Artificial nerve tubes and their application for repair of peripheral nerve injury: an update of current concepts

Injury

Volumn 39, Issue SUPPL.4, 2008, Pages 29-39

  Ichihara, Satoshi ^a,c   Inada, Yuji ^a,b   Nakamura, Tatsuo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Inada Hospital   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

autogenous nerve grafts; nerve guides; nerve injury; Nerve tubes

Indexed keywords

ARTICLE; ARTIFICIAL NERVE TUBE; AUTOGRAFT; BIOMEDICINE; CLINICAL PRACTICE; HAND SURGERY; HUMAN; MORBIDITY; MOTOR NERVE; NERVE ENDING; NERVE FUNCTION; NERVE GRAFT; NERVE REGENERATION; NERVE TRANSPLANTATION; NONHUMAN; ORGAN DONOR; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; POLITEF IMPLANT; PRIORITY JOURNAL; SCHWANN CELL; SILASTIC TUBE; SURGEON; TISSUE ENGINEERING; TRANSPLANTATION TOLERANCE; TREATMENT INDICATION;

GUIDED TISSUE REGENERATION; HUMANS; NERVE REGENERATION; PERIPHERAL NERVES; PROSTHESIS IMPLANTATION; TISSUE SCAFFOLDS; TRANSPLANTATION, AUTOLOGOUS;

EID: 51649113948     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2008.08.029     Document Type: Article

References (120)

1. Aebischer P., Guenard V., Winn S.R., et al. Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump. Brain Res. 454 (1988) 179-187
2. Almgren K.G. Revascularization of free pheripheral nerve grafts. An experimental study in the rabbit. ActaOrthop Scand Suppl. 154 (1975) 1-104
3. Archibald S.J., Krarup C., Shefner J., et al. A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. J Comp Neurol. 306 (1991) 685-696
4. Archibald S.J., Shefner J., Krarup C., et al. Monkey median nerve repaired by nerve graft or collagen nerve guide tube. J Neurosci. 15 (1995) 4109-4123
5. Battiston B., Geuna S., Ferrero M., and Tos P. Nerve repair by means of tubulization: literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair. Microsurgery 25 4 (2005) 258-267
6. Bertleff M.J., Meek M.F., and Nicolai J.P. Aprospective clinical evaluation of biodegradable neurolac nerve guides for sensory nerve repair in the hand. J Hand Surg [Am]. 30 (2005) 513-518
7. Braga-Silva J. The use of silicone tubing in the late repair of the median and ulnar nerves in the forearm. J Hand Surg [Br]. 24 6 (1999) 703-706
8. Brown R.E., Erdmann D., Lyons S.F., et al. The use of cultured Schwann cells in nerve repair in a rabbit hind-limb model. J Reconstr Microsurg. 12 (1996) 149-152
9. Bunger O.V. Uber die Degenerations- und Regenerationsvorgange am Nerven nach Verletzungen. Beitr. Pathol. Anat. 10 (1981) 321-387
10. Casella G.T., Bunge R.P., and Wood P.M. Improved method for harvesting human Schwann cells from mature peripheral nerve and expansion in vitro. Glia. 17 (1996) 327-338
11. Chang J.Y., Lin J.H., Yao C.H., et al. In vivo evaluation of a biodegradable EDC/NHS-cross-linked gelatin peripheral nerve guide conduit material. Macromol Biosci. 7 (2007) 500-507
12. Chang C.J., Hsu S.H., Yen H.J., et al. Effects of unidirectional permeability in asymmetric poly(DL-lactic acid-co-glycolic acid) conduits on peripheral nerve regeneration: an in vitro and in vivo study. J Biomed Mater Res B Appl Biomater 83 (2007) 206-215
13. Chen H.T., Yao C.H., Lee Chao P.D., et al. Effect of serum metabolites of pueraria lobata in rats on peripheral nerve regeneration: in vitro and in vivo studies. J Biomed Mater Res Part B: Appl Biomater. 84B (2008) 256-262
14. Chew S.Y., Mi R., Hoke A., et al. The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. Biomaterials 29 (2008) 653-661
15. Crawley W.A., and Dellon A.L. Inferior alveolar nerve reconstruction with a polyglycolic acid bioabsorbable nerve conduit. Plast Reconstr Surgb. 90 2 (1992) 300-302
16. Dahlin L.B., Anagnostaki L., and Lundborg G. Tissue response to silicone tubes used to repair human median and ulnar nerves. Scand J Plast Reconstr Surg Hand Surg. 35 1 (2001) 29-34
