Imaging of doxorubicin release from theranostic macromolecular prodrugs via fluorescence resonance energy transfer

Journal of Controlled Release

Volumn 194, Issue , 2014, Pages 189-196

  Krüger, Harald R ^a   Schütz, Irene ^a   Justies, Aileen ^a   Licha, Kai ^b   Welker, Pia ^b   Haucke, Volker ^a   Calderón, Marcelo ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Mivenion GmbH   (Germany)

Author keywords

Drug delivery; FRET imaging; Intracellular release; Polymer therapeutic

Indexed keywords

DRUG DELIVERY; ENERGY TRANSFER; FORSTER RESONANCE ENERGY TRANSFER; FUNCTIONAL POLYMERS; MACROMOLECULES; PH SENSORS; TARGETED DRUG DELIVERY; THERANOSTICS;

CLEAVAGE KINETICS; CLOSE PROXIMITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDRAZONE BONDS; INTRACELLULAR RELEASE; MODE OF ACTION; POLYGLYCEROLS; POLYMER THERAPEUTIC;

CONTROLLED DRUG DELIVERY;

DOXORUBICIN; HYDRAZONE DERIVATIVE; NANOCARRIER; POLYGLYCEROL; PRODRUG; THERANOSTIC MACROMOLECULAR PRODRUG; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DRUG CARRIER; FLUORESCENT DYE; GLYCEROL; NANOPARTICLE; POLYMER;

ACIDITY; ARTICLE; CANCER CELL; CHEMICAL BOND; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RELEASE; DRUG STABILITY; FLUORESCENCE ANALYSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MTT ASSAY; PH; CHEMISTRY; DIAGNOSTIC IMAGING; HELA CELL LINE; KINETICS; PROCEDURES;

ANTIBIOTICS, ANTINEOPLASTIC; DIAGNOSTIC IMAGING; DOXORUBICIN; DRUG CARRIERS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; GLYCEROL; HELA CELLS; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; KINETICS; NANOPARTICLES; POLYMERS; PRODRUGS;

EID: 84907191580     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.08.018     Document Type: Article

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