A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 2712-2731

  Choi, Jin Huk ^a   Jonsson Schmunk, Kristina ^a   Qiu, Xiangguo ^b   Shedlock, Devon J ^c   Strong, Jim ^b   Xu, Jason X ^a   Michie, Kelly L ^a   Audet, Jonathan ^b   Fernando, Lisa ^b   Myers, Mark J ^a   Weiner, David ^c   Bajrovic, Irnela ^d   Tran, Lilian Q ^a   Wong, Gary ^b   Bello, Alexander ^b   Kobinger, Gary P ^b,c   Schafer, Stephen C ^a   Croyle, Maria A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d University of Texas at Austin   (United States)

Author keywords

adenovirus; Ebola; non human primate; respiratory; sublingual; vaccine

Indexed keywords

ADENOVIRUS VACCINE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; NITROGEN; PHOSPHATE; UREA; VIRUS GLYCOPROTEIN; VIRUS RNA; EBOLA VACCINE; RECOMBINANT VACCINE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY TEMPERATURE; BODY WEIGHT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL OBSERVATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; EBOLA HEMORRHAGIC FEVER; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNIZATION; LIMIT OF DETECTION; MACACA FASCICULARIS; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEROTYPE; SINGLE DRUG DOSE; THROMBOCYTE COUNT; UREA NITROGEN BLOOD LEVEL; VIRUS GENOME; VIRUS PARTICLE; ADENOVIRIDAE; ANIMAL; CELL CULTURE; CHLOROCEBUS AETHIOPS; EBOLAVIRUS; GENETICS; HEK293 CELL LINE; HEMORRHAGIC FEVER, EBOLA; HUMAN; IMMUNOLOGY; PROCEDURES; VACCINATION; VERO CELL LINE;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; EBOLA VACCINES; EBOLAVIRUS; HEK293 CELLS; HEMORRHAGIC FEVER, EBOLA; HUMANS; MACACA FASCICULARIS; MALE; VACCINATION; VACCINES, SYNTHETIC; VERO CELLS;

EID: 84938320743     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500646d     Document Type: Article

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