17. Danielsen N., Williams L.R., Dahlin L.B., et al. Peripheral nerve regeneration in Gore-tex chambers. Scand J Plast Reconstr Surg Hand Surg. 22 3 (1988) 207-210
18. Danielsen N., and Varon S. Characterization of neurotrophic activity in the silicone-chamber model for nerve regeneration. J Reconstr Microsurg. 11 (1995) 231-235
19. Dellon A.L., and Mackinnon S.E. An alternative to the classical nerve graft for the management of the short nerve gap. Plast Reconstr Surg. 82 (1988) 849-856
20. den Dunnen W.F., Stokroos I., Blaauw E.H., et al. Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide-epsilon-caprolacton) nerve guide. J Biomed Mater Res. 31 (1996) 105-115
21. Ducic I., Maloney Jr. C.T., and Dellon A.L. Reconstruction of the spinal accessory nerve with autograft or neurotube? Two case reports. J Reconstr Microsurg. 21 1 (2005) 29-33 discussion: 34
22. Evans G.R. Challenges to nerve regeneration. Semin Surg Oncol. 19 (2000) 312-318
23. Fu S.Y., and Gordon T. The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol. 14 (1997) 67-116
24. Gibson K.L., Remson L., Smith A., et al. Comparison of nerve regeneration through different types of neural prostheses. Microsurgery 12 (1991) 80-85
25. Gomez N., Cuadras J., Buti M., et al. Histologic assessment of sciatic nerve regeneration following resection and graft or tube repair in the mouse. Rest Neurol Neurosci. 10 (1996) 187-196
26. Griffin JW, Hoffman PN. Degeneration and regeneration in the peripheral nervous system. In: Dyck PJ, Thomas P, eds. Peripheral Neuropathy. WB Saunders 1993.
27. Grumbles R.M., Wood P., Rudinsky M., et al. Muscle reinnervation with delayed or immediate transplant of embryonic ventral spinal cord cells into adult rat peripheral nerve. Cell Transplant. 11 (2002) 241-250
28. Grumbles R.M., Casella G.T., Rudinsky M.J., et al. The immunophilin ligand FK506, but not the P38 kinase inhibitor SB203580, improves function of adult rat muscle reinnervated from transplants of embryonic neurons. Neuroscience 130 (2005) 619-630
29. Grumbles R.M., Casella G.T., Rudinsky M.J., et al. Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. J Neurosci Res. 85 9 (2007) 1933-1942
30. Habas C. Basic principles of diffusion tensor MR tractography. J Radiol. 85 (2004) 281-286
31. Hagiwara A., Nakashima S., Itoh T., et al. Clinical application of PGA-tube for regeneration of intrapelvic nerves during extended surgery for intrapelvic recurrent rectal cancer. Gan To Kagaku Ryoho. 29 (2002) 2002-2004
32. Heath C.A., and Rutkowski G.E. The development of bioartificial nerve grafts for peripheral-nerve regeneration. Trends Biotechnol. 16 (1998) 163-168
33. Hentz V.R., Rosen J.M., Xiao S.J., et al. A comparison of suture and tubulization nerve repair techniques in a primate. J Hand Surg [Am]. 16 (1991) 251-261
34. Heumann R. Regulation of the synthesis of nerve growth factor. J Exp Biol. 132 (1987) 133-150
35. Hsu S.H., Lu P.S., Ni H.C., et al. H. Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits. Biomed Microdevices 9 (2007) 665-674
36. Ide C. Peripheral nerve regeneration. Neurosci Res 25 (1996) 101-121
37. Inada Y., Morimoto S., Takakura Y., et al. Regeneration of peripheral nerve gaps with a polyglycolic acid-collagen tube. Neurosurgery 55 3 (2004) 640-646 discussion: 646-648
38. Inada Y., Morimoto S., Moroi K., et al. Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. Pain. 117 (2005) 251-258
39. Inada Y., Moroi K., Morimoto S., et al. Effective surgical relief of complex regional pain syndrome (CRPS) using a PGA-collagen nerve guide tube, with successful weaning from spinal cord stimulation. Clin J Pain. 23 9 (2007) 829-830
40. Inada Y, Morimoto S, Tsutsumi H, et al. Regeneration of peripheral motor nerve gaps with a polyglycolic acid-collagen tube. Neurosurgery. 2007; in press.
