Triazine-Substituted and Acyl Hydrazones: Experiment and Computation Reveal a Stability Inversion at Low pH

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 2924-2927

  Ji, Kun ^a   Lee, Changsuk ^a   Janesko, Benjamin G ^a   Simanek, Eric E ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

computation; hydrazine; hydrazone; pH labile; release; triazine

Indexed keywords

ALDEHYDE; ALIPHATIC KETONE; AROMATIC KETONE; FORMALDEHYDE; HYDRAZONE DERIVATIVE; KETONE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DENSITY FUNCTIONAL THEORY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; SUBSTITUTION REACTION; ACYLATION; CHEMISTRY; COMPUTER SIMULATION; KINETICS;

ACYLATION; ALDEHYDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; HYDRAZONES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KETONES; KINETICS; TRIAZINES;

EID: 84938347834     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00205     Document Type: Article

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