105 , pp. 170-182
    • Pevet, P.1    Challet, E.2
  • 19
    • 84885185579 scopus 로고    scopus 로고
    • The role of melatonin in the cells of the innate immunity: a review
    • Calvo JR, Gonzalez-Yanes C, Maldonado MD,. The role of melatonin in the cells of the innate immunity: a review. J Pineal Res 2013; 55: 103-120.
    • (2013) J Pineal Res , vol.55 , pp. 103-120
    • Calvo, J.R.1    Gonzalez-Yanes, C.2    Maldonado, M.D.3
  • 20
    • 84899439162 scopus 로고    scopus 로고
    • A review of metal-catalyzed molecular damage: protection by melatonin
    • Romero A, Ramos E, De Los Rios C, et al., A review of metal-catalyzed molecular damage: protection by melatonin. J Pineal Res 2014; 56: 343-370.
    • (2014) J Pineal Res , vol.56 , pp. 343-370
    • Romero, A.1    Ramos, E.2    De Los Rios, C.3
  • 21
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    • Galano A, Tan DX, Reiter RJ,. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54: 245-257.
    • (2013) J Pineal Res , vol.54 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 22
    • 84925835510 scopus 로고    scopus 로고
    • Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
    • Zhang HM, Zhang Y,. Melatonin: a well-documented antioxidant with conditional pro-oxidant actions. J Pineal Res 2014; 57: 131-146.
    • (2014) J Pineal Res , vol.57 , pp. 131-146
    • Zhang, H.M.1    Zhang, Y.2
  • 23
    • 84880118137 scopus 로고    scopus 로고
    • Melatonin in Alzheimer's disease
    • Lin L, Huang QX, Yang SS, et al., Melatonin in Alzheimer's disease. Int J Mol Sci 2013; 14: 14575-14593.
    • (2013) Int J Mol Sci , vol.14 , pp. 14575-14593
    • Lin, L.1    Huang, Q.X.2    Yang, S.S.3
  • 24
    • 78549284583 scopus 로고    scopus 로고
    • Clinical aspects of melatonin intervention in Alzheimer's disease progression
    • Cardinali DP, Furio AM, Brusco LI,. Clinical aspects of melatonin intervention in Alzheimer's disease progression. Curr Neuropharmacol 2010; 8: 218-227.
    • (2010) Curr Neuropharmacol , vol.8 , pp. 218-227
    • Cardinali, D.P.1    Furio, A.M.2    Brusco, L.I.3
  • 25
    • 84925546092 scopus 로고    scopus 로고
    • The senescence-accelerated oxys rats-a genetic model of premature aging and age-dependent degenerative diseases
    • Kolosova NG, Stefanova NA, Kolbolina EE, et al., The senescence-accelerated oxys rats-a genetic model of premature aging and age-dependent degenerative diseases. Adv Gerontol 2014; 27: 336-340.
    • (2014) Adv Gerontol , vol.27 , pp. 336-340
    • Kolosova, N.G.1    Stefanova, N.A.2    Kolbolina, E.E.3
  • 26
    • 77957336568 scopus 로고    scopus 로고
    • Behavioral effects induced by mitochondria-targeted antioxidant SkQ1 in Wistar and senescence-accelerated OXYS rats
    • Stefanova NA, Fursova AZ, Kolosova NG,. Behavioral effects induced by mitochondria-targeted antioxidant SkQ1 in Wistar and senescence-accelerated OXYS rats. J Alzheimers Dis 2010; 21: 479-491.
    • (2010) J Alzheimers Dis , vol.21 , pp. 479-491
    • Stefanova, N.A.1    Fursova, A.Z.2    Kolosova, N.G.3
  • 27
    • 81255157452 scopus 로고    scopus 로고
    • Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats
    • Stefanova NA, Fursova AZH, Sarsenbaev KN, et al., Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats. J Ethnopharmacol 2011; 138: 624-632.
    • (2011) J Ethnopharmacol , vol.138 , pp. 624-632
    • Stefanova, N.A.1    Fursova, A.Z.H.2    Sarsenbaev, K.N.3
  • 28
    • 84898000916 scopus 로고    scopus 로고
    • Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease
    • Stefanova NA, Kozhevnikova OS, Vitovtov AO, et al., Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle 2014; 13: 898-909.
    • (2014) Cell Cycle , vol.13 , pp. 898-909
    • Stefanova, N.A.1    Kozhevnikova, O.S.2    Vitovtov, A.O.3
  • 29
    • 84889684332 scopus 로고    scopus 로고
    • Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1
    • Stefanova NA, Muraleva NA, Skulachev VP, et al., Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1. J Alzheimers Dis 2014; 38: 681-694.