41. IJkema-Paassen J., Jansen K., Gramsbergen A., et al. Transection of peripheral nerves, bridging strategies and effect evaluation. Biomaterials. 25 (2004) 1583-1592
42. Jansen K., van der Werff J.F., van Wachem P.B., et al. A hyaluronan-based nerve guide: in vitro cytotoxicity, subcutaneous tissue reactions, and degradation in the rat. Biomaterials. 25 (2004) 483-489
43. Kandenwein J.A., Kretschmer T., Engelhardt M., et al. Surgical interventions for traumatic lesions of the brachial plexus: a retrospective study of 134 cases. J Neurosurg. 103 (2005) 614-621
44. Kay S.P. Obstetrical brachial palsy. Br J Plast Surg. 51 (1998) 43-50
45. Keeley R.D., Nguyen K.D., Stephanides M.J., et al. The artificial nerve graft: a comparison of blended elastomer-hydrogel with polyglycolic acid conduits. J Reconstr Microsurg. 7 (1991) 93-100
46. Kemp S.W., Walsh S.K., Zochodne D.W., et al. A novel method for establishing daily in vivo concentration gradients of soluble nerve growth factor (NGF). J Neurosci Methods. 165 (2007) 83-88
47. Kim D.H., Connolly S.E., Zhao S., et al. Comparison of macropore, semipermeable, and nonpermeable collagen conduits in nerve repair. J Reconstr Microsurg. 9 (1993) 415-420
48. Kim J., and Dellon A.L. Reconstruction of a painful post-traumatic medial plantar neuroma with a bioabsorbable nerve conduit: a case report. J Foot Ankle Surg. 40 5 (2001) 318-323
49. Kingham P.J., and Terenghi G. Bioengineered nerve regeneration and muscle reinnervation. J Anat. 209 (2006) 511-526
50. Kiyotani T., Nakamura T., Shimizu Y., et al. Experimental study of nerve regeneration in a biodegradable tube made from collagen and polyglycolic acid. Asaio J. 41 (1995) M657-661
51. Krarup C., Archibald S.J., and Madison R.D. Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve. Ann Neurol. 51 (2002) 69-81
52. Kretschmer T., Antoniadis G., Braun V., et al. Evaluation of iatrogenic lesions in 722 surgically treated cases of peripheral nerve trauma. J Neurosurg. 94 (2001) 905-912
53. Labrador R.O., Buti M., and Navarro X. Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair. Exp Neurol. 149 (1998) 243-252
54. Langone F., Lora S., Veronese F.M., et al. Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis. Biomaterials 16 (1995) 347-353
55. Laroas G., Battiston G., Sard A., et al. Digital nerve reconstruction with the bioabsorbable Neurotube. Clin Exp Plast Surg. 35 (2003) 125-128
56. Li S.T., Archibald S.J., Krarup C., et al. Peripheral nerve repair with collagen conduits. Clin Mater. 9 (1992) 195-200
57. Lietz M., Ullrich A., Schulte-Eversum C., et al. Physical and biological performance of a novel block copolymer nerve guide. Biotechnol Bioeng. (2006) 99-109
58. Lindholm D., Heumann R., Meyer M., et al. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330 (1987) 658-659
59. Longo F.M., Manthorpe M., Skaper S.D., et al. Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Res. 261 (1983) 109-116
