Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Markovets, Anton M ^a   Fursova, Anzhella Z ^a   Kolosova, Natalia G ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; EYE DROPS; MESSENGER RNA; PIGMENT EPITHELIUM DERIVED FACTOR; PLASTOQUINONYL DECYL TRIPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG; VASCULOTROPIN A; 10 (6' PLASTOQUINONYL)DECYLTRIPHENYLPHOSPHONIUM; 10-(6'-PLASTOQUINONYL)DECYLTRIPHENYLPHOSPHONIUM; DRUG DERIVATIVE; EYE PROTEIN; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; PLASTOQUINONE; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE PROTECTION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; MALE; NONHUMAN; OPHTHALMOSCOPY; OUTCOME ASSESSMENT; PIGMENT EPITHELIUM DERIVED FACTOR GENE; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINOPATHY; VASCULOTROPIN A GENE; ANIMAL; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; RETINA; RETINA MACULA DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; WISTAR RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANTIOXIDANTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; GENE EXPRESSION; HUMANS; MACULAR DEGENERATION; MALE; MITOCHONDRIA; NERVE GROWTH FACTORS; OPHTHALMOSCOPY; PLASTOQUINONE; RATS; RATS, WISTAR; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERPINS; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79959919415     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021682     Document Type: Article

References (28)

1. AREDS (Age-related eye disease study research group) (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol 119: 1417-1437.
2. Gale C, Hall N, Phillips D, Martyn C (2007) Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 44: 2461-2465.
3. Chong E, Wong T, Kreis A, Simpson J, Guymer R (2007) Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 335(7623): 755.
4. Tan JS, Mitchell P, Smith W, Wang JJ (2007) Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology 114(6): 1143-1150.
5. Kolosova NG, Lebedev PA, Aidagulova SV, Morozkova TS (2003) OXYS rats as a model of senile cataract. Bull Exp Biol Med 136(4): 415-419.
6. Zhdankina A, Fursova AZh, Logvinov SV, Kolosova NG (2008) Clinical and Morphological Characteristicsof Chorioretinal Degeneration in Early Aging OXYS Rats. Bull Exp Biol Med 146(4): 455-458.
7. Neroev VV, Archipova MM, Bakeeva LE, Fursova AZh, Grigorian EN, et al. (2008) Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals. Biochemistry (Mosc) 73(12): 1317-1328.
8. Saprunova VB, Pilipenko DI, Alexeevsky AV, Fursova AZh, Kolosovs NG, et al. (2010) Lipofuscin granule dynamics during the development of age-related macular degeneration. Biochemistry (Mosc) 75(2): 130-138.
9. Markovets AM, Saprunova VB, Zhdankina AA, Fursova AZn, Bakeeva LE, et al. (2011) Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats. Aging (Albany NY) 3(1): 44-54.
10. Solovyeva NA, Morozkova TS, Salganik RI (1975) Development of a rat subline with symptoms of hereditary galactosemia and study of its biochemical characteristics. Genetika 11(5): 63-71.
11. Obukhova LA, Skulachev VP, Kolosova NG (2009) Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats. Aging (Albany NY) 1(4): 389-401.
12. Shabalina IG, Kolpakov AR, Solov'ev VN, Kolosova NG, Panin LE (1995) Energy status of rat liver during the dynamics of cold adaptation. Biokhimiia 60(3): 441-449.
13. Kolosova NG, Aidagulova SV, Nepomnyashchikh GI, Shabalina IG, Shalbueva NI (2001) Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats. Bull Exp Biol Med 132(2): 814-819.
14. Marsili S, Salganik RI, Albright CD, Freel CD, Johnsen S, et al. (2004) Cataract formation in a strain of rats selected for high oxidative stress. Exp Eye Res 79(5): 595-612.
15. Skulachev VP (2007) A biochemical approach to the problem of aging: ''megaproject'' on membrane-penetrating ions. The first results and prospects. Biochemistry (Mosc) 72(12): 1385-1396.
16. Grisanti S, Tatar O (2008) The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration. Prog Retin Eye Res 27(4): 372-390.).
17. Ferrara N, Gerber H, LeCouter J (2003) The biology of VEGF and its receptor. Nat Med 9(6): 669-676.
18. Filleur S, Nelius T, de Riese W, Kennedy RC (2009) Characterization of PEDF: a multi-functional serpin family protein. J Cell Biochem 106(5): 769-775.
19. Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE (2000) Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am J Pathol 157(1): 135-144.
20. Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C, et al. (2006) Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp Eye Res 82(1): 99-110.
21. Skulachev VP, Anisimov VN, Antonenko YN, Bakeeva LE, Chernyak BV, et al. (2009) An attemnpt to prevent senescence: a mitochondrial approach. Blochim Biophys Acta 1787: 437-446.
22. Witmer AN, Dai J, Weich HA, Vrensen GF, Schlingemann RO (2002) Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia J Histochem Cytochem. 50(6): 767-777.
23. Feher J, Kovacs I, Artico M, Cavallotti C, Papale A, et al. (2006) Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging 27(7): 983-993.
24. Severin FF, Severina II, Antonenko YN, Rokitskaya TI, Cherepanov DA, et al. (2010) Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore. PNAS 107(2): 663-668.
25. Kliffen H, Sharma C, Mooy S, Kerkvliet P, de Jong TVM (1997) Increased expression of angiogenic growth factors in age-related maculopathy. M Br J Ophthalmol 81(2): 154-162.
26. Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, et al. (2010) Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell 21(18): 3247-3257.
27. Wolf S (2008) Current status of anti-vascular endothelial growth factor therapy in Europe Jpn J Ophthalmol. 52: 433-439.
28. Nolan T, Hands RE, Bustin SA (2006) Quantification of mRNA using real-time RT-PCR. Nat Protoc 1(3): 1559-1582.