    • (2014) J Alzheimers Dis , vol.38 , pp. 681-694
    • Stefanova, N.A.1    Muraleva, N.A.2    Skulachev, V.P.3
  • 30
    • 84922732740 scopus 로고    scopus 로고
    • Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats
    • Stefanova NA, Muraleva NA, Korbolina EE, et al., Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats. Oncotarget 2015; 6: 1396-1413.
    • (2015) Oncotarget , vol.6 , pp. 1396-1413
    • Stefanova, N.A.1    Muraleva, N.A.2    Korbolina, E.E.3
  • 31
    • 79955798781 scopus 로고    scopus 로고
    • Effect of malate on the development of rotenone-induced brain changes in Wistar and OXYS rats: an MRI study
    • Kolosova NG, Akulov AE, Stefanova NA, et al., Effect of malate on the development of rotenone-induced brain changes in Wistar and OXYS rats: an MRI study. Dokl Biol Sci 2011; 437: 72-75.
    • (2011) Dokl Biol Sci , vol.437 , pp. 72-75
    • Kolosova, N.G.1    Akulov, A.E.2    Stefanova, N.A.3
  • 32
    • 84938414709 scopus 로고    scopus 로고
    • Beneficial effects of melatonin in a rat model of sporadic Alzheimer's disease
    • Rudnitskaya EA, Maksimova KY, Muraleva NA, et al., Beneficial effects of melatonin in a rat model of sporadic Alzheimer's disease. Biogerontology 2015; 16: 303-316.
    • (2015) Biogerontology , vol.16 , pp. 303-316
    • Rudnitskaya, E.A.1    Maksimova, K.Y.2    Muraleva, N.A.3
  • 34
    • 0019440757 scopus 로고
    • Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading
    • Brun A, Englund E,. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading. Histopathology 1981; 5: 549-564.
    • (1981) Histopathology , vol.5 , pp. 549-564
    • Brun, A.1    Englund, E.2
  • 35
    • 84875640007 scopus 로고    scopus 로고
    • Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease
    • Wright AL, Zinn R, Hohensinn B, et al., Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease. PLoS ONE 2013; 8: e59586.
    • (2013) PLoS ONE , vol.8
    • Wright, A.L.1    Zinn, R.2    Hohensinn, B.3
  • 36
  • 37
    • 84857275902 scopus 로고    scopus 로고
    • Propagation of tau pathology in a model of early Alzheimer's disease
    • De Calignon A, Polydoro M, Suarez-Calvet M, et al., Propagation of tau pathology in a model of early Alzheimer's disease. Neuron 2012; 73: 685-697.
    • (2012) Neuron , vol.73 , pp. 685-697
    • De Calignon, A.1    Polydoro, M.2    Suarez-Calvet, M.3
  • 38
    • 7244223228 scopus 로고    scopus 로고
    • Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    • Gylys KH, Fein JA, Yang F, et al., Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol 2004; 165: 1809-1817.
    • (2004) Am J Pathol , vol.165 , pp. 1809-1817
    • Gylys, K.H.1    Fein, J.A.2    Yang, F.3
  • 39
    • 84897954510 scopus 로고    scopus 로고
    • Is synaptic loss a unique hallmark of Alzheimer's disease?
    • Scheff SW, Neltner JH, Nelson PT,. Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol 2014; 88: 517-528.
    • (2014) Biochem Pharmacol , vol.88 , pp. 517-528
    • Scheff, S.W.1    Neltner, J.H.2    Nelson, P.T.3
  • 40
    • 34247611481 scopus 로고    scopus 로고
    • Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    • Scheff SW, Price DA, Schmitt FA, et al., Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 2007; 68: 1501-1508.
    • (2007) Neurology , vol.68 , pp. 1501-1508
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3
  • 41
    • 0344672942 scopus 로고    scopus 로고
    • APP processing and synaptic function
    • Kamenetz F, Tomita T, Hsieh H, et al., APP processing and synaptic function. Neuron 2003; 37: 925-937.
    • (2003) Neuron , vol.37 , pp. 925-937
    • Kamenetz, F.1    Tomita, T.2    Hsieh, H.3
  • 42
    • 29144487182 scopus 로고    scopus 로고
    • Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
    • Cirrito JR, Yamada KA, Finn MB, et al., Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 2005; 48: 913-922.