60. Longo F.M., Skaper S.D., Manthorpe M., et al. Temporal changes of neuronotrophic activities accumulating in vivowithin nerve regeneration chambers. Exp Neurol. 81 (1983) 756-769
61. Longo F.M., Hayman E.G., Davis G.E., et al. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res. 309 (1984) 105-117
62. Lundborg G., Dahlin L.B., Danielsen N., et al. Nerve regeneration across an extended gap: a neurobiological viewof nerve repair and the possible involvement of neuronotrophic factors. J Hand Surg [Am]. 7 (1982) 580-587
63. Lundborg G., Longo F.M., and Varon S. Nerve regeneration model and trophic factors in vivo. Brain Res. 232 (1982) 157-161
64. Lundborg G., Dahlin L.B., Danielsen N., et al. Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp Neurol. 76 (1982) 361-375
65. Lundborg G., Gelberman R.H., Longo F.M., et al. In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap. J Neuropathol Exp Neurol. 41 (1982) 412-422
66. Lundborg G, Nerve injury and Repair. 1st ed. Edinburgh: Churchill Livingstone; 1988.
67. Lundborg G., Dahlin L.B., and Danielsen N. Ulnar nerve repair by the silicone chamber technique. Case report. Scand. J Plast Reconstr Surg Hand Surg. 25 1 (1991) 79-82
68. Lundborg G., Rosen B., Abrahamson S.O., et al. Tubular repair of themedian nerve in the human forearm. Preliminary findings. J Hand Surg [Br]. 19 3 (1994) 273-276
69. Lundborg G., Rosen B., Dahlin L., et al. Tubular versus conventional repair of median and ulnar nerves in the human forearm: early results from a prospective, randomized, clinical study. J Hand Surg [Am]. 22 (1997) 99-106
70. Lundborg G. Nerve injury and Repair. 2nd ed. Edinburgh: Churchill Livingstone; 2004.
71. Lundborg G., Rosen B., Dahlin L., et al. Tubular repair of the median or ulnar nerve in the human forearm: a 5-year followup. J Hand Surg. [Br] 29 (2004) 100-107
72. Luo Y., Wang T., and Fang H. Clinical application of implantation of vascular bundle into silicone tube to bridge the peripheral nerve defect. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 11 6 (1997) 340-342
73. Lykissas M.G., Sakellarion E., Vekris M.D., et al. Axonal regeneration stimulated by erythropoietin: an experimental study in rats. J Neurosci Methods 164 (2007) 107-115
74. Mackinnon S.E., and Dellon A.L. Astudy of nerve regeneration across synthetic (Maxon) and biologic (collagen) nerve conduits for nerve gaps up to 5 cm in the primate. J Reconstr Microsurg 6 (1990) 117-121
75. Mackinnon S.E., and Dellon A.L. Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube. Plast Reconstr Surg. 85 (1990) 419-424
76. Madison RM, Archibald SJ, Krarup C.Wound Healing. In: Cohen IK, Diegelmann RF, Lindblad ed. Philadelphia: Saunders 1992, 450.
77. Madison RD, Archibald SJ. Potential value of synthetic tubes for nerve repair. In: Wilkins RH, Rengachary SS, eds. Neurosurgery. 2nd ed. New York: McGraw-Hill; 1996.
