A single sublingual dose of an adenovirus-based vaccine protects against lethal ebola challenge in mice and guinea pigs

Molecular Pharmaceutics

Volumn 9, Issue 1, 2012, Pages 156-167

  Choi, Jin Huk ^a   Schafer, Stephen C ^a   Zhang, Lihong ^b   Kobinger, Gary P ^c   Juelich, Terry ^b   Freiberg, Alexander N ^b   Croyle, Maria A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

adenovirus 5; CD4 T cell; Ebola Zaire; guinea pig; memory response; mouse; pre existing immunity; sublingual; toxicity; vaccine

Indexed keywords

ADENOVIRUS VECTOR; EBOLA VACCINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; EBOLA HEMORRHAGIC FEVER; GUINEA PIG; IMMUNOHISTOCHEMISTRY; MALE; MESENTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC ANIMAL;

ADENOVIRIDAE; ADMINISTRATION, SUBLINGUAL; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD11C; ANTIGENS, VIRAL; CELL LINE; EBOLA VACCINES; EBOLAVIRUS; GUINEA PIGS; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNITY, CELLULAR; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; MALE; MICE; MOUTH MUCOSA; RECOMBINANT PROTEINS; SURVIVAL ANALYSIS; TRANSGENES;

EID: 84855424528     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200392g     Document Type: Article

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