    • (2005) Neuron , vol.48 , pp. 913-922
    • Cirrito, J.R.1    Yamada, K.A.2    Finn, M.B.3
  • 43
    • 77953019895 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease
    • Gouras GK, Tampellini D, Takahashi RH, et al., Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol 2010; 119: 523-541.
    • (2010) Acta Neuropathol , vol.119 , pp. 523-541
    • Gouras, G.K.1    Tampellini, D.2    Takahashi, R.H.3
  • 44
    • 84881546833 scopus 로고    scopus 로고
    • The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease
    • Crimins JL, Pooler A, Polydoro M, et al., The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Res Rev 2013; 12: 757-763.
    • (2013) Ageing Res Rev , vol.12 , pp. 757-763
    • Crimins, J.L.1    Pooler, A.2    Polydoro, M.3
  • 45
    • 0034733799 scopus 로고    scopus 로고
    • Tau aggregation into fibrillar polymers: taupathies
    • Avila J,. Tau aggregation into fibrillar polymers: taupathies. FEBS Lett 2000; 476: 82-92.
    • (2000) FEBS Lett , vol.476 , pp. 82-92
    • Avila, J.1
  • 46
    • 0033782845 scopus 로고    scopus 로고
    • Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease
    • Zhu X, Rottkamp CA, Boux H, et al., Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 2000; 59: 880-888.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 880-888
    • Zhu, X.1    Rottkamp, C.A.2    Boux, H.3
  • 47
    • 0345701340 scopus 로고    scopus 로고
    • Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells
    • 42
    • Gomez-Ramos A, Diaz-Nido J, Smith MA, et al., Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. J Neurosci Res 2003; 71: 863-870. 42
    • (2003) J Neurosci Res , vol.71 , pp. 863-870
    • Gomez-Ramos, A.1    Diaz-Nido, J.2    Smith, M.A.3
  • 48
    • 12844250694 scopus 로고    scopus 로고
    • Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3
    • Lovell MA, Xiong S, XIE C, et al., Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. J Alzheimers Dis 2004; 6: 659-671.
    • (2004) J Alzheimers Dis , vol.6 , pp. 659-671
    • Lovell, M.A.1    Xiong, S.2    Xie, C.3
  • 49
    • 84862693569 scopus 로고    scopus 로고
    • Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
    • Krstic D, Madhusudan A, Doehner J, et al., Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation 2012; 9: 151.
    • (2012) J Neuroinflammation , vol.9 , pp. 151
    • Krstic, D.1    Madhusudan, A.2    Doehner, J.3
  • 50
    • 79960032374 scopus 로고    scopus 로고
    • Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    • Kanaan NM, Morfini GA, Lapointe NE, et al., Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci 2011; 31: 9858-9868.
    • (2011) J Neurosci , vol.31 , pp. 9858-9868
    • Kanaan, N.M.1    Morfini, G.A.2    Lapointe, N.E.3
  • 51
    • 40449093880 scopus 로고    scopus 로고
    • Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching
    • Shemesh OA, Erez H, Ginzburg I, et al., Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Traffic 2008; 9: 458-471.
    • (2008) Traffic , vol.9 , pp. 458-471
    • Shemesh, O.A.1    Erez, H.2    Ginzburg, I.3
  • 52
    • 84857073309 scopus 로고    scopus 로고
    • Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease
    • Shahpasand K, Uemura I, Saito T, et al., Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. J Neurosci 2012; 32: 2430-2441.
    • (2012) J Neurosci , vol.32 , pp. 2430-2441
    • Shahpasand, K.1    Uemura, I.2    Saito, T.3
  • 53
    • 0034930671 scopus 로고    scopus 로고
    • Free radical-mediated molecular damage: mechanisms for the protective actions of melatonin in the central nervous system
    • Reiter RJ, Acuna-Castroviejo D, Tan DX, et al., Free radical-mediated molecular damage: mechanisms for the protective actions of melatonin in the central nervous system. Ann NY Acad Sci 2001; 939: 200-215.
    • (2001) Ann NY Acad Sci , vol.939 , pp. 200-215
    • Reiter, R.J.1    Acuna-Castroviejo, D.2    Tan, D.X.3
  • 54
    • 30144433689 scopus 로고    scopus 로고
    • Role of melatonin in Alzheimer-like neurodegeneration
    • Wang JZ, Wang ZF,. Role of melatonin in Alzheimer-like neurodegeneration. Acta Pharmacol Sin 2006; 27: 41-49.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 41-49
    • Wang, J.Z.1    Wang, Z.F.2
  • 55
    • 17544375586 scopus 로고    scopus 로고
    • The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway
    • Schuster C, Williams LM, Morris A, et al., The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol 2005; 17: 170-178.