78. Matsumoto K., Ohnishi K., Kiyotani T., et al. Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res. 868 (2000) 315-328
79. Maquet V., Martin D., Malgrange B., et al. Peripheral nerve regeneration using bioresorbable macroporous polylactide scaffolds. J Biomed Mater Res. 52 (2000) 639-651
80. Meek M.F., Bertleff M.J., Ritt M.J., et al. [A degradable artificial nerve guide to bridge peripheral nerve defects]. Ned Tijdschr Geneeskd. 147 (2003) 717-721
81. Merle M., Dellon A.L., Campbell J.N., et al. Complications from silicon-polymer intubulation of nerves. Microsurgery 10 (1989) 130-133
82. Millesi H. Nerve transplantation for reconstruction of peripheral nerves injured by the use of the microsurgical technic. Minerva Chir. 22 (1967) 950-951
83. Moneim M, Omer G. Clinical outcome following acute nerve repair. In: Omeg G, Spinner M, Van Beek A, editors. Management of peripheral nerve problems. Philadelphia: Saunders. 1998, 414-419.
84. Muller H.W., and Stoll G. Nerve injury and regeneration: basic insights and therapeutic interventions. Curr Opin Neurol. 11 (1998) 557-562
85. Nakamura T., Inada Y., Fukuda S., et al. Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube. Brain Res. 1027 (2004) 18-29
86. Navarro X., Rodriguez F.J., Labrador R.O., et al. Peripheral nerve regeneration through bioresorbable and durable nerve guides. J Peripher Nerv Syst. 1 (1996) 53-64
87. Navissano M., Malan F., Carnino R., et al. Neurotube for facial nerve repair. Microsurgery 25 4 (2005) 268-271
88. Nichols C.M., Myckatyn T.M., Rickman S.R., et al. Choosing the correct functional assay: a comprehensive assessment of functional tests in the rat. Behav Brain Res. 163 (2005) 143-158
89. Nicoli Aldini N., Perego G., Cella G.D., et al. Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves. Biomaterials 17 10 (1996) 959-962
90. Pieraut S., Laurent-Matha V., Sar C., et al. NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons. J Neurosci. 27 (2007) 6751-6759
91. Pitta M.C., Wolford L.M., Mehra P., and Hopkin J. Use of Gore-Tex tubing as a conduit for inferior alveolar and lingual nerve repair: experience with 6 cases. J Oral Maxillofac Surg. 59 5 (2001) 493-496 discussion: 497
92. Pogrel M.A., McDonald A.R., and Kaban L.B. Gore-Tex tubing as a conduit for repair of lingual and inferior alveolar nerve continuity defects: a preliminary report. J Oral Maxillofac Surg. 56 3 (1998) 319-321 discussion: 321-322
93. Rodriguez F.J., Gomez N., Perego G., et al. Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps. Biomaterials 20 (1999) 1489-1500
94. Rodriguez F.J., Verdu E., Ceballos D., et al. Nerve guides seeded with autogenous schwann cells improve nerve regeneration. Exp Neurol. 161 (2000) 571-584
95. Rosen J.M., Padilla J.A., Nguyen K.D., et al. Artificial nerve graft using collagen as an extracellular matrix for nerve repair compared with sutured autograft in a rat model. Ann Plast Surg. 25 (1990) 375-387
96. Rosson GD, Swier P, Kim J, et al. Reconstruction of forearm median nerve deficit with four interfascicular interposition NeurotubeTM reconstructions. J Bone Joint Surg. In press.
97. Rosson GD, Dellon AL. Reconstruction of the motor function with the NeurotubeTM. Report of a case and review of the literature. J Reconstr Microsurg. In press.
98. Rosson GD, Dellon AL. Reconstruction of the motor function with the NeurotubeTM. Report of a case and review of the literature. J Reconstr Microsurg. In press.
