Tetraarsenictetrasulfide and arsenic trioxide exert synergistic effects on induction of apoptosis and differentiation in acute promyelocytic leukemia cells

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Wang, Shuping ^a   Zhou, Min ^b   Ouyang, Jian ^b   Geng, Zhirong ^a   Wang, Zhilin ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR BETA; TETRAARSENICTETRASULFIDE; UNCLASSIFIED DRUG; ORGANOARSENIC DERIVATIVE; OXIDE; SULFIDE; TETRAARSENIC TETRASULFIDE; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER INHIBITION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PROMYELOCYTIC LEUKEMIA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA, PROMYELOCYTIC, ACUTE; METABOLISM; PATHOLOGY;

APOPTOSIS; ARSENICALS; CELL DIFFERENTIATION; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASM PROTEINS; OXIDES; REACTIVE OXYGEN SPECIES; SULFIDES;

EID: 84938341734     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130343     Document Type: Article

References (42)

1. Degos L (2003) The history of acute promyelocytic leukaemia. Brit J Haematol 122: 539-553. PMID: 12899709
2. De Thé H, Chomienne C, Lanotte M, Degos L, Dejean A (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 347: 558-561. PMID: 2170850
3. Wang ZY, Chen Z (2008) Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 111: 2505-2515. doi: 10.1182/blood-2007-07-102798 PMID: 18299451
4. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, et al. (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72: 567-572. PMID: 3165295
5. Iland HJ, Seymour JF (2013) Role of arsenic trioxide in acute promyelocytic leukemia. Curr Treat Option On 14: 170-184. doi: 10.1007/s11864-012-0223-3 PMID: 23322117
6. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, et al. (2004) All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. P Natl Acad Sci USA 101: 5328-5335. PMID: 15044693
7. Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, et al. (1997) Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 89: 3345-3353. PMID: 9129041
8. Zhang XW, Yan XJ, Zhou ZR, Yang FF, Wu ZY, Sun HB, et al. (2010) Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 328: 240-243. doi: 10.1126/science.1183424 PMID: 20378816
9. Ratnaike RN (2003) Acute and chronic arsenic toxicity. Postgrad Med J 79: 391-396. PMID: 12897217
10. Lengfelder E, Hofmann WK, Nowak D (2012) Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia. Leukemia 26: 433-442. doi: 10.1038/leu.2011.245 PMID: 21904379
11. Tapio S, Grosche B (2006) Arsenic in the aetiology of cancer. Mutat Res 612: 215-246. PMID: 16574468
12. Wang SP, Geng ZR, Shi Nan, Li XL, Wang ZL (2014) The functions of crucial cysteine residues in the arsenite methylation catalyzed by recombinant human arsenic (III) methyltransferase. PloS One 9: e110924. doi: 10.1371/journal.pone.0110924 PMID: 25349987
13. Thomas DJ, Styblo M, Lin S (2001) The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharm 176: 127-144. PMID: 11601889
14. Sharma VK, Sohn M (2009) Aquatic arsenic: toxicity, speciation, transformations, and remediation. Environ Int 35: 743-759. doi: 10.1016/j.envint.2009.01.005 PMID: 19232730
15. Chen SJ, Zhou GB, Zhang XW, Mao JH, de Thé H, Chen Z (2011) From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood 117: 6425-6437. doi: 10.1182/blood-2010-11-283598 PMID: 21422471
16. Wu J, Shao Y, Liu J, Chen G, Ho PC (2011) The medicinal use of realgar (As4S4) and its recent development as an anticancer agent. J Ethnopharmacol 135: 595-602. doi: 10.1016/j.jep.2011.03.071 PMID: 21497649
17. Liu J, Liang SX, Lu YF, Miao JW, Wu Q, Shi JS (2011) Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate. J Ethnopharmacol 134: 26-31. doi: 10.1016/j.jep.2010.11.052 PMID: 21129479
18. Lu DP, Qiu JY, Jiang B, Wang Q, Liu KY, Liu YR, et al. (2002) Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood 99: 3136-3143. PMID: 11964275
19. Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yan Xj, et al. (2008) Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. P Natl Acad Sci USA 105: 4826-4831. doi: 10.1073/pnas.0712365105 PMID: 18344322
20. Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis, an overview of cell death. Am J Pathol 146: 3-15. PMID: 7856735
21. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516. PMID: 17562483
22. Kumar S, Yedjou CG, Tchounwou PB (2014) Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. J Exp Clin Cancer Res 33: 42. doi: 10.1186/1756-9966-33-42 PMID: 24887205
23. Mathas S, Lietz A, Janz M, Hinz M, Jundt F, Scheidereit C, et al. (2003) Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis. Blood 102: 1028-1034. PMID: 12676792
24. Liu Q, Hilsenbeck S, Gazitt Y (2003) Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL. Blood 101: 4078-4087. PMID: 12531793
25. Chen J, Wei H, Xie B, Wang B, Cheng J, Cheng J (2012) Endoplasmic reticulum stress contributes to arsenic trioxide-induced apoptosis in drug-sensitive and-resistant leukemia cells. Leuk Res 36: 1526-1535. doi: 10.1016/j.leukres.2012.08.018 PMID: 22959511
26. Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, et al. (2000) The function of PML in p53-dependent apoptosis. Nat Cell Biol 2: 730-736. PMID: 11025664
27. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R (1991) NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77: 1080-1086. PMID: 1995093
28. Wang SP, Geng ZR, Shi N, Li XL, Wang ZL (2014) Dose-dependent effects of selenite (Se4+) on arsenite (As3+)-induced apoptosis and differentiation in acute promyelocytic leukemia cells. Cell Death Disease doi: 10.1038/cddis.2014.563
29. Wang SP, Shi N, Geng ZR, Li XL, Hu X, Wang ZL (2014) Inhibitory mechanism of dimercaptopropane-sulfonic acid (DMPS) in the cellular biomethylation of arsenic. Biochimie 106: 167-174. doi: 10.1016/j.biochi.2014.08.017 PMID: 25194983
30. Chou TC, Motzer RJ, Tong Y, Bosl GJ (1994) Computerized quantitation of synergism and antagonism of Taxol, topotecan and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 86: 1517-1524. PMID: 7932806
31. Zhang G, Gurtu V, Kain SR, Yan G (1997) Early detection of apoptosis using a fluorescent conjugate of annexin V. Biotechniques 23: 525-531. PMID: 9298227
32. Eruslanov E, Kusmartsev S (2010) Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 594: 57-72. doi: 10.1007/978-1-60761-411-1-4 PMID: 20072909
33. Jakoby M, Schnittger A (2004) Cell cycle and differentiation. Curr Opin Plant Biol 7: 661-669. PMID: 15491914
34. Darzynkiewicz Z, Zhao H, Halicka HD, Rybak P, Dobrucki J, Woldkowic D (2011) DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. Crit Rev Cl Lab Sci 49: 199-217.
35. He Y, Xu K, Keiner B, Zhou JF, Czudai V, Li TX, et al. (2010) Influenza A virus replication induces cell cycle arrest in G0/G1 phase. J Virol 84: 12832-12840. doi: 10.1128/JVI.01216-10 PMID: 20861262
36. Morse D, Choi AM (2005) Heme oxygenase-1: from bench to bedside. Am J Resp Crit Care 172: 660-670. PMID: 15901614
37. Pastorek M, Gronesova P, Cholujova D, Hunakova L, Bujnakova Z, Balaz P, et al. (2014) Realgar (As4S4) nanoparticles and arsenic trioxide (As2O3) induced autophagy and apoptosis in human melanoma cells in vitro. Neoplasma 61: 700-709. doi: 10.4149/neo-2014-085 PMID: 25150315
38. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Gene Dev, 13: 1899-1911. PMID: 10444588
39. Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC (2003) Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22: 8608-8618. PMID: 14634622
40. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. (2003) p53 Has a Direct Apoptogenic Role at the Mitochondria. Mol Cell 11: 577-590. PMID: 12667443
41. Li J, Lee B, Lee AS (2006) Endoplasmic Reticulum Stress-induced Apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem 281: 7260-7270. PMID: 16407291
42. Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, et al. (2000) Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia 14: 262-270. PMID: 10673743