    • (2005) J Neuroendocrinol , vol.17 , pp. 170-178
    • Schuster, C.1    Williams, L.M.2    Morris, A.3
  • 56
    • 0036720357 scopus 로고    scopus 로고
    • Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1
    • Peschke E, Muhlbauer E, Musshoff U, et al., Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1. J Pineal Res 2002; 33: 63-71.
    • (2002) J Pineal Res , vol.33 , pp. 63-71
    • Peschke, E.1    Muhlbauer, E.2    Musshoff, U.3
  • 57
    • 84919674973 scopus 로고    scopus 로고
    • Liposomal melatonin rescues methamphetamine-elicited mitochondrial burdens, pro-apoptosis, and dopaminergic degeneration through the inhibition PKCδ gene
    • Nguyen XKT, Lee J, Shin EJ, et al., Liposomal melatonin rescues methamphetamine-elicited mitochondrial burdens, pro-apoptosis, and dopaminergic degeneration through the inhibition PKCδ gene. J Pineal Res 2015; 58: 86-106.
    • (2015) J Pineal Res , vol.58 , pp. 86-106
    • Nguyen, X.K.T.1    Lee, J.2    Shin, E.J.3
  • 58
    • 0038045434 scopus 로고    scopus 로고
    • Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells
    • Rivera-Bermudez MA, Gerdin MJ, Earnest DJ, et al., Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells. Neurosci Lett 2003; 346: 37-40.
    • (2003) Neurosci Lett , vol.346 , pp. 37-40
    • Rivera-Bermudez, M.A.1    Gerdin, M.J.2    Earnest, D.J.3
  • 59
    • 84890114613 scopus 로고    scopus 로고
    • Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism
    • Tian Y, Yabuki Y, Moriguchi S, et al., Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism. J Pineal Res 2014; 56: 1-11.
    • (2014) J Pineal Res , vol.56 , pp. 1-11
    • Tian, Y.1    Yabuki, Y.2    Moriguchi, S.3
  • 60
    • 33645099807 scopus 로고    scopus 로고
    • Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins
    • Rimler A, Jockers R, Lupowitz Z, et al., Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins. J Pineal Res 2006; 40: 144-152.
    • (2006) J Pineal Res , vol.40 , pp. 144-152
    • Rimler, A.1    Jockers, R.2    Lupowitz, Z.3
  • 61
    • 84921488132 scopus 로고    scopus 로고
    • Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex
    • Domínguez-Alonso A, Valdés-Tovar M, Solís-Chagoyán H, et al., Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex. Int J Mol Sci 2015; 16: 1907-1927.
    • (2015) Int J Mol Sci , vol.16 , pp. 1907-1927
    • Domínguez-Alonso, A.1    Valdés-Tovar, M.2    Solís-Chagoyán, H.3
  • 62
    • 33746560617 scopus 로고    scopus 로고
    • Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
    • Yin J, Liu YH, Xu YF, et al., Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. J Pineal Res 2006; 41: 124-129.
    • (2006) J Pineal Res , vol.41 , pp. 124-129
    • Yin, J.1    Liu, Y.H.2    Xu, Y.F.3
  • 63
    • 0037565622 scopus 로고    scopus 로고
    • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
    • Matsubara E, Bryant-Thomas T, Pacheco Quinto J, et al., Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J Neurochem 2003; 85: 1101-1108.
    • (2003) J Neurochem , vol.85 , pp. 1101-1108
    • Matsubara, E.1    Bryant-Thomas, T.2    Pacheco Quinto, J.3
  • 64
    • 14944341045 scopus 로고    scopus 로고
    • Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials
    • Quinn J, Kulhanek D, Nowlin J, et al., Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials. Brain Res 2005; 1037: 209-213.
    • (2005) Brain Res , vol.1037 , pp. 209-213
    • Quinn, J.1    Kulhanek, D.2    Nowlin, J.3
  • 65
    • 0032571381 scopus 로고    scopus 로고
    • Inhibition of Alzheimer beta-fibrillogenesis by melatonin
    • Pappolla M, Bozner P, Soto C, et al., Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem 1998; 273: 7185-7188.
    • (1998) J Biol Chem , vol.273 , pp. 7185-7188
    • Pappolla, M.1    Bozner, P.2    Soto, C.3
  • 66
    • 0035846613 scopus 로고    scopus 로고
    • Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide
    • Poeggeler B, Miravalle L, Zagorski MG, et al., Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry 2001; 40: 14995-15001.