99. Sanders F.K., and Young J.Z. The influence of peripheral connexion on the diameter of regenerating nerve fibers. J Exp Biol. 22 (1946) 203-212
100. Schlosshauer B., Muller E., Schroder B., et al. W. Rat Schwann cells in bioresorbable nerve guides to promote and accelerate axonal regeneration. Brain Res. 963 (2003) 321-326
101. Schlosshauer B., Dreesmann L., Schaller H.E., et al. Synthetic nerve guide implants in humans: a comprehensive survey. Neurosurgery. 59 (2006) 740-747 discussion 747-748
102. Seckel B.R., Chiu T.H., Nyilas E., et al. Nerve regeneration through synthetic biodegradable nerve guides: regulation by the target organ. Plast Reconstr Surg. 74 (1984) 173-181
103. Seo K, Inada Y, Terumitsu T, et al. One year prognosis of damaged lingual nerve repair using a PGA-collagen tube: a case report. J Oral Maxillofacial Surg. 2007. in press.
104. Sinis N., Schaller H.E., Schulte-Eversum C., et al. Nerve regeneration across a 2-cm gap in the rat median nerve using a resorbable nerve conduit filled with Schwann cells. J Neurosurg. 103 (2005) 1067-1076
105. Stanec S., and Stanec Z. Reconstruction of upper-extremity peripheral-nerve injuries with ePTFE conduits. J Reconstr Microsurg. 14 (1998) 227-232
106. Stanec S., and Stanec Z. Ulnar nerve reconstruction with an expanded polytetrafluoroethylene conduit. Br J Plast Surg. 51 8 (1998) 637-639
107. Tanaka S., Takigawa T., Ichihara S., and Nakamura T. Mechanical properties of the bioabsorbable polyglycolic acid-collagen nerve guide tube. Polym. Eng. Sci. 47 (2006) 1461-1467
108. Terzis J.K., and Papakonstantinou K.C. The surgical treatment of brachial plexus injuries in adults. Plast Reconstr Surg. 106 (2000) 1097-1122
109. Thoenen H., Bandtlow C., Heumann R., et al. Nerve growth factor: cellular localization and regulation of synthesis. Cell Mol Neurobiol. 8 (1988) 35-40
110. Thomas C.K., Erb D.E., Grumbles R.M., et al. Embryonic cord transplants in peripheral nerve restore skeletal muscle function. J Neurophysiol. 84 (2000) 591-595
111. Utley D.S., Lewin S.L., Cheng E.T., et al. Brain-derived neurotrophic factor and collagen tubulization enhance functional recovery after peripheral nerve transection and repair. Arch Otolaryngol Head Neck Surg. 122 (1996) 407-413
112. van Dijk J.G., Pondaag W., and Malessy M.J. Obstetric lesions of the brachial plexus. Muscle Nerve. 24 (2001) 1451-1461
113. Waitayawinyu T., Parisi D.M., Miller B., et al. A comparison of polyglycolic Acid versus type 1 collagen bioabsorbable nerve conduits in a rat model: an alternative to autografting. J Hand Surg [Am]. 32 (2007) 1521-1529
114. Waller A. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alteration produced thereby in the structure of their primitive fibers. Philos. Trans. R. Soc. London (Biol. ) 140 (1850) 423-429
115. Weber R.A., Breidenbach W.C., Brown R.E., et al. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg. 106 (2000) 1036-1045 discussion 1046-1048
116. Wiberg M., and Terenghi G. Will it be possible to produce peripheral nerves?. Surg Technol Int 11 (2003) 303-310
117. Williams L.R., Longo F.M., Powell H.C., et al. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol. 218 (1983) 460-470
118. Yannas I.V., Zhang M., and Spilker M.H. Standardized criterion to analyze and directly compare various materials and models for peripheral nerve regeneration. J Biomater Sci Polym Ed. 18 (2007) 943-966
119. Yoshitani M., Fukuda S., Itoi S., et al. Experimental repair of phrenic nerve using a polyglycolic acid and collagen tube. J Thorac Cardiovasc Surg. 133 (2007) 726-732
120. Yoshii S., Oka M., Ikeda N., et al. Bridging a peripheral nerve defect using collagen filaments. J Hand Surg. [Am] 26 (2001) 52-59