    • (2001) Biochemistry , vol.40 , pp. 14995-15001
    • Poeggeler, B.1    Miravalle, L.2    Zagorski, M.G.3
  • 67
    • 0035200670 scopus 로고    scopus 로고
    • Interaction between synthetic amyloid-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry
    • Skribanek Z, Balaspiri L, Mak M,. Interaction between synthetic amyloid-peptide (1-40) and its aggregation inhibitors studied by electrospray ionization mass spectrometry. J Mass Spectrom 2001; 36: 1226-1229.
    • (2001) J Mass Spectrom , vol.36 , pp. 1226-1229
    • Skribanek, Z.1    Balaspiri, L.2    Mak, M.3
  • 68
    • 0029447037 scopus 로고
    • Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation
    • Shabalina IG, Kolosova NG, Grishanova AIU, et al., Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation. Biokhimiia 1995; 60: 2045-2052.
    • (1995) Biokhimiia , vol.60 , pp. 2045-2052
    • Shabalina, I.G.1    Kolosova, N.G.2    Grishanova, A.I.U.3
  • 69
    • 0035712726 scopus 로고    scopus 로고
    • Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats
    • Kolosova NG, Aidagulova SV, Nepomnyashchikh GI, et al., Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats. Bull Exp Biol Med 2001; 132: 814-819.
    • (2001) Bull Exp Biol Med , vol.132 , pp. 814-819
    • Kolosova, N.G.1    Aidagulova, S.V.2    Nepomnyashchikh, G.I.3
  • 70
    • 79959919415 scopus 로고    scopus 로고
    • Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression
    • Markovets AM, Fursova AZ, Kolosova NG,. Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression. PLoS ONE 2011; 6: e21682.
    • (2011) PLoS ONE , vol.6
    • Markovets, A.M.1    Fursova, A.Z.2    Kolosova, N.G.3
  • 71
    • 84897911125 scopus 로고    scopus 로고
    • Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure
    • Vays VB, Eldarov CM, Vangely IM, et al., Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure. Aging 2014; 6: 140-148.
    • (2014) Aging , vol.6 , pp. 140-148
    • Vays, V.B.1    Eldarov, C.M.2    Vangely, I.M.3
  • 72
    • 84886891597 scopus 로고    scopus 로고
    • Potential of melatonin for prevention of age-related macular degeneration: experimental study
    • Stefanova N, Zhdankina A, Fursova A, et al., Potential of melatonin for prevention of age-related macular degeneration: experimental study. Adv Gerontol 2013; 26: 122-129.
    • (2013) Adv Gerontol , vol.26 , pp. 122-129
    • Stefanova, N.1    Zhdankina, A.2    Fursova, A.3
  • 73
    • 0034930202 scopus 로고    scopus 로고
    • Melatonin, vitamin E, and estrogen reduce damage induced by kainic acid in the hippocampus: potassium-stimulated GABA release
    • Ortiz GG, Sanchez-Ruiz MY, Tan DX, et al., Melatonin, vitamin E, and estrogen reduce damage induced by kainic acid in the hippocampus: potassium-stimulated GABA release. J Pineal Res 2001; 31: 62-67.
    • (2001) J Pineal Res , vol.31 , pp. 62-67
    • Ortiz, G.G.1    Sanchez-Ruiz, M.Y.2    Tan, D.X.3
  • 74
    • 84887789491 scopus 로고    scopus 로고
    • Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration
    • Sarlak G, Jenwitheesuk A, Chetsawang B, et al., Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. J Pharmacol Sci 2013; 123: 9-24.
    • (2013) J Pharmacol Sci , vol.123 , pp. 9-24
    • Sarlak, G.1    Jenwitheesuk, A.2    Chetsawang, B.3
  • 76
    • 69949118284 scopus 로고    scopus 로고
    • Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
    • Streit WJ, Braak H, Xue QS, et al., Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol 2009; 118: 475-485.
    • (2009) Acta Neuropathol , vol.118 , pp. 475-485
    • Streit, W.J.1    Braak, H.2    Xue, Q.S.3
  • 77
    • 43249126038 scopus 로고    scopus 로고
    • Oligodendroglial impact on axonal function and survival - a hypothesis
    • Kassmann CM, Nave KA,. Oligodendroglial impact on axonal function and survival-a hypothesis. Curr Opin Neurol 2008; 21: 235-241.
    • (2008) Curr Opin Neurol , vol.21 , pp. 235-241
    • Kassmann, C.M.1    Nave